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2019
6 Citations (Scopus)

Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway

Xia, Y., Ye, B., Ding, J., Yu, Y., Alptekin, A., Thangaraju, M., Prasad, P. D., Ding, Z. C., Park, E. J., Choi, J. H., Gao, B., Fiehn, O., Yan, C., Dong, Z., Zha, Y. & Ding, H. F., Aug 1 2019, In : Cancer Research. 79, 15, p. 3837-3850 14 p.

Research output: Contribution to journalArticle

Open Access
Physiological Stress
Biosynthetic Pathways
Glycine
Serine
Carbon
2018
6 Citations (Scopus)

Canonical wnt signaling in CD11c + APCs regulates microbiota-Induced inflammation and immune cell homeostasis in the colon

Swafford, D., Shanmugam, A., Ranganathan, P., Hussein, M. S., Koni, P. A., Prasad, P. D., Thangaraju, M. & Manicassamy, S., May 1 2018, In : Journal of Immunology. 200, 9, p. 3259-3268 10 p.

Research output: Contribution to journalArticle

Microbiota
Colon
Homeostasis
Inflammation
Lipoproteins
12 Citations (Scopus)

GPR81, a cell-surface receptor for lactate, regulates intestinal homeostasis and protects mice from experimental colitis

Ranganathan, P., Shanmugam, A. K., Swafford, D., Suryawanshi, A., Bhattacharjee, P., Hussein, M. S., Koni, P., Prasad, P. D., Kurago, Z. B., Thangaraju, M., Ganapathy, V. & Manicassamy, S., Mar 1 2018, In : Journal of Immunology. 200, 5, p. 1781-1789 9 p.

Research output: Contribution to journalArticle

Cell Surface Receptors
Colitis
Lactic Acid
Homeostasis
Inflammation
2017

The Relationship Between Probiotics and Dietary Fiber Consumption and Cardiovascular Health

Prasad, P. D., Gurav, A., Zhu, H., Martin, P. M., Vijay-Kumar, M. & Singh, N., Jul 13 2017, Dietary Fiber for the Prevention of Cardiovascular Disease: Fiber's Interaction between Gut Micoflora, Sugar Metabolism, Weight Control and Cardiovascular Health. Elsevier Inc., p. 73-90 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Probiotics
Dietary Fiber
Cardiovascular Diseases
Health
Vegetables
2016
19 Citations (Scopus)

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer

Coothankandaswamy, V., Cao, S., Xu, Y., Prasad, P. D., Singh, P. K., Reynolds, C. P., Yang, S., Ogura, J., Ganapathy, V. & Bhutia, Y. D., Jan 1 2016, In : British Journal of Pharmacology. 173, 23, p. 3292-3306 15 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Pancreatic Neoplasms
Pharmaceutical Preparations
Pharmacology
Up-Regulation
58 Citations (Scopus)

Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis

Sivaprakasam, S., Prasad, P. D. & Singh, N., Aug 1 2016, In : Pharmacology and Therapeutics. 164, p. 144-151 8 p.

Research output: Contribution to journalReview article

Volatile Fatty Acids
Dietary Fiber
Carcinogenesis
Inflammation
Intestinal Neoplasms
61 Citations (Scopus)

Combined inhibition of DNMT and HDAC blocks the tumorigenicity of cancer stem-like cells and attenuates mammary tumor growth

Pathania, R., Ramachandran, S., Mariappan, G., Thakur, P., Shi, H., Choi, J. H., Manicassamy, S., Kolhe, R., Prasad, P. D., Sharma, S., Lokeshwar, B. L., Ganapathy, V. & Thangaraju, M., Jun 1 2016, In : Cancer Research. 76, 11, p. 3224-3235 12 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Epigenomics
Azacitidine
Butyrates
Breast Neoplasms
7 Citations (Scopus)

Increased retinal expression of the pro-angiogenic receptor GPR91 via BMP6 in a mouse model of juvenile hemochromatosis

Arjunan, P., Gnanaprakasam, J. P., Ananth, S., Romej, M. A., Rajalakshmi, V. K., Prasad, P. D., Martin, P. M., Gurusamy, M., Thangaraju, M., Bhutia, Y. D. & Ganapathy, V., Apr 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 4, p. 1612-1619 8 p.

