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• 2021

  Mice with a specific deficiency of Pfkfb3 in myeloid cells are protected from hypoxia-induced pulmonary hypertension

  Wang, L., Zhang, X., Cao, Y., Ma, Q., Mao, X., Xu, J., Yang, Q., Zhou, Y., Lucas, R., Fulton, D. J., Su, Y., Barman, S. A., Hong, M., Liu, Z. & Huo, Y., Mar 2021, In: British Journal of Pharmacology. 178, 5, p. 1055-1072 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell Hypoxia
  • Myeloid Cells
  • Pulmonary Hypertension
  • Macrophages
  • Semaxinib
• 2020

  Impact of bacterial toxins in the lungs

  Lucas, R., Hadizamani, Y., Gonzales, J., Gorshkov, B., Bodmer, T., Berthiaume, Y., Moehrlen, U., Lode, H., Huwer, H., Hudel, M., Mraheil, M. A., Toque, H. A. F., Chakraborty, T. & Hamacher, J., Apr 2020, In: Toxins. 12, 4, 223.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pulmonary diseases
  • Bacterial Toxins
  • Alveolar Macrophages
  • Lung
  • Cell signaling
  2 Scopus citations

• Loaded Leukosomes: A Smart Bomb to Halt Vascular Inflammation

  Csányi, G., Lucas, R. & Annex, B. H., Jan 3 2020, In: Circulation research. 126, 1, p. 38-40 3 p.

  Research output: Contribution to journal › Editorial › peer-review

• Short report: Does the 6-minute walk test in hospitalized COPD patients exclusively correlate with lung function parameters or should psychological factors also be taken into account?

  Borgmann, M., Ivanda, M., Hadizamani, Y., Mohaupt, M., Bals, R., Lucas, R., Hamacher, J. & Köllner, V., May 2020, In: PloS one. 15, 5, e0232587.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • psychosocial factors
  • Pulmonary diseases
  • lung function
  • Walk Test
  • anxiety
• 2019

  Reactive Oxygen Species-Dependent Calpain Activation Contributes to Airway and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease

  Zhu, J., Kovacs, L., Han, W., Liu, G., Huo, Y., Lucas, R., Fulton, D., Greer, P. A. & Su, Y., Oct 20 2019, In: Antioxidants and Redox Signaling. 31, 12, p. 804-818 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Pulmonary diseases
  • Calpain
  • Vascular Remodeling
  • Tobacco
  • Chemical activation
  5 Scopus citations

• The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

  Madaio, M. P., Czikora, I., Kvirkvelia, N., McMenamin, M., Yue, Q., Liu, T., Flores Toque, H. A., Sridhar, S., Covington, K., Alaisami, R., O'Connor, P. M., Caldwell, R. W., Chen, J., Clauss, M., Brands, M. W., Eaton, D. C., Romero Lucas, M. J. & Lucas, R., Jun 2019, In: Kidney International. 95, 6, p. 1359-1372 14 p.

  Research output: Contribution to journal › Article › peer-review

  • AP301 peptide
  • Epithelial Sodium Channels
  • Nephritis
  • Tumor Necrosis Factor-alpha
  • Serum
  2 Scopus citations
• 2018

  A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome

  Benson, T. W., Weintraub, N. L., Kim, H. W., Seigler, N., Kumar, S., Pye, J., Horimatsu, T., Pellenberg, R., Stepp, D. W., Lucas, R., Bogdanov, V. Y., Litwin, S. E., Brittain, J. E. & Harris, R. A., Oct 1 2018, In: Laboratory Investigation. 98, 10, p. 1300-1310 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Coronary Syndrome
  • Peroxidase
  • Meals
  • Erythrocytes
  • Fats
  5 Scopus citations

• Cytokine-ion channel interactions in pulmonary inflammation

  Hamacher, J., Hadizamani, Y., Borgmann, M., Mohaupt, M., Männel, D. N., Moehrlen, U., Lucas, R. & Stammberger, U., Jan 4 2018, In: Frontiers in immunology. 8, JAN, 1644.

