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• 2020

  Distinctive sphingolipid patterns in chronic multiple sclerosis lesions

  Podbielska, M., Szulc, Z. M., Ariga, T., Pokryszko-Dragan, A., Fortuna, W., Bilinska, M., Podemski, R., Jaskiewicz, E., Kurowska, E., Yu, R. K. & Hogan, E. L., Nov 2020, In: Journal of Lipid Research. 61, 11, p. 1464-1479 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biomarkers
  • Sphingolipids
  • dihydroceramide
  • Multiple Sclerosis
  • ceramide 1-phosphate

• Enhanced Susceptibility to Chemoconvulsant-Induced Seizures in Ganglioside GM3 Synthase Knockout Mice

  Tang, F. L., Wang, J., Itokazu, Y. & Yu, R. K., 2020, In: ASN Neuro. 12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • haematoside synthetase
  • G(M3) Ganglioside
  • Knockout Mice
  • Seizures
  • Neurogenesis

• Ganglioside GD3 regulates dendritic growth in newborn neurons in adult mouse hippocampus via modulation of mitochondrial dynamics

  Tang, F., Wang, J., Itokazu, Y. & Yu, R. K., 2020, (Accepted/In press) In: Journal of Neurochemistry.

  Research output: Contribution to journal › Article › peer-review

  • GD3 ganglioside
  • Mitochondrial Dynamics
  • Neurons
  • Brain
  • Hippocampus
  1 Scopus citations
• 2019

  Intracerebroventricular Infusion of Gangliosides Augments the Adult Neural Stem Cell Pool in Mouse Brain

  Itokazu, Y., Li, D. & Yu, R. K., 2019, In: ASN Neuro. 11

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intraventricular Infusions
  • Gangliosides
  • Adult Stem Cells
  • Neural Stem Cells
  • GD3 ganglioside
• 2018

  Gangliosides in Nerve Cell Specification

  Itokazu, Y., Wang, J. & Yu, R. K., Jan 1 2018, Progress in Molecular Biology and Translational Science. Schnaar, R. L. & Lopez, P. H. H. (eds.). Elsevier B.V., p. 241-263 23 p. (Progress in Molecular Biology and Translational Science; vol. 156).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Gangliosides
  • Neural Stem Cells
  • Neurons
  • Brain
  • Epigenomics
  7 Scopus citations
• 2017

  Epigenetic regulation of ganglioside expression in neural stem cells and neuronal cells

  Itokazu, Y., Tsai, Y. T. & Yu, R. K., Dec 1 2017, In: Glycoconjugate Journal. 34, 6, p. 749-756 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Stem cells
  • Gangliosides
  • Neural Stem Cells
  • Genes
  • Epigenomics
  15 Scopus citations

• Special issue: Glycobiology on stem cells ---editorial

  Kawasaki, T. & Yu, R. K., Dec 1 2017, In: Glycoconjugate Journal. 34, 6, p. 691 1 p.

  Research output: Contribution to journal › Editorial › peer-review
  1 Scopus citations
• 2016

  A2B5+/GFAP+ Cells of Rat Spinal Cord Share a Similar Lipid Profile with Progenitor Cells: A Comparative Lipidomic Study

  Itokazu, Y., Tajima, N., Kerosuo, L., Somerharju, P., Sariola, H., Yu, R. K. & Käkelä, R., Jul 1 2016, In: Neurochemical Research. 41, 7, p. 1527-1544 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Rats
  • Glial Fibrillary Acidic Protein
  • Cells
  • Spinal Cord
  • Stem Cells
  5 Scopus citations

• Anti-Sulfoglucuronosyl Paragloboside Antibody: A Potential Serologic Marker of Amyotrophic Lateral Sclerosis

  Li, D., Usuki, S., Quarles, B., Rivner, M. H., Ariga, T. & Yu, R. K., Sep 1 2016, In: ASN Neuro. 8, 5

