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  • Mark W Hamrick
2020

Accumulation of kynurenine elevates oxidative stress and alters microRNA profile in human bone marrow stromal cells

Dalton, S., Smith, K., Singh, K., Kaiser, H., Kolhe, R., Mondal, A. K., Khayrullin, A., Isales, C. M., Hamrick, M. W., Hill, W. D. & Fulzele, S., Feb 2020, In : Experimental Gerontology. 130, 110800.

Research output: Contribution to journalArticle

4 Scopus citations

Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells

Elmansi, A. M., Hussein, K. A., Herrero, S. M., Periyasamy-Thandavan, S., Aguilar-Pérez, A., Kondrikova, G., Kondrikov, D., Eisa, N. H., Pierce, J. L., Kaiser, H., Ding, K. H., Walker, A. L., Jiang, X., Bollag, W. B., Elsalanty, M., Zhong, Q., Shi, X. M., Su, Y., Johnson, M., Hunter, M. & 7 others, Reitman, C., Volkman, B. F., Hamrick, M. W., Isales, C. M., Fulzele, S., McGee-Lawrence, M. E. & Hill, W. D., Jun 2020, In : Bone Reports. 12, 100270.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton

Hagan, M. L., Yu, K., Zhu, J., Vinson, B. N., Roberts, R. L., Montesinos Cartagena, M., Johnson, M. H., Wang, L., Isales, C. M., Hamrick, M. W., McNeil, P. L. & McGee-Lawrence, M. E., Jan 1 2020, In : Aging Cell. 19, 1, e13056.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Deletion of PPARγin Mesenchymal Lineage Cells Protects Against Aging-Induced Cortical Bone Loss in Mice

Cao, J., Ding, K., Pan, G., Rosario, R., Su, Y., Bao, Y., Zhou, H., Xu, J., McGee Lawrence, M. E., Hamrick, M. W., Isales, C. M. & Shi, X., Apr 17 2020, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 75, 5, p. 826-834 9 p.

Research output: Contribution to journalArticle

Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo

Elashiry, M., Elashiry, M. M., Elsayed, R., Rajendran, M., Auersvald, C., Zeitoun, R., Rashid, M. H., Ara, R., Meghil, M. M., Liu, Y., Arbab, A. S., Arce, R. M., Hamrick, M., Elsalanty, M., Brendan, M., Pacholczyk, R. & Cutler, C. W., Jan 1 2020, In : Journal of Extracellular Vesicles. 9, 1, 1795362.

Research output: Contribution to journalArticle

Open Access

Freeze-Dried Extracellular Vesicles From Adipose-Derived Stem Cells Prevent Hypoxia-Induced Muscle Cell Injury

El Baradie, K. B. Y., Nouh, M., O’Brien, F., Liu, Y., Fulzele, S., Eroglu, A. & Hamrick, M. W., Mar 20 2020, In : Frontiers in Cell and Developmental Biology. 8, 181.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway

Kondrikov, D. Y., Elmansi, A., Bragg, R. T., Mobley, T., Barrett, T., Eisa, N., Kondrikova, G., Schoeinlein, P., Aguilar-Perez, A., Shi, X. M., Fulzele, S., Lawrence, M. M. G., Hamrick, M., Isales, C. & Hill, W. D., Feb 2020, In : Experimental Gerontology. 130, 110805.

Research output: Contribution to journalArticle

7 Scopus citations

Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan

Kaiser, H., Parker, E. & Hamrick, M. W., Feb 2020, In : Experimental Gerontology. 130, 110797.

Research output: Contribution to journalReview article

1 Scopus citations

Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo

Pierce, J. L., Roberts, R. L., Yu, K., Kendall, R. K., Kaiser, H., Davis, C., Johnson, M. H., Hill, W. D., Isales, C. M., Bollag, W. B., Hamrick, M. W. & McGee-Lawrence, M. E., Feb 2020, In : Experimental Gerontology. 130, 110818.

Research output: Contribution to journalArticle

2 Scopus citations

Picolinic acid, a tryptophan oxidation product, does not impact bone mineral density but increases marrow adiposity

Ding, K., McGee-Lawrence, M. E., Kaiser, H., Sharma, A. K., Pierce, J. L., Irsik, D. L., Bollag, W. B., Xu, J., Zhong, Q., Hill, W. D., Shi, X. M., Fulzele, S., Kennedy, E. J., Elsalanty, M. E., Hamrick, M. W. & Isales, C. M., May 2020, In : Experimental Gerontology. 133, 110885.

