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• 2020

  Astrocyte-derived estrogen regulates reactive astrogliosis and is neuroprotective following ischemic brain injury

  Wang, J., Sareddy, G. R., Lu, Y., Pratap, U. P., Tang, F., Greene, K. M., Meyre, P. L., Tekmal, R. R., Vadlamudi, R. K. & Brann, D. W., Dec 9 2020, In: Journal of Neuroscience. 40, 50, p. 9751-9771 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain Injuries
  • Glial Fibrillary Acidic Protein
  • Astrocytes
  • Estrogens
  • Aromatase

• G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: Implications for neuronal self-defense

  Bai, N., Zhang, Q., Zhang, W., Liu, B., Yang, F., Brann, D. & Wang, R., Feb 1 2020, In: Journal of Neuroinflammation. 17, 1, 45.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-1 Receptors
  • G-Protein-Coupled Receptors
  • Brain Ischemia
  • Estrogen Receptors
  • Hippocampus
  3 Scopus citations

• Neuron-derived estrogen is critical for astrocyte activation and neuroprotection of the ischemic brain

  Lu, Y., Sareddy, G. R., Wang, J., Zhang, Q., Tang, F. L., Pratap, U. P., Tekmal, R. R., Vadlamudi, R. K. & Brann, D. W., Sep 16 2020, In: Journal of Neuroscience. 40, 38, p. 7355-7374 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroprotection
  • Mouse Cyp19a1 protein
  • Astrocytes
  • Estrogens
  • Prosencephalon
  1 Scopus citations
• 2016

  Acetylated α-Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Proline(Ac-SDKP) Exerts the Anti-fibrotic Effect in Rat Lung Fibrosis Induced by Silica

  Xiaojun, W., Yan, L., Hong, X., Xianghong, Z., Shifeng, L., Dingjie, X., Xuemin, G., Lijuan, Z., Bonan, Z., Zhongqiu, W., Ruimin, W., Brann, D. & Fang, Y., Aug 31 2016, In: Scientific reports. 6, 32257.

  Research output: Contribution to journal › Article › peer-review

  • goralatide
  • Silicon Dioxide
  • Tubulin
  • Silicosis
  • Fibrosis
  10 Scopus citations

• Neuroprotection Mediated through GluN2C-Containing N-methyl-D-aspartate (NMDA) Receptors Following Ischemia

  Chung, C., Marson, J. D., Zhang, Q., Kim, J., Wu, W. H., Brann, D. W. & Chen, B. S., Nov 15 2016, In: Scientific reports. 6, 37033.

  Research output: Contribution to journal › Article › peer-review

  • Neuroprotection
  • N-Methyl-D-Aspartate Receptors
  • Ischemia
  • Neurons
  • Spatial Memory
  11 Scopus citations

• NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17 β -Estradiol

  Thakkar, R., Wang, R., Sareddy, G., Wang, J., Thiruvaiyaru, D., Vadlamudi, R., Zhang, Q. & Brann, D., 2016, In: Oxidative medicine and cellular longevity. 2016, 8309031.

  Research output: Contribution to journal › Article › peer-review

  • human PELP1 protein
  • Inflammasomes
  • Brain Ischemia
  • Chemical activation
  • Estradiol
  36 Scopus citations

• Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-β1/ROCK1 pathway in silicosis in rat

  Deng, H., Xu, H., Zhang, X., Sun, Y., Wang, R., Brann, D. W. & Yang, F., Mar 1 2016, In: Toxicology and Applied Pharmacology. 294, p. 1-10 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Alveolar Epithelial Cells
  • goralatide
  • Silicosis
  • Rats
  • Epithelial-Mesenchymal Transition
  17 Scopus citations
• 2015

  Cell-permeable peptide targeting the Nrf2-keap1 interaction: A potential novel therapy for global cerebral ischemia

  Tu, J., Zhang, X., Zhu, Y., Dai, Y., Li, N., Yang, F., Zhang, Q., Brann, D. W. & Wang, R., Nov 4 2015, In: Journal of Neuroscience. 35, 44, p. 14727-14739 13 p.

  Research output: Contribution to journal › Article › peer-review

  • NF-E2-Related Factor 2
  • Trans-Activators
  • Brain Ischemia
  • Peptides
  • Kelch-Like ECH-Associated Protein 1
  43 Scopus citations

• Proline-, glutamic acid-, and leucine-rich protein 1 mediates estrogen rapid signaling and neuroprotection in the brain

  Sareddy, G. R., Zhang, Q., Wang, R., Scott, E., Zou, Y., O'Connor, J. C., Chen, Y., Dong, Y., Vadlamudi, R. K. & Brann, D. W., Dec 1 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 48, p. E6673-E6682

  Research output: Contribution to journal › Article › peer-review

  • human PELP1 protein
  • Neuroprotection
  • Estrogens
  • Glycogen Synthase Kinase 3
  • Brain
  25 Scopus citations

• Prosurvival NMDA 2A receptor signaling mediates postconditioning neuroprotection in the hippocampus

  Zhang, X., Zhang, Q., Tu, J., Zhu, Y., Yang, F., Liu, B., Brann, D. W. & Wang, R., Mar 1 2015, In: Hippocampus. 25, 3, p. 286-296 11 p.

