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• 2011

  Cutting edge: IRF8 regulates bax transcription in vivo in primary myeloid cells

  Yang, J., Hu, X., Zimmerman, M., Torres, C. M., Yang, D., Smith, S. B. & Liu, K., Nov 1 2011, In: Journal of Immunology. 187, 9, p. 4426-4430 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Myeloid Cells
  • Knockout Mice
  • Cell Lineage
  • Genetic Promoter Regions
  • Bone Marrow Cells
  17 Scopus citations

• D-serine and serine racemase in the retina

  Smith, S. B., Ha, Y. & Ganapathy, V., Nov 24 2011, Amino Acids in Human Nutrition and Health. CABI Publishing, p. 137-149 13 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • serine racemase
  • retina
  • Serine
  • serine
  • Retina

• Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium

  Gnana-Prakasam, J. P., Ananth, S., Prasad, P. D., Zhang, M., Atherton, S. S., Martin, P. M., Smith, S. B. & Ganapathy, V., May 2011, In: Investigative Ophthalmology and Visual Science. 52, 6, p. 3751-3758 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Succinic Acid
  • Retinal Pigment Epithelium
  • Vascular Endothelial Growth Factor A
  • Iron
  • Hemochromatosis
  28 Scopus citations

• Functional characterization of folate transport proteins in staten's seruminstitut rabbit corneal epithelial cell line

  Jwala, J., Boddu, S. H. S., Paturi, D. K., Shah, S., Smith, S. B., Pal, D. & Mitra, A. K., May 2011, In: Current Eye Research. 36, 5, p. 404-416 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Folic Acid Transporters
  • Folic Acid
  • Epithelial Cells
  • Rabbits
  • Cell Line
  8 Scopus citations

• Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells

  Ganapathy, P. S., Perry, R. L., Tawfik, A. M., Smith, R. M., Perry, E., Roon, P., Renee Bozard, B., Ha, Y. & Smith, S. B., Jul 2011, In: Investigative Ophthalmology and Visual Science. 52, 8, p. 5551-5558 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondrial Dynamics
  • Retinal Ganglion Cells
  • Homocysteine
  • Mitochondria
  • Ganglia
  33 Scopus citations

• Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1)

  Ha, Y., Saul, A. B., Tawfik, A. M., Williams, C., Bollinger, K. E., Smith, R., Tachikawa, M., Zorrilla, E., Ganapathy, V. & Smith, S. B., Sep 2011, In: Investigative Ophthalmology and Visual Science. 52, 10, p. 7749-7760 12 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor
  • Intraocular Pressure
  • Lenses
  • Eye
  • Retina
  38 Scopus citations

• Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis

  Gnana-Prakasam, J. P., Reddy, S. K., Veeranan-Karmegam, R., Smith, S. B., Martin, P. M. & Ganapathy, V., Nov 2011, In: Investigative Ophthalmology and Visual Science. 52, 12, p. 9279-9286 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Hemochromatosis
  • Iron Overload
  • Retinal Pigment Epithelium
  • Heme
  • Retina
  18 Scopus citations

• Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons

  Ha, Y., Dun, Y., Thangaraju, M., Duplantier, J., Dong, Z., Liu, K., Ganapathy, V. & Smith, S. B., Jan 2011, In: Investigative Ophthalmology and Visual Science. 52, 1, p. 527-540 14 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor
  • Pentazocine
  • Retinal Neurons
  • Endoplasmic Reticulum Stress
  • Oxidative Stress
  59 Scopus citations

• The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells

  Ganapathy, P. S., White, R. E., Ha, Y., Renee Bozard, B., McNeil, P. L., Caldwell, R. W., Kumar, S., Black, S. M. & Smith, S. B., Jul 2011, In: Investigative Ophthalmology and Visual Science. 52, 8, p. 5515-5524 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinal Ganglion Cells
  • Homocysteine
  • N-Methyl-D-Aspartate Receptors
  • D-Aspartic Acid
  • aspartic acid receptor
  58 Scopus citations

• Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis

  Chothe, P. P., Gnana-Prakasam, J. P., Ananth, S., Martin, P. M., Kannan, R., Hinton, D. R., Smith, S. B. & Ganapathy, V., Feb 11 2011, In: Biochemical and Biophysical Research Communications. 405, 2, p. 244-249 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Epithelial Cells
  • Oligopeptides
  • Hepcidins
  • Retinal Pigments
  • Peptide Hormones
  8 Scopus citations

• Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells

  Babu, E., Ananth, S., Veeranan-Karmegam, R., Coothankandaswamy, V., Smith, S. B., Boettger, T., Ganapathy, V. & Martin, P. M., Jul 2011, In: Investigative Ophthalmology and Visual Science. 52, 8, p. 5749-5757 9 p.

  Research output: Contribution to journal › Article › peer-review

  • 2-oxothiazolidine-4-carboxylic acid
  • Retinal Pigments
  • Glutathione
  • Epithelial Cells
  • Retina
  13 Scopus citations
• 2012

  Age-related changes in visual function in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia

  Yu, M., Sturgill-Short, G., Ganapathy, P., Tawfik, A., Peachey, N. S. & Smith, S. B., Mar 2012, In: Experimental eye research. 96, 1, p. 124-131 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystathionine beta-Synthase
  • Hyperhomocysteinemia
  • Homocysteine
  • Retinal Pigments
  • Visual Evoked Potentials
  37 Scopus citations

• Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor

  Ha, Y., Saul, A. B., Tawfik, A. M., Zorrilla, E. P., Ganapathy, V. & Smith, S. B., Nov 30 2012, In: Molecular Vision. 18, p. 2860-2870 11 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma Receptors
  • Retinal Ganglion Cells
  • Intraocular Pressure
  • Neuroprotective Agents
  • sigma-1 receptor
  37 Scopus citations

• GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.

  Gambhir, D., Ananth, S., Veeranan-Karmegam, R., Elangovan, S., Hester, S., Jennings, E., Offermanns, S., Nussbaum, J. J., Smith, S. B., Thangaraju, M., Ganapathy, V. & Martin, P. M., Apr 2012, In: Investigative ophthalmology & visual science. 53, 4, p. 2208-2217 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinal Pigments
  • Retinal Pigment Epithelium
  • Diabetic Retinopathy
  • Anti-Inflammatory Agents
  • Epithelial Cells
  55 Scopus citations

• Iron-mediated retinal degeneration in haemojuvelin-knockout mice

  Gnana-Prakasam, J. P., Tawfik, A., Romej, M., Ananth, S., Martin, P. M., Smith, S. B. & Ganapathy, V., Jan 15 2012, In: Biochemical Journal. 441, 2, p. 599-608 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinal Degeneration
  • Retinal Pigments
  • Retinal Pigment Epithelium
  • Knockout Mice
  • Iron
  20 Scopus citations

• Mechanisms of ER Stress in Retinal Disease

  Smith, S. B., Dec 1 2012, Retina Fifth Edition. Elsevier Inc., Vol. 1. p. 529-536 8 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  2 Scopus citations

• Regulation of proton-coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate

  Bozard, B. R., Chothe, P. P., Tawfik, A., Williams, C., Fulzele, S., Prasad, P. D., Martin, P. M., Ganapathy, V. & Smith, S. B., Mar 2012, In: Glia. 60, 3, p. 333-342 10 p.