Research output: Contribution to journalArticle

2 Scopus citations

Special issue: The kynurenine pathway in aging

Hamrick, M. W. & Isales, C. M., Jun 2020, In : Experimental Gerontology. 134, 110895.

Research output: Contribution to journalEditorial

Therapeutic application of extracellular vesicles for musculoskeletal repair & regeneration

Youssef El Baradie, K. B. & Hamrick, M. W., 2020, (Accepted/In press) In : Connective Tissue Research.

Research output: Contribution to journalArticle

The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice

Sharma, A. K., Roberts, R. L., Benson, R. D., Pierce, J. L., Yu, K., Hamrick, M. W. & McGee-Lawrence, M. E., May 20 2020, In : Frontiers in Cell and Developmental Biology. 8, 354.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Age-dependent oxidative stress elevates arginase 1 and uncoupled nitric oxide synthesis in skeletal muscle of aged mice

Pandya, C. D., Lee, B., Toque, H. A., Mendhe, B., Bragg, R. T., Pandya, B., Atawia, R. T., Isales, C., Hamrick, M., Caldwell, R. W. & Fulzele, S., 2019, In : Oxidative medicine and cellular longevity. 2019, 1704650.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture

Kim, B. J., Yoo, H. J., Park, S. J., Kwak, M. K., Lee, S. H., Kim, S. J., Hamrick, M. W., Isales, C. M., Ahn, S. H. & Koh, J. M., May 1 2019, In : Osteoporosis International. 30, 5, p. 1071-1078 8 p.

Research output: Contribution to journalArticle

Bone Marrow Derived Extracellular Vesicles Activate Osteoclast Differentiation in Traumatic Brain Injury Induced Bone Loss

Singleton, Q., Vaibhav, K., Braun, M., Patel, C., Khayrullin, A., Mendhe, B., Lee, B. R., Kolhe, R., Kaiser, H., Awad, M. E., Fariyike, T., Elsayed, R., Elsalanty, M., Isales, C. M., Liu, Y., Hamrick, M. W., Dhandapani, K. M. & Fulzele, S., Jan 17 2019, In : Fuel Cells. 8, 1

Research output: Contribution to journalArticle

Elevated ceramides 18:0 and 24:1 with aging are associated with hip fracture risk through increased bone resorption

Kim, B. J., Lee, J. Y., Park, S. J., Lee, S. H., Kim, S. J., Yoo, H. J., De Pena, S. I. R., McGee-Lawrence, M., Isales, C. M., Koh, J. M. & Hamrick, M. W., 2019, In : Aging. 11, 21, p. 9388-9404 17 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
4 Scopus citations

Lower hand grip strength in older adults with non-alcoholic fatty liver disease: A nationwide population-based study

Kim, B. J., Ahn, S. H., Lee, S. H., Hong, S., Hamrick, M. W., Isales, C. M. & Koh, J. M., Jul 1 2019, In : Aging. 11, 13, p. 4547-4560 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Meta-analysis and evidence base for the efficacy of autologous bone marrow mesenchymal stem cells in knee cartilage repair: Methodological guidelines and quality assessment

Awad, M. E., Hussein, K. A., Helwa, I., Abdelsamid, M. F., Aguilar-Perez, A., Mohsen, I., Hunter, M., Hamrick, M. W., Isales, C. M., Elsalanty, M., Hill, W. D. & Fulzele, S., 2019, In : Stem Cells International. 2019, 3826054.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

MicroRNA-141-3p Negatively Modulates SDF-1 Expression in Age-Dependent Pathophysiology of Human and Murine Bone Marrow Stromal Cells

Periyasamy-Thandavan, S., Burke, J., Mendhe, B., Kondrikova, G., Kolhe, R., Hunter, M., Isales, C. M., Hamrick, M. W., Hill, W. D., Fulzele, S., Beerman, I. & Hare, J., Aug 16 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 9, p. 1368-1374 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

Fulzele, S. T., Mendhe, B., Khayrullin, A., Johnson, M. H., Kaiser, H., Liu, Y., Isales, C. M. & Hamrick, M. W., Mar 31 2019, In : Aging. 11, 6, p. 1791-1803 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview

Fariyike, B., Singleton, Q., Hunter, M., Hill, W. D., Isales, C. M., Hamrick, M. W. & Fulzele, S., Mar 2019, In : Mechanisms of Ageing and Development. 178, p. 9-15 7 p.

