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• Article

  Acute progression of BCR-FGFR1 induced murine B-lympho/myeloproliferative disorder suggests involvement of lineages at the pro-B cell stage

  Ren, M. Q., Tidwell, J. A., Sharma, S. & Cowell, J. K., Jun 6 2012, In: PloS one. 7, 6, e38265.

  Research output: Contribution to journal › Article › peer-review

  • Myeloproliferative Disorders
  • B-Lymphoid Precursor Cells
  • B-lymphocytes
  • Cells
  • human diseases
  19 Scopus citations

• Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization

  Hawthorn, L. & Cowell, J. K., 2011, In: PloS one. 6, 4, e18941.

  Research output: Contribution to journal › Article › peer-review

  • comparative genomic hybridization
  • Wilms Tumor
  • Comparative Genomic Hybridization
  • Tumors
  • Single Nucleotide Polymorphism
  19 Scopus citations

• Celecoxib ameliorates seizure susceptibility in autosomal dominant lateral temporal epilepsy

  Zhou, L., Zhou, L., Su, L. D., Cao, S. L., Xie, Y. J., Wang, N., Shao, C. Y., Wang, Y. N., Zhou, J. H., Cowell, J. K. & Shen, Y., Mar 28 2018, In: Journal of Neuroscience. 38, 13, p. 3346-3357 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Celecoxib
  • Temporal Lobe Epilepsy
  • Leucine
  • Glioma
  • Seizures
  7 Scopus citations

• Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease

  Ren, M. Q. & Cowell, J. K., Jun 23 2011, In: Blood. 117, 25, p. 6837-6847 11 p.

  Research output: Contribution to journal › Article › peer-review

  • T-cells
  • Stem cells
  • T-Cell Lymphoma
  • Chemical activation
  • Lymphoma
  30 Scopus citations

• COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis

  Shao, J., Teng, Y., Padia, R., Hong, S., Noh, H., Xie, X., Mumm, J. S., Dong, Z., Ding, H. F., Cowell, J., Kim, J., Han, J. & Huang, S., Sep 2013, In: Neoplasia (United States). 15, 9, p. 1075-1085 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycogen Synthase Kinase 3
  • Carcinogenesis
  • Breast Neoplasms
  • Proto-Oncogene Proteins c-jun
  • Proteins
  34 Scopus citations

• Critical individual roles of the BCR and FGFR1 kinase domains in BCR-FGFR1-driven stem cell leukemia/lymphoma syndrome

  Chong, Y., Liu, Y., Lu, S., Cai, B., Qin, H., Chang, C. S., Ren, M., Cowell, J. K. & Hu, T., Apr 15 2020, In: International Journal of Cancer. 146, 8, p. 2243-2254 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Lymphoma
  • Leukemia
  • Phosphotransferases
  • Stem Cells
  • SHP099

• Critical role of the WASF3 gene in JAK2/STAT3 regulation of cancer cell motility

  Teng, Y., Ghoshal, P., Ngoka, L., Mei, Y. & Cowell, J. K., Sep 2013, In: Carcinogenesis. 34, 9, p. 1994-1999 6 p.

  Research output: Contribution to journal › Article › peer-review

  • STAT3 Transcription Factor
  • Cell Movement
  • Genes
  • Neoplasms
  • NSC 74859
  29 Scopus citations

• Distinct signaling programs associated with progression of FGFR1 driven leukemia in a mouse model of stem cell leukemia lymphoma syndrome

  Silva, M. J., Chang, C. S., Hu, T., Qin, H., Kitamura, E., Hawthorn, L., Ren, M. & Cowell, J. K., Dec 2019, In: Genomics. 111, 6, p. 1566-1573 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Lymphoma
  • Leukemia
  • Stem Cells
  • Stem Cell Niche
  • T-Lymphocytes
  2 Scopus citations

• DNA methyltransferase 1–mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1– driven leukemogenesis

  Hu, T., Chong, Y., Cai, B., Liu, Y., Lu, S. & Cowell, J. K., Nov 29 2019, In: Journal of Biological Chemistry. 294, 48, p. 18122-18130 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Methylation
  • Receptor, Fibroblast Growth Factor, Type 1
  • Methyltransferases
  • MicroRNAs
  • Leukemia
  5 Scopus citations

• Downregulation of PUMA underlies resistance to FGFR1 inhibitors in the stem cell leukemia/lymphoma syndrome

  Liu, Y., Cai, B., Chong, Y., Zhang, H., Kemp, C. A., Lu, S., Chang, C. S., Ren, M., Cowell, J. K. & Hu, T., Oct 1 2020, In: Cell Death and Disease. 11, 10, 884.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lymphoma
  • Leukemia
  • Stem Cells
  • Down-Regulation
  • Apoptosis