Research output: Contribution to journalArticle

Retina
Succinic Acid
Bone Morphogenetic Protein 6
Iron
Hemochromatosis
2015
27 Citations (Scopus)

Deletion of the amino acid transporter SLC6A14 suppresses tumour growth in spontaneous mouse models of breast cancer

Babu, E., Bhutia, Y. D., Ramachandran, S., Gnana-Prakasam, J. P., Prasad, P. D., Thangaraju, M. & Ganapathy, V., Jul 1 2015, In : Biochemical Journal. 469, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Tumors
Breast Neoplasms
Amino Acids
Growth
105 Citations (Scopus)

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

Pathania, R., Ramachandran, S., Elangovan, S., Padia, R., Yang, P., Cinghu, S., Veeranan-Karmegam, R., Arjunan, P., Gnana-Prakasam, J. P., Sadanand, F., Pei, L., Chang, C. S., Choi, J. H., Shi, H., Manicassamy, S., Prasad, P. D., Sharma, S., Ganapathy, V., Jothi, R. & Thangaraju, M., Apr 22 2015, In : Nature Communications. 6, 6910.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
stem cells
Stem cells
maintenance
Carcinogenesis
16 Citations (Scopus)
Methylenetetrahydrofolate Reductase (NADPH2)
Hyperhomocysteinemia
Retinal Ganglion Cells
Immunohistochemistry
Electroretinography
7 Citations (Scopus)

Species-specific influence of lithium on the activity of SLC13A5 (NACT): Lithium-induced activation is specific for the transporter in primates

Gopal, E., Babu, E., Ramachandran, S., Bhutia, Y. D., Prasad, P. D. & Ganapathy, V., Apr 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 353, 1, p. 17-26 10 p.

Research output: Contribution to journalArticle

Lithium
Primates
Citric Acid Cycle
Human Activities
Tryptophan
2014
607 Citations (Scopus)

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., Lee, J. R., Offermanns, S. & Ganapathy, V., Jan 16 2014, In : Immunity. 40, 1, p. 128-139 12 p.

Research output: Contribution to journalArticle

Butyrates
Niacin
Colonic Neoplasms
Carcinogenesis
Inflammation
3 Citations (Scopus)

Butyrate-Mediated Protection Against Colonic Inflammation And Colon Carcinogenesis: Role Of Butyrate Transporters And Butyrate Receptors

Vadivel, G., Prasad, P. D., Thangaraju, M., Martin, P. M. & Singh, N., Apr 1 2014, Butyrate: Food Sources, Functions and Health Benefits. Nova Science Publishers, Inc., p. 157-176 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Butyrates
Colon
Carcinogenesis
Inflammation
Neurons
1 Citation (Scopus)

Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues

Blackburn, A. R., Hamrick, M. W., Chutkan, N., Sangani, R., Waller, J. L., Corpe, R., Prasad, P. D., Isales, C. M., Ganapathy, V. & Fulzele, S., Jan 8 2014, In : BMC Musculoskeletal Disorders. 15, 1, 9.

Research output: Contribution to journalArticle

Sodium-Coupled Vitamin C Transporters
Articular Cartilage
Osteoarthritis
Real-Time Polymerase Chain Reaction
Hematoxylin
35 Citations (Scopus)

The amino acid transporter SLC6A14 in cancer and its potential use in chemotherapy

Bhutia, Y. D., Babu, E., Prasad, P. D. & Ganapathy, V., Dec 1 2014, In : Asian Journal of Pharmaceutical Sciences. 9, 6, p. 293-303 11 p.

Research output: Contribution to journalReview article

Amino Acid Transport Systems
Drug Therapy
Amino Acids
Neoplasms
Prodrugs
47 Citations (Scopus)

The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival

Elangovan, S., Pathania, R., Ramachandran, S., Ananth, S., Padia, R. N., Lan, L., Singh, N., Martin, P. M., Hawthorn, L., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Feb 15 2014, In : Cancer Research. 74, 4, p. 1166-1178 13 p.

Research output: Contribution to journalArticle

Butyrates
Niacin
Cell Survival
Carcinogenesis
Breast
2013
9 Citations (Scopus)

Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth

Sonne, S. R., Bhalla, V. K., Barman, S. A., White, R. E., Zhu, S., Newman, T. M., Prasad, P. D., Smith, S. B., Offermanns, S. & Ganapathy, V., May 14 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 8, p. 1149-1158 10 p.