  Research output: Contribution to journal › Article › peer-review

  • sulfate-3-glucuronyl paragloboside
  • Amyotrophic Lateral Sclerosis
  • Antibodies
  • Motor Neurons
  • Amyotrophic lateral sclerosis 1
  1 Scopus citations

• Dietary isomers of sialyllactose increase ganglioside sialic acid concentrations in the corpus callosum and cerebellum and modulate the colonic microbiota of formula-fed piglets

  Jacobi, S. K., Yatsunenko, T., Li, D., Dasgupta, S., Yu, R. K., Berg, B. M., Chichlowski, M. & Odle, J., 2016, In: Journal of Nutrition. 146, 2, p. 200-208 9 p.

  Research output: Contribution to journal › Article › peer-review

  • N-acetylneuraminoyllactose
  • 6'-sialyllactose
  • Gangliosides
  • N-Acetylneuraminic Acid
  • Corpus Callosum
  35 Scopus citations

• Erratum: Novel GM1 ganglioside-like peptide mimics prevent the association of cholera toxin to human intestinal epithelial in vitro

  Yu, R. K., Usuki, S., Itokazu, Y. & Wu, H. C., May 1 2016, In: Glycobiology. 26, 5, p. 540 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  1 Scopus citations

• GM1 ganglioside is involved in epigenetic activation loci of neuronal cells

  Tsai, Y. T., Itokazu, Y. & Yu, R. K., Oct 24 2016, In: Neurochemical Research. 41, 1-2, p. 107-115 9 p.

  Research output: Contribution to journal › Article › peer-review

  • G(M1) Ganglioside
  • Histones
  • Gangliosides
  • Genes
  • Chemical activation
  18 Scopus citations
• 2015

  Ganglioside-dependent neural stem cell proliferation in alzheimer’s disease model mice

  Koon, N. A., Itokazu, Y. & Yu, R. K., Nov 9 2015, In: ASN Neuro. 7, 6

  Research output: Contribution to journal › Article › peer-review

  • Gangliosides
  • Neural Stem Cells
  • Alzheimer Disease
  • Cell Proliferation
  • Glycoconjugates
  5 Scopus citations

• Glycolipid Antigens in Neural Stem Cells

  Itokazu, Y. & Yu, R. K., Apr 15 2015, Neural Surface Antigens: From Basic Biology Towards Biomedical Applications. Elsevier Inc., p. 91-102 12 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • neural stem cells
  • Stem cells
  • Glycolipids
  • Neural Stem Cells
  • glycolipids

• Neuroglycobiology: Role of glycans in neurobiology and neuroscience glycoconjugate antigens in neural stem cells

  Itokazu, Y. & Yu, R. K., Jan 1 2015, Glycoscience: Biology and Medicine. Springer Japan, p. 495-504 10 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Neurobiology
  • Stem cells
  • Glycoconjugates
  • Neural Stem Cells
  • Neurosciences

• Novel GM1 ganglioside-like peptide mimics prevent the association of cholera toxin to human intestinal epithelial cells in vitro

  Yu, R. K., Usuki, S., Itokazu, Y. & Wu, H. C., Jun 11 2015, In: Glycobiology. 26, 1, p. 63-73 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Epithelial Cells
  • G(M1) Ganglioside
  • Cholera Toxin
  • Peptides
  • In Vitro Techniques
  9 Scopus citations
• 2014

  Amyloid β-Peptide 1–42 Modulates the Proliferation of Mouse Neural Stem Cells: Upregulation of Fucosyltransferase IX and Notch Signaling

  Itokazu, Y. & Yu, R. K., Oct 2 2014, In: Molecular Neurobiology. 50, 1, p. 186-196 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Fucosyltransferases
  • Neural Stem Cells
  • Amyloid
  • Up-Regulation
  • Peptides
  18 Scopus citations

