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• 2020

  Arginase Pathway in Acute Retina and Brain Injury: Therapeutic Opportunities and Unexplored Avenues

  Fouda, A. Y., Eldahshan, W., Narayanan, S. P., Caldwell, R. W. & Caldwell, R. B., Mar 17 2020, In: Frontiers in Pharmacology. 11, 277.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Arginase
  • Brain Injuries
  • Retina
  • Nervous System Trauma
  • Traumatic Brain Injury
  5 Scopus citations

• Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche

  Liu, Z., Xu, J., Ma, Q., Zhang, X., Yang, Q., Wang, L., Cao, Y., Xu, Z., Tawfik, A., Sun, Y., Weintraub, N. L., Fulton, D. J., Hong, M., Dong, Z., Smith, L. E. H., Caldwell, R. B., Sodhi, A. & Huo, Y., Aug 5 2020, In: Science Translational Medicine. 12, 555, eAAY1371.

  Research output: Contribution to journal › Article › peer-review

  • Glycolysis
  • Myeloid Cells
  • Microglia
  • Endothelial Cells
  • Macrophages
  5 Scopus citations

• Utility of LysM-Cre and CdH5-Cre driver mice in retinal and brain research: An imaging study using tdtomato reporter mouse

  Fouda, A. Y., Xu, Z., Priya Narayanan, S., William Caldwell, R. & Caldwell, R. B., Mar 2020, In: Investigative Ophthalmology and Visual Science. 61, 3, 51.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microglia
  • Genetic Recombination
  • Retina
  • Brain
  • Macrophages
  2 Scopus citations
• 2019

  Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress

  Lv, H., Zhu, C., Wu, R., Ni, H., Lian, J., Xu, Y., Xia, Y., Shi, G., Li, Z., Caldwell, R. B., Caldwell, R. W., Yao, L. & Chen, Y., Jul 2019, In: Journal of Psychiatric Research. 114, p. 55-66 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative Stress
  • Inhibition (Psychology)
  • Anxiety
  • Anxiety Disorders
  • acetovanillone
  8 Scopus citations

• Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis

  Palani, C. D., Fouda, A. Y., Liu, F., Xu, Z., Mohamed, E., Giri, S., Smith, S. B., Caldwell, R. B. & Narayanan, S. P., Dec 1 2019, In: Molecular Neurobiology. 56, 12, p. 8589-8602 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Autoimmune Experimental Encephalomyelitis
  • Mouse Arg2 protein
  • Multiple Sclerosis
  • Retina
  1 Scopus citations

• Hyperglycemia-impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways

  Chandra, S., Fulton, D. J. R., Caldwell, R. B., Caldwell, R. W. & Toque, H. A., Feb 5 2019, In: European Journal of Pharmacology. 844, p. 26-37 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Vasodilation
  • Hyperglycemia
  • p38 Mitogen-Activated Protein Kinases
  • Phosphotransferases
  7 Scopus citations

• Mechanisms of obesity-induced metabolic and vascular dysfunctions

  Atawia, R. T., Bunch, K. L., Toque, H. A., Caldwell, R. B. & Caldwell, R. W., Mar 1 2019, In: Frontiers in Bioscience - Landmark. 24, 5, p. 890-934 45 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Nitric Oxide
  • Adipocytes
  • Obesity
  • Blood Vessels
  16 Scopus citations

• Role of arginase 2 in systemic metabolic activity and adipose tissue fatty acid metabolism in diet-induced obese mice

  Atawia, R. T., Toque, H. A., Meghil, M. M., Benson, T. W., Yiew, N. K. H., Cutler, C. W., Weintraub, N. L., Caldwell, R. B. & Caldwell, R. W., Mar 2 2019, In: International journal of molecular sciences. 20, 6, 1462.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • diets
  • adipose tissues
  • Sugar (sucrose)
  • fatty acids
  • Arginase
  3 Scopus citations

• Targeting polyamine oxidase to prevent excitotoxicity-induced retinal neurodegeneration

