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  • Sylvia B Smith
2020
Open Access
2 Scopus citations

The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress

Lee, H., Smith, S. B., Sheu, S. S. & Yoon, Y., May 8 2020, In : Journal of Biological Chemistry. 295, 19, p. 6543-6560 18 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT2B, 5-HT7, or σ1 Receptor Ligands

Porter, M. R., Xiao, H., Wang, J., Smith, S. B. & Topczewski, J. J., Oct 10 2019, In : ACS Medicinal Chemistry Letters. 10, 10, p. 1436-1442 7 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A Novel Mechanism of Sigma 1 Receptor Neuroprotection: Modulation of miR-214-3p

Wang, J. & Smith, S. B., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer, p. 463-467 5 p. (Advances in Experimental Medicine and Biology; vol. 1185).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Excess homocysteine upregulates the NRF2-antioxidant pathway in retinal Müller glial cells

Navneet, S., Cui, X., Zhao, J., Wang, J., Kaidery, N. A., Thomas, B., Bollinger, K. E., Yoon, Y. & Smith, S. B., Jan 2019, In : Experimental eye research. 178, p. 228-237 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2

Navneet, S., Zhao, J., Wang, J., Mysona, B. A., Barwick, S., Ammal Kaidery, N., Saul, A. B., Kaddour-Djebbar, I., Bollag, W. B., Thomas, B., Bollinger, K. E. & Smith, S. B., Jun 2019, In : Redox Biology. 24, 101199.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus

Khaled, M. L., Bykhovskaya, Y., Gu, C., Liu, A., Drewry, M. D., Chen, Z., Mysona, B. A., Parker, E., McNabb, R. P., Yu, H., Lu, X., Wang, J., Li, X., Al-Muammar, A., Rotter, J. I., Porter, L. F., Estes, A., Watsky, M. A., Smith, S. B., Xu, H. & 5 others, Abu-Amero, K. K., Kuo, A., Shears, S. B., Rabinowitz, Y. S. & Liu, Y., Dec 1 2019, In : Scientific reports. 9, 1, 19406.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2

Wang, J., Zhao, J., Cui, X., Mysona, B. A., Navneet, S., Saul, A., Ahuja, M., Lambert, N., Gazaryan, I. G., Thomas, B., Bollinger, K. E. & Smith, S. B., Apr 2019, In : Free Radical Biology and Medicine. 134, p. 604-616 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017
13 Scopus citations

Analysis of MTHFR, CBS, glutathione, taurine, and hydrogen sulfide levels in retinas of hyperhomocysteinemic mice

Cui, X., Navneet, S., Wang, J., Roon, P., Chen, W., Xian, M. & Smith, S. B., Apr 2017, In : Investigative Ophthalmology and Visual Science. 58, 4, p. 1954-1963 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Detailed electroretinographic findings in rd8 mice

Saul, A. B., Cui, X., Markand, S. & Smith, S. B., Jun 1 2017, In : Documenta Ophthalmologica. 134, 3, p. 195-203 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Hyperhomocysteinemia alters retinal endothelial cells barrier function and angiogenic potential via activation of oxidative stress

Mohamed, R., Sharma, I., Ibrahim, A. S., Saleh, H., Elsherbiny, N. M., Fulzele, S., Elmasry, K., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., Dec 1 2017, In : Scientific reports. 7, 1, 09731.

Research output: Contribution to journalArticle

12 Scopus citations
8 Scopus citations

p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection

Zhu, S., Luo, H., Liu, H., Ha, Y., Mays, E. R., Lawrence, R. E., Winkelmann, E., Barrett, A. D., Smith, S. B., Wang, M., Wang, T. & Zhang, W., Sep 2017, In : Antiviral Research. 145, p. 70-81 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
16 Scopus citations
8 Scopus citations

The role of sigma1R in mammalian retina

Wang, J., Cui, X., Roon, P., Saul, A. & Smith, S. B., Jan 1 2017, In : Advances in experimental medicine and biology. 964, p. 267-284 18 p.