• A new approach to ELISA-based anti-glycolipid antibody evaluation of highly adhesive serum samples

  Usuki, S., O'Brien, D., Rivner, M. H. & Yu, R. K., Jun 2014, In: Journal of Immunological Methods. 408, p. 52-63 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycolipids
  • Adhesives
  • Chronic Inflammatory Demyelinating Polyradiculoneuropathy
  • Anti-Idiotypic Antibodies
  • Glycosphingolipids
  4 Scopus citations

• Epigenetic activation of mouse ganglioside synthase genes: Implications for neurogenesis

  Tsai, Y. T. & Yu, R. K., Jan 2014, In: Journal of Neurochemistry. 128, 1, p. 101-110 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene encoding
  • Gangliosides
  • Glycosyltransferases
  • Neurogenesis
  • Histones
  21 Scopus citations

• Ganglioside GD3 is required for neurogenesis and long-term maintenance of neural stem cells in the postnatal mouse brain

  Wang, J., Cheng, A., Wakade, C. & Yu, R. K., Oct 8 2014, In: Journal of Neuroscience. 34, 41, p. 13790-13800 11 p.

  Research output: Contribution to journal › Article › peer-review

  • GD3 ganglioside
  • Neural Stem Cells
  • Neurogenesis
  • Gangliosides
  • Knockout Mice
  35 Scopus citations

• Glycolipid and glycoprotein expression during neural development

  Yu, R. K. & Itokazu, Y., 2014, In: Advances in neurobiology. 9, p. 185-222 38 p.

  Research output: Contribution to journal › Article › peer-review

  • Neural Tube
  • Glycolipids
  • Neurology
  • Neural Crest
  • Molecules
• 2013

  Antibodies to heteromeric glycolipid complexes in guillain-barré syndrome

  Rinaldi, S., Brennan, K. M., Kalna, G., Walgaard, C., Van Doorn, P., Jacobs, B. C., Yu, R. K., Mansson, J. E., Goodyear, C. S. & Willison, H. J., Dec 16 2013, In: PloS one. 8, 12, e82337.

  Research output: Contribution to journal › Article › peer-review

  • Glycolipids
  • glycolipids
  • gangliosides
  • Gangliosides
  • Electrophysiology
  40 Scopus citations

• Antibodies to heteromeric glycolipid complexes in multifocal motor neuropathy

  Galban-Horcajo, F., Fitzpatrick, A. M., Hutton, A. J., Dunn, S. M., Kalna, G., Brennan, K. M., Rinaldi, S., Yu, R. K., Goodyear, C. S. & Willison, H. J., Jan 2013, In: European Journal of Neurology. 20, 1, p. 62-70 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycolipids
  • Enzyme-Linked Immunosorbent Assay
  • Antibodies
  • anti-IgM
  • Anti-Idiotypic Antibodies
  45 Scopus citations

• Anti-Chol-1 Antigen, GQ1bα, Antibodies Are Associated with Alzheimer's Disease

  Ariga, T., Kubota, M., Nakane, M., Oguro, K., Yu, R. K. & Ando, S., May 23 2013, In: PloS one. 8, 5, e63326.

  Research output: Contribution to journal › Article › peer-review

  • chol-1 antigen
  • Alzheimer disease
  • Anti-Idiotypic Antibodies
  • Alzheimer Disease
  • dementia
  8 Scopus citations

• Brain gangliosides of a transgenic mouse model of Alzheimer's disease with deficiency in GD3-synthase: Expression of elevated levels of a cholinergic-specific ganglioside, GT1aα

  Ariga, T., Itokazu, Y., McDonald, M. P., Hirabayashi, Y., Ando, S. & Yu, R. K., 2013, In: ASN Neuro. 5, 2, p. 141-148 8 p.