  Pichavaram, P., Palani, C. D., Patel, C., Xu, Z., Shosha, E., Fouda, A. Y., Caldwell, R. B. & Narayanan, S. P., 2019, In: Frontiers in Neuroscience. 13, JAN, 956.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • polyamine oxidase
  • N-Methylaspartate
  • MDL 72527
  • Retina
  • Aspartic Acid
  2 Scopus citations
• 2018

  Arginase: A multifaceted enzyme important in health and disease

  Caldwell, R. W., Rodriguez, P. C., Toque, H. A., Priya Narayanan, S. & Caldwell, R. B., Apr 2018, In: Physiological reviews. 98, 2, p. 641-665 25 p.

  Research output: Contribution to journal › Review article › peer-review

  • Arginase
  • Enzymes
  • Health
  • Ornithine
  • Urea
  66 Scopus citations

• Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

  Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In: Cell Death and Disease. 9, 10, 1001.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Ischemia
  • Macrophages
  • Reperfusion Injury
  • Knockout Mice
  9 Scopus citations

• Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy

  Rojas, M. A., Shen, Z. T., Caldwell, R. B. & Sigalov, A. B., Sep 2018, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 9, p. 2761-2768 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Triggering Receptor Expressed on Myeloid Cells-1
  • Oxygen
  • Retinal Neovascularization
  • Pathologic Neovascularization
  • Macrophage Colony-Stimulating Factor
  3 Scopus citations

• Mechanisms of diabetes-induced endothelial cell senescence: Role of arginase 1

  Shosha, E., Xu, Z., Priya Narayanan, S., Lemtalsi, T., Fouda, A. Y., Rojas, M., Xing, J., Fulton, D., William Caldwell, R. & Caldwell, R. B., Apr 17 2018, In: International journal of molecular sciences. 19, 4, 1215.

  Research output: Contribution to journal › Article › peer-review

  • Endothelial cells
  • Arginase
  • Medical problems
  • Cellular Senescence
  • Galactosidases
  11 Scopus citations

• Neurofibromin deficiency induces endothelial cell proliferation and retinal neovascularization

  Zhang, H., Hudson, F. Z., Xu, Z., Tritz, R., Rojas, M., Patel, C., Haigh, S. B., Bordán, Z., Ingram, D. A., Fulton, D. J., Weintraub, N. L., Caldwell, R. B. & Stansfield, B. K., May 2018, In: Investigative Ophthalmology and Visual Science. 59, 6, p. 2520-2528 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Neurofibromin 1
  • Retinal Neovascularization
  • Neurofibromatosis 1
  • Retina
  • Endothelial Cells
  9 Scopus citations
• 2017

  Correction: Diabetes-induced superoxide anion and breakdown of the blood-retinal barrier: Role of the VEGF/uPAR pathway (PLoS ONE (2013) 8:8 (e71868) DOI: 10.1371/journal.pone.0071868)

  El-Remessy, A. B., Franklin, T., Ghaley, N., Yang, J., Brands, M. W., Caldwell, R. B. & Behzadian, M. A., Oct 2017, In: PloS one. 12, 10, e0186749.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Blood-Retinal Barrier
  • Medical problems
  • diabetes
  • Superoxides
  • superoxide anion

• Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis

  Liu, Z., Yan, S., Wang, J., Xu, Y., Wang, Y., Zhang, S., Xu, X., Yang, Q., Zeng, X., Zhou, Y., Gu, X., Lu, S., Fu, Z., Fulton, D. J., Weintraub, N. L., Caldwell, R. B., Zhang, W., Wu, C., Liu, X. L., Chen, J. F. & 10 others, Ahmad, A., Kaddour-Djebbar, I., Al-Shabrawey, M., Li, Q., Jiang, X., Sun, Y., Sodhi, A., Smith, L., Hong, M. & Huo, Y., Dec 1 2017, In: Nature communications. 8, 1, 584.

