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2020
Accumulation of kynurenine elevates oxidative stress and alters microRNA profile in human bone marrow stromal cells
Dalton, S., Smith, K., Singh, K., Kaiser, H., Kolhe, R., Mondal, A. K., Khayrullin, A., Isales, C. M., Hamrick, M. W., Hill, W. D. & Fulzele, S., Feb 2020, In: Experimental Gerontology. 130, 110800.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells
Elmansi, A. M., Hussein, K. A., Herrero, S. M., Periyasamy-Thandavan, S., Aguilar-Pérez, A., Kondrikova, G., Kondrikov, D., Eisa, N. H., Pierce, J. L., Kaiser, H., Ding, K. H., Walker, A. L., Jiang, X., Bollag, W. B., Elsalanty, M., Zhong, Q., Shi, X. M., Su, Y., Johnson, M., Hunter, M. & 7 others, , Jun 2020, In: Bone Reports. 12, 100270.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton
Hagan, M. L., Yu, K., Zhu, J., Vinson, B. N., Roberts, R. L., Montesinos Cartagena, M., Johnson, M. H., Wang, L., Isales, C. M., Hamrick, M. W., McNeil, P. L. & McGee-Lawrence, M. E., Jan 1 2020, In: Aging Cell. 19, 1, e13056.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Deletion of PPARγin Mesenchymal Lineage Cells Protects Against Aging-Induced Cortical Bone Loss in Mice
Cao, J., Ding, K., Pan, G., Rosario, R., Su, Y., Bao, Y., Zhou, H., Xu, J., McGee Lawrence, M. E., Hamrick, M. W., Isales, C. M. & Shi, X., Apr 17 2020, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 75, 5, p. 826-834 9 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo
Elashiry, M., Elashiry, M. M., Elsayed, R., Rajendran, M., Auersvald, C., Zeitoun, R., Rashid, M. H., Ara, R., Meghil, M. M., Liu, Y., Arbab, A. S., Arce, R. M., Hamrick, M., Elsalanty, M., Brendan, M., Pacholczyk, R. & Cutler, C. W., Jan 1 2020, In: Journal of Extracellular Vesicles. 9, 1, 1795362.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Freeze-Dried Extracellular Vesicles From Adipose-Derived Stem Cells Prevent Hypoxia-Induced Muscle Cell Injury
El Baradie, K. B. Y., Nouh, M., O’Brien, F., Liu, Y., Fulzele, S., Eroglu, A. & Hamrick, M. W., Mar 20 2020, In: Frontiers in Cell and Developmental Biology. 8, 181.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway
Kondrikov, D., Elmansi, A., Bragg, R. T., Mobley, T., Barrett, T., Eisa, N., Kondrikova, G., Schoeinlein, P., Aguilar-Perez, A., Shi, X. M., Fulzele, S., Lawrence, M. M. G., Hamrick, M., Isales, C. & Hill, W., Feb 2020, In: Experimental Gerontology. 130, 110805.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Kynurenine promotes rankl–induced osteoclastogenesis in vitro by activating the aryl hydrocarbon receptor pathway
Eisa, N. H., Reddy, S. V., Elmansi, A. M., Kondrikova, G., Kondrikov, D., Shi, X. M., Novince, C. M., Hamrick, M. W., McGee-Lawrence, M. E., Isales, C. M., Fulzele, S. & Hill, W. D., Nov 1 2020, In: International journal of molecular sciences. 21, 21, p. 1-16 16 p., 7931.Research output: Contribution to journal › Article › peer-review
Open Access -
Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan
Kaiser, H., Parker, E. & Hamrick, M. W., Feb 2020, In: Experimental Gerontology. 130, 110797.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo
Pierce, J. L., Roberts, R. L., Yu, K., Kendall, R. K., Kaiser, H., Davis, C., Johnson, M. H., Hill, W. D., Isales, C. M., Bollag, W. B., Hamrick, M. W. & McGee-Lawrence, M. E., Feb 2020, In: Experimental Gerontology. 130, 110818.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Lack of association between circulating apelin level and frailty-related functional parameters in older adults: a cross-sectional study