• Dysregulated signaling pathways in the development of CNTRL-FGFR1–induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models

  Ren, M., Qin, H., Kitamura, E. & Cowell, J. K., Aug 8 2013, In: Blood. 122, 6, p. 1007-1016 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Hematopoietic Stem Cells
  • Neoplasms
  • Bone Marrow Neoplasms
  • Chemotherapy
  • Stem cells
  17 Scopus citations

• Essential roles of leucine-rich glioma inactivated 1 in the development of embryonic and postnatal cerebellum

  Xie, Y. J., Zhou, L., Jiang, N., Zhang, N., Zou, N., Zhou, L., Wang, Y., Cowell, J. K. & Shen, Y., Jan 16 2015, In: Scientific reports. 5, 7827.

  Research output: Contribution to journal › Article › peer-review

  • Leucine
  • Glioma
  • Embryonic Development
  • Cerebellum
  • Ependymoglial Cells
  13 Scopus citations

• Evaluating human cancer cell metastasis in zebrafish

  Teng, Y., Xie, X., Walker, S., White, D. T., Mumm, J. S. & Cowell, J. K., Oct 4 2013, In: BMC Cancer. 13, 453.

  Research output: Contribution to journal › Article › peer-review

  • Zebrafish
  • Neoplasm Metastasis
  • Neoplasms
  • Fishes
  • Fiji
  101 Scopus citations

• Functional interrelationship between the WASF3 and KISS1 metastasis-associated genes in breast cancer cells

  Teng, Y., Liu, M. & Cowell, J. K., Dec 15 2011, In: International Journal of Cancer. 129, 12, p. 2825-2835 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Matrix Metalloproteinase 9
  • NF-kappa B
  • Breast Neoplasms
  • Neoplasm Metastasis
  • Tumor Suppressor Genes
  44 Scopus citations

• HIF1A induces expression of the WASF3 metastasis-associated gene under hypoxic conditions

  Ghoshal, P., Teng, Y., Lesoon, L. A. & Cowell, J. K., Sep 15 2012, In: International Journal of Cancer. 131, 6, p. E905-E915

  Research output: Contribution to journal › Article › peer-review

  • Neoplasm Metastasis
  • Hypoxia
  • Response Elements
  • Genetic Promoter Regions
  • Genes
  22 Scopus citations

• Homozygous deletion of the LGI1 gene in mice leads to developmental abnormalities resulting in cortical dysplasia

  Silva, J., Sharma, S. & Cowell, J. K., Sep 1 2015, In: Brain Pathology. 25, 5, p. 587-597 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Malformations of Cortical Development
  • Gene Deletion
  • Synapses
  • Neurons
  • Spine
  11 Scopus citations

• Inactivation of Lgi1 in murine neuronal precursor cells leads to dysregulation of axon guidance pathways

  Silva, J., Hawthorn, L. & Cowell, J. K., Mar 2020, In: Genomics. 112, 2, p. 1167-1172 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Axon Guidance
  • Cell Movement
  • Malformations of Cortical Development
  • Epileptic Syndromes
  • Null Lymphocytes

• LGI1: From zebrafish to human epilepsy

  Cowell, J. K., Jan 1 2014, In: Progress in Brain Research. 213, C, p. 159-179 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Zebrafish
  • Epilepsy
  • Seizures
  • Neuronal Plasticity
  • Autosomal Dominant Lateral Temporal Lobe Epilepsy
  10 Scopus citations

• Loss of the BCR-FGFR1 GEF domain suppresses RhoA activation and enhances B-lymphomagenesis in mice

  Hu, T., Chong, Y., Lu, S., Qin, H., Ren, M., Savage, N. M., Chang, C. S. & Cowell, J. K., Jan 1 2019, In: Cancer Research. 79, 1, p. 114-124 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Guanidine
  • Nucleotides
  • Lymphoma
  • Leukemia
  • Stem Cells
  3 Scopus citations

• Loss of zebrafish lgi1b leads to hydrocephalus and sensitization to pentylenetetrazol induced seizure-like behavior

  Teng, Y., Xie, X., Walker, S., Saxena, M., Kozlowski, D. J., Mumm, J. S. & Cowell, J. K., Sep 16 2011, In: PloS one. 6, 9, e24596.

  Research output: Contribution to journal › Article › peer-review

  • hydrocephalus
  • Pentylenetetrazole
  • seizures
  • Hydrocephalus
  • Danio rerio
  31 Scopus citations

• MiR-339 promotes development of stem cell leukemia/lymphoma syndrome via downregulation of the BCL2L11 and BAX proapoptotic genes

  Hu, T., Chong, Y., Lu, S., Wang, R., Qin, H., Silva, J., Kitamura, E., Chang, C. S., Hawthorn, L. A. & Cowell, J. K., Jul 1 2018, In: Cancer Research. 78, 13, p. 3522-3531 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Lymphoma
  • Leukemia
  • Stem Cells
  • Down-Regulation
  • B-Lymphoid Precursor Cells
  13 Scopus citations

• Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

  Ouzounova, M., Lee, E., Piranlioglu, R., El Andaloussi, A., Kolhe, R., Demirci, M. F., Marasco, D., Asm, I., Chadli, A., Hassan, K. A., Thangaraju, M., Zhou, G., Arbab, A. S., Cowell, J. K. & Korkaya, H., 2017, In: Nature communications. 8, 14979.

  Research output: Contribution to journal › Article › peer-review

  • suppressors
  • Myeloid-Derived Suppressor Cells
  • Tumors
  • tumors
  • Plasticity
  125 Scopus citations

• Mutation in the FGFR1 tyrosine kinase domain or inactivation of PTEN is associated with acquired resistance to FGFR inhibitors in FGFR1-driven leukemia/lymphomas

  Cowell, J. K., Qin, H., Hu, T., Wu, Q., Bhole, A. & Ren, M., Nov 1 2017, In: International Journal of Cancer. 141, 9, p. 1822-1829 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Fibroblast Growth Factor, Type 1
  • 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea
  • Lymphoma
  • Leukemia
  • Mutation
  19 Scopus citations

• Novel FGFR inhibitor ponatinib suppresses the growth of non-small cell lung cancer cells overexpressing FGFR1

  Ren, M., Hong, M., Liu, G., Wang, H., Patel, V. S., Biddinger, P. W., Silva, M. J., Cowell, J. K. & Hao, Z., Jun 2013, In: Oncology Reports. 29, 6, p. 2181-2190 10 p.

  Research output: Contribution to journal › Article › peer-review

  • ponatinib
  • Receptor, Fibroblast Growth Factor, Type 1
  • Non-Small Cell Lung Carcinoma
  • Growth
  • Lung Neoplasms
  46 Scopus citations

• Ponatinib suppresses the development of myeloid and lymphoid malignancies associated with FGFR1 abnormalities

  Ren, M., Qin, H., Ren, R. & Cowell, J. K., Jan 2013, In: Leukemia. 27, 1, p. 32-40 9 p.

  Research output: Contribution to journal › Article › peer-review

  • ponatinib
  • Receptor, Fibroblast Growth Factor, Type 1
  • Stem Cells
  • Lymphoma
  • Leukemia
  53 Scopus citations

• Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

  Piranlioglu, R., Lee, E. M., Ouzounova, M., Bollag, R. J., Vinyard, A., Arbab, A. S., Marasco, D., Guzel, M., Cowell, J. K., Thangaraju, M., Chadli, A., Hassan, K. A., Wicha, M. S., Celis, E. & Korkaya, H., Dec 1 2019, In: Nature communications. 10, 1, 1430.

  Research output: Contribution to journal › Article › peer-review

  • immunity
  • mice
  • Tumors
  • Cells
  • tumors
  19 Scopus citations

• Promotion of invasion by mutant RAS is dependent on activation of the WASF3 metastasis promoter gene

  Teng, Y., Ngoka, L. & Cowell, J. K., Jun 2017, In: Genes Chromosomes and Cancer. 56, 6, p. 493-500 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Neoplasm Metastasis
  • Genes
  • Wiskott-Aldrich Syndrome Protein Family
  • Phosphatidylinositol 3-Kinases
  • Actin Cytoskeleton
  2 Scopus citations

• Selective inactivation of LGI1 in neuronal precursor cells leads to cortical dysplasia in mice

  Silva, J., Qin, H. & Cowell, J. K., Feb 1 2019, In: Genesis. 57, 2, e23268.

  Research output: Contribution to journal › Article › peer-review

  • Malformations of Cortical Development
  • Leucine
  • Glioma
  • Seizures
  • Parvalbumins
  1 Scopus citations

• Src activation plays an important key role in lymphomagenesis induced by FGFR1 fusion kinases

  Ren, M., Qin, H., Ren, R., Tidwell, J. & Cowell, J. K., Dec 1 2011, In: Cancer Research. 71, 23, p. 7312-7322 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Fibroblast Growth Factor Receptors
  • Phosphotransferases
  • src-Family Kinases
  • Lymphoma
  • Leukemia
  22 Scopus citations

• The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis

  Eisa, N. H., Jilani, Y., Kainth, K., Redd, P., Lu, S., Bougrine, O., Sater, H. A., Patwardhan, C. A., Shull, A., Shi, H., Liu, K., Elsherbiny, N. M., Eissa, L. A., El-Shishtawy, M. M., Horuzsko, A., Bollag, R., Maihle, N., Roig, J., Korkaya, H., Cowell, J. K. & 1 others, Chadli, A., Apr 5 2019, In: Journal of Biological Chemistry. 294, 14, p. 5246-5260 15 p.