  Research output: Contribution to journal › Article › peer-review

  • Glycolysis
  • glycolysis
  • adenosines
  • angiogenesis
  • Endothelial cells
  30 Scopus citations

• Netrin-1 is a novel regulator of vascular endothelial function in diabetes

  Toque, H. A., Fernandez-Flores, A., Mohamed, R., Caldwell, R. B., Ramesh, G. & Caldwell, R. W., Oct 2017, In: PloS one. 12, 10, e0186734.

  Research output: Contribution to journal › Article › peer-review

  • Netrin-1
  • Medical problems
  • diabetes
  • blood vessels
  • Blood Vessels
  13 Scopus citations

• Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

  Bhatta, A., Yao, L., Xu, Z., Toque, H. A., Chen, J., Atawia, R. T., Fouda, A. Y., Bagi, Z., Lucas, R., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In: Cardiovascular Research. 113, 13, p. 1664-1676 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Endothelial Cells
  • Obesity
  • Blood Vessels
  • Sucrose
  46 Scopus citations

• Obesity-induced vascular inflammation involves elevated arginase activity

  Yao, L., Bhatta, A., Xu, Z., Chen, J., Toque, H. A., Chen, Y., Xu, Y., Bagi, Z., Lucas, R., Huo, Y., Caldwell, R. B. & Caldwell, R. W., Nov 2017, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 313, 5, p. R560-R571

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Intra-Abdominal Fat
  • Obesity
  • Endothelial Cells
  • Inflammation
  15 Scopus citations
• 2016

  Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury

  Shosha, E., Xu, Z., Yokota, H., Saul, A., Rojas, M., William Caldwell, R., Caldwell, R. B. & Priya Narayanan, S., 2016, In: Cell Death and Disease. 7, 11, e2483.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Reperfusion Injury
  • Ischemia
  • Electroretinography
  • Reperfusion
  25 Scopus citations

• Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

  Bhatta, A., Sangani, R., Kolhe, R., Toque, H. A., Cain, M., Wong, A., Howie, N., Shinde, R., Elsalanty, M., Yao, L., Chutkan, N., Hunter, M., Caldwell, R. B., Isales, C., Caldwell, R. W. & Fulzele, S., 2016, In: Molecular and Cellular Endocrinology. 422, p. 211-220 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Nutrition
  • Deregulation
  • High Fat Diet
  • Sucrose
  12 Scopus citations

• Neuroprotective effect of water-dispersible hesperetin in retinal ischemia reperfusion injury

  Shimouchi, A., Yokota, H., Ono, S., Matsumoto, C., Tamai, T., Takumi, H., Narayanan, S. P., Kimura, S., Kobayashi, H., Caldwell, R. B., Nagaoka, T. & Yoshida, A., Jan 1 2016, In: Japanese Journal of Ophthalmology. 60, 1, p. 51-61 11 p.

  Research output: Contribution to journal › Article › peer-review

  • hesperetin
  • Neuroprotective Agents
  • Reperfusion Injury
  • Water
  • Ganglia
  28 Scopus citations

• Retraction: Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration [J. Cell Sci., 118, (2015) (243-252)] DOI:10.1242/jcs.01612

  El-Remessy, A. B., Bartoli, M., Platt, D. H., Fulton, D. & Caldwell, R. B., Jan 1 2016, In: Journal of Cell Science. 129, 16, 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Phosphatidylinositol 3-Kinases
  • Tyrosine
  • Scientific Misconduct
  • Vascular Endothelial Growth Factor A
  • Oxidative Stress
  3 Scopus citations

• Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy

  Patel, C., Xu, Z., Shosha, E., Xing, J., Lucas, R., Caldwell, R. W., Caldwell, R. B. & Narayanan, S. P., Sep 1 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 9, p. 1628-1639 12 p.