  Research output: Contribution to journal › Review article › peer-review

  • Ion Channels
  • Pneumonia
  • Cytokines
  • Lung
  • Replantation
  13 Scopus citations

• Editorial: Cytokine-ion channel interactions in pulmonary inflammation

  Vadász, I. & Lucas, R., Nov 6 2018, In: Frontiers in immunology. 9, NOV, 2598.

  Research output: Contribution to journal › Review article › peer-review

• Hsp70 suppresses mitochondrial reactive oxygen species and preserves pulmonary microvascular barrier integrity following exposure to bacterial toxins

  Li, X., Yu, Y., Gorshkov, B., Haigh, S., Bordan, Z., Weintraub, D., Rudic, R. D., Chakraborty, T., Barman, S. A., Verin, A. D., Su, Y., Lucas, R., Stepp, D. W., Chen, F. & Fulton, D. J., Jun 12 2018, In: Frontiers in immunology. 9, JUN, 1309.

  Research output: Contribution to journal › Article › peer-review

  • Streptococcus pneumoniae plY protein
  • Bacterial Toxins
  • geranylgeranylacetone
  • Reactive Oxygen Species
  • Lung
  17 Scopus citations

• Kidney-targeted inhibition of protein kinase C-α ameliorates nephrotoxic nephritis with restoration of mitochondrial dysfunction

  Kvirkvelia, N., McMenamin, M., Warren, M., Jadeja, R. N., Kodeboyina, S. K., Sharma, A., Zhi, W., O'Connor, P. M., Raju, R., Lucas, R. & Madaio, M. P., Aug 2018, In: Kidney International. 94, 2, p. 280-291 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Nephritis
  • Protein Kinase C
  • Kidney
  • Protein C Inhibitor
  • Mitochondrial Proteins
  3 Scopus citations

• Listeriolysin O causes ENaC dysfunction in human airway epithelial cells

  Yang, G., Pillich, H., White, R., Czikora, I., Pochic, I., Yue, Q., Hudel, M., Gorshkov, B. A., Verin, A. D., Sridhar, S., Isales, C. M., Eaton, D. C., Hamacher, J., Chakraborty, T. & Lucas, R., Feb 11 2018, In: Toxins. 10, 2, 79.

  Research output: Contribution to journal › Article › peer-review

  • Listeria monocytogenes hlyA protein
  • Epithelial Cells
  • AP301 peptide
  • Chemical activation
  • Pulmonary Edema
  1 Scopus citations
• 2017

  Epithelial sodium channel-α mediates the protective effect of the TNF-derived TIP peptide in pneumolysin-induced endothelial barrier dysfunction

  Czikora, I., Alli, A. A., Sridhar, S., Matthay, M. A., Pillich, H., Hudel, M., Berisha, B., Gorshkov, B. A., Romero Lucas, M. J., Gonzales, J. N., Wu, G., Huo, Y., Su, Y., Verin, A. D., Fulton, D. J., Chakraborty, T., Eaton, D. C. & Lucas, R., Jul 21 2017, In: Frontiers in immunology. 8, JUL, 842.

  Research output: Contribution to journal › Article › peer-review

  • AP301 peptide
  • Streptococcus pneumoniae plY protein
  • Epithelial Sodium Channels
  • Endothelial Cells
  • Acid Sensing Ion Channels
  15 Scopus citations

• Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: A phase IIa randomized placebo-controlled trial

  Krenn, K., Lucas, R., Croizé, A., Boehme, S., Klein, K. U., Hermann, R., Markstaller, K. & Ullrich, R., Jul 27 2017, In: Critical Care. 21, 1, 194.

  Research output: Contribution to journal › Article › peer-review

  • Extravascular Lung Water
  • Adult Respiratory Distress Syndrome
  • Pulmonary Edema
  • Placebos
  • Randomized Controlled Trials
  21 Scopus citations

• Listeriolysin O regulates the expression of optineurin, an autophagy adaptor that inhibits the growth of Listeria monocytogenes

  Puri, M., La Pietra, L., Mraheil, M. A., Lucas, R., Chakraborty, T. & Pillich, H., Sep 5 2017, In: Toxins. 9, 9, 273.

