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  • John Kenneth Cowell
2020

Critical individual roles of the BCR and FGFR1 kinase domains in BCR-FGFR1-driven stem cell leukemia/lymphoma syndrome

Chong, Y., Liu, Y., Lu, S., Cai, B., Qin, H., Chang, C. S., Ren, M., Cowell, J. K. & Hu, T., Apr 15 2020, In : International Journal of Cancer. 146, 8, p. 2243-2254 12 p.

Research output: Contribution to journalArticle

Inactivation of Lgi1 in murine neuronal precursor cells leads to dysregulation of axon guidance pathways

Silva, J., Hawthorn, L. & Cowell, J. K., Mar 2020, In : Genomics. 112, 2, p. 1167-1172 6 p.

Research output: Contribution to journalArticle

Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome

Hu, T., Chong, Y., Lu, S., McGuinness, M., Williams, D. A. & Cowell, J. K., Jan 31 2020, In : Haematologica. 105, 2, p. E68-E71

Research output: Contribution to journalLetter

Open Access
2019

Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20 (Oncogene, (2019), 38, 4, (469-482), 10.1038/s41388-018-0472-0)

Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jul 11 2019, In : Oncogene. 38, 28, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Distinct signaling programs associated with progression of FGFR1 driven leukemia in a mouse model of stem cell leukemia lymphoma syndrome

Silva, M. J., Chang, C. S., Hu, T., Qin, H., Kitamura, E., Hawthorn, L., Ren, M. & Cowell, J. K., Dec 2019, In : Genomics. 111, 6, p. 1566-1573 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

DNA methyltransferase 1–mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1– driven leukemogenesis

Hu, T., Chong, Y., Cai, B., Liu, Y., Lu, S. & Cowell, J. K., Nov 29 2019, In : Journal of Biological Chemistry. 294, 48, p. 18122-18130 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Loss of the BCR-FGFR1 GEF domain suppresses RhoA activation and enhances B-lymphomagenesis in mice

Hu, T., Chong, Y., Lu, S., Qin, H., Ren, M., Savage, N. M., Chang, C. S. & Cowell, J. K., Jan 1 2019, In : Cancer Research. 79, 1, p. 114-124 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

Piranlioglu, R., Lee, E. M., Ouzounova, M., Bollag, R. J., Vinyard, A., Arbab, A. S., Marasco, D., Guzel, M., Cowell, J. K., Thangaraju, M., Chadli, A., Hassan, K. A., Wicha, M. S., Celis, E. & Korkaya, H., Dec 1 2019, In : Nature communications. 10, 1, 1430.

Research output: Contribution to journalArticle

8 Scopus citations

Selective inactivation of LGI1 in neuronal precursor cells leads to cortical dysplasia in mice

Silva, J., Qin, H. & Cowell, J. K., Feb 1 2019, In : Genesis. 57, 2, e23268.

Research output: Contribution to journalArticle

1 Scopus citations

The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis

Eisa, N. H., Jilani, Y., Kainth, K., Redd, P., Lu, S., Bougrine, O., Sater, H. A., Patwardhan, C. A., Shull, A., Shi, H., Liu, K., Elsherbiny, N. M., Eissa, L. A., El-Shishtawy, M. M., Horuzsko, A., Bollag, R., Maihle, N., Roig, J., Korkaya, H., Cowell, J. K. & 1 others, Chadli, A., Apr 5 2019, In : Journal of Biological Chemistry. 294, 14, p. 5246-5260 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20

Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jan 24 2019, In : Oncogene. 38, 4, p. 469-482 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Wasf3 Deficiency Reveals Involvement in Metastasis in a Mouse Model of Breast Cancer

Qin, H., Lu, S., Thangaraju, M. & Cowell, J. K., Dec 2019, In : American Journal of Pathology. 189, 12, p. 2450-2458 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

Ouzounova, M., Lee, E., Piranlioglu, R., El Andaloussi, A., Kolhe, R., Demirci, M. F., Marasco, D., Asm, I., Chadli, A., Hassan, K. A., Thangaraju, M., Zhou, G., Arbab, A. S., Cowell, J. K. & Korkaya, H., Apr 6 2017, In : Nature communications. 8, 14979.

Research output: Contribution to journalArticle

97 Scopus citations
13 Scopus citations

Promotion of invasion by mutant RAS is dependent on activation of the WASF3 metastasis promoter gene

Teng, Y., Ngoka, L. & Cowell, J. K., Jun 2017, In : Genes Chromosomes and Cancer. 56, 6, p. 493-500 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

A model of BCR-FGFR1 driven human AML in immunocompromised mice

Cowell, J. K., Qin, H., Chang, C. S., Kitamura, E. & Ren, M., Nov 1 2016, In : British Journal of Haematology. 175, 3, p. 542-545 4 p.