Jang, I. Y., Lee, S., Kim, J. H., Lee, E., Lee, J. Y., Park, S. J., Kim, D. A., Hamrick, M. W., Park, J. H. & Kim, B. J., Dec 1 2020, In: BMC Geriatrics. 20, 1, 420.Research output: Contribution to journal › Article › peer-review
Open Access -
Metabolic regulation of aging and age-related disease
Hamrick, M. W. & Stranahan, A. M., Dec 2020, In: Ageing Research Reviews. 64, 101175.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Picolinic acid, a tryptophan oxidation product, does not impact bone mineral density but increases marrow adiposity
Ding, K., McGee-Lawrence, M. E., Kaiser, H., Sharma, A. K., Pierce, J. L., Irsik, D. L., Bollag, W. B., Xu, J., Zhong, Q., Hill, W., Shi, X. M., Fulzele, S., Kennedy, E. J., Elsalanty, M., Hamrick, M. W. & Isales, C. M., May 2020, In: Experimental Gerontology. 133, 110885.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Sex-specific differences in extracellular vesicle protein cargo in synovial fluid of patients with osteoarthritis
Kolhe, R., Owens, V., Sharma, A., Lee, T. J., Zhi, W., Ghilzai, U., Mondal, A. K., Liu, Y., Isales, C. M., Hamrick, M. W., Hunter, M. & Fulzele, S., Dec 2020, In: Life. 10, 12, p. 1-13 13 p., 337.Research output: Contribution to journal › Article › peer-review
Open Access -
Special issue: The kynurenine pathway in aging
Hamrick, M. W. & Isales, C. M., Jun 2020, In: Experimental Gerontology. 134, 110895.Research output: Contribution to journal › Editorial › peer-review
1 Scopus citations -
The association of circulating kynurenine, a tryptophan metabolite, with frailty in older adults
Jang, I. Y., Park, J. H., Kim, J. H., Lee, S., Lee, E., Lee, J. Y., Park, S. J., Kim, D. A., Hamrick, M. W. & Kim, B. J., Nov 2020, In: Aging. 12, 21, p. 22253-22265 13 p.Research output: Contribution to journal › Article › peer-review
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The role of tryptophan metabolites in musculoskeletal stem cell aging
Anaya, J. M., Bollag, W. B., Hamrick, M. W. & Isales, C. M., Sep 2 2020, In: International journal of molecular sciences. 21, 18, p. 1-13 13 p., 6670.Research output: Contribution to journal › Article › peer-review
Open Access -
The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice
Sharma, A. K., Roberts, R. L., Benson, R. D., Pierce, J. L., Yu, K., Hamrick, M. W. & McGee-Lawrence, M. E., May 20 2020, In: Frontiers in Cell and Developmental Biology. 8, 354.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2019
Age-dependent oxidative stress elevates arginase 1 and uncoupled nitric oxide synthesis in skeletal muscle of aged mice
Pandya, C. D., Lee, B., Toque, H. A., Mendhe, B., Bragg, R. T., Pandya, B., Atawia, R. T., Isales, C., Hamrick, M., Caldwell, R. W. & Fulzele, S., 2019, In: Oxidative medicine and cellular longevity. 2019, 1704650.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture
Kim, B. J., Yoo, H. J., Park, S. J., Kwak, M. K., Lee, S. H., Kim, S. J., Hamrick, M. W., Isales, C. M., Ahn, S. H. & Koh, J. M., May 1 2019, In: Osteoporosis International. 30, 5, p. 1071-1078 8 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Bone Marrow Derived Extracellular Vesicles Activate Osteoclast Differentiation in Traumatic Brain Injury Induced Bone Loss