  Research output: Contribution to journal › Article › peer-review

  • Listeria
  • Listeria monocytogenes hlyA protein
  • Listeria monocytogenes
  • Autophagy
  • Phosphorylation
  10 Scopus citations

• Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

  Bhatta, A., Yao, L., Xu, Z., Toque, H. A., Chen, J., Atawia, R. T., Fouda, A. Y., Bagi, Z., Lucas, R., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In: Cardiovascular Research. 113, 13, p. 1664-1676 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Endothelial Cells
  • Obesity
  • Blood Vessels
  • Sucrose
  46 Scopus citations

• Obesity-induced vascular inflammation involves elevated arginase activity

  Yao, L., Bhatta, A., Xu, Z., Chen, J., Toque, H. A., Chen, Y., Xu, Y., Bagi, Z., Lucas, R., Huo, Y., Caldwell, R. B. & Caldwell, R. W., Nov 2017, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 313, 5, p. R560-R571

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Intra-Abdominal Fat
  • Obesity
  • Endothelial Cells
  • Inflammation
  15 Scopus citations

• Restoration of epithelial sodium channel function by synthetic peptides in pseudohypoaldosteronism type 1B mutants

  Willam, A., Aufy, M., Tzotzos, S., Evanzin, H., Chytracek, S., Geppert, S., Fischer, B., Fischer, H., Pietschmann, H., Czikora, I., Lucas, R., Lemmens-Gruber, R. & Shabbir, W., Feb 24 2017, In: Frontiers in Pharmacology. 8, FEB, 85.

  Research output: Contribution to journal › Article › peer-review

  • AP301 peptide
  • Pseudohypoaldosteronism
  • Epithelial Sodium Channels
  • AP318 peptide
  • Peptides
  3 Scopus citations

• RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G⁺-bacterial toxins

  Chen, F., Wang, Y., Rafikov, R., Haigh, S., Kumar, S., Rafikova, O., Lucas, R., Verin, A. D., Black, S. M. & Fulton, D. J. R., Mar 1 2017, In: Biochemical Pharmacology. 127, p. 34-45 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Bacterial Toxins
  • Nitric Oxide
  • glutathione-independent formaldehyde dehydrogenase
  • Listeria monocytogenes hlyA protein
  • Enzyme activity
  7 Scopus citations

• Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction

  Dou, H., Feher, A., Davila, A. C., Romero, M. J., Patel, V. S., Kamath, V. M., Gooz, M. B., Rudic, R. D., Lucas, R., Fulton, D. J., Weintraub, N. L. & Bagi, Z., Jun 1 2017, In: Arteriosclerosis, thrombosis, and vascular biology. 37, 6, p. 1180-1193 14 p.

  Research output: Contribution to journal › Article › peer-review

  • ADAM17 Protein
  • Adipose Tissue
  • Caveolin 1
  • Tumor Necrosis Factor-alpha
  • Obesity
  14 Scopus citations

• Solnatide Demonstrates Profound Therapeutic Activity in a Rat Model of Pulmonary Edema Induced by Acute Hypobaric Hypoxia and Exercise

  Zhou, Q., Wang, D., Liu, Y., Yang, X., Lucas, R. & Fischer, B., Mar 1 2017, In: CHEST. 151, 3, p. 658-667 10 p.

  Research output: Contribution to journal › Article › peer-review

  • AP301 peptide
  • Pulmonary Edema
  • Hypoxia
  • Occludin
  • Dimercaprol
  11 Scopus citations

• TNF lectin-like domain restores epithelial sodium channel function in frameshift mutants associated with pseudohypoaldosteronism type 1B

  Willam, A., Aufy, M., Tzotzos, S., El-Malazi, D., Poser, F., Wagner, A., Unterköfler, B., Gurmani, D., Martan, D., Iqbal, S. M., Fischer, B., Fischer, H., Pietschmann, H., Czikora, I., Lucas, R., Lemmens-Gruber, R. & Shabbir, W., May 29 2017, In: Frontiers in immunology. 8, MAY, 601.