  Research output: Contribution to journal › Article › peer-review

  • N-methyl D-aspartate receptor subtype 2A
  • Neuroprotection
  • Brain Ischemia
  • Hippocampus
  • Phosphorylation
  21 Scopus citations

• Selective estrogen receptor modulators (SERMs) enhance neurogenesis and spine density following focal cerebral ischemia

  Khan, M. M., Wakade, C. G., De Sevilla, L. & Brann, D. W., Feb 2015, In: Journal of Steroid Biochemistry and Molecular Biology. 146, p. 38-47 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Selective Estrogen Receptor Modulators
  • Rats
  • Neurogenesis
  • Brain Ischemia
  • Spine
  39 Scopus citations
• 2014

  Beneficial effects of estrogens in the brain and cardiovascular system

  Brann, D. W. & Mahesh, V. B., May 25 2014, In: Molecular and Cellular Endocrinology. 389, 1-2, 1 p.

  Research output: Contribution to journal › Editorial › peer-review
  3 Scopus citations

• Brain-derived estrogen exerts anti-inflammatory and neuroprotective actions in the rat hippocampus

  Zhang, Q., Wang, R., Tang, H., Dong, Y., Chan, A., Sareddy, G. R., Vadlamudi, R. K. & Brann, D. W., May 25 2014, In: Molecular and Cellular Endocrinology. 389, 1-2, p. 84-91 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Aromatase
  • Rats
  • Brain Ischemia
  • Astrocytes
  • Brain
  63 Scopus citations

• GPR30 mediates estrogen rapid signaling and neuroprotection

  Tang, H., Zhang, Q., Yang, L., Dong, Y., Khan, M. B., Yang, F., Brann, D. W. & Wang, R., Apr 25 2014, In: Molecular and Cellular Endocrinology. 387, 1-2, p. 52-58 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuroprotection
  • G-Protein-Coupled Receptors
  • GTP-Binding Proteins
  • Estrogen Receptors
  • estradiol-bovine serum albumin
  63 Scopus citations

• Low dose Hsp90 inhibitor 17AAG protects neural progenitor cells from ischemia induced death

  Bradley, E., Zhao, X., Wang, R., Brann, D. W., Bieberich, E. & Wang, G., Dec 30 2014, In: Journal of Cell Communication and Signaling. 8, 4, p. 353-362 10 p.

  Research output: Contribution to journal › Article › peer-review

  • tanespimycin
  • Cell death
  • Ischemia
  • Stem Cells
  • Regenerative Medicine
  10 Scopus citations

• PELP1 oncogenic functions involve alternative splicing via PRMT6

  Mann, M., Zou, Y., Chen, Y., Brann, D. & Vadlamudi, R., Mar 2014, In: Molecular Oncology. 8, 2, p. 389-400 12 p.

  Research output: Contribution to journal › Article › peer-review

  • human PELP1 protein
  • Alternative Splicing
  • Estrogen Receptors
  • Breast Neoplasms
  • Genes
  13 Scopus citations

• Premature menopause and risk of neurological disease: Basic mechanisms and clinical implications

  Scott, E. L., Zhang, Q. G., Vadlamudi, R. K. & Brann, D. W., May 25 2014, In: Molecular and Cellular Endocrinology. 389, 1-2, p. 2-6 5 p.

  Research output: Contribution to journal › Review article › peer-review

  • Premature Menopause
  • Brain Ischemia
  • Nervous System Diseases
  • Estradiol
  • Dementia
  19 Scopus citations

• Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response

  Nair, B. C., Krishnan, S. R., Sareddy, G. R., Mann, M., Xu, B., Natarajan, M., Hasty, P., Brann, D., Tekmal, R. R. & Vadlamudi, R. K., Sep 2014, In: Cell Death and Differentiation. 21, 9, p. 1409-1418 10 p.