Singleton, Q., Vaibhav, K., Braun, M., Patel, C., Khayrullin, A., Mendhe, B., Lee, B. R., Kolhe, R., Kaiser, H., Awad, M. E., Fariyike, T., Elsayed, R., Elsalanty, M., Isales, C. M., Liu, Y., Hamrick, M. W., Dhandapani, K. M. & Fulzele, S., Jan 2019, In: Fuel Cells. 8, 1Research output: Contribution to journal › Article › peer-review
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Elevated ceramides 18:0 and 24:1 with aging are associated with hip fracture risk through increased bone resorption
Kim, B. J., Lee, J. Y., Park, S. J., Lee, S. H., Kim, S. J., Yoo, H. J., De Pena, S. I. R., McGee-Lawrence, M., Isales, C. M., Koh, J. M. & Hamrick, M. W., 2019, In: Aging. 11, 21, p. 9388-9404 17 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Kynurenine, a Tryptophan Metabolite That Increases with Age, Induces Muscle Atrophy and Lipid Peroxidation
Kaiser, H., Yu, K., Pandya, C., Mendhe, B., Isales, C. M., McGee-Lawrence, M. E., Johnson, M., Fulzele, S. & Hamrick, M. W., 2019, In: Oxidative medicine and cellular longevity. 2019, 9894238.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Lower hand grip strength in older adults with non-alcoholic fatty liver disease: A nationwide population-based study
Kim, B. J., Ahn, S. H., Lee, S. H., Hong, S., Hamrick, M. W., Isales, C. M. & Koh, J. M., Jul 1 2019, In: Aging. 11, 13, p. 4547-4560 14 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Meta-analysis and evidence base for the efficacy of autologous bone marrow mesenchymal stem cells in knee cartilage repair: Methodological guidelines and quality assessment
Awad, M. E., Hussein, K. A., Helwa, I., Abdelsamid, M. F., Aguilar-Perez, A., Mohsen, I., Hunter, M., Hamrick, M. W., Isales, C. M., Elsalanty, M., Hill, W. D. & Fulzele, S., 2019, In: Stem Cells International. 2019, 3826054.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
MicroRNA-141-3p Negatively Modulates SDF-1 Expression in Age-Dependent Pathophysiology of Human and Murine Bone Marrow Stromal Cells
Periyasamy-Thandavan, S., Burke, J., Mendhe, B., Kondrikova, G., Kolhe, R., Hunter, M., Isales, C. M., Hamrick, M. W., Hill, W. D., Fulzele, S., Beerman, I. & Hare, J., Aug 16 2019, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 9, p. 1368-1374 7 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells
Fulzele, S. T., Mendhe, B., Khayrullin, A., Johnson, M. H., Kaiser, H., Liu, Y., Isales, C. M. & Hamrick, M. W., Mar 31 2019, In: Aging. 11, 6, p. 1791-1803 13 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview
Fariyike, B., Singleton, Q., Hunter, M., Hill, W. D., Isales, C. M., Hamrick, M. W. & Fulzele, S., Mar 2019, In: Mechanisms of Ageing and Development. 178, p. 9-15 7 p.Research output: Contribution to journal › Review article › peer-review
9 Scopus citations -
Stromal cell-derived factor-1 (CXCL12) and its role in bone and muscle biology
Gilbert, W., Bragg, R., Elmansi, A. M., McGee Lawrence, M. E., Isales, C. M., Hamrick, M. W., Hill, W. D. & Fulzele, S. T., Nov 2019, In: Cytokine. 123, 154783.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
Stromal cell-derived factor-1 as a potential therapeutic target for osteoarthritis and rheumatoid arthritis
Bragg, R., Gilbert, W., Elmansi, A. M., Isales, C. M., Hamrick, M. W., Hill, W. D. & Fulzele, S., 2019, In: Therapeutic Advances in Chronic Disease. 10Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