  Research output: Contribution to journal › Article › peer-review

  • polyamine oxidase
  • Hyperoxia
  • Vascular System Injuries
  • Retinal Vessels
  • MDL 72527
  6 Scopus citations
• 2015

  Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function

  Bhatta, A., Yao, L., Toque, H. A., Shatanawi, A., Xu, Z., Caldwell, R. B. & Caldwell, R. W., Mar 25 2015, In: PloS one. 10, 3, e0121727.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • arginase
  • fibrosis
  • Cell proliferation
  • angiotensin II
  19 Scopus citations

• Angiotensin II limits NO production by upregulating arginase through a p38 MAPK-ATF-2 pathway

  Shatanawi, A., Lemtalsi, T., Yao, L., Patel, C., Caldwell, R. B. & Caldwell, R. W., Jan 5 2015, In: European Journal of Pharmacology. 746, p. 106-114 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Mitogen-Activated Protein Kinase 1
  • p38 Mitogen-Activated Protein Kinases
  • Angiotensin II
  • Nitric Oxide
  31 Scopus citations

• Arginase: An old enzyme with new tricks

  Caldwell, R. B., Toque, H. A., Narayanan, S. P. & Caldwell, R. W., 2015, In: Trends in Pharmacological Sciences. 36, 6, p. 395-405 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Arginase
  • Enzymes
  • Cardiovascular system
  • Ornithine
  • Neurology
  138 Scopus citations

• Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia

  Wang, L., Bhatta, A., Flores Toque, H. A., Rojas, M. A., Yao, L., Xu, Z., Patel, C., Caldwell, R. B. & Caldwell, R. W., Mar 1 2015, In: Microvascular Research. 98, p. 1-8 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelial cells
  • Arginase
  • Hypoxia
  • Endothelial Cells
  • Vascular Endothelial Growth Factor A
  13 Scopus citations

• Correction: Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function

  Bhatta, A., Yao, L., Toque, H. A., Shatanawi, A., Xu, Z., Caldwell, R. B. & Caldwell, R. W., Apr 21 2015, In: PloS one. 10, 4, e0127110.

  Research output: Contribution to journal › Comment/debate › peer-review
  2 Scopus citations

• Elevated serum levels of soluble TNF receptors and adhesion molecules are associated with diabetic retinopathy in patients with type-1 diabetes

  Sharma, S., Purohit, S. B., Sharma, A. K., Hopkins, D., Steed, L., Bode, B., Anderson, S. W., Caldwell, R. B. & She, J-X., 2015, In: Mediators of Inflammation. 2015, 279393.

  Research output: Contribution to journal › Article › peer-review

  • Tumor Necrosis Factor Receptors
  • Diabetic Retinopathy
  • Type 1 Diabetes Mellitus
  • Cytokine Receptor gp130
  • Serum
  24 Scopus citations

• Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma

  Ha, Y., Liu, H., Xu, Z., Yokota, H., Narayanan, S. P., Lemtalsi, T., Smith, S. B., Caldwell, R. W., Caldwell, R. B. & Zhang, W., Oct 1 2015, In: Cell Death and Disease. 6, 10, e1900.

  Research output: Contribution to journal › Article › peer-review

  • Endoplasmic Reticulum Stress
  • Glaucoma
  • Intraocular Pressure
  • Inflammation
  • Wounds and Injuries
  30 Scopus citations

• Erratum: Extracellular signal-regulated kinase (ERK) inhibition decreases arginase activity and improves corpora cavernosal relaxation in streptozotocin (STZ)-induced diabetic mice (The Journal of Sexual Medicine (2011) 8(12) (3335–3344)(S1743609515333580)(10.1111/j.1743-6109.2011.02499.x))

  Nunes, K. P., Toque, H. A., Caldwell, R. B., Caldwell, R. W. & Webb, R. C., Jul 2015, In: Journal of Sexual Medicine. 12, 7, 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Arginase
  • Organized Financing
  • Extracellular Signal-Regulated MAP Kinases
  • Streptozocin
  • Medicine
• 2014

  Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy

  Patel, C., Narayanan, S. P., Zhang, W., Xu, Z., Sukumari-Ramesh, S., Dhandapani, K. M., Caldwell, R. W. & Caldwell, R. B., Nov 1 2014, In: American Journal of Pathology. 184, 11, p. 3040-3051 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Pathologic Neovascularization
  • Endothelins
  • Oxygen
  • Physiologic Neovascularization
  • cyclo(Trp-Asp-Pro-Val-Leu)
  15 Scopus citations

• Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin

  Jittiporn, K., Suwanpradid, J., Patel, C., Rojas, M., Thirawarapan, S., Moongkarndi, P., Suvitayavat, W. & Caldwell, R. B., May 2014, In: Microvascular Research. 93, p. 72-79 8 p.