  Research output: Contribution to journal › Article › peer-review

  • human PELP1 protein
  • DNA Damage
  • Ataxia Telangiectasia
  • Camptothecin
  • p53 Genes
  26 Scopus citations

• Reprint of "GPR30 mediates estrogen rapid signaling and neuroprotection"

  Tang, H., Zhang, Q., Yang, L., Dong, Y., Khan, M. B., Yang, F., Brann, D. W. & Wang, R., May 25 2014, In: Molecular and Cellular Endocrinology. 389, 1-2, p. 92-98 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuroprotection
  • G-Protein-Coupled Receptors
  • GTP-Binding Proteins
  • Estrogen Receptors
  • estradiol-bovine serum albumin
  22 Scopus citations

• Surgical menopause enhances hippocampal amyloidogenesis following global cerebral ischemia

  Scott, E. L., Zhang, Q., Dong, Y., Han, D., Wang, R. M., Vadlamudi, R. K. & Brann, D. W., Sep 2014, In: Journal of Sport and Health Science. 3, 3, p. 206-216 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Menopause
  • Brain Ischemia
  • Ovariectomy
  • Nervous System Diseases
  • Dementia
  2 Scopus citations
• 2013

  Early effects of high-fat diet on neurovascular function and focal ischemic brain injury

  Li, W., Prakash, R., Chawla, D., Du, W., Didion, S. P., Filosa, J. A., Zhang, Q., Brann, D. W., Lima, V. V., Tostes, R. C. & Ergul, A., 2013, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 304, 11, p. R1001-R1008

  Research output: Contribution to journal › Article › peer-review

  • High Fat Diet
  • Brain Injuries
  • Neurovascular Coupling
  • Basilar Artery
  • Middle Cerebral Artery Infarction
  65 Scopus citations

• Erratum: GADD34 induces cell death through inactivation of Akt following traumatic brain injury (Cell Death and Disease (2013) 4 (e754) DOI: 10.1038/cddis.2013.280)

  Farook, J. M., Shields, J., Tawfik, A., Markand, S., Sen, T., Smith, S. B., Brann, D., Dhandapani, K. M. & Sen, N., Sep 2013, In: Cell Death and Disease. 4, 9, e813.

  Research output: Contribution to journal › Comment/debate › peer-review

• Estrogen regulation of Dkk1 and Wnt/β-Catenin signaling in neurodegenerative disease

  Scott, E. L. & Brann, D. W., Jun 13 2013, In: Brain Research. 1514, p. 63-74 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Catenins
  • Wnt Signaling Pathway
  • Neurodegenerative Diseases
  • Estrogens
  • Hormones
  46 Scopus citations

• Estrogen regulation of spine density and excitatory synapses in rat prefrontal and somatosensory cerebral cortex

  Khan, M. M., Dhandapani, K. M., Zhang, Q. & Brann, D. W., Jun 2013, In: Steroids. 78, 6, p. 614-623 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Rats
  • Somatosensory Cortex
  • Cerebral Cortex
  • Neurons
  • Synapses
  40 Scopus citations

• GADD34 induces cell death through inactivation of Akt following traumatic brain injury

  Farook, J. M., Shields, J., Tawfik, A., Markand, S., Sen, T., Smith, S. B., Brann, D., Dhandapani, K. M. & Sen, N., Aug 2013, In: Cell Death and Disease. 4, 8, e754.

  Research output: Contribution to journal › Article › peer-review

  • TNF Receptor-Associated Factor 6
  • Traumatic Brain Injury
  • Cell Death
  • Activating Transcription Factor 4
  • Phosphorylation
  45 Scopus citations

• Genistein attenuates ischemic oxidative damage and behavioral deficits via eNOS/Nrf2/HO-1 signaling

  Wang, R., Tu, J., Zhang, Q., Zhang, X., Zhu, Y., Ma, W., Cheng, C., Brann, D. W. & Yang, F., Jul 1 2013, In: Hippocampus. 23, 7, p. 634-647 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Genistein
  • Heme Oxygenase-1
  • Brain Ischemia
  • Oxidative Stress
  • Neurons
  76 Scopus citations

• Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause

  Zhang, Q., Wang, R. M., Scott, E., Han, D., Dong, Y., Tu, J. Y., Yang, F., Reddy Sareddy, G., Vadlamudi, R. K. & Brann, D. W., May 2013, In: Brain. 136, 5, p. 1432-1445 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Hippocampal CA3 Region
  • Anatomic Models
  • Ovariectomy
  • Menopause
  • Hypersensitivity
  34 Scopus citations

• KDM1 is a novel therapeutic target for the treatment of gliomas

  Sareddy, G. R., Nair, B. C., Krishnan, S. K., Gonugunta, V. K., Zhang, Q. G., Suzuki, T., Miyata, N., Brenner, A. J., Brann, D. W. & Vadlamudi, R. K., 2013, In: Oncotarget. 4, 1, p. 18-28 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Glioma
  • Heterografts
  • p53 Genes
  • Epigenomics
  • Therapeutics
  33 Scopus citations

• Long-term estrogen deprivation leads to elevation of Dickkopf-1 and dysregulation of Wnt/β-Catenin signaling in hippocampal CA1 neurons

  Scott, E. L., Zhang, Q. G., Han, D., Desai, B. N. & Brann, D. W., Jun 2013, In: Steroids. 78, 6, p. 624-632 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Catenins
  • Rats
  • Brain Ischemia
  • Neurons
  • Estrogens
  18 Scopus citations
• 2012

  A new antifibrotic target of Ac-SDKP: Inhibition of myofibroblast differentiation in rat lung with silicosis

  Xu, H., Yang, F., Sun, Y., Yuan, Y., Cheng, H., Wei, Z., Li, S., Cheng, T., Brann, D. W. & Wang, R., Jul 3 2012, In: PloS one. 7, 7, e40301.