Research output: Contribution to journalArticle

Hyperhomocysteinemia
Premature Birth
Homocysteine
Pregnancy
Dinoprostone
17 Citations (Scopus)

Molecular mechanism of SLC5A8 inactivation in breast cancer

Elangovan, S., Pathania, R., Ramachandran, S., Ananth, S., Padia, R. N., Srinivas, S. R., Babu, E., Hawthorn, L., Schoenlein, P. V., Boettger, T., Smith, S. B., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Nov 6 2013, In : Molecular and Cellular Biology. 33, 19, p. 3920-3935 16 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Human Mammary Glands
Breast
Mouse mammary tumor virus
9 Citations (Scopus)

Sodium-coupled vitamin C transporter (SVCT2): Expression, function, and regulation in intervertebral disc cells

Chothe, P. P., Chutkan, N., Sangani, R., Wenger, K. H., Prasad, P. D., Thangaraju, M., Hamrick, M. W., Isales, C. M., Ganapathy, V. & Fulzele, S., May 1 2013, In : Spine Journal. 13, 5, p. 549-557 9 p.

Research output: Contribution to journalArticle

Sodium-Coupled Vitamin C Transporters
Intervertebral Disc
Ascorbic Acid
Somatomedins
Dexamethasone
18 Citations (Scopus)

Sodium-dependent vitamin C transporter SVCT2: Expression and function in bone marrow stromal cells and in osteogenesis

Fulzele, S., Chothe, P., Sangani, R., Chutkan, N., Hamrick, M., Bhattacharyya, M., Prasad, P. D., Zakhary, I., Bowser, M., Isales, C. & Ganapathy, V., Jan 1 2013, In : Stem Cell Research. 10, 1, p. 36-47 12 p.

Research output: Contribution to journalArticle

Sodium-Coupled Vitamin C Transporters
Mesenchymal Stromal Cells
Osteogenesis
Ascorbic Acid
Bone and Bones
22 Citations (Scopus)

The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function

Coothankandaswamy, V., Elangovan, S., Singh, N., Prasad, P. D., Thangaraju, M. & Ganapathy, V., Feb 15 2013, In : Biochemical Journal. 450, 1, p. 169-178 10 p.

Research output: Contribution to journalArticle

Membrane Transport Proteins
Cell membranes
Histone Deacetylase Inhibitors
Tumors
Cells
99 Citations (Scopus)
Volatile Fatty Acids
Dietary Fiber
Bacteria
Colon
Membrane Transport Proteins
2012
9 Citations (Scopus)

Regulation of proton-coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate

Bozard, B. R., Chothe, P. P., Tawfik, A., Williams, C., Fulzele, S., Prasad, P. D., Martin, P. M., Ganapathy, V. & Smith, S. B., Mar 1 2012, In : Glia. 60, 3, p. 333-342 10 p.

Research output: Contribution to journalArticle

Proton-Coupled Folate Transporter
Neuroglia
Fumarates
Pharmaceutical Preparations
Retinal Diseases
2011
27 Citations (Scopus)

Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium

Gnana-Prakasam, J. P., Ananth, S., Prasad, P. D., Zhang, M., Atherton, S. S., Martin, P. M., Smith, S. B. & Ganapathy, V., May 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 6, p. 3751-3758 8 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Succinic Acid
Vascular Endothelial Growth Factor A
Iron
Hemochromatosis
83 Citations (Scopus)

Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters

Rosario, F. J., Jansson, N., Kanai, Y., Prasad, P. D., Powell, T. L. & Jansson, T., Mar 1 2011, In : Endocrinology. 152, 3, p. 1119-1129 11 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Down-Regulation
Mothers
Insulin
Proteins
48 Citations (Scopus)

Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate

Babu, E., Ramachandran, S., Coothankandaswamy, V., Elangovan, S., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Sep 22 2011, In : Oncogene. 30, 38, p. 4026-4037 12 p.

Research output: Contribution to journalArticle

Membrane Transport Proteins
Cell Membrane
Neoplasms
DNA Methylation
Colonic Neoplasms
76 Citations (Scopus)

SIRT1 is essential for oncogenic signaling by estrogen/ estrogen receptor α in breast cancer

Elangovan, S., Ramachandran, S., Venkatesan, N., Ananth, S., Gnana-Prakasam, J. P., Martin, P. M., Browning, D. D., Schoenlein, P. V., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Nov 1 2011, In : Cancer Research. 71, 21, p. 6654-6664 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Breast Neoplasms
Cyclin G2
Neoplasms
68 Citations (Scopus)

SLC6A14 (ATB 0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer

Karunakaran, S., Ramachandran, S., Coothankandaswamy, V., Elangovan, S., Babu, E., Periyasamy-Thandavan, S., Gurav, A., Gnanaprakasam, J. P., Singh, N., Schoenlein, P. V., Prasad, P. D., Thangaraju, M. & Ganapathy, V., Sep 9 2011, In : Journal of Biological Chemistry. 286, 36, p. 31830-31838 9 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Estrogen Receptors
Breast Neoplasms
Cells
Pharmaceutical Preparations