  Research output: Contribution to journal › Article › peer-review

  • citraconic acid
  • Proton-Coupled Folate Transporter
  • Fumarates
  • Neuroglia
  • Pharmaceutical Preparations
  9 Scopus citations

• Transport of the synthetic opioid peptide DADLE ([d-Ala²,d-Leu⁵]-Enkephalin) in neuronal cells

  Ananth, S., Thakkar, S. V., Gnana-prakasam, J. P., Martin, P. M., Ganapathy, P. S., Smith, S. B. & Ganapathy, V., Jan 2012, In: Journal of Pharmaceutical Sciences. 101, 1, p. 154-163 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Opioid Peptides
  • Enkephalins
  • Oligopeptides
  • Ala(2)-deltorphin II
  • Peptidomimetics
  7 Scopus citations
• 2014

  Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: A model of mild to moderate hyperhomocysteinemia

  Tawfik, A., Markand, S., Al-Shabrawey, M., Mayo, J. N., Reynolds, J., Bearden, S. E., Ganapathy, V. & Smith, S. B., Sep 2014, In: American Journal of Pathology. 184, 9, p. 2573-2585 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystathionine
  • Hyperhomocysteinemia
  • Zonula Occludens-1 Protein
  • Occludin
  • Glial Fibrillary Acidic Protein
  23 Scopus citations

• Deletion of hemojuvelin, an iron-regulatory protein, in mice results in abnormal angiogenesis and vasculogenesis in retina along with reactive gliosis

  Tawfik, A., Gnana-Prakasam, J. P., Smith, S. B. & Ganapathy, V., May 8 2014, In: Investigative Ophthalmology and Visual Science. 55, 6, p. 3616-3625 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Iron-Regulatory Proteins
  • Gliosis
  • Retina
  • Microglia
  • Blood Vessels
  8 Scopus citations

• Dysregulation of system x_c^- expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice

  Frederick, N. M., Bertho, J., Patel, K. K., Petr, G. T., Bakradze, E., Smith, S. B. & Rosenberg, P. A., Oct 2014, In: Neurochemistry International. 76, p. 59-69 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Corpus Striatum
  • Huntington Disease
  • Oxidative Stress
  • Cell Line
  • Proteins
  17 Scopus citations

• Folate Transport in Retina and Consequences on Retinal Structure and Function of Hyperhomocysteinemia

  Smith, S. B., Ganapathy, P. S., Bozard, R. B. & Ganapathy, V., Apr 10 2014, Handbook of Nutrition, Diet and the Eye. Elsevier Inc., p. 349-359 11 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Hyperhomocysteinemia
  • Folic Acid
  • Retina
  • Proton-Coupled Folate Transporter
  • Reduced Folate Carrier Protein
  1 Scopus citations

• Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells

  Mo, J., Zhang, M., Marshall, B., Smith, S., Covar, J. & Atherton, S., Aug 14 2014, In: Molecular Vision. 20, p. 1161-1173 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Muromegalovirus
  • Retinal Pigments
  • Cytomegalovirus Infections
  • Autophagy
  • Epithelial Cells
  9 Scopus citations

• Monomethylfumarate induces γ-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina.

  Promsote, W., Makala, L., Li, B., Smith, S. B., Singh, N., Ganapathy, V., Pace, B. S. & Martin, P. M., Aug 2014, In: Investigative ophthalmology & visual science. 55, 8, p. 5382-5393 12 p.

  Research output: Contribution to journal › Article › peer-review

  • citraconic acid
  • Fetal Hemoglobin
  • Erythroid Cells
  • Globins
  • Retinal Pigments
  21 Scopus citations

• Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid

  Ananth, S., Gnana-Prakasam, J. P., Bhutia, Y. D., Veeranan-Karmegam, R., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 2014, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 4, p. 603-612 10 p.

  Research output: Contribution to journal › Article › peer-review

  • ATP Binding Cassette Transporter, Subfamily G, Member 1
  • 2,5-dihydroxybenzoic acid
  • Siderophores
  • Hemochromatosis
  • Retina
  21 Scopus citations

• Retinal expression of the serine protease matriptase-2 (tmprss6) and its role in retinal iron homeostasis

  Gnana-Prakasam, J. P., Baldowski, R. B., Ananth, S., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 26 2014, In: Molecular Vision. 20, p. 561-574 14 p.