  Research output: Contribution to journal › Article › peer-review

  • goralatide
  • Silicosis
  • Rats
  • Myofibroblasts
  • collagen
  51 Scopus citations

• Critical role of nadph oxidase in neuronal oxidative damage and microglia activation following traumatic brain injury

  Zhang, Q., Laird, M. D., Han, D., Nguyen, K., Scott, E., Dong, Y., Dhandapani, K. M. & Brann, D. W., Apr 2 2012, In: PloS one. 7, 4, e34504.

  Research output: Contribution to journal › Article › peer-review

  • Microglia
  • Oxidative stress
  • NADPH Oxidases
  • neuroglia
  • Traumatic Brain Injury
  141 Scopus citations

• Estrogen neuroprotection and the critical period hypothesis

  Scott, E., Zhang, Q. G., Wang, R., Vadlamudi, R. & Brann, D., Jan 2012, In: Frontiers in Neuroendocrinology. 33, 1, p. 85-104 20 p.

  Research output: Contribution to journal › Review article › peer-review

  • Neuroprotection
  • Estradiol
  • Estrogens
  • Menopause
  • Brain Ischemia
  91 Scopus citations

• Oestrogen signalling and neuroprotection in cerebral ischaemia

  Brann, D., Raz, L., Wang, R., Vadlamudi, R. & Zhang, Q., Jan 2012, In: Journal of Neuroendocrinology. 24, 1, p. 34-47 14 p.

  Research output: Contribution to journal › Review article › peer-review

  • Neuroprotection
  • Menopause
  • Brain Ischemia
  • Estrogens
  • Brain
  36 Scopus citations

• Therapeutic significance of estrogen receptor β agonists in gliomas

  Sareddy, G. R., Nair, B. C., Gonugunta, V. K., Zhang, Q. G., Brenner, A., Brann, D. W., Tekmal, R. R. & Vadlamudi, R. K., 2012, In: Molecular cancer therapeutics. 11, 5, p. 1174-1182 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Glioma
  • Estrogens
  • liquiritigenin
  • Neoplasms
  54 Scopus citations
• 2011

  Acetylation of the pro-apoptotic factor, p53 in the hippocampus following cerebral ischemia and modulation by estrogen

  Raz, L., Zhang, Q., Han, D., Dong, Y., de Sevilla, L. & Brann, D. W., 2011, In: PloS one. 6, 10, e27039.

  Research output: Contribution to journal › Article › peer-review

  • Acetylation
  • hippocampus
  • ischemia
  • acetylation
  • Brain Ischemia
  26 Scopus citations

• C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-α and the critical period hypothesis of estrogen neuroprotection

  Zhang, Q., Han, D., Wang, R. M., Dong, Y., Yang, F., Vadlamudi, R. K. & Brann, D. W., Aug 30 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 35, p. E617-E624

  Research output: Contribution to journal › Article › peer-review

  • HSC70 Heat-Shock Proteins
  • Neuroprotection
  • Proteolysis
  • Estrogen Receptors
  • Estrogens
  103 Scopus citations

• Delayed ischemic postconditioning protects hippocampal CA1 neurons by preserving mitochondrial integrity via Akt/GSK3β signaling

  Zhou, C., Tu, J., Zhang, Q., Lu, D., Zhu, Y., Zhang, W., Yang, F., Brann, D. W. & Wang, R., Nov 1 2011, In: Neurochemistry International. 59, 6, p. 749-758 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Ischemic Postconditioning
  • Brain Ischemia
  • Hippocampal CA1 Region
  • Neurons
  • Cytochromes c
  53 Scopus citations

• VPS35 haploinsufficiency increases Alzheimer's disease neuropathology

  Wen, L., Tang, F., Hong, Y., Luo, S. W., Wang, C. L., He, W., Shen, C., Jung, J. U., Xiong, F., Lee, D. H., Zhang, Q., Brann, D. W., Kim, T. W., Yan, R., Mei, L. & Xiong, W., Nov 2011, In: Journal of Cell Biology. 195, 5, p. 765-779 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Haploinsufficiency
  • Neuropathology
  • Alzheimer Disease
  • Endosomes
  • Hippocampus
  150 Scopus citations