  Research output: Contribution to journal › Article › peer-review

  • AP301 peptide
  • Pseudohypoaldosteronism
  • Epithelial Sodium Channels
  • Lectins
  • Tumor Necrosis Factor-alpha
  1 Scopus citations
• 2016

  Role of growth hormone-releasing hormone in dyslipidemia associated with experimental type 1 diabetes

  Romero Lucas, M. J., Lucas, R., Dou, H., Sridhar, S., Czikora, I., Mosieri, E. M., Rick, F. G., Block, N. L., Sridhar, S., Fulton, D. J., Weintraub, N. L. & Bagi, Z., Feb 16 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. 1895-1900 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Growth Hormone-Releasing Hormone
  • Glucagon-Like Peptide 1
  • Dyslipidemias
  • GHRH(1-29)NH2, (PhAc-Ada)(0)-Tyr(1), Arg(2), Fpa(5,6), Ala(8), Har(9), Tyr(Me)(10), His(11), Orn(12,) Abu(15), His(20), Orn(21), Nle(27), Arg(28), Har(29)-
  • Type 1 Diabetes Mellitus
  7 Scopus citations

• The lectin-like domain of TNF increases ENaC open probability through a novel site at the interface between the second transmembrane and C-terminal domains of the α-subunit

  Lucas, R., Yue, Q., Alli, A., Duke, B. J., Al-Khalili, O., Thai, T. L., Hamacher, J., Sridhar, S., Lebedyeva, I., Su, H., Tzotzos, S., Fischer, B., Gameiro, A. F., Loose, M., Chakraborty, T., Shabbir, W., Aufy, M., Lemmens-Gruber, R., Eaton, D. C. & Czikora, I., Nov 4 2016, In: Journal of Biological Chemistry. 291, 45, p. 23440-23451 12 p.

  Research output: Contribution to journal › Article › peer-review

  • AP301 peptide
  • Lectins
  • Membranes
  • Epithelial Sodium Channels
  • Cell membranes
  10 Scopus citations

• Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy

  Patel, C., Xu, Z., Shosha, E., Xing, J., Lucas, R., Caldwell, R. W., Caldwell, R. B. & Narayanan, S. P., Sep 1 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 9, p. 1628-1639 12 p.

  Research output: Contribution to journal › Article › peer-review

  • polyamine oxidase
  • Hyperoxia
  • Vascular System Injuries
  • Retinal Vessels
  • MDL 72527
  6 Scopus citations
• 2015

  Caveolin-1 prevents sustained angiotensin II-induced resistance artery constriction and obesity-induced high blood pressure

  Czikora, I., Feher, A., Lucas, R., Fulton, D. J. R. & Bagi, Z., Mar 1 2015, In: American Journal of Physiology - Heart and Circulatory Physiology. 308, 5, p. H376-H385

  Research output: Contribution to journal › Article › peer-review

  • Caveolin 1
  • Angiotensin II
  • Constriction
  • Arteries
  • Obesity
  12 Scopus citations

• Endothelial nitric oxide synthase deficient mice are protected from lipopolysaccharide induced acute lung injury

  Gross, C. M., Rafikov, R., Kumar, S., Aggarwal, S., Ham, P. B., Meadows, M. L., Cherian-Shaw, M., Kangath, A., Sridhar, S., Lucas, R. & Black, S. M., Mar 18 2015, In: PloS one. 10, 3, e0119918.

  Research output: Contribution to journal › Article › peer-review

  • endothelial nitric oxide synthase
  • Acute Lung Injury
  • Nitric Oxide Synthase Type III
  • lipopolysaccharides
  • Lipopolysaccharides
  28 Scopus citations

• Glycosylation-dependent activation of epithelial sodium channel by solnatide

  Shabbir, W., Tzotzos, S., Bedak, M., Aufy, M., Willam, A., Kraihammer, M., Holzner, A., Czikora, I., Scherbaum-Hazemi, P., Fischer, H., Pietschmann, H., Fischer, B., Lucas, R. & Lemmens-Gruber, R., Dec 15 2015, In: Biochemical Pharmacology. 98, 4, p. 740-753 14 p.

