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2020
Critical individual roles of the BCR and FGFR1 kinase domains in BCR-FGFR1-driven stem cell leukemia/lymphoma syndrome
Chong, Y., Liu, Y., Lu, S., Cai, B., Qin, H., Chang, C. S., Ren, M., Cowell, J. K. & Hu, T., Apr 15 2020, In: International Journal of Cancer. 146, 8, p. 2243-2254 12 p.Research output: Contribution to journal › Article › peer-review
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Downregulation of PUMA underlies resistance to FGFR1 inhibitors in the stem cell leukemia/lymphoma syndrome
Liu, Y., Cai, B., Chong, Y., Zhang, H., Kemp, C. A., Lu, S., Chang, C. S., Ren, M., Cowell, J. K. & Hu, T., Oct 1 2020, In: Cell Death and Disease. 11, 10, 884.Research output: Contribution to journal › Article › peer-review
Open Access -
Inactivation of Lgi1 in murine neuronal precursor cells leads to dysregulation of axon guidance pathways
Silva, J., Hawthorn, L. & Cowell, J. K., Mar 2020, In: Genomics. 112, 2, p. 1167-1172 6 p.Research output: Contribution to journal › Article › peer-review
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Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome
Hu, T., Chong, Y., Lu, S., McGuinness, M., Williams, D. A. & Cowell, J. K., Jan 31 2020, In: Haematologica. 105, 2, p. E68-E71Research output: Contribution to journal › Letter › peer-review
Open Access -
2019
Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20 (Oncogene, (2019), 38, 4, (469-482), 10.1038/s41388-018-0472-0)
Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jul 11 2019, In: Oncogene. 38, 28, 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Distinct signaling programs associated with progression of FGFR1 driven leukemia in a mouse model of stem cell leukemia lymphoma syndrome
Silva, M. J., Chang, C. S., Hu, T., Qin, H., Kitamura, E., Hawthorn, L., Ren, M. & Cowell, J. K., Dec 2019, In: Genomics. 111, 6, p. 1566-1573 8 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
DNA methyltransferase 1–mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1– driven leukemogenesis
Hu, T., Chong, Y., Cai, B., Liu, Y., Lu, S. & Cowell, J. K., Nov 29 2019, In: Journal of Biological Chemistry. 294, 48, p. 18122-18130 9 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Loss of the BCR-FGFR1 GEF domain suppresses RhoA activation and enhances B-lymphomagenesis in mice
Hu, T., Chong, Y., Lu, S., Qin, H., Ren, M., Savage, N. M., Chang, C. S. & Cowell, J. K., Jan 1 2019, In: Cancer Research. 79, 1, p. 114-124 11 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
Piranlioglu, R., Lee, E. M., Ouzounova, M., Bollag, R. J., Vinyard, A., Arbab, A. S., Marasco, D., Guzel, M., Cowell, J. K., Thangaraju, M., Chadli, A., Hassan, K. A., Wicha, M. S., Celis, E. & Korkaya, H., Dec 1 2019, In: Nature communications. 10, 1, 1430.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Selective inactivation of LGI1 in neuronal precursor cells leads to cortical dysplasia in mice
Silva, J., Qin, H. & Cowell, J. K., Feb 1 2019, In: Genesis. 57, 2, e23268.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis
Eisa, N. H., Jilani, Y., Kainth, K., Redd, P., Lu, S., Bougrine, O., Sater, H. A., Patwardhan, C. A., Shull, A., Shi, H., Liu, K., Elsherbiny, N. M., Eissa, L. A., El-Shishtawy, M. M., Horuzsko, A., Bollag, R., Maihle, N., Roig, J., Korkaya, H., Cowell, J. K. & 1 others, , Apr 5 2019, In: Journal of Biological Chemistry. 294, 14, p. 5246-5260 15 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20
Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jan 24 2019, In: Oncogene. 38, 4, p. 469-482 14 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Wasf3 Deficiency Reveals Involvement in Metastasis in a Mouse Model of Breast Cancer
Qin, H., Lu, S., Thangaraju, M. & Cowell, J. K., Dec 2019, In: American Journal of Pathology. 189, 12, p. 2450-2458 9 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
2018
Celecoxib ameliorates seizure susceptibility in autosomal dominant lateral temporal epilepsy
Zhou, L., Zhou, L., Su, L. D., Cao, S. L., Xie, Y. J., Wang, N., Shao, C. Y., Wang, Y. N., Zhou, J. H., Cowell, J. K. & Shen, Y., Mar 28 2018, In: Journal of Neuroscience. 38, 13, p. 3346-3357 12 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia/lymphoma syndrome
Hu, T., Wu, Q., Chong, Y., Qin, H., Poole, C. J., van Riggelen, J., Ren, M. & Cowell, J. K., Nov 1 2018, In: Leukemia. 32, 11, p. 2363-2373 11 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
MiR-339 promotes development of stem cell leukemia/lymphoma syndrome via downregulation of the BCL2L11 and BAX proapoptotic genes
Hu, T., Chong, Y., Lu, S., Wang, R., Qin, H., Silva, J., Kitamura, E., Chang, C. S., Hawthorn, L. A. & Cowell, J. K., Jul 1 2018, In: Cancer Research. 78, 13, p. 3522-3531 10 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
The MIR-17/92 cluster is involved in the molecular etiology of the SCLL syndrome driven by the BCR-FGFR1 chimeric kinase
Hu, T., Chong, Y., Qin, H., Kitamura, E., Chang, C. S., Silva, J., Ren, M. & Cowell, J. K., Apr 1 2018, In: Oncogene. 37, 14, p. 1926-1938 13 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
2017
Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
Ouzounova, M., Lee, E., Piranlioglu, R., El Andaloussi, A., Kolhe, R., Demirci, M. F., Marasco, D., Asm, I., Chadli, A., Hassan, K. A., Thangaraju, M., Zhou, G., Arbab, A. S., Cowell, J. K. & Korkaya, H., Apr 6 2017, In: Nature communications. 8, 14979.Research output: Contribution to journal › Article › peer-review
107 Scopus citations -
Mutation in the FGFR1 tyrosine kinase domain or inactivation of PTEN is associated with acquired resistance to FGFR inhibitors in FGFR1-driven leukemia/lymphomas
Cowell, J. K., Qin, H., Hu, T., Wu, Q., Bhole, A. & Ren, M., Nov 1 2017, In: International Journal of Cancer. 141, 9, p. 1822-1829 8 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Promotion of invasion by mutant RAS is dependent on activation of the WASF3 metastasis promoter gene
Teng, Y., Ngoka, L. & Cowell, J. K., Jun 2017, In: Genes Chromosomes and Cancer. 56, 6, p. 493-500 8 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
2015
Essential roles of leucine-rich glioma inactivated 1 in the development of embryonic and postnatal cerebellum
Xie, Y. J., Zhou, L., Jiang, N., Zhang, N., Zou, N., Zhou, L., Wang, Y., Cowell, J. K. & Shen, Y., Jan 16 2015, In: Scientific reports. 5, 7827.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Homozygous deletion of the LGI1 gene in mice leads to developmental abnormalities resulting in cortical dysplasia
Silva, J., Sharma, S. & Cowell, J. K., Sep 1 2015, In: Brain Pathology. 25, 5, p. 587-597 11 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
The promise of zebrafish as a chemical screening tool in cancer therapy
Xie, X., Ross, J. L., Cowell, J. K. & Teng, Y., Aug 1 2015, In: Future Medicinal Chemistry. 7, 11, p. 1395-1405 11 p.Research output: Contribution to journal › Review article › peer-review
9 Scopus citations -
2014
Abstract 1023: NOV C-ter: A novel preclinical anti-angiogenic agent