Research output: Contribution to journalReview article

7 Scopus citations

Stromal cell-derived factor-1 (CXCL12) and its role in bone and muscle biology

Gilbert, W., Bragg, R., Elmansi, A. M., McGee Lawrence, M. E., Isales, C. M., Hamrick, M. W., Hill, W. D. & Fulzele, S. T., Nov 2019, In : Cytokine. 123, 154783.

Research output: Contribution to journalReview article

2 Scopus citations

Stromal cell-derived factor-1 as a potential therapeutic target for osteoarthritis and rheumatoid arthritis

Bragg, R., Gilbert, W., Elmansi, A. M., Isales, C. M., Hamrick, M. W., Hill, W. D. & Fulzele, S., 2019, In : Therapeutic Advances in Chronic Disease. 10

Research output: Contribution to journalReview article

Open Access

The detrimental effects of kynurenine, a tryptophan metabolite, on human bone metabolism

Kim, B. J., Hamrick, M. W., Yoo, H. J., Lee, S. H., Kim, S. J., Koh, J. M. & Isales, C. M., Jun 1 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 6, p. 2334-2342 9 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

The effects of myokines on osteoclasts and osteoblasts

Lee, J. Y., Park, S. J., Han, S. A., Lee, S. H., Koh, J. M., Hamrick, M. W. & Kim, B. J., Oct 1 2019, In : Biochemical and Biophysical Research Communications. 517, 4, p. 749-754 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands

Elmansi, A. M., Awad, M. E., Eisa, N. H., Kondrikov, D., Hussein, K. A., Aguilar-Pérez, A., Herberg, S., Periyasamy-Thandavan, S., Fulzele, S., Hamrick, M. W., McGee-Lawrence, M. E., Isales, C. M., Volkman, B. F. & Hill, W. D., Jun 2019, In : Pharmacology and Therapeutics. 198, p. 90-108 19 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Amino acids as signaling molecules modulating bone turnover

Ding, K., Cain, M., Davis, M., Bergson, C. M., McGee Lawrence, M. E., Perkins, C., Hardigan, T., Shi, X. M., Zhong, Q., Xu, J., Bollag, W. B., Hill, W. D., Elsalanty, M. E., Hunter, D. M., Isales, M. C., Lopez, P., Hamrick, M. W. & Isales, C. M., Oct 2018, In : Bone. 115, p. 15-24 10 p.

Research output: Contribution to journalReview article

8 Scopus citations

Association of serum TSH with handgrip strength in community-dwelling euthyroid elderly

Kim, B. J., Lee, S. H., Isales, C. M., Hamrick, M. W., Kwak, M. K. & Koh, J. M., Jan 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 11, p. 3986-3992 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Blocking Bone Loss with L-BAIBA

Hamrick, M. W. & McGee Lawrence, M. E., May 1 2018, In : Trends in Endocrinology and Metabolism. 29, 5, p. 284-286 3 p.

Research output: Contribution to journalShort survey

Emerging role of extracellular vesicles in musculoskeletal diseases

Murphy, C., Withrow, J., Hunter, M., Liu, Y., Tang, Y. L., Fulzele, S. & Hamrick, M. W., Apr 2018, In : Molecular Aspects of Medicine. 60, p. 123-128 6 p.

Research output: Contribution to journalReview article

21 Scopus citations

Impact of muscle atrophy on bone metabolism and bone strength: implications for muscle-bone crosstalk with aging and disuse

Bettis, T., Kim, B. J. & Hamrick, M. W., Aug 1 2018, In : Osteoporosis International. 29, 8, p. 1713-1720 8 p.

Research output: Contribution to journalReview article

23 Scopus citations

Inverse relationship between serum hsCRP concentration and hand grip strength in older adults: A nationwide population-based study

Kim, B. J., Lee, S. H., Kwak, M. K., Isales, C. M., Koh, J. M. & Hamrick, M. W., Aug 1 2018, In : Aging. 10, 8, p. 2051-2061 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone

Yu, K., Sellman, D. P., Bahraini, A., Hagan, M. L., Elsherbini, A., Vanpelt, K. T., Marshall, P. L., Hamrick, M. W., McNeil, A., McNeil, P. L. & McGee Lawrence, M. E., Feb 1 2018, In : Journal of Orthopaedic Research. 36, 2, p. 653-662 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Modulation of miRNAS by vitamin C in human bone marrow stromal cells

Kolhe, R., Mondal, A. K., Pundkar, C., Periyasamy-Thandavan, S., Mendhe, B., Hunter, M., Isales, C. M., Hill, W. D., Hamrick, M. W. & Fulzele, S., Feb 8 2018, In : Nutrients. 10, 2, 186.