  Research output: Contribution to journal › Article › peer-review

  • matriptase 2
  • Serine Proteases
  • Retina
  • Iron
  • Homeostasis
  5 Scopus citations

• Role of bax in death of uninfected retinal cells during murine cytomegalovirus retinitis

  Mo, J., Marshall, B., Covar, J., Zhang, N. Y., Smith, S. B., Atherton, S. S. & Zhang, M., Sep 23 2014, In: Investigative Ophthalmology and Visual Science. 55, 11, p. 7137-7146 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytomegalovirus Retinitis
  • Muromegalovirus
  • Receptor-Interacting Protein Serine-Threonine Kinases
  • Caspases
  • Eye
  5 Scopus citations

• Sigma receptor 1 modulates ER stress and Bcl2 in murine retina

  Ha, Y., Shanmugam, A. K., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Apr 2014, In: Cell and Tissue Research. 356, 1, p. 15-27 13 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor
  • Endoplasmic Reticulum Stress
  • Neuroprotection
  • Retina
  • Transcriptome
  33 Scopus citations

• Sigma receptor ligand, (+)-pentazocine, suppresses inflammatory responses of retinal microglia

  Zhao, J., Ha, Y., Liou, G. I., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., May 8 2014, In: Investigative Ophthalmology and Visual Science. 55, 6, p. 3375-3384 10 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma Receptors
  • Pentazocine
  • Microglia
  • Ligands
  • Lipopolysaccharides
  34 Scopus citations
• 2015

  A lipidomic screen of hyperglycemia-treated hrecs links 12/15-lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase

  Ibrahim, A. S., Elshafey, S., Sellak, H., Hussein, K. A., El-Sherbiny, M., Abdelsaid, M., Rizk, N., Beasley, S., Tawfik, A. M., Smith, S. B. & Al-Shabrawey, M., Mar 1 2015, In: Journal of Lipid Research. 56, 3, p. 599-611 13 p.

  Research output: Contribution to journal › Article › peer-review

  • 12-15-lipoxygenase
  • 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
  • 15-hydroxy-5,8,11,13-eicosatetraenoic acid
  • Arachidonate 15-Lipoxygenase
  • NADPH Oxidases
  31 Scopus citations

• Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma

  Ha, Y., Liu, H., Xu, Z., Yokota, H., Narayanan, S. P., Lemtalsi, T., Smith, S. B., Caldwell, R. W., Caldwell, R. B. & Zhang, W., Oct 1 2015, In: Cell Death and Disease. 6, 10, e1900.

  Research output: Contribution to journal › Article › peer-review

  • Endoplasmic Reticulum Stress
  • Glaucoma
  • Intraocular Pressure
  • Inflammation
  • Wounds and Injuries
  30 Scopus citations

• Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in The susceptibility of diabetic models to ischemic acute kidney injury

  Peng, J., Li, X., Zhang, D., Chen, J. K., Su, Y., Smith, S. B. & Dong, Z., Jan 3 2015, In: Kidney International. 87, 1, p. 137-150 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Kidney Injury
  • Hyperglycemia
  • Apoptosis
  • Kidney
  • Glucose
  74 Scopus citations

• Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids

  Ibrahim, A. S., Tawfik, A. M., Hussein, K. A., Elshafey, S., Markand, S., Rizk, N., Duh, E. J., Smith, S. B. & Al-Shabrawey, M., Mar 2015, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1851, 3, p. 290-298 9 p.

  Research output: Contribution to journal › Article › peer-review

  • 12-15-lipoxygenase
  • pigment epithelium-derived factor
  • Eicosanoids
  • 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
  • Hydroxyeicosatetraenoic Acids
  24 Scopus citations

• Retinal ganglion cell loss and mild vasculopathy in methylene tetrahydrofolate reductase (Mthfr)-deficient mice: A model of mild hyperhomocysteinemia

  Markand, S., Saul, A., Roon, P., Prasad, P., Martin, P., Rozen, R., Ganapathy, V. & Smith, S. B., 2015, In: Investigative Ophthalmology and Visual Science. 56, 4, p. 2684-2695 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Hyperhomocysteinemia
  • Retinal Ganglion Cells
  • Immunohistochemistry
  • Electroretinography
  • Fluorescein Angiography
  18 Scopus citations

• Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system x_c^-, the Na⁺-independent glutamate-cystine exchanger

  Wang, J., Shanmugam, A., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Jun 14 2015, In: Free Radical Biology and Medicine. 86, p. 25-36 12 p., 12387.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • Neuroglia
  • sigma-1 receptor
  • Cystine
  • Glutamic Acid
  63 Scopus citations

• Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells

  Shanmugam, A., Wang, J., Markand, S., Perry, R. L., Tawfik, A., Zorrilla, E., Ganapathy, V. & Smith, S. B., Mar 1 2015, In: Journal of Neurochemistry. 132, 5, p. 546-558 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuroglia
  • sigma-1 receptor
  • Interleukin-12
  • Chemical activation
  • Lipopolysaccharides
  11 Scopus citations
• 2016

  (+)-pentazocine reduces NMDA-induced murine retinal ganglion cell death through a σr1-dependent mechanism

  Zhao, J., Mysona, B. A., Qureshi, A., Kim, L., Fields, T., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., Feb 2016, In: Investigative Ophthalmology and Visual Science. 57, 2, p. 453-461 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Pentazocine
  • Retinal Ganglion Cells
  • N-Methylaspartate
  • Cell Death
  • sigma-1 receptor
  15 Scopus citations

• Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration

  Wang, J., Saul, A., Roon, P. & Smith, S. B., Jun 28 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. E3764-E3772

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor
  • Retinal Degeneration
  • Molecular Chaperones
  • Photoreceptor Cells
  • Retinal Diseases
  41 Scopus citations

• Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration

  Ibrahim, A. S., Mander, S., Hussein, K. A., Elsherbiny, N. M., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., 2016, In: Oncotarget. 7, 8, p. 8532-8545 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Hyperhomocysteinemia
  • Retinal Pigments
  • Macular Degeneration
  • Homocysteine
  • Choroidal Neovascularization
  16 Scopus citations

• Mthfr as a modifier of the retinal phenotype of Crb1^rd8/rd8 mice

  Markand, S., Saul, A., Tawfik, A., Cui, X., Rozen, R. & Smith, S. B., Apr 1 2016, In: Experimental eye research. 145, p. 164-172 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinal Degeneration
  • Phenotype
  • Mutation
  • Leber Congenital Amaurosis
  • Retinitis Pigmentosa
  6 Scopus citations

• Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease

  Promsote, W., Powell, F. L., Veean, S., Thounaojam, M., Markand, S., Saul, A., Gutsaeva, D., Bartoli, M., Smith, S. B., Ganapathy, V. & Martin, P. M., Dec 10 2016, In: Antioxidants and Redox Signaling. 25, 17, p. 921-935 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Fumarates
  • Sickle Cell Anemia
  • Oxidative stress
  • hemoglobin AA
  • Pathology
  7 Scopus citations

• Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina

  Shanmugam, A. K., Mysona, B. A., Wang, J., Zhao, J., Tawfik, A., Sanders, A., Markand, S., Zorrilla, E., Ganapathy, V., Bollinger, K. E. & Smith, S. B., Aug 2 2016, In: Current Eye Research. 41, 8, p. 1105-1112 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Progesterone Receptors
  • Retina
  • Membranes
  • Intestines
  • sigma-2 receptor
  3 Scopus citations

• Role of sigma 1 receptor in retinal degeneration of the Ins2^Akita/+ murine model of diabetic retinopathy