Luo, J., Teng, Y., Li, M., Johnson, T. S., Cuttitta, F., Chu, Z., Qi, X., Cowell, J. K. & Rixe, O., Oct 1 2014, p. 1023-1023.Research output: Contribution to conference › Paper › peer-review
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LGI1: From zebrafish to human epilepsy
Cowell, J. K., Jan 1 2014, In: Progress in Brain Research. 213, C, p. 159-179 21 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells
Teng, Y., Mei, Y., Hawthorn, L. & Cowell, J. K., Jan 9 2014, In: Oncogene. 33, 2, p. 203-211 9 p.Research output: Contribution to journal › Article › peer-review
58 Scopus citations -
2013
COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis
Shao, J., Teng, Y., Padia, R., Hong, S., Noh, H., Xie, X., Mumm, J. S., Dong, Z., Ding, H. F., Cowell, J., Kim, J., Han, J. & Huang, S., Sep 2013, In: Neoplasia (United States). 15, 9, p. 1075-1085 11 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
Corrigendum to "WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, And MMP-9 expression" [Exp. Cell Res. 308 (2005) 135-145]
Sossey-Alaoui, K., Ranalli, T. A., Li, X., Bakin, A. V. & Cowell, J. K., Mar 10 2013, In: Experimental Cell Research. 319, 5, 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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Critical role of the WASF3 gene in JAK2/STAT3 regulation of cancer cell motility
Teng, Y., Ghoshal, P., Ngoka, L., Mei, Y. & Cowell, J. K., Sep 2013, In: Carcinogenesis. 34, 9, p. 1994-1999 6 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Dysregulated signaling pathways in the development of CNTRL-FGFR1–induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models
Ren, M., Qin, H., Kitamura, E. & Cowell, J. K., Aug 8 2013, In: Blood. 122, 6, p. 1007-1016 10 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Evaluating human cancer cell metastasis in zebrafish
Teng, Y., Xie, X., Walker, S., White, D. T., Mumm, J. S. & Cowell, J. K., Oct 4 2013, In: BMC Cancer. 13, 453.Research output: Contribution to journal › Article › peer-review
96 Scopus citations -
Evaluation of phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) and epidermal growth factor receptor (EGFR) gene mutations in pancreaticobiliary adenocarcinoma
Weiss, G. A., Rossi, M. R., Khushalani, N. I., Lo, K., Gibbs, J. F., Bharthuar, A., Cowell, J. K. & Iyer, R., Mar 2013, In: Journal of Gastrointestinal Oncology. 4, 1, p. 20-29 10 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
HOXC9 directly regulates distinct sets of genes to coordinate diverse cellular processes during neuronal differentiation
Wang, X., Choi, J-H., Ding, J., Yang, L., Ngoka, L. C., Lee, E. J., Zha, Y., Mao, L., Jin, B., Ren, M., Cowell, J. K., Huang, S., Shi, H., Cui, H. & Ding, H., Nov 25 2013, In: BMC Genomics. 14, 1, 830.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Novel FGFR inhibitor ponatinib suppresses the growth of non-small cell lung cancer cells overexpressing FGFR1
Ren, M., Hong, M., Liu, G., Wang, H., Patel, V. S., Biddinger, P. W., Silva, M. J., Cowell, J. K. & Hao, Z., Jun 2013, In: Oncology Reports. 29, 6, p. 2181-2190 10 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
Ponatinib suppresses the development of myeloid and lymphoid malignancies associated with FGFR1 abnormalities
Ren, M., Qin, H., Ren, R. & Cowell, J. K., Jan 2013, In: Leukemia. 27, 1, p. 32-40 9 p.Research output: Contribution to journal › Article › peer-review
53 Scopus citations -
2012
Acute progression of BCR-FGFR1 induced murine B-lympho/myeloproliferative disorder suggests involvement of lineages at the pro-B cell stage