The detrimental effects of kynurenine, a tryptophan metabolite, on human bone metabolism
Kim, B. J., Hamrick, M. W., Yoo, H. J., Lee, S. H., Kim, S. J., Koh, J. M. & Isales, C. M., Jun 1 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 6, p. 2334-2342 9 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
The effects of myokines on osteoclasts and osteoblasts
Lee, J. Y., Park, S. J., Han, S. A., Lee, S. H., Koh, J. M., Hamrick, M. W. & Kim, B. J., Oct 1 2019, In: Biochemical and Biophysical Research Communications. 517, 4, p. 749-754 6 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
The glucocorticoid receptor in osteoprogenitors regulates bone mass and marrow fat
Pierce, J. L., Ding, K. H., Xu, J., Sharma, A. K., Yu, K., Arbona, N. M., Rodr guez-Santos, Z., Bernard, P. J., Bollag, W. B., Johnson, M. H., Hamrick, M. W., Begun, D. L., Shi, X. M., Isales, C. M. & McGee-Lawrence, M. E., Oct 2019, In: Journal of Endocrinology. 243, 1, p. 27-42 16 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands
Elmansi, A. M., Awad, M. E., Eisa, N. H., Kondrikov, D., Hussein, K. A., Aguilar-Pérez, A., Herberg, S., Periyasamy-Thandavan, S., Fulzele, S., Hamrick, M. W., McGee-Lawrence, M. E., Isales, C. M., Volkman, B. F. & Hill, W. D., Jun 2019, In: Pharmacology and Therapeutics. 198, p. 90-108 19 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
2018
Amino acids as signaling molecules modulating bone turnover
Ding, K., Cain, M., Davis, M., Bergson, C. M., McGee Lawrence, M. E., Perkins, C., Hardigan, T., Shi, X. M., Zhong, Q., Xu, J., Bollag, W. B., Hill, W. D., Elsalanty, M. E., Hunter, D. M., Isales, M. C., Lopez, P., Hamrick, M. W. & Isales, C. M., Oct 2018, In: Bone. 115, p. 15-24 10 p.Research output: Contribution to journal › Review article › peer-review
9 Scopus citations -
Association of serum TSH with handgrip strength in community-dwelling euthyroid elderly
Kim, B. J., Lee, S. H., Isales, C. M., Hamrick, M. W., Kwak, M. K. & Koh, J. M., 2018, In: Journal of Clinical Endocrinology and Metabolism. 103, 11, p. 3986-3992 7 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Blocking Bone Loss with L-BAIBA
Hamrick, M. W. & McGee Lawrence, M. E., May 1 2018, In: Trends in Endocrinology and Metabolism. 29, 5, p. 284-286 3 p.Research output: Contribution to journal › Short survey › peer-review
1 Scopus citations -
Emerging role of extracellular vesicles in musculoskeletal diseases
Murphy, C., Withrow, J., Hunter, M., Liu, Y., Tang, Y. L., Fulzele, S. & Hamrick, M. W., Apr 2018, In: Molecular Aspects of Medicine. 60, p. 123-128 6 p.Research output: Contribution to journal › Review article › peer-review
28 Scopus citations -
Impact of muscle atrophy on bone metabolism and bone strength: implications for muscle-bone crosstalk with aging and disuse
Bettis, T., Kim, B. J. & Hamrick, M. W., Aug 1 2018, In: Osteoporosis International. 29, 8, p. 1713-1720 8 p.Research output: Contribution to journal › Review article › peer-review
33 Scopus citations -
Inverse relationship between serum hsCRP concentration and hand grip strength in older adults: A nationwide population-based study
Kim, B. J., Lee, S. H., Kwak, M. K., Isales, C. M., Koh, J. M. & Hamrick, M. W., Aug 1 2018, In: Aging. 10, 8, p. 2051-2061 11 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone
Yu, K., Sellman, D. P., Bahraini, A., Hagan, M. L., Elsherbini, A., Vanpelt, K. T., Marshall, P. L., Hamrick, M. W., McNeil, A., McNeil, P. L. & McGee Lawrence, M. E., Feb 1 2018, In: Journal of Orthopaedic Research. 36, 2, p. 653-662 10 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Modulation of miRNAS by vitamin C in human bone marrow stromal cells
Kolhe, R., Mondal, A. K., Pundkar, C., Periyasamy-Thandavan, S., Mendhe, B., Hunter, M., Isales, C. M., Hill, W. D., Hamrick, M. W. & Fulzele, S., Feb 8 2018, In: Nutrients. 10, 2, 186.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
The positive association of total protein intake with femoral neck strength (KNHANES IV)
Kim, B. J., Lee, S. H., Isales, C. M., Koh, J. M. & Hamrick, M. W., Jun 1 2018, In: Osteoporosis International. 29, 6, p. 1397-1405 9 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
2017
A comparative study of serum exosome isolation using differential ultracentrifugation and three commercial reagents
Helwa, I., Cai, J., Drewry, M. D., Zimmerman, A., Dinkins, M. B., Khaled, M. L., Seremwe, M., Dismuke, W. M., Bieberich, E., Stamer, W. D., Hamrick, M. W. & Liu, Y., Jan 2017, In: PloS one. 12, 1, e0170628.Research output: Contribution to journal › Article › peer-review
222 Scopus citations -
Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study
Carbone, L. D., Bůžková, P., Fink, H. A., Robbins, J. A., Bethel, M., Hamrick, M. W. & Hill, W. D., Jun 1 2017, In: Calcified Tissue International. 100, 6, p. 599-608 10 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Complex Anatomic Abnormalities of the Lower Leg Muscles and Tendons Associated With Phocomelia: A Case Report
Hodo, T., Hamrick, M. & Melenevsky, Y., Nov 2017, In: Journal of Foot and Ankle Surgery. 56, 6, p. 1335-1338 4 p.Research output: Contribution to journal › Article › peer-review
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Function of microRNAs in the osteogenic differentiation and therapeutic application of adipose-derived stem cells (ASCs)
Hodges, W. M., O’Brien, F., Fulzele, S. & Hamrick, M. W., Dec 2 2017, In: International journal of molecular sciences. 18, 12, 2597.Research output: Contribution to journal › Review article › peer-review
19 Scopus citations -
Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis
Kolhe, R. B., Hunter, D. M., Liu, S., Jadeja, R. N., Pundkar, C., Mondal, A. K., Mendhe, B., Drewry, M., Rojiani, M. V., Liu, Y., Isales, C. M., Guldberg, R. E., Hamrick, M. W. & Fulzele, S. T., Dec 1 2017, In: Scientific reports. 7, 1, 2029.Research output: Contribution to journal › Article › peer-review
74 Scopus citations -
Insulin Resistance and the IGF-I-Cortical Bone Relationship in Children Ages 9 to 13 Years
Kindler, J. M., Pollock, N. K., Laing, E. M., Oshri, A., Jenkins, N. T., Isales, C. M., Hamrick, M. W., Ding, K. H., Hausman, D. B., McCabe, G. P., Martin, B. R., Hill Gallant, K. M., Warden, S. J., Weaver, C. M., Peacock, M. & Lewis, R. D., Jul 2017, In: Journal of Bone and Mineral Research. 32, 7, p. 1537-1545 9 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss
Refaey, M. E., McGee-Lawrence, M. E., Fulzele, S., Kennedy, E. J., Bollag, W. B., Elsalanty, M., Zhong, Q., Ding, K. H., Bendzunas, N. G., Shi, X. M., Xu, J., Hill, W. D., Johnson, M. H., Hunter, M., Pierce, J. L., Yu, K., Hamrick, M. W. & Isales, C. M., Nov 2017, In: Journal of Bone and Mineral Research. 32, 11, p. 2182-2193 12 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations