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WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells
Teng, Y., Mei, Y., Hawthorn, L. & Cowell, J. K., Jan 9 2014, In: Oncogene. 33, 2, p. 203-211 9 p.Research output: Contribution to journal › Article › peer-review
60 Scopus citations -
WASF3 provides the conduit to facilitate invasion and metastasis in breast cancer cells through HER2/HER3 signaling
Teng, Y., Pi, W., Wang, Y. & Cowell, J. K., Sep 1 2016, In: Oncogene. 35, 35, p. 4633-4640 8 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Variant profiles of genes mapping to chromosome 16q loss in wilms tumors reveals link to cilia-related genes and pathways
Kitamura, E., Cowell, J. K., Chang, C. S. & Hawthorn, L., 2020, In: Genes and Cancer. 11, 3-4, p. 137-153 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility
Zhou, H. M., Fang, Y. Y., Weinberger, P. M., Ding, L. L., Cowell, J. K., Hudson, F. Z., Ren, M., Lee, J. R., Chen, Q. K., Su, H., Dynan, W. S. & Lin, Y., Feb 4 2016, In: BMC Cancer. 16, 1, 55.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
Transformation of human CD34+ hematopoietic progenitor cells with DEK-NUP214 induces AML in an immunocompromised mouse model
Qin, H., Malek, S., Cowell, J. K. & Ren, M., Oct 27 2016, In: Oncogene. 35, 43, p. 5686-5691 6 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
The WASF3-NCKAP1-CYFIP1 complex is essential for breast cancer metastasis
Teng, Y., Qin, H., Bahassan, A., Bendzunas, N. G., Kennedy, E. J. & Cowell, J. K., Sep 1 2016, In: Cancer Research. 76, 17, p. 5133-5142 10 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
The temporal and spatial expression pattern of the LGI1 epilepsy predisposition gene during mouse embryonic cranial development
Silva, J., Wang, G. & Cowell, J. K., May 13 2011, In: BMC Neuroscience. 12, 43.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
The promise of zebrafish as a chemical screening tool in cancer therapy
Xie, X., Ross, J. L., Cowell, J. K. & Teng, Y., Aug 1 2015, In: Future Medicinal Chemistry. 7, 11, p. 1395-1405 11 p.Research output: Contribution to journal › Review article › peer-review
9 Scopus citations -
The MIR-17/92 cluster is involved in the molecular etiology of the SCLL syndrome driven by the BCR-FGFR1 chimeric kinase
Hu, T., Chong, Y., Qin, H., Kitamura, E., Chang, C. S., Silva, J., Ren, M. & Cowell, J. K., Apr 1 2018, In: Oncogene. 37, 14, p. 1926-1938 13 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Targeting the WASF3-CYFIP1 complex using stapled peptides suppresses cancer cell invasion
Teng, Y., Bahassan, A., Dong, D., Hanold, L. E., Ren, X., Kennedy, E. J. & Cowell, J. K., Feb 15 2016, In: Cancer Research. 76, 4, p. 965-973 9 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Targeting FGFR1 to suppress leukemogenesis in syndromic and de novo AML in murine models
Wu, Q., Bhole, A., Qin, H., Karp, J., Malek, S., Cowell, J. K. & Ren, M., 2016, In: Oncotarget. 7, 31, p. 49733-49742 10 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Src activation plays an important key role in lymphomagenesis induced by FGFR1 fusion kinases
Ren, M., Qin, H., Ren, R., Tidwell, J. & Cowell, J. K., Dec 1 2011, In: Cancer Research. 71, 23, p. 7312-7322 11 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome
Hu, T., Chong, Y., Lu, S., McGuinness, M., Williams, D. A. & Cowell, J. K., Jan 31 2020, In: Haematologica. 105, 2, p. E68-E71Research output: Contribution to journal › Letter › peer-review
Open Access -
Promotion of invasion by mutant RAS is dependent on activation of the WASF3 metastasis promoter gene
Teng, Y., Ngoka, L. & Cowell, J. K., Jun 2017, In: Genes Chromosomes and Cancer. 56, 6, p. 493-500 8 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Ponatinib suppresses the development of myeloid and lymphoid malignancies associated with FGFR1 abnormalities
Ren, M., Qin, H., Ren, R. & Cowell, J. K., Jan 2013, In: Leukemia. 27, 1, p. 32-40 9 p.Research output: Contribution to journal › Article › peer-review
53 Scopus citations -
Novel FGFR inhibitor ponatinib suppresses the growth of non-small cell lung cancer cells overexpressing FGFR1
Ren, M., Hong, M., Liu, G., Wang, H., Patel, V. S., Biddinger, P. W., Silva, M. J., Cowell, J. K. & Hao, Z., Jun 2013, In: Oncology Reports. 29, 6, p. 2181-2190 10 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
Mutation in the FGFR1 tyrosine kinase domain or inactivation of PTEN is associated with acquired resistance to FGFR inhibitors in FGFR1-driven leukemia/lymphomas
Cowell, J. K., Qin, H., Hu, T., Wu, Q., Bhole, A. & Ren, M., Nov 1 2017, In: International Journal of Cancer. 141, 9, p. 1822-1829 8 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
Ouzounova, M., Lee, E., Piranlioglu, R., El Andaloussi, A., Kolhe, R., Demirci, M. F., Marasco, D., Asm, I., Chadli, A., Hassan, K. A., Thangaraju, M., Zhou, G., Arbab, A. S., Cowell, J. K. & Korkaya, H., 2017, In: Nature communications. 8, 14979.Research output: Contribution to journal › Article › peer-review
116 Scopus citations -
Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein
Teng, Y., Ren, X., Li, H., Shull, A., Kim, J. & Cowell, J. K., Jan 21 2016, In: Oncogene. 35, 3, p. 333-343 11 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
MiR-339 promotes development of stem cell leukemia/lymphoma syndrome via downregulation of the BCL2L11 and BAX proapoptotic genes
Hu, T., Chong, Y., Lu, S., Wang, R., Qin, H., Silva, J., Kitamura, E., Chang, C. S., Hawthorn, L. A. & Cowell, J. K., Jul 1 2018, In: Cancer Research. 78, 13, p. 3522-3531 10 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Loss of zebrafish lgi1b leads to hydrocephalus and sensitization to pentylenetetrazol induced seizure-like behavior
Teng, Y., Xie, X., Walker, S., Saxena, M., Kozlowski, D. J., Mumm, J. S. & Cowell, J. K., Sep 16 2011, In: PloS one. 6, 9, e24596.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5 + CK8 + epithelial cells
Wang, Z., Kim, J., Teng, Y., Ding, H., Zhang, J., Hai, T., Cowell, J. K. & Yan, C., Jul 7 2016, In: Oncogene. 35, 27, p. 3555-3564 10 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
LGI1: From zebrafish to human epilepsy
Cowell, J. K., Jan 1 2014, In: Progress in Brain Research. 213, C, p. 159-179 21 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Inactivation of Lgi1 in murine neuronal precursor cells leads to dysregulation of axon guidance pathways
Silva, J., Hawthorn, L. & Cowell, J. K., Mar 2020, In: Genomics. 112, 2, p. 1167-1172 6 p.Research output: Contribution to journal › Article › peer-review
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HOXC9 directly regulates distinct sets of genes to coordinate diverse cellular processes during neuronal differentiation
Wang, X., Choi, J-H., Ding, J., Yang, L., Ngoka, L. C., Lee, E. J., Zha, Y., Mao, L., Jin, B., Ren, M., Cowell, J. K., Huang, S., Shi, H., Cui, H. & Ding, H., Nov 25 2013, In: BMC Genomics. 14, 1, 830.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Homozygous deletion of the LGI1 gene in mice leads to developmental abnormalities resulting in cortical dysplasia
Silva, J., Sharma, S. & Cowell, J. K., Sep 1 2015, In: Brain Pathology. 25, 5, p. 587-597 11 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Genetic analysis of Down syndrome-associated heart defects in mice
Liu, C., Morishima, M., Yu, T., Matsui, S. I., Zhang, L., Fu, D., Pao, A., Costa, A. C., Gardiner, K. J., Cowell, J. K., Nowak, N. J., Parmacek, M. S., Liang, P., Baldini, A. & Yu, Y. E., Nov 2011, In: Human Genetics. 130, 5, p. 623-632 10 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Functional interrelationship between the WASF3 and KISS1 metastasis-associated genes in breast cancer cells
Teng, Y., Liu, M. & Cowell, J. K., Dec 15 2011, In: International Journal of Cancer. 129, 12, p. 2825-2835 11 p.Research output: Contribution to journal › Article › peer-review
43 Scopus citations -
FGFR1OP2-FGFR1 induced myeloid leukemia and T-cell lymphoma in a mouse model
Qin, H., Wu, Q., Cowell, J. K. & Ren, M., 2016, In: Haematologica. 101, 3, p. e91-e94Research output: Contribution to journal › Letter › peer-review
8 Scopus citations -
FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia/lymphoma syndrome
Hu, T., Wu, Q., Chong, Y., Qin, H., Poole, C. J., van Riggelen, J., Ren, M. & Cowell, J. K., Nov 1 2018, In: Leukemia. 32, 11, p. 2363-2373 11 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Evaluation of phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) and epidermal growth factor receptor (EGFR) gene mutations in pancreaticobiliary adenocarcinoma
Weiss, G. A., Rossi, M. R., Khushalani, N. I., Lo, K., Gibbs, J. F., Bharthuar, A., Cowell, J. K. & Iyer, R., Mar 2013, In: Journal of Gastrointestinal Oncology. 4, 1, p. 20-29 10 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
Evaluating human cancer cell metastasis in zebrafish