Research output: Contribution to journalLetter

9 Scopus citations

Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice

Ren, M., Qin, H., Wu, Q., Savage, N. M., George, T. I. & Cowell, J. K., Aug 15 2016, In : International Journal of Cancer. 139, 4, p. 836-840 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

FGFR1OP2-FGFR1 induced myeloid leukemia and T-cell lymphoma in a mouse model

Qin, H., Wu, Q., Cowell, J. K. & Ren, M., 2016, In : Haematologica. 101, 3, p. e91-e94

Research output: Contribution to journalLetter

7 Scopus citations

Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5 + CK8 + epithelial cells

Wang, Z., Kim, J., Teng, Y., Ding, H., Zhang, J., Hai, T., Cowell, J. K. & Yan, C., Jul 7 2016, In : Oncogene. 35, 27, p. 3555-3564 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein

Teng, Y., Ren, X., Li, H., Shull, A., Kim, J. & Cowell, J. K., Jan 21 2016, In : Oncogene. 35, 3, p. 333-343 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Targeting FGFR1 to suppress leukemogenesis in syndromic and de novo AML in murine models

Wu, Q., Bhole, A., Qin, H., Karp, J., Malek, S., Cowell, J. K. & Ren, M., 2016, In : Oncotarget. 7, 31, p. 49733-49742 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Targeting the WASF3-CYFIP1 complex using stapled peptides suppresses cancer cell invasion

Teng, Y., Bahassan, A., Dong, D., Hanold, L. E., Ren, X., Kennedy, E. J. & Cowell, J. K., Feb 15 2016, In : Cancer Research. 76, 4, p. 965-973 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

The WASF3-NCKAP1-CYFIP1 complex is essential for breast cancer metastasis

Teng, Y., Qin, H., Bahassan, A., Bendzunas, N. G., Kennedy, E. J. & Cowell, J. K., Sep 1 2016, In : Cancer Research. 76, 17, p. 5133-5142 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Transformation of human CD34+ hematopoietic progenitor cells with DEK-NUP214 induces AML in an immunocompromised mouse model

Qin, H., Malek, S., Cowell, J. K. & Ren, M., Oct 27 2016, In : Oncogene. 35, 43, p. 5686-5691 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility

Zhou, H. M., Fang, Y. Y., Weinberger, P. M., Ding, L. L., Cowell, J. K., Hudson, F. Z., Ren, M., Lee, J. R., Chen, Q. K., Su, H., Dynan, W. S. & Lin, Y., Feb 4 2016, In : BMC Cancer. 16, 1, 55.

Research output: Contribution to journalArticle

18 Scopus citations

WASF3 provides the conduit to facilitate invasion and metastasis in breast cancer cells through HER2/HER3 signaling

Teng, Y., Pi, W., Wang, Y. & Cowell, J. K., Sep 1 2016, In : Oncogene. 35, 35, p. 4633-4640 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Essential roles of leucine-rich glioma inactivated 1 in the development of embryonic and postnatal cerebellum

Xie, Y. J., Zhou, L., Jiang, N., Zhang, N., Zou, N., Zhou, L., Wang, Y., Cowell, J. K. & Shen, Y., Jan 16 2015, In : Scientific reports. 5, 7827.

Research output: Contribution to journalArticle

13 Scopus citations

Homozygous deletion of the LGI1 gene in mice leads to developmental abnormalities resulting in cortical dysplasia

Silva, J., Sharma, S. & Cowell, J. K., Sep 1 2015, In : Brain Pathology. 25, 5, p. 587-597 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

The promise of zebrafish as a chemical screening tool in cancer therapy

Xie, X., Ross, J. L., Cowell, J. K. & Teng, Y., Aug 1 2015, In : Future Medicinal Chemistry. 7, 11, p. 1395-1405 11 p.

Research output: Contribution to journalReview article

9 Scopus citations
2014

Abstract 1023: NOV C-ter: A novel preclinical anti-angiogenic agent

Luo, J., Teng, Y., Li, M., Johnson, T. S., Cuttitta, F., Chu, Z., Qi, X., Cowell, J. K. & Rixe, O., Oct 1 2014, p. 1023-1023.

Research output: Contribution to conferencePaper

LGI1: From zebrafish to human epilepsy

Cowell, J. K., Jan 1 2014, In : Progress in Brain Research. 213, C, p. 159-179 21 p.

Research output: Contribution to journalArticle

10 Scopus citations
57 Scopus citations
2013

COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis

Shao, J., Teng, Y., Padia, R., Hong, S., Noh, H., Xie, X., Mumm, J. S., Dong, Z., Ding, H. F., Cowell, J., Kim, J., Han, J. & Huang, S., Sep 2013, In : Neoplasia (United States). 15, 9, p. 1075-1085 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Corrigendum to "WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, And MMP-9 expression" [Exp. Cell Res. 308 (2005) 135-145]

Sossey-Alaoui, K., Ranalli, T. A., Li, X., Bakin, A. V. & Cowell, J. K., Mar 10 2013, In : Experimental Cell Research. 319, 5, 1 p.

Research output: Contribution to journalComment/debate

Critical role of the WASF3 gene in JAK2/STAT3 regulation of cancer cell motility

Teng, Y., Ghoshal, P., Ngoka, L., Mei, Y. & Cowell, J. K., Sep 2013, In : Carcinogenesis. 34, 9, p. 1994-1999 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Dysregulated signaling pathways in the development of CNTRL-FGFR1–induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models

Ren, M., Qin, H., Kitamura, E. & Cowell, J. K., Aug 8 2013, In : Blood. 122, 6, p. 1007-1016 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Evaluating human cancer cell metastasis in zebrafish

Teng, Y., Xie, X., Walker, S., White, D. T., Mumm, J. S. & Cowell, J. K., Oct 4 2013, In : BMC Cancer. 13, 453.

Research output: Contribution to journalArticle

91 Scopus citations

Evaluation of phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) and epidermal growth factor receptor (EGFR) gene mutations in pancreaticobiliary adenocarcinoma

Weiss, G. A., Rossi, M. R., Khushalani, N. I., Lo, K., Gibbs, J. F., Bharthuar, A., Cowell, J. K. & Iyer, R., Mar 2013, In : Journal of Gastrointestinal Oncology. 4, 1, p. 20-29 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

HOXC9 directly regulates distinct sets of genes to coordinate diverse cellular processes during neuronal differentiation

Wang, X., Choi, J-H., Ding, J., Yang, L., Ngoka, L. C., Lee, E. J., Zha, Y., Mao, L., Jin, B., Ren, M., Cowell, J. K., Huang, S., Shi, H., Cui, H. & Ding, H., Nov 25 2013, In : BMC Genomics. 14, 1, 830.

Research output: Contribution to journalArticle

15 Scopus citations

Novel FGFR inhibitor ponatinib suppresses the growth of non-small cell lung cancer cells overexpressing FGFR1

Ren, M., Hong, M., Liu, G., Wang, H., Patel, V. S., Biddinger, P. W., Silva, M. J., Cowell, J. K. & Hao, Z., Jun 1 2013, In : Oncology Reports. 29, 6, p. 2181-2190 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Ponatinib suppresses the development of myeloid and lymphoid malignancies associated with FGFR1 abnormalities

Ren, M., Qin, H., Ren, R. & Cowell, J. K., Jan 2013, In : Leukemia. 27, 1, p. 32-40 9 p.

Research output: Contribution to journalArticle

52 Scopus citations
2012

Acute progression of BCR-FGFR1 induced murine B-lympho/myeloproliferative disorder suggests involvement of lineages at the pro-B cell stage

Ren, M. Q., Tidwell, J. A., Sharma, S. & Cowell, J. K., Jun 6 2012, In : PloS one. 7, 6, e38265.

Research output: Contribution to journalArticle

18 Scopus citations

HIF1A induces expression of the WASF3 metastasis-associated gene under hypoxic conditions

Ghoshal, P., Teng, Y., Lesoon, L. A. & Cowell, J. K., Sep 15 2012, In : International Journal of Cancer. 131, 6, p. E905-E915

Research output: Contribution to journalArticle

20 Scopus citations

HSP90 and HSP70 Proteins are essential for stabilization and activation of WASF3 metastasis-promoting protein

Teng, Y., Ngoka, L., Mei, Y., Lesoon, L. & Cowell, J. K., Mar 23 2012, In : Journal of Biological Chemistry. 287, 13, p. 10051-10059 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Ubiquitin-conjugating enzyme UBE2C: Molecular biology, role in tumorigenesis, and potential as a biomarker

Hao, Z., Zhang, H. & Cowell, J., Jun 1 2012, In : Tumor Biology. 33, 3, p. 723-730 8 p.

Research output: Contribution to journalReview article

60 Scopus citations
2011

Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization

Hawthorn, L. & Cowell, J. K., 2011, In : PloS one. 6, 4, e18941.

Research output: Contribution to journalArticle

18 Scopus citations

CML: a model disease with a defined oncogenic driver.

Hao, Z. & Cowell, J. K., Mar 1 2011, In : Clinical advances in hematology & oncology : H&O. 9, 3, p. 247-248 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease

Ren, M. Q. & Cowell, J. K., Jun 23 2011, In : Blood. 117, 25, p. 6837-6847 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Erratum: Genetic analysis of Down syndrome-associated heart defects in mice (Human Genetics DOI: 10.1007/s00439-011-0980-2)

Liu, C., Morishima, M., Yu, T., Matsui, S. I., Zhang, L., Fu, D., Pao, A., Costa, A. C., Gardiner, K. J., Cowell, J. K., Nowak, N. J., Parmacek, M. S., Liang, P., Baldini, A. & Yu, Y. E., Nov 1 2011, In : Human Genetics. 130, 5, 1 p.

Research output: Contribution to journalComment/debate

Functional interrelationship between the WASF3 and KISS1 metastasis-associated genes in breast cancer cells

Teng, Y., Liu, M. & Cowell, J. K., Dec 15 2011, In : International Journal of Cancer. 129, 12, p. 2825-2835 11 p.

Research output: Contribution to journalArticle

43 Scopus citations