  Research output: Contribution to journal › Article › peer-review

  • trisialoganglioside GT1
  • Gangliosides
  • Cholinergic Agents
  • Transgenic Mice
  • Alzheimer Disease
  15 Scopus citations

• Effects of amyloid β-peptides and gangliosides on mouse neural stem cells

  Itokazu, Y., Kato-Negishi, M., Nakatani, Y., Ariga, T. & Yu, R. K., Oct 2013, In: Neurochemical Research. 38, 10, p. 2019-2027 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Stem cells
  • Gangliosides
  • Neural Stem Cells
  • Amyloid
  • Cell proliferation
  11 Scopus citations

• Human Anti-Glycosphingolipids Antibodies in Guillain-Barré Syndrome

  Yu, R. K. & Usuki, S., Dec 1 2013, Autoantibodies: Third Edition. Elsevier B.V., p. 581-594 14 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Glycosphingolipids
  • Gangliosides
  • Anti-Idiotypic Antibodies
  • Campylobacter jejuni
  • Acidic Glycosphingolipids

• Interaction of ganglioside GD3 with an EGF receptor sustains the self-renewal ability of mouse neural stem cells in vitro

  Wang, J. & Yu, R. K., Nov 19 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 47, p. 19137-19142 6 p.

  Research output: Contribution to journal › Article › peer-review

  • GD3 ganglioside
  • Neural Stem Cells
  • ErbB Receptors
  • In Vitro Techniques
  • Neurogenesis
  65 Scopus citations

• O-acetylated n-acetylneuraminic acid as a novel target for therapy in human pre-b acute lymphoblastic leukemia

  Parameswaran, R., Lim, M., Arutyunyan, A., Abdel-Azim, H., Hurtz, C., Lau, K., Müschen, M., Yu, R. K., von Itzstein, M., Heisterkamp, N. & Groffen, J., 2013, In: Journal of Experimental Medicine. 210, 4, p. 805-819 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Acids
  • Acetylesterase
  • Esterases
  • Acetylation
  19 Scopus citations
• 2012

  Anti-glycolipid antibodies in guillain-barré syndrome and related neuropathies: Therapeutic strategies for disease treatment

  Yu, R. K., Usuki, S. & Ariga, T., Oct 1 2012, Anticarbohydrate Antibodies: From Molecular Basis to Clinical Application. Springer-Verlag Wien, Vol. 9783709108703. p. 327-359 33 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Glycolipids
  • Gangliosides
  • Anti-Idiotypic Antibodies
  • Campylobacter jejuni
  • Antibodies
  2 Scopus citations

• Functional roles of gangliosides in Neurodevelopment: An overview of recent advances

  Yu, R. K., Tsai, Y. T. & Ariga, T., Jun 2012, In: Neurochemical Research. 37, 6, p. 1230-1244 15 p.

  Research output: Contribution to journal › Review article › peer-review

  • Gangliosides
  • Signal transduction
  • Cell membranes
  • Lipids
  • Glycosphingolipids
  113 Scopus citations

• Lewis X-carrying N-glycans regulate the proliferation of mouse embryonic neural stem cells via the notch signaling pathway

  Yagi, H., Saito, T., Yanagisawa, M., Yu, R. K. & Kato, K., Jul 13 2012, In: Journal of Biological Chemistry. 287, 29, p. 24356-24364 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Stem cells
  • Mouse Embryonic Stem Cells
  • Neural Stem Cells
  • Polysaccharides
  • Glycosylation
  39 Scopus citations

• Pathobiochemical effect of acylated steryl-β-glucoside on aggregation and cytotoxicity of α-synuclein

  Usuki, S., Kamitani, T., Matsuo, Y. & Yu, R. K., Jun 2012, In: Neurochemical Research. 37, 6, p. 1261-1266 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Cytotoxicity
  • Glucosides
  • Agglomeration
  • Parkinsonian Disorders
  6 Scopus citations

• Preface to the special issue honoring Bob Ledeen

  Yu, R. K., Jun 2012, In: Neurochemical Research. 37, 6, p. 1133-1136 4 p.

