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Author

  • Muhammad Ashraf
2020
Open Access
2019

MiRNAs in Extracellular Vesicles from iPS-Derived Cardiac Progenitor Cells Effectively Reduce Fibrosis and Promote Angiogenesis in Infarcted Heart

Xuan, W., Wang, L., Xu, M., Weintraub, N. L. & Ashraf, M., Jan 1 2019, In : Stem Cells International. 2019, 3726392.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

Cardiac progenitors induced from human induced pluripotent stem cells with cardiogenic small molecule effectively regenerate infarcted hearts and attenuate fibrosis

Xuan, W., Wang, Y., Tang, Y. L., Ali, A., Hu, H., Maienschein-Cline, M. & Ashraf, M., Jan 1 2018, In : Shock. 50, 6, p. 627-639 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
6 Scopus citations

Regenerative therapy for cardiomyopathies

Wang, Z., Su, X., Ashraf, M., Kim, I. M., Weintraub, N. L., Jiang, M. & Tang, Y., Jan 1 2018, In : Journal of Cardiovascular Translational Research. 11, 5, p. 357-365 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Stem cell and gene-based approaches for cardiac repair

Elmadbouh, I. & Ashraf, M., Jan 27 2018, Design of Nanostructures for Versatile Therapeutic Applications. Elsevier, p. 31-96 66 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2017

Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis

Gong, M., Yu, B., Wang, J., Wang, Y., Liu, M., Paul, C., Millard, R. W., Xiao, D. S., Ashraf, M. & Xu, M., Jan 1 2017, In : Oncotarget. 8, 28, p. 45200-45212 13 p.

Research output: Contribution to journalArticle

72 Scopus citations
10 Scopus citations

The expression of smad signaling pathway in myocardium and potential therapeutic effects

Duan, Y., Zhu, W., Liu, M., Ashraf, M. & Xu, M., Jul 2017, In : Histology and Histopathology. 32, 7, p. 651-659 9 p.

Research output: Contribution to journalReview article

4 Scopus citations
2016

Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase

Okada, M., Kim, H. W., Matsu-Ura, K., Wang, Y. G., Xu, M. & Ashraf, M., Jan 1 2016, In : Stem Cells. 34, 1, p. 148-159 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Attenuation of teratoma formation by p27 overexpression in induced pluripotent stem cells

Matsu-Ura, T., Sasaki, H., Okada, M., Mikoshiba, K. & Ashraf, M., Feb 15 2016, In : Stem Cell Research and Therapy. 7, 1, 286.

Research output: Contribution to journalArticle

2 Scopus citations

Clusterin/Akt up-regulation is critical for GATA-4 mediated cytoprotection of mesenchymal stem cells against ischemia injury

Yu, B., Yang, Y., Liu, H., Gong, M., Millard, R. W., Wang, Y. G., Ashraf, M. & Xu, M., Mar 2016, In : PloS one. 11, 3, e0151542.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury

Zhu, P., Zhao, M. Y., Li, X. H., Fu, Q., Zhou, Z. F., Huang, C. F., Zhang, X. S., Huang, H. L., Tan, Y., Li, J. X., Li, J. N., Huang, S., Ashraf, M., Lu, C., Chen, J. M., Zhuang, J. & Guo, H. M., Sep 8 2015, In : Genetics and Molecular Research. 14, 3, p. 10490-10499 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection

Yu, B., Kim, H. W., Gong, M., Wang, J., Millard, R. W., Wang, Y., Ashraf, M. & Xu, M., Jan 1 2015, In : International Journal of Cardiology. 182, C, p. 349-360 12 p.

Research output: Contribution to journalArticle

163 Scopus citations

Influence of sirolimus-induced TGF-β secretion on mouse Treg cell proliferation

Li, J. N., Li, J. X., Huang, H. L., Zhu, X. L., Ding, H., Huang, C. F., Lin, J., Huang, J. G., Wu, Z. C., Ashraf, M., Wang, Y. G., Li, X. K., Zheng, S. Y., Chen, J. M., Guo, H. M., Zhuang, J. & Zhu, P., Dec 28 2015, In : Genetics and Molecular Research. 14, 4, p. 18569-18579 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
7 Scopus citations

Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles in Cardioprotection and Myocardium Repair

Yu, B., Ashraf, M. & Xu, M., Jan 1 2015, Mesenchymal Stem Cell Derived Exosomes: The Potential for Translational Nanomedicine. Elsevier Inc., p. 1-20 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Erratum: Heat shock improves sca-1+ stem cells survival and directs ischemic cardiomyocytes toward a prosurvival phenotype via exosomal transfer: A critical role for HSF1/miR-34a/HSP70 pathway (Stem Cells (2014) 32 (462-472) DOI 10.1002/stem.1571)

Feng, Y., Huang, W., Meng, W., Jegga, A. G., Wang, Y., Cai, W., Kim, H. W., Wen, Z., Rao, F., Modi, R. M., Yu, X. & Ashraf, M., Apr 2014, In : Stem Cells. 32, 4, 1 p.