Research output: Contribution to journalArticle

4 Scopus citations

The positive association of total protein intake with femoral neck strength (KNHANES IV)

Kim, B. J., Lee, S. H., Isales, C. M., Koh, J. M. & Hamrick, M. W., Jun 1 2018, In : Osteoporosis International. 29, 6, p. 1397-1405 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

A comparative study of serum exosome isolation using differential ultracentrifugation and three commercial reagents

Helwa, I., Cai, J., Drewry, M. D., Zimmerman, A., Dinkins, M. B., Khaled, M. L., Seremwe, M., Dismuke, W. M., Bieberich, E., Stamer, W. D., Hamrick, M. W. & Liu, Y., Jan 2017, In : PloS one. 12, 1, e0170628.

Research output: Contribution to journalArticle

189 Scopus citations

Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study

Carbone, L. D., Bůžková, P., Fink, H. A., Robbins, J. A., Bethel, M., Hamrick, M. W. & Hill, W. D., Jun 1 2017, In : Calcified Tissue International. 100, 6, p. 599-608 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Complex Anatomic Abnormalities of the Lower Leg Muscles and Tendons Associated With Phocomelia: A Case Report

Hodo, T., Hamrick, M. & Melenevsky, Y., Nov 2017, In : Journal of Foot and Ankle Surgery. 56, 6, p. 1335-1338 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis

Kolhe, R. B., Hunter, D. M., Liu, S., Jadeja, R. N., Pundkar, C., Mondal, A. K., Mendhe, B., Drewry, M., Rojiani, M. V., Liu, Y., Isales, C. M., Guldberg, R. E., Hamrick, M. W. & Fulzele, S. T., Dec 1 2017, In : Scientific reports. 7, 1, 2029.

Research output: Contribution to journalArticle

62 Scopus citations

Insulin Resistance and the IGF-I-Cortical Bone Relationship in Children Ages 9 to 13 Years

Kindler, J. M., Pollock, N. K., Laing, E. M., Oshri, A., Jenkins, N. T., Isales, C. M., Hamrick, M. W., Ding, K. H., Hausman, D. B., McCabe, G. P., Martin, B. R., Hill Gallant, K. M., Warden, S. J., Weaver, C. M., Peacock, M. & Lewis, R. D., Jul 2017, In : Journal of Bone and Mineral Research. 32, 7, p. 1537-1545 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss

Refaey, M. E., McGee-Lawrence, M. E., Fulzele, S., Kennedy, E. J., Bollag, W. B., Elsalanty, M., Zhong, Q., Ding, K. H., Bendzunas, N. G., Shi, X. M., Xu, J., Hill, W. D., Johnson, M. H., Hunter, M., Pierce, J. L., Yu, K., Hamrick, M. W. & Isales, C. M., Nov 2017, In : Journal of Bone and Mineral Research. 32, 11, p. 2182-2193 12 p.

Research output: Contribution to journalArticle

34 Scopus citations
50 Scopus citations

Whole-body vibration mimics the metabolic effects of exercise in male leptin receptor-deficient mice

McGee-Lawrence, M. E., Wenger, K. H., Misra, S., Davis, C. L., Pollock, N. K., Elsalanty, M., Ding, K., Isales, C. M., Hamrick, M. W., Wosiski-Kuhn, M., Arounleut, P., Mattson, M. P., Cutler, R. G., Yu, J. C. & Stranahan, A. M., May 1 2017, In : Endocrinology. 158, 5, p. 1160-1171 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle

Khayrullin, A., Smith, L., Mistry, D., Dukes, A., Pan, Y. C. A. & Hamrick, M. W., Oct 21 2016, In : Biochemical and Biophysical Research Communications. 479, 3, p. 590-595 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis

Withrow, J., Murphy, C., Liu, Y., Hunter, M., Fulzele, S. & Hamrick, M. W., Dec 1 2016, In : Arthritis Research and Therapy. 18, 1, 286.

Research output: Contribution to journalReview article

76 Scopus citations

Insulin resistance negatively influences the muscle- dependent igf-1-bone mass relationship in premenarcheal girls

Kindler, J. M., Pollock, N. K., Laing, E. M., Jenkins, N. T., Oshri, A., Isales, C., Hamrick, M. & Lewis, R. D., Jan 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 1, p. 199-205 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
35 Scopus citations