  Research output: Contribution to journal › Editorial › peer-review
• 2011

  Expression of GD2 and GD3 gangliosides in human embryonic neural stem cells

  Yanagisawa, M., Yoshimura, S. & Yu, R. K., Apr 7 2011, In: ASN Neuro. 3, 2

  Research output: Contribution to journal › Article › peer-review

  • GD2 ganglioside
  • GD3 ganglioside
  • Human Embryonic Stem Cells
  • Neural Stem Cells
  • Gangliosides
  39 Scopus citations

• Genome-wide target profiling of piggyBac and Tol2 in HEK 293: Pros and cons for gene discovery and gene therapy

  Meir, Y. J. J., Weirauch, M. T., Yang, H. S., Chung, P. C., Yu, R. K. & Wu, S. C. Y., Mar 30 2011, In: BMC Biotechnology. 11, 28.

  Research output: Contribution to journal › Article › peer-review

  • Transposases
  • Genetic Association Studies
  • Genetic Therapy
  • Genome
  • DNA Transposable Elements
  56 Scopus citations

• Histone acetylation-mediated glycosyltransferase gene regulation in mouse brain during development

  Suzuki, Y., Yanagisawa, M., Ariga, T. & Yu, R. K., Mar 2011, In: Journal of Neurochemistry. 116, 5, p. 874-880 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Acetylation
  • Glycosyltransferases
  • Gene expression
  • Histones
  • Gangliosides
  33 Scopus citations

• IGF-1 induction by acylated steryl β-glucosides found in a pre-germinated brown rice diet reduces oxidative stress in streptozotocin-induced diabetes

  Usuki, S., Tsai, Y. Y., Morikawa, K., Nonaka, S., Okuhara, Y., Kise, M. & Yu, R. K., Dec 14 2011, In: PloS one. 6, 12, e28693.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • streptozotocin
  • Glucosides
  • Nutrition
  • brown rice
  16 Scopus citations

• Pathological roles of ganglioside mimicry in guillain-barré syndrome and related neuropathies

  Yu, R. K., Ariga, T., Usuki, S. & Kaida, K. I., Dec 19 2011, The Molecular Immunology of Complex Carbohydrates-3. Wu, A. (ed.). p. 349-365 17 p. (Advances in Experimental Medicine and Biology; vol. 705).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Gangliosides
  • Myelin Sheath
  • Ranvier's Nodes
  • Axons
  • Cell membranes
  13 Scopus citations

• Structures, biosynthesis, and functions of gangliosides-an overview

  Yu, R. K., Tsai, Y. T., Ariga, T. & Yanagisawa, M., 2011, In: Journal of Oleo Science. 60, 10, p. 537-544 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Biosynthesis
  • Carbohydrates
  • Gangliosides
  • Sphingomyelins
  • Cholesterol
  174 Scopus citations

• Sulfoglucuronosyl paragloboside promotes endothelial cell apoptosis in inflammation: Elucidation of a novel glycosphingolipid-signaling pathway

  Dasgupta, S., Wang, G. & Yu, R. K., Nov 2011, In: Journal of Neurochemistry. 119, 4, p. 749-759 11 p.

  Research output: Contribution to journal › Article › peer-review

  • sulfate-3-glucuronyl paragloboside
  • Endothelial cells
  • Glycosphingolipids
  • Endothelial Cells
  • Apoptosis
  7 Scopus citations

• The pathological roles of ganglioside metabolism in Alzheimer's disease: Effects of gangliosides on neurogenesis

  Yu, R. K., Ariga, T. & Wakade, C., 2011, In: International Journal of Alzheimer's Disease. 193618.

  Research output: Contribution to journal › Review article › peer-review

  • Gangliosides
  • Neurogenesis
  • Alzheimer Disease
  • Neuroepithelial Cells
  • chol-1 antigen
  30 Scopus citations