Research output: Contribution to journalComment/debate

Heat shock improves sca-1+ stem cell survival and directs ischemic cardiomyocytes toward a prosurvival phenotype via exosomal transfer: A critical role for HSF1/miR-34a/HSP70 pathway

Feng, Y., Huang, W., Meng, W., Jegga, A. G., Wang, Y., Cai, W., Kim, H. W., Pasha, Z., Wen, Z., Rao, F., Modi, R. M., Yu, X. & Ashraf, M., Feb 2014, In : Stem Cells. 32, 2, p. 462-472 11 p.

Research output: Contribution to journalArticle

67 Scopus citations

Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22

Feng, Y., Huang, W., Wani, M., Yu, X. & Ashraf, M., Feb 18 2014, In : PloS one. 9, 2, e88685.

Research output: Contribution to journalArticle

175 Scopus citations

Reversal of ischemic cardiomyopathy with Sca-1+ stem cells modified with multiple growth factors

Li, N., Pasha, Z. & Ashraf, M., Apr 4 2014, In : PloS one. 9, 4, e93645.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Activation of diverse signaling pathways by Ex-vivo delivery of multiple cytokines for myocardial repair

Konoplyannikov, M., Haider, K. H., Lai, V. K., Ahmed, R. P. H., Jiang, S. & Ashraf, M., Jan 15 2013, In : Stem Cells and Development. 22, 2, p. 204-215 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury

Chen, L., Wang, Y., Pan, Y., Zhang, L., Shen, C., Qin, G., Ashraf, M., Weintraub, N., Ma, G. & Tang, Y., Feb 15 2013, In : Biochemical and Biophysical Research Communications. 431, 3, p. 566-571 6 p.

Research output: Contribution to journalArticle

190 Scopus citations

Cardiac stem cells with electrical stimulation improve ischaemic heart function through regulation of connective tissue growth factor and miR-378

Kim, S. W., Kim, H. W., Huang, W., Okada, M., Welge, J. A., Wang, Y. & Ashraf, M., Nov 1 2013, In : Cardiovascular Research. 100, 2, p. 241-251 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Cardiomyocyte Protection by GATA-4 Gene Engineered Mesenchymal Stem Cells Is Partially Mediated by Translocation of miR-221 in Microvesicles

Yu, B., Gong, M., Wang, Y., Millard, R. W., Pasha, Z., Yang, Y., Ashraf, M. & Xu, M., Aug 28 2013, In : PloS one. 8, 8, e73304.

Research output: Contribution to journalArticle

66 Scopus citations

Enhanced mesenchymal stem cell survival induced by GATA-4 overexpression is partially mediated by regulation of the miR-15 family

Yu, B., Gong, M., He, Z., Wang, Y. G., Millard, R. W., Ashraf, M. & Xu, M., Oct 28 2013, In : International Journal of Biochemistry and Cell Biology. 45, 12, p. 2724-2735 12 p.

Research output: Contribution to journalArticle

15 Scopus citations
12 Scopus citations

Molecular Strategy to Reduce In Vivo Collagen Barrier Promotes Entry of NCX1 Positive Inducible Pluripotent Stem Cells (iPSCNCX1+) into Ischemic (or Injured) Myocardium

Huang, W., Dai, B., Wen, Z., Millard, R. W., Yu, X. Y., Luther, K., Xu, M., Zhao, T. C., Yang, H. T., Qi, Z., LaSance, K., Ashraf, M. & Wang, Y., Aug 21 2013, In : PloS one. 8, 8, e70023.

Research output: Contribution to journalArticle

10 Scopus citations

Protein Kinase G1 α Overexpression Increases Stem Cell Survival and Cardiac Function after Myocardial Infarction

Wang, L., Pasha, Z., Wang, S., Li, N., Feng, Y., Lu, G., Millard, R. W. & Ashraf, M., Mar 25 2013, In : PloS one. 8, 3, e60087.

Research output: Contribution to journalArticle

18 Scopus citations
2012

Activation of IL-11/STAT3 pathway in preconditioned human skeletal myoblasts blocks apoptotic cascade under oxidant stress

Idris, N. M., Ashraf, M., Ahmed, R. P. H., Shujia, J. & Haider, K. H., Jan 1 2012, In : Regenerative Medicine. 7, 1, p. 47-57 11 p.

Research output: Contribution to journalArticle

13 Scopus citations
6 Scopus citations

Cardiac progenitors derived from reprogrammed mesenchymal stem cells contribute to angiomyogenic repair of the infarcted heart

Buccini, S., Haider, K. H., Ahmed, R. P. H., Jiang, S. & Ashraf, M., Oct 18 2012, In : Basic Research in Cardiology. 107, 6, 301.