  Research output: Contribution to journal › Article › peer-review

  • NIMA-Related Kinases
  • Myosins
  • Phosphotransferases
  • Carcinogenesis
  • Cell proliferation
  7 Scopus citations

• The MIR-17/92 cluster is involved in the molecular etiology of the SCLL syndrome driven by the BCR-FGFR1 chimeric kinase

  Hu, T., Chong, Y., Qin, H., Kitamura, E., Chang, C. S., Silva, J., Ren, M. & Cowell, J. K., Apr 1 2018, In: Oncogene. 37, 14, p. 1926-1938 13 p.

  Research output: Contribution to journal › Article › peer-review

  • MicroRNAs
  • Phosphotransferases
  • B-Cell Leukemia
  • Cell Proliferation
  • Porifera
  9 Scopus citations

• The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20

  Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jan 24 2019, In: Oncogene. 38, 4, p. 469-482 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Breast Neoplasms
  • Cell Death
  • Triple Negative Breast Neoplasms
  • Heterografts
  • Cell Line
  13 Scopus citations

• Variant profiles of genes mapping to chromosome 16q loss in wilms tumors reveals link to cilia-related genes and pathways

  Kitamura, E., Cowell, J. K., Chang, C. S. & Hawthorn, L., 2020, In: Genes and Cancer. 11, 3-4, p. 137-153 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chromosome Mapping
  • Wilms Tumor
  • Cilia
  • Chromosomes
  • Loss of Heterozygosity

• Wasf3 Deficiency Reveals Involvement in Metastasis in a Mouse Model of Breast Cancer

  Qin, H., Lu, S., Thangaraju, M. & Cowell, J. K., Dec 2019, In: American Journal of Pathology. 189, 12, p. 2450-2458 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Wiskott-Aldrich Syndrome Protein Family
  • Breast Neoplasms
  • Neoplasm Metastasis
  • Oncogenes
  • Exons
  2 Scopus citations

• WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells

  Teng, Y., Mei, Y., Hawthorn, L. & Cowell, J. K., Jan 9 2014, In: Oncogene. 33, 2, p. 203-211 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Breast Neoplasms
  • Mesoderm
  • Neoplasm Metastasis
  • Chromosomes, Human, Pair 1
  • Cadherins
  60 Scopus citations
• Comment/debate

  CML: a model disease with a defined oncogenic driver.

  Hao, Z. & Cowell, J. K., Mar 1 2011, In: Clinical advances in hematology & oncology : H&O. 9, 3, p. 247-248 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  1 Scopus citations

• Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20 (Oncogene, (2019), 38, 4, (469-482), 10.1038/s41388-018-0472-0)

  Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jul 11 2019, In: Oncogene. 38, 28, p. 5749 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Financial Management
  • Oncogenes
  • Breast Neoplasms
  • Laboratory Animals
  • Genomics

• Corrigendum to "WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, And MMP-9 expression" [Exp. Cell Res. 308 (2005) 135-145]

  Sossey-Alaoui, K., Ranalli, T. A., Li, X., Bakin, A. V. & Cowell, J. K., Mar 10 2013, In: Experimental Cell Research. 319, 5, 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review
• Letter

  Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome

  Hu, T., Chong, Y., Lu, S., McGuinness, M., Williams, D. A. & Cowell, J. K., Jan 31 2020, In: Haematologica. 105, 2, p. E68-E71

  Research output: Contribution to journal › Letter › peer-review

  Open Access
• Paper

  Abstract 1023: NOV C-ter: A novel preclinical anti-angiogenic agent

  Luo, J., Teng, Y., Li, M., Johnson, T. S., Cuttitta, F., Chu, Z., Qi, X., Cowell, J. K. & Rixe, O., Oct 1 2014, p. 1023-1023.

  Research output: Contribution to conference › Paper › peer-review
• Review article

  The promise of zebrafish as a chemical screening tool in cancer therapy

  Xie, X., Ross, J. L., Cowell, J. K. & Teng, Y., Aug 1 2015, In: Future Medicinal Chemistry. 7, 11, p. 1395-1405 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Zebrafish
  • Neoplasms
  • Therapeutics
  • Heterologous Transplantation
  • Preclinical Drug Evaluations
  11 Scopus citations

• Ubiquitin-conjugating enzyme UBE2C: Molecular biology, role in tumorigenesis, and potential as a biomarker

  Hao, Z., Zhang, H. & Cowell, J., Jun 1 2012, In: Tumor Biology. 33, 3, p. 723-730 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Ubiquitin-Conjugating Enzymes
  • Molecular Biology
  • Carcinogenesis
  • Biomarkers
  • M Phase Cell Cycle Checkpoints
  66 Scopus citations