  Research output: Contribution to journal › Article › peer-review

  • AP301 peptide
  • Glycosylation
  • Epithelial Sodium Channels
  • Chemical activation
  • Acute Lung Injury
  10 Scopus citations

• Pneumococcal hydrogen peroxide-induced stress signaling regulates inflammatory genes

  Loose, M., Hudel, M., Zimmer, K. P., Garcia, E., Hammerschmidt, S., Lucas, R., Chakraborty, T. & Pillich, H., Jan 15 2015, In: Journal of Infectious Diseases. 211, 2, p. 306-316 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Endoplasmic Reticulum Stress
  • Hydrogen Peroxide
  • Mitogens
  • Pyruvate Oxidase
  • Protein Kinases
  16 Scopus citations
• 2014

  A FIM study to assess safety and exposure of inhaled single doses of AP301 - A specific ENaC channel activator for the treatment of acute lung injury

  Schwameis, R., Eder, S., Pietschmann, H., Fischer, B., Mascher, H., Tzotzos, S., Fischer, H., Lucas, R., Zeitlinger, M. & Hermann, R., Mar 2014, In: Journal of Clinical Pharmacology. 54, 3, p. 341-350 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Lung Injury
  • Healthy Volunteers
  • Safety
  • Placebos
  • Bronchial Spasm
  15 Scopus citations

• A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation

  Czikora, I., Alli, A., Bao, H. F., Kaftan, D., Sridhar, S., Apell, H. J., Gorshkov, B., White, R., Zimmermann, A., Wendel, A., Pauly-Evers, M., Hamacher, J., Garcia-Gabay, I., Fischer, B., Verin, A., Bagi, Z., Pittet, J. F., Shabbir, W., Lemmens-Gruber, R., Chakraborty, T. & 4 others, Lazrak, A., Matthay, M. A., Eaton, D. C. & Lucas, R., Sep 1 2014, In: American journal of respiratory and critical care medicine. 190, 5, p. 522-532 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Epithelial Sodium Channels
  • Tumor Necrosis Factor-alpha
  • Streptococcus pneumoniae plY protein
  • AP301 peptide
  • Lectins
  32 Scopus citations

• Arginase in the vascular endothelium: Friend or foe?

  Lucas, R., Fulton, D., Caldwell, R. W. & Romero, M. J., 2014, In: Frontiers in immunology. 5, NOV, 589.

  Research output: Contribution to journal › Editorial › peer-review
  11 Scopus citations

• Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury

  Aggarwal, S., Gross, C. M., Kumar, S., Dimitropoulou, C., Sharma, S., Gorshkov, B. A., Sridhar, S., Lu, Q., Bogatcheva, N. V., Jezierska-Drutel, A. J., Lucas, R., Verin, A. D., Catravas, J. D. & Black, S. M., Mar 2014, In: American journal of respiratory cell and molecular biology. 50, 3, p. 614-625 12 p.

  Research output: Contribution to journal › Article › peer-review

  • dimethylargininase
  • N,N-dimethylarginine
  • Acute Lung Injury
  • Oxidative stress
  • Lung
  27 Scopus citations

• Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA

  Rafikov, R., Dimitropoulou, C., Aggarwal, S., Kangath, A., Gross, C., Pardo, D., Sharma, S., Jezierska-Drutel, A., Patel, V., Snead, C., Lucas, R., Verin, A., Fulton, D., Catravas, J. D. & Black, S. M., Feb 21 2014, In: Journal of Biological Chemistry. 289, 8, p. 4710-4722 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Nitration
  • Acute Lung Injury
  • Lung Injury
  • Chemical activation
  • Lipopolysaccharides
  35 Scopus citations

• PKC-dependent phosphorylation of eNOS at T495 regulates eNOS coupling and endothelial barrier function in response to G⁺ -toxins

  Chen, F., Kumar, S., Yu, Y., Aggarwal, S., Gross, C., Wang, Y., Chakraborty, T., Verin, A. D., Catravas, J. D., Lucas, R., Black, S. M. & Fulton, D. J. R., Jul 14 2014, In: PloS one. 9, 7, e99823.