Research output: Contribution to journalArticle

34 Scopus citations

Concomitant activation of miR-107/PDCD10 and hypoxamir-210/Casp8ap2 and their role in cytoprotection during ischemic preconditioning of stem cells

Kim, H. W., Mallick, F., Durrani, S., Ashraf, M., Jiang, S. & Haider, K. H., Oct 15 2012, In : Antioxidants and Redox Signaling. 17, 8, p. 1053-1065 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Cytoprotective and proangiogenic activity of Ex-vivo netrin-1 transgene overexpression protects the heart against ischemia/reperfusion injury

Durrani, S., Haider, K. H., Ahmed, R. P. H., Jiang, S. & Ashraf, M., Jul 1 2012, In : Stem Cells and Development. 21, 10, p. 1769-1778 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Delta-opioid receptor activation promotes mesenchymal stem cell survival via PKC/STAT3 signaling pathway

Higuchi, S., Ii, M., Zhu, P. & Ashraf, M., Jan 1 2012, In : Circulation Journal. 76, 1, p. 204-212 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
17 Scopus citations

Mesenchymal stem cells overexpressing CXCR4 attenuate remodeling of postmyocardial infarction by releasing matrix metalloproteinase-9

Huang, W., Wang, T., Zhang, D., Zhao, T., Dai, B., Ashraf, A., Wang, X., Xu, M., Millard, R. W., Fan, G. C., Ashraf, M., Yu, X. Y. & Wang, Y., Mar 20 2012, In : Stem Cells and Development. 21, 5, p. 778-789 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

MicroRNA-143 is a critical regulator of cell cycle activity in stem cells with co-overexpression of Akt and angiopoietin-1 via transcriptional regulation of Erk5/cyclin D1 signaling

Lai, V. K., Ashraf, M., Jiang, S. & Haider, K. H., Feb 15 2012, In : Cell Cycle. 11, 4, p. 767-777 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Non-hypoxic stabilization of HIF-Iα during coordinated interaction between Akt and angiopoietin-1 enhances endothelial commitment of bone marrow stem cells

Lai, V. K., Afzal, M. R., Ashraf, M., Jiang, S. & Haider, H. K., Jun 1 2012, In : Journal of Molecular Medicine. 90, 6, p. 719-730 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Paracrine effect of wnt11-overexpressing mesenchymal stem cells on ischemic injury

Zuo, S., Jones, W. K., Li, H., He, Z., Pasha, Z., Yang, Y., Wang, Y., Fan, G. C., Ashraf, M. & Xu, M., Mar 1 2012, In : Stem Cells and Development. 21, 4, p. 598-608 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Preconditioning approach in stem cell therapy for the treatment of infarcted heart

Haider, K. H. & Ashraf, M., 2012, Progress in Molecular Biology and Translational Science. Elsevier B.V., p. 323-356 34 p. (Progress in Molecular Biology and Translational Science; vol. 111).

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Scopus citations

Preconditioning in regenerative medicine

Pasha, Z. & Ashraf, M., Nov 1 2012, In : Cardiovascular Research. 96, 2, p. 210-213 4 p.

Research output: Contribution to journalReview article

1 Scopus citations

Role of GATA-4 in differentiation and survival of bone marrow mesenchymal stem cells

Xu, M., Millard, R. W. & Ashraf, M., 2012, Progress in Molecular Biology and Translational Science. Elsevier B.V., p. 217-241 25 p. (Progress in Molecular Biology and Translational Science; vol. 111).

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations
42 Scopus citations

Subcellular preconditioning of stem cells: Mito-Cx43 gene targeting is cytoprotective via shift of mitochondrial Bak and Bcl-xL balance

Lu, G., Jiang, S., Ashraf, M. & Haider, K. H., May 1 2012, In : Regenerative Medicine. 7, 3, p. 323-334 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Suicide Gene Reveals the Myocardial Neovascularization Role of Mesenchymal Stem Cells Overexpressing CXCR4 (MSCCXCR4)

Liang, J., Huang, W., Yu, X., Ashraf, A., Wary, K. K., Xu, M., Millard, R. W., Ashraf, M. & Wang, Y., Sep 28 2012, In : PloS one. 7, 9, e46158.

Research output: Contribution to journalArticle

23 Scopus citations

The role of notch 1 activation in cardiosphere derived cell differentiation

Chen, L., Ashraf, M., Wang, Y., Zhou, M., Zhang, J., Qin, G., Rubinstein, J., Weintraub, N. L. & Tang, Y. L., Aug 10 2012, In : Stem Cells and Development. 21, 12, p. 2122-2129 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2011

Cardiac tumorgenic potential of induced pluripotent stem cells in an immunocompetent host with myocardial infarction

Ahmed, R. P., Ashraf, M., Buccini, S., Shujia, J. & Haider, H. K., Mar 1 2011, In : Regenerative Medicine. 6, 2, p. 171-178 8 p.

Research output: Contribution to journalArticle

54 Scopus citations