Ren, M. Q., Tidwell, J. A., Sharma, S. & Cowell, J. K., Jun 6 2012, In: PloS one. 7, 6, e38265.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
HIF1A induces expression of the WASF3 metastasis-associated gene under hypoxic conditions
Ghoshal, P., Teng, Y., Lesoon, L. A. & Cowell, J. K., Sep 15 2012, In: International Journal of Cancer. 131, 6, p. E905-E915Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
HSP90 and HSP70 Proteins are essential for stabilization and activation of WASF3 metastasis-promoting protein
Teng, Y., Ngoka, L., Mei, Y., Lesoon, L. & Cowell, J. K., Mar 23 2012, In: Journal of Biological Chemistry. 287, 13, p. 10051-10059 9 p.Research output: Contribution to journal › Article › peer-review
50 Scopus citations -
Ubiquitin-conjugating enzyme UBE2C: Molecular biology, role in tumorigenesis, and potential as a biomarker
Hao, Z., Zhang, H. & Cowell, J., Jun 1 2012, In: Tumor Biology. 33, 3, p. 723-730 8 p.Research output: Contribution to journal › Review article › peer-review
61 Scopus citations -
2011
Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization
Hawthorn, L. & Cowell, J. K., 2011, In: PloS one. 6, 4, e18941.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
CML: a model disease with a defined oncogenic driver.
Hao, Z. & Cowell, J. K., Mar 1 2011, In: Clinical advances in hematology & oncology : H&O. 9, 3, p. 247-248 2 p.Research output: Contribution to journal › Comment/debate › peer-review
1 Scopus citations -
Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease
Ren, M. Q. & Cowell, J. K., Jun 23 2011, In: Blood. 117, 25, p. 6837-6847 11 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
Erratum: Genetic analysis of Down syndrome-associated heart defects in mice (Human Genetics DOI: 10.1007/s00439-011-0980-2)
Liu, C., Morishima, M., Yu, T., Matsui, S. I., Zhang, L., Fu, D., Pao, A., Costa, A. C., Gardiner, K. J., Cowell, J. K., Nowak, N. J., Parmacek, M. S., Liang, P., Baldini, A. & Yu, Y. E., Nov 2011, In: Human Genetics. 130, 5, p. 633 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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Functional interrelationship between the WASF3 and KISS1 metastasis-associated genes in breast cancer cells
Teng, Y., Liu, M. & Cowell, J. K., Dec 15 2011, In: International Journal of Cancer. 129, 12, p. 2825-2835 11 p.Research output: Contribution to journal › Article › peer-review
43 Scopus citations -
Genetic analysis of Down syndrome-associated heart defects in mice
Liu, C., Morishima, M., Yu, T., Matsui, S. I., Zhang, L., Fu, D., Pao, A., Costa, A. C., Gardiner, K. J., Cowell, J. K., Nowak, N. J., Parmacek, M. S., Liang, P., Baldini, A. & Yu, Y. E., Nov 2011, In: Human Genetics. 130, 5, p. 623-632 10 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Loss of zebrafish lgi1b leads to hydrocephalus and sensitization to pentylenetetrazol induced seizure-like behavior
Teng, Y., Xie, X., Walker, S., Saxena, M., Kozlowski, D. J., Mumm, J. S. & Cowell, J. K., Sep 16 2011, In: PloS one. 6, 9, e24596.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
Src activation plays an important key role in lymphomagenesis induced by FGFR1 fusion kinases
Ren, M., Qin, H., Ren, R., Tidwell, J. & Cowell, J. K., Dec 1 2011, In: Cancer Research. 71, 23, p. 7312-7322 11 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
The temporal and spatial expression pattern of the LGI1 epilepsy predisposition gene during mouse embryonic cranial development
Silva, J., Wang, G. & Cowell, J. K., May 13 2011, In: BMC Neuroscience. 12, 43.Research output: Contribution to journal › Article › peer-review
13 Scopus citations