  Research output: Contribution to journal › Article › peer-review

  • mangostin
  • Garcinia mangostana
  • Xanthones
  • Endothelial cells
  • Vascular Endothelial Growth Factor A
  23 Scopus citations

• Arginase 2 deficiency prevents oxidative stress and limits hyperoxia-induced retinal vascular degeneration

  Suwanpradid, J., Rojas, M., Behzadian, M. A., Caldwell, R. W. & Caldwell, R. B., Nov 6 2014, In: PloS one. 9, 11, 110604.

  Research output: Contribution to journal › Article › peer-review

  • Hyperargininemia
  • Oxidative stress
  • hyperoxia
  • Arginase
  • arginase
  22 Scopus citations

• Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism

  Narayanan, S. P., Xu, Z., Putluri, N., Sreekumar, A., Lemtalsi, T., Caldwell, R. W. & Caldwell, R. B., Feb 2014, In: Cell Death and Disease. 5, 2, e1075.

  Research output: Contribution to journal › Article › peer-review

  • Hyperargininemia
  • Hyperoxia
  • Polyamines
  • Oxygen
  • Arginase
  28 Scopus citations

• Endothelial PFKFB3 plays a critical role in angiogenesis

  Xu, Y., An, X., Guo, X., Habtetsion, T. G., Wang, Y., Xu, X., Kandala, S., Li, Q., Li, H., Zhang, C., Caldwell, R. B., Fulton, D. J., Su, Y., Hoda, MD. N., Zhou, G., Wu, C. & Huo, Y., Jun 2014, In: Arteriosclerosis, thrombosis, and vascular biology. 34, 6, p. 1231-1239 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphofructokinase-2
  • Protein Isoforms
  • Glycolysis
  • Endothelial Cells
  • Lactic Acid
  109 Scopus citations

• High glucose upregulates arginase 1 and decreases nitric oxide production through ATF-2 and c-Jun transcription factors

  Shatanawi, A., Gharaibeh, M. N., Caldwell, R. B. & Caldwell, R. W., Jan 1 2014, In: Life Science Journal. 11, 5, p. 374-379 6 p., 50.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Nitric Oxide
  • Transcription Factors
  • Up-Regulation
  • Endothelial cells
  5 Scopus citations
• 2013

  Activated rho kinase mediates diabetes-induced elevation of vascular arginase activation and contributes to impaired corpora cavernosa relaxation: Possible involvement of p38 MAPK activation

  Toque, H. A., Nunes, K. P., Yao, L., Liao, J. K., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Jun 2013, In: Journal of Sexual Medicine. 10, 6, p. 1502-1515 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • rho-Associated Kinases
  • p38 Mitogen-Activated Protein Kinases
  • Blood Vessels
  • Nitrergic Neurons
  36 Scopus citations

• Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function

  Toque, H. A., Nunes, K. P., Yao, L., Xu, Z., Kondrikov, D., Su, Y., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., 2013, In: PloS one. 8, 8, p. e72277

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • arginase
  • Medical problems
  • blood vessels
  • aorta
  20 Scopus citations

• Arginase 1 mediates increased blood pressure and contributes to vascular endothelial dysfunction in deoxycorticosterone acetate-salt hypertension

  Toque, H. A., Nunes, K. P., Rojas, M., Bhatta, A., Yao, L., Xu, Z., Romero, M. J., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., 2013, In: Frontiers in immunology. 4, JUL, Article 219.