Research output: Contribution to journalArticle

4 Scopus citations
49 Scopus citations
2016

(+)-pentazocine reduces NMDA-induced murine retinal ganglion cell death through a σr1-dependent mechanism

Zhao, J., Mysona, B. A., Qureshi, A., Kim, L., Fields, T., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., Feb 2016, In : Investigative Ophthalmology and Visual Science. 57, 2, p. 453-461 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
37 Scopus citations

Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration

Ibrahim, A. S., Mander, S., Hussein, K. A., Elsherbiny, N. M., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., 2016, In : Oncotarget. 7, 8, p. 8532-8545 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Mthfr as a modifier of the retinal phenotype of Crb1rd8/rd8 mice

Markand, S., Saul, A., Tawfik, A., Cui, X., Rozen, R. & Smith, S. B., Apr 1 2016, In : Experimental eye research. 145, p. 164-172 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease

Promsote, W., Powell, F. L., Veean, S., Thounaojam, M., Markand, S., Saul, A., Gutsaeva, D., Bartoli, M., Smith, S. B., Ganapathy, V. & Martin, P. M., Dec 10 2016, In : Antioxidants and Redox Signaling. 25, 17, p. 921-935 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina

Shanmugam, A. K., Mysona, B. A., Wang, J., Zhao, J., Tawfik, A., Sanders, A., Markand, S., Zorrilla, E., Ganapathy, V., Bollinger, K. E. & Smith, S. B., Aug 2 2016, In : Current Eye Research. 41, 8, p. 1105-1112 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Role of sigma 1 receptor in retinal degeneration of the Ins2Akita/+ murine model of diabetic retinopathy

Wang, J., Cui, X., Roon, P. & Smith, S. B., May 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 6, p. 2770-2781 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

A lipidomic screen of hyperglycemia-treated hrecs links 12/15-lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase

Ibrahim, A. S., Elshafey, S., Sellak, H., Hussein, K. A., El-Sherbiny, M., Abdelsaid, M., Rizk, N., Beasley, S., Tawfik, A. M., Smith, S. B. & Al-Shabrawey, M., Mar 1 2015, In : Journal of Lipid Research. 56, 3, p. 599-611 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma

Ha, Y., Liu, H., Xu, Z., Yokota, H., Narayanan, S. P., Lemtalsi, T., Smith, S. B., Caldwell, R. W., Caldwell, R. B. & Zhang, W., Oct 1 2015, In : Cell Death and Disease. 6, 10, e1900.

Research output: Contribution to journalArticle

28 Scopus citations
72 Scopus citations

Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids

Ibrahim, A. S., Tawfik, A. M., Hussein, K. A., Elshafey, S., Markand, S., Rizk, N., Duh, E. J., Smith, S. B. & Al-Shabrawey, M., Mar 2015, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1851, 3, p. 290-298 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
17 Scopus citations

Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc-, the Na+-independent glutamate-cystine exchanger

Wang, J., Shanmugam, A., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Jun 14 2015, In : Free Radical Biology and Medicine. 86, p. 25-36 12 p., 12387.

Research output: Contribution to journalArticle

59 Scopus citations

Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells

Shanmugam, A., Wang, J., Markand, S., Perry, R. L., Tawfik, A., Zorrilla, E., Ganapathy, V. & Smith, S. B., Mar 1 2015, In : Journal of Neurochemistry. 132, 5, p. 546-558 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: A model of mild to moderate hyperhomocysteinemia

Tawfik, A., Markand, S., Al-Shabrawey, M., Mayo, J. N., Reynolds, J., Bearden, S. E., Ganapathy, V. & Smith, S. B., Sep 2014, In : American Journal of Pathology. 184, 9, p. 2573-2585 13 p.