Teng, Y., Xie, X., Walker, S., White, D. T., Mumm, J. S. & Cowell, J. K., Oct 4 2013, In: BMC Cancer. 13, 453.Research output: Contribution to journal › Article › peer-review
98 Scopus citations -
Essential roles of leucine-rich glioma inactivated 1 in the development of embryonic and postnatal cerebellum
Xie, Y. J., Zhou, L., Jiang, N., Zhang, N., Zou, N., Zhou, L., Wang, Y., Cowell, J. K. & Shen, Y., Jan 16 2015, In: Scientific reports. 5, 7827.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Erratum: Genetic analysis of Down syndrome-associated heart defects in mice (Human Genetics DOI: 10.1007/s00439-011-0980-2)
Liu, C., Morishima, M., Yu, T., Matsui, S. I., Zhang, L., Fu, D., Pao, A., Costa, A. C., Gardiner, K. J., Cowell, J. K., Nowak, N. J., Parmacek, M. S., Liang, P., Baldini, A. & Yu, Y. E., Nov 2011, In: Human Genetics. 130, 5, p. 633 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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Dysregulated signaling pathways in the development of CNTRL-FGFR1–induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models
Ren, M., Qin, H., Kitamura, E. & Cowell, J. K., Aug 8 2013, In: Blood. 122, 6, p. 1007-1016 10 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Downregulation of PUMA underlies resistance to FGFR1 inhibitors in the stem cell leukemia/lymphoma syndrome
Liu, Y., Cai, B., Chong, Y., Zhang, H., Kemp, C. A., Lu, S., Chang, C. S., Ren, M., Cowell, J. K. & Hu, T., Oct 1 2020, In: Cell Death and Disease. 11, 10, 884.Research output: Contribution to journal › Article › peer-review
Open Access -
Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice
Ren, M., Qin, H., Wu, Q., Savage, N. M., George, T. I. & Cowell, J. K., Aug 15 2016, In: International Journal of Cancer. 139, 4, p. 836-840 5 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Critical role of the WASF3 gene in JAK2/STAT3 regulation of cancer cell motility
Teng, Y., Ghoshal, P., Ngoka, L., Mei, Y. & Cowell, J. K., Sep 2013, In: Carcinogenesis. 34, 9, p. 1994-1999 6 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Critical individual roles of the BCR and FGFR1 kinase domains in BCR-FGFR1-driven stem cell leukemia/lymphoma syndrome
Chong, Y., Liu, Y., Lu, S., Cai, B., Qin, H., Chang, C. S., Ren, M., Cowell, J. K. & Hu, T., Apr 15 2020, In: International Journal of Cancer. 146, 8, p. 2243-2254 12 p.Research output: Contribution to journal › Article › peer-review
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Corrigendum to "WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, And MMP-9 expression" [Exp. Cell Res. 308 (2005) 135-145]
Sossey-Alaoui, K., Ranalli, T. A., Li, X., Bakin, A. V. & Cowell, J. K., Mar 10 2013, In: Experimental Cell Research. 319, 5, 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis
Shao, J., Teng, Y., Padia, R., Hong, S., Noh, H., Xie, X., Mumm, J. S., Dong, Z., Ding, H. F., Cowell, J., Kim, J., Han, J. & Huang, S., Sep 2013, In: Neoplasia (United States). 15, 9, p. 1075-1085 11 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease
Ren, M. Q. & Cowell, J. K., Jun 23 2011, In: Blood. 117, 25, p. 6837-6847 11 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
CML: a model disease with a defined oncogenic driver.
Hao, Z. & Cowell, J. K., Mar 1 2011, In: Clinical advances in hematology & oncology : H&O. 9, 3, p. 247-248 2 p.Research output: Contribution to journal › Comment/debate › peer-review
1 Scopus citations -
Celecoxib ameliorates seizure susceptibility in autosomal dominant lateral temporal epilepsy
Zhou, L., Zhou, L., Su, L. D., Cao, S. L., Xie, Y. J., Wang, N., Shao, C. Y., Wang, Y. N., Zhou, J. H., Cowell, J. K. & Shen, Y., Mar 28 2018, In: Journal of Neuroscience. 38, 13, p. 3346-3357 12 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization
Hawthorn, L. & Cowell, J. K., 2011, In: PloS one. 6, 4, e18941.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
A model of BCR-FGFR1 driven human AML in immunocompromised mice
Cowell, J. K., Qin, H., Chang, C. S., Kitamura, E. & Ren, M., Nov 1 2016, In: British Journal of Haematology. 175, 3, p. 542-545 4 p.Research output: Contribution to journal › Letter › peer-review
10 Scopus citations -
Abstract 1023: NOV C-ter: A novel preclinical anti-angiogenic agent
Luo, J., Teng, Y., Li, M., Johnson, T. S., Cuttitta, F., Chu, Z., Qi, X., Cowell, J. K. & Rixe, O., Oct 1 2014, p. 1023-1023.Research output: Contribution to conference › Paper › peer-review