  Research output: Contribution to journal › Article › peer-review

  • Phosphorylation
  • endothelial nitric oxide synthase
  • Nitric Oxide Synthase Type III
  • Listeria monocytogenes hlyA protein
  • phosphorylation
  38 Scopus citations

• Protective effect of adenosine receptors against lipopolysaccharide-induced acute lung injury

  Gonzales, J. N., Gorshkov, B. A., Varn, M. N., Zemskova, M. A., Zemskov, E. A., Sridhar, S., Lucas, R. & Verin, A. D., Mar 15 2014, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 306, 6, p. L497-L507

  Research output: Contribution to journal › Article › peer-review

  • Purinergic P1 Receptors
  • Acute Lung Injury
  • Adenosine-5'-(N-ethylcarboxamide)
  • Adenosine
  • Lipopolysaccharides
  37 Scopus citations

• Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction

  Czikora, I., Sridhar, S., Gorshkov, B. A., Alieva, I. B., Kasa, A., Gonzales, J. N., Potapenko, O., Siddaramappa, U. N., Pillich, H., Rick, F. G., Block, N. L., Verin, A. D., Chakraborty, T., Matthay, M. A., Schally, A. V. & Lucas, R., 2014, In: Frontiers in Physiology. 5 JUL, 00259.

  Research output: Contribution to journal › Article › peer-review

  • Streptococcus pneumoniae plY protein
  • Bacterial Toxins
  • Growth Hormone-Releasing Hormone
  • Cyclic AMP-Dependent Protein Kinases
  • Endothelial Cells
  12 Scopus citations

• Regulation of NADPH oxidase 5 by protein kinase C isoforms

  Chen, F., Yu, Y., Haigh, S., Johnson, J., Lucas, R., Stepp, D. W. & Fulton, D. J. R., Feb 5 2014, In: PloS one. 9, 2, e88405.

  Research output: Contribution to journal › Article › peer-review

  • NADPH Oxidase 5
  • protein kinase C
  • NADP
  • NADP (coenzyme)
  • Protein Kinase C
  61 Scopus citations
• 2013

  A Combined impedance and alphaLISA-based approach to identify anti-inflammatory and barrier-protective compounds in human endothelium

  Pflüger, M., Kapuscik, A., Lucas, R., Koppensteiner, A., Katzlinger, M., Jokela, J., Eger, A., Jacobi, N., Wiesner, C., Hofmann, E., Önder, K., Kopecky, J., Schütt, W. & Hundsberger, H., Jan 2013, In: Journal of Biomolecular Screening. 18, 1, p. 67-74 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelial cells
  • Monolayers
  • Intercellular Adhesion Molecule-1
  • Electric Impedance
  • Interleukin-8
  13 Scopus citations

• Adenosine A1 Receptors Promote Vasa Vasorum Endothelial Cell Barrier Integrity via G_i and Akt-Dependent Actin Cytoskeleton Remodeling

  Siddaramappa Umapathy, N., Kaczmarek, E., Fatteh, N., Burns, N., Lucas, R., Stenmark, K. R., Verin, A. D. & Gerasimovskaya, E. V., Apr 16 2013, In: PloS one. 8, 4, e59733.

  Research output: Contribution to journal › Article › peer-review

  • Vasa Vasorum
  • Endothelial cells
  • Adenosine A1 Receptors
  • microfilaments
  • adenosine
  26 Scopus citations

• AP301, a synthetic peptide mimicking the lectin-like domain of TNF, enhances amiloride-sensitive Na⁺ current in primary dog, pig and rat alveolar type II cells

  Tzotzos, S., Fischer, B., Fischer, H., Pietschmann, H., Lucas, R., Dupré, G., Lemmens-Gruber, R., Hazemi, P., Prymaka, V. & Shabbir, W., Jun 2013, In: Pulmonary Pharmacology and Therapeutics. 26, 3, p. 356-363 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Amiloride
  • Rats
  • Alveolar Epithelial Cells
  • Lectins
  • Swine
  18 Scopus citations

• Arginase 1: An unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury

  Lucas, R., Czikora, I., Sridhar, S., Zemskov, E. A., Oseghale, A., Circo, S., Cederbaum, S. D., Chakraborty, T., Fulton, D. J., Caldwell, R. W. & Romero Lucas, M. J., 2013, In: Frontiers in immunology. 4, AUG, Article 228.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Acute Lung Injury
  • Nitric Oxide Synthase Type III
  • Bacterial Toxins
  • Lung
  11 Scopus citations

• Correction: Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via G_i and akt-dependent actin cytoskeleton remodeling (PLoS ONE, 8, 4 (e59733) DOI: 10.1371/journal.pone.0059733)