  Research output: Contribution to journal › Article › peer-review

  • Desoxycorticosterone
  • Arginase
  • Acetates
  • Salts
  • Hypertension
  30 Scopus citations

• Arginase as a mediator of diabetic retinopathy

  Patel, C., Rojas, M., Narayanan, S. P., Zhang, W., Xu, Z., Lemtalsi, T., Jittiporn, K., Caldwell, R. W. & Caldwell, R. B., 2013, In: Frontiers in immunology. 4, JUL, Article 173.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Diabetic Retinopathy
  • Retinal Vessels
  • Retina
  • 3-nitrotyrosine
  30 Scopus citations

• Arginase in retinopathy

  Narayanan, S. P., Rojas, M., Suwanpradid, J., Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Sep 2013, In: Progress in Retinal and Eye Research. 36, p. 260-280 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Polyamines
  • Superoxides
  • Glutamic Acid
  • Peroxynitrous Acid
  43 Scopus citations

• Diabetes-Induced Superoxide Anion and Breakdown of the Blood-Retinal Barrier: Role of the VEGF/uPAR Pathway

  El-Remessy, A. B., Franklin, T., Ghaley, N., Yang, J., Brands, M. W., Caldwell, R. B. & Behzadian, M. A., Aug 7 2013, In: PloS one. 8, 8, e71868.

  Research output: Contribution to journal › Article › peer-review

  • Blood-Retinal Barrier
  • Retinaldehyde
  • Urokinase Plasminogen Activator Receptors
  • vascular endothelial growth factors
  • u-plasminogen activator
  20 Scopus citations

• Hyperoxia causes regression of vitreous neovascularization by downregulating VEGF/VEGFR2 pathway

  Liu, H., Zhang, W., Xu, Z., Caldwell, R. W., Caldwell, R. B. & Brooks, S. E., Feb 2013, In: Investigative Ophthalmology and Visual Science. 54, 2, p. 918-931 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Hyperoxia
  • aflibercept
  • Vascular Endothelial Growth Factor A
  • Down-Regulation
  • Apoptosis
  20 Scopus citations

• Insights into the arginine paradox: Evidence against the importance of subcellular location of arginase and eNOS

  Elms, S., Chen, F., Wang, Y., Qian, J., Askari, B., Yu, Y., Pandey, D., Iddings, J., Caldwell, R. B. & Fulton, D. J. R., Sep 1 2013, In: American Journal of Physiology - Heart and Circulatory Physiology. 305, 5, p. H651-H666

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Nitric Oxide Synthase Type III
  • Arginine
  • Nitric Oxide
  • Ornithine
  39 Scopus citations

• L-citrulline protects from kidney damage in type 1 diabetic mice

  Romero Lucas, M. J., Yao, L., Sridhar, S., Bhatta, A., Dou, H., Ramesh, G., Brands, M. W., Pollock, D. M., Caldwell, R. B., Cederbaum, S. D., Alvin Head, C., Bagi, Z., Lucas, R. & Caldwell, R. W., 2013, In: Frontiers in immunology. 4, DEC, Article 480.

  Research output: Contribution to journal › Article › peer-review

  • Citrulline
  • Arginase
  • Kidney
  • Streptozocin
  • Knockout Mice
  19 Scopus citations

• Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout

  Yao, L., Chandra, S., Toque, H. A., Bhatta, A., Rojas, M., Caldwell, R. B. & Caldwell, R. W., Mar 1 2013, In: Cardiovascular Research. 97, 3, p. 509-519 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • rho-Associated Kinases
  • Blood Vessels
  • Aorta
  • Protein Isoforms
  65 Scopus citations

• Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury

  Rojas, M., Zhang, W., Xu, Z., Lemtalsi, T., Chandler, P., Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Dec 17 2013, In: PloS one. 8, 12, e84357.

  Research output: Contribution to journal › Article › peer-review

  • Retinal Vessels
  • Vascular System Injuries
  • Medical problems
  • bone marrow
  • diabetes
  33 Scopus citations

• The role of arginase i in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes

  Elms, S. C., Toque, H. A., Rojas, M., Xu, Z., Caldwell, R. W. & Caldwell, R. B., Mar 2013, In: Diabetologia. 56, 3, p. 654-662 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Retinal Vessels
  • Myography
  • Vasodilation
  • Experimental Diabetes Mellitus
  40 Scopus citations