Research output: Contribution to journalArticle

20 Scopus citations
8 Scopus citations

Dysregulation of system xc- expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice

Frederick, N. M., Bertho, J., Patel, K. K., Petr, G. T., Bakradze, E., Smith, S. B. & Rosenberg, P. A., Oct 2014, In : Neurochemistry International. 76, p. 59-69 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Folate Transport in Retina and Consequences on Retinal Structure and Function of Hyperhomocysteinemia

Smith, S. B., Ganapathy, P. S., Bozard, R. B. & Ganapathy, V., Apr 10 2014, Handbook of Nutrition, Diet and the Eye. Elsevier Inc., p. 349-359 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells

Mo, J., Zhang, M., Marshall, B., Smith, S., Covar, J. & Atherton, S., Aug 14 2014, In : Molecular Vision. 20, p. 1161-1173 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
21 Scopus citations

Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid

Ananth, S., Gnana-Prakasam, J. P., Bhutia, Y. D., Veeranan-Karmegam, R., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 4, p. 603-612 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Retinal expression of the serine protease matriptase-2 (tmprss6) and its role in retinal iron homeostasis

Gnana-Prakasam, J. P., Baldowski, R. B., Ananth, S., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 26 2014, In : Molecular Vision. 20, p. 561-574 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Role of bax in death of uninfected retinal cells during murine cytomegalovirus retinitis

Mo, J., Marshall, B., Covar, J., Zhang, N. Y., Smith, S. B., Atherton, S. S. & Zhang, M., Sep 23 2014, In : Investigative Ophthalmology and Visual Science. 55, 11, p. 7137-7146 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Sigma receptor 1 modulates ER stress and Bcl2 in murine retina

Ha, Y., Shanmugam, A. K., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Apr 2014, In : Cell and Tissue Research. 356, 1, p. 15-27 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Sigma receptor ligand, (+)-pentazocine, suppresses inflammatory responses of retinal microglia

Zhao, J., Ha, Y., Liou, G. I., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., May 8 2014, In : Investigative Ophthalmology and Visual Science. 55, 6, p. 3375-3384 10 p.

Research output: Contribution to journalArticle

34 Scopus citations
2013

Alterations of retinal vasculature in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia

Tawfik, A., Al-Shabrawey, M., Roon, P., Sonne, S., Covar, J. A., Matragoon, S., Ganapathy, P. S., Atherton, S. S., El-Remessy, A., Ganapathy, V. & Smith, S. B., Feb 2013, In : Investigative Ophthalmology and Visual Science. 54, 2, p. 939-949 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Cystathionine beta synthase expression in mouse retina

Markand, S., Tawfik, A., Ha, Y., Gnana-Prakasam, J., Sonne, S., Ganapathy, V., Sen, N., Xian, M. & Smith, S. B., May 2013, In : Current Eye Research. 38, 5, p. 597-604 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Diabetes and Overexpression of proNGF Cause Retinal Neurodegeneration via Activation of RhoA Pathway

Al-Gayyar, M. M. H., Mysona, B. A., Matragoon, S., Abdelsaid, M. A., El-Azab, M. F., Shanab, A. Y., Ha, Y., Smith, S. B., Bollinger, K. E. & El-Remessy, A. B., Jan 30 2013, In : PloS one. 8, 1, e54692.

Research output: Contribution to journalArticle

28 Scopus citations

GADD34 induces cell death through inactivation of Akt following traumatic brain injury

Farook, J. M., Shields, J., Tawfik, A., Markand, S., Sen, T., Smith, S. B., Brann, D., Dhandapani, K. M. & Sen, N., Aug 2013, In : Cell Death and Disease. 4, 8, e754.

Research output: Contribution to journalArticle

44 Scopus citations

Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth

Sonne, S. R., Bhalla, V. K., Barman, S. A., White, R. E., Zhu, S., Newman, T. M., Prasad, P. D., Smith, S. B., Offermanns, S. & Ganapathy, V., May 14 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 8, p. 1149-1158 10 p.

Research output: Contribution to journalArticle

10 Scopus citations