  Wang, J., Cui, X., Roon, P. & Smith, S. B., May 1 2016, In: Investigative Ophthalmology and Visual Science. 57, 6, p. 2770-2781 12 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor
  • Retinal Degeneration
  • Diabetic Retinopathy
  • Pentazocine
  • Gliosis
  7 Scopus citations
• 2017

  Absence of sigma 1 receptor accelerates photoreceptor cell death in a murine model of retinitis pigmentosa

  Wang, J., Saul, A., Cui, X., Roon, P. & Smith, S. B., Sep 2017, In: Investigative Ophthalmology and Visual Science. 58, 11, p. 4545-4558 14 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor
  • Photoreceptor Cells
  • Retinitis Pigmentosa
  • Cell Death
  • Gliosis
  14 Scopus citations

• Analysis of MTHFR, CBS, glutathione, taurine, and hydrogen sulfide levels in retinas of hyperhomocysteinemic mice

  Cui, X., Navneet, S., Wang, J., Roon, P., Chen, W., Xian, M. & Smith, S. B., Apr 2017, In: Investigative Ophthalmology and Visual Science. 58, 4, p. 1954-1963 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Glutathione Synthase
  • Cystathionine
  • Hydrogen Sulfide
  • Taurine
  • Retina
  7 Scopus citations

• Detailed electroretinographic findings in rd8 mice

  Saul, A. B., Cui, X., Markand, S. & Smith, S. B., Jun 1 2017, In: Documenta Ophthalmologica. 134, 3, p. 195-203 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Retina
  • Light
  • Amacrine Cells
  • Retinal Degeneration
  • Phenotype
  3 Scopus citations

• Hyperhomocysteinemia alters retinal endothelial cells barrier function and angiogenic potential via activation of oxidative stress

  Mohamed, R., Sharma, I., Ibrahim, A. S., Saleh, H., Elsherbiny, N. M., Fulzele, S., Elmasry, K., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., Dec 1 2017, In: Scientific reports. 7, 1, 09731.

  Research output: Contribution to journal › Article › peer-review

  • Hyperhomocysteinemia
  • Oxidative Stress
  • Endothelial Cells
  • Homocysteine
  • Blood-Retinal Barrier
  15 Scopus citations

• Introduction to sigma receptors: Their role in disease and as therapeutic targets

  Smith, S. B., 2017, In: Advances in experimental medicine and biology. 964, p. 1-4 4 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor
  • sigma Receptors
  • sigma-2 receptor
  • Molecular imaging
  • Neurodegenerative diseases
  10 Scopus citations

• p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection

  Zhu, S., Luo, H., Liu, H., Ha, Y., Mays, E. R., Lawrence, R. E., Winkelmann, E., Barrett, A. D., Smith, S. B., Wang, M., Wang, T. & Zhang, W., Sep 2017, In: Antiviral Research. 145, p. 70-81 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus Infection
  • Zika Virus
  • Phenotype
  • Intercellular Signaling Peptides and Proteins
  • Posterior Uveitis
  10 Scopus citations

• Protective effects of agonists of growth hormone-releasing hormone (GHRH) in early experimental diabetic retinopathy

  Thounaojam, M. C., Powell, F. L., Patel, S., Gutsaeva, D. R., Tawfik, A., Smith, S. B., Nussbaum, J., Block, N. L., Martin, P. M., Schally, A. V. & Bartoli, M., Dec 12 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 50, p. 13248-13253 6 p.

  Research output: Contribution to journal › Article › peer-review

  • N-Me-Tyr1,D-Ala2,Asn8,Arg29-NHCH3-JI-38
  • Growth Hormone-Releasing Hormone
  • Diabetic Retinopathy
  • GHRH(1-29)NH2, (PhAc-Ada)(0)-Tyr(1), Arg(2), Fpa(5,6), Ala(8), Har(9), Tyr(Me)(10), His(11), Orn(12,) Abu(15), His(20), Orn(21), Nle(27), Arg(28), Har(29)-
  • Retina
  17 Scopus citations