  Umapathy, N. S., Kaczmarek, E., Fatteh, N., Burns, N., Lucas, R., Stenmark, K. R., Verin, A. D. & Gerasimovskaya, E. V., May 1 2013, In: PloS one. 8, 5

  Research output: Contribution to journal › Comment/debate › peer-review

• L-citrulline protects from kidney damage in type 1 diabetic mice

  Romero Lucas, M. J., Yao, L., Sridhar, S., Bhatta, A., Dou, H., Ramesh, G., Brands, M. W., Pollock, D. M., Caldwell, R. B., Cederbaum, S. D., Alvin Head, C., Bagi, Z., Lucas, R. & Caldwell, R. W., 2013, In: Frontiers in immunology. 4, DEC, Article 480.

  Research output: Contribution to journal › Article › peer-review

  • Citrulline
  • Arginase
  • Kidney
  • Streptozocin
  • Knockout Mice
  19 Scopus citations

• Mechanism of action of novel lung edema therapeutic AP301 by activation of the epithelial sodium channel

  Shabbir, W., Scherbaum-Hazemi, P., Tzotzos, S., Fischer, B., Fischer, H., Pietschmann, H., Lucas, R. & Lemmens-Gruber, R., Dec 2013, In: Molecular pharmacology. 84, 6, p. 899-910 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Epithelial Sodium Channels
  • Edema
  • Lung
  • AP318 peptide
  • Amiloride
  16 Scopus citations

• Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs

  Lucas, R., Czikora, I., Sridhar, S., Zemskov, E. A., Gorshkov, B. A., Siddaramappa, U. N., Oseghale, A., Lawson, J., Verin, A. D., Rick, F. G., Block, N. L., Pillich, H., Romero Lucas, M. J., Leustik, M., Schally, A. V. & Chakraborty, T., Jul 2013, In: Toxins. 5, 7, p. 1244-1260 17 p.

  Research output: Contribution to journal › Review article › peer-review

  • Streptococcus pneumoniae plY protein
  • Alveolar Epithelial Cells
  • Anti-Bacterial Agents
  • Sodium
  • Edema
  19 Scopus citations

• The subcellular compartmentalization of arginine metabolizing enzymes and their role in endothelial dysfunction

  Chen, F., Lucas, R. & Fulton, D., 2013, In: Frontiers in immunology. 4, JUL, Article 184.

  Research output: Contribution to journal › Short survey › peer-review

  • Arginine
  • Nitric Oxide Synthase Type III
  • Nitric Oxide
  • Enzymes
  • Arginase
  23 Scopus citations
• 2012

  A computational study of the oligosaccharide binding sites in the lectin-like domain of tumor necrosis factor and the TNF-derived TIP peptide

  Dulebo, A., Ettrich, R., Lucas, R. & Kaftan, D., 2012, In: Current Pharmaceutical Design. 18, 27, p. 4236-4243 8 p.

  Research output: Contribution to journal › Article › peer-review

  • AP301 peptide
  • Oligosaccharides
  • Lectins
  • Binding Sites
  • Tumor Necrosis Factor-alpha
  8 Scopus citations

• Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema

  Lucas, R., Sridhar, S., Rick, F. G., Gorshkov, B. A., Siddaramappa, U. N., Yang, G., Oseghale, A., Verin, A. D., Chakraborty, T., Matthay, M. A., Zemskov, E. A., White, R., Block, N. L. & Schally, A. V., Feb 7 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 6, p. 2084-2089 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Streptococcus pneumoniae plY protein
  • Growth Hormone-Releasing Hormone
  • Pulmonary Edema
  • Permeability
  • Edema
  37 Scopus citations

• Genetic polymorphism analysis of killer cell immunoglobulin-like receptor genes in the Chinese Uygur population

  Wang, H. D., Zhu, B. F., Shen, C. M., Yuan, G. L., Yang, G., Guo, J. N., Yan, J. W., Qin, H. X., Guo, J. X., Zhang, L. P., Jia, X. Q. & Lucas, R., Mar 2012, In: Molecular Biology Reports. 39, 3, p. 3017-3028 12 p.

  Research output: Contribution to journal › Article › peer-review

  • KIR Receptors
  • Genetic Polymorphisms
  • Genes
  • Population
  • Gene Frequency
  8 Scopus citations