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• Article

  Acute progression of BCR-FGFR1 induced murine B-lympho/myeloproliferative disorder suggests involvement of lineages at the pro-B cell stage

  Ren, M. Q., Tidwell, J. A., Sharma, S. & Cowell, J. K., Jun 6 2012, In: PloS one. 7, 6, e38265.

  Research output: Contribution to journal › Article › peer-review

  • Myeloproliferative Disorders
  • B-Lymphoid Precursor Cells
  • B-lymphocytes
  • Cells
  • human diseases
  19 Scopus citations

• Celecoxib ameliorates seizure susceptibility in autosomal dominant lateral temporal epilepsy

  Zhou, L., Zhou, L., Su, L. D., Cao, S. L., Xie, Y. J., Wang, N., Shao, C. Y., Wang, Y. N., Zhou, J. H., Cowell, J. K. & Shen, Y., Mar 28 2018, In: Journal of Neuroscience. 38, 13, p. 3346-3357 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Celecoxib
  • Temporal Lobe Epilepsy
  • Leucine
  • Glioma
  • Seizures
  7 Scopus citations

• COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis

  Shao, J., Teng, Y., Padia, R., Hong, S., Noh, H., Xie, X., Mumm, J. S., Dong, Z., Ding, H. F., Cowell, J., Kim, J., Han, J. & Huang, S., Sep 2013, In: Neoplasia (United States). 15, 9, p. 1075-1085 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycogen Synthase Kinase 3
  • Carcinogenesis
  • Breast Neoplasms
  • Proto-Oncogene Proteins c-jun
  • Proteins
  34 Scopus citations

• Critical individual roles of the BCR and FGFR1 kinase domains in BCR-FGFR1-driven stem cell leukemia/lymphoma syndrome

  Chong, Y., Liu, Y., Lu, S., Cai, B., Qin, H., Chang, C. S., Ren, M., Cowell, J. K. & Hu, T., Apr 15 2020, In: International Journal of Cancer. 146, 8, p. 2243-2254 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Lymphoma
  • Leukemia
  • Phosphotransferases
  • Stem Cells
  • SHP099

• Critical role of the WASF3 gene in JAK2/STAT3 regulation of cancer cell motility

  Teng, Y., Ghoshal, P., Ngoka, L., Mei, Y. & Cowell, J. K., Sep 2013, In: Carcinogenesis. 34, 9, p. 1994-1999 6 p.

  Research output: Contribution to journal › Article › peer-review

  • STAT3 Transcription Factor
  • Cell Movement
  • Genes
  • Neoplasms
  • NSC 74859
  29 Scopus citations

• Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice

  Ren, M., Qin, H., Wu, Q., Savage, N. M., George, T. I. & Cowell, J. K., Aug 15 2016, In: International Journal of Cancer. 139, 4, p. 836-840 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Fibroblast Growth Factor, Type 1
  • Acute Myeloid Leukemia
  • Phosphotransferases
  • Chromosomes
  • Myeloproliferative Disorders
  9 Scopus citations

• Downregulation of PUMA underlies resistance to FGFR1 inhibitors in the stem cell leukemia/lymphoma syndrome

  Liu, Y., Cai, B., Chong, Y., Zhang, H., Kemp, C. A., Lu, S., Chang, C. S., Ren, M., Cowell, J. K. & Hu, T., Oct 1 2020, In: Cell Death and Disease. 11, 10, 884.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lymphoma
  • Leukemia
  • Stem Cells
  • Down-Regulation
  • Apoptosis

• Dysregulated signaling pathways in the development of CNTRL-FGFR1–induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models

  Ren, M., Qin, H., Kitamura, E. & Cowell, J. K., Aug 8 2013, In: Blood. 122, 6, p. 1007-1016 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Hematopoietic Stem Cells
  • Neoplasms
  • Bone Marrow Neoplasms
  • Chemotherapy
  • Stem cells
  17 Scopus citations

• Essential roles of leucine-rich glioma inactivated 1 in the development of embryonic and postnatal cerebellum

  Xie, Y. J., Zhou, L., Jiang, N., Zhang, N., Zou, N., Zhou, L., Wang, Y., Cowell, J. K. & Shen, Y., Jan 16 2015, In: Scientific reports. 5, 7827.

  Research output: Contribution to journal › Article › peer-review

  • Leucine
  • Glioma
  • Embryonic Development
  • Cerebellum
  • Ependymoglial Cells
  13 Scopus citations

• Evaluating human cancer cell metastasis in zebrafish

  Teng, Y., Xie, X., Walker, S., White, D. T., Mumm, J. S. & Cowell, J. K., Oct 4 2013, In: BMC Cancer. 13, 453.

  Research output: Contribution to journal › Article › peer-review

  • Zebrafish
  • Neoplasm Metastasis
  • Neoplasms
  • Fishes
  • Fiji
  101 Scopus citations

• HIF1A induces expression of the WASF3 metastasis-associated gene under hypoxic conditions

  Ghoshal, P., Teng, Y., Lesoon, L. A. & Cowell, J. K., Sep 15 2012, In: International Journal of Cancer. 131, 6, p. E905-E915

  Research output: Contribution to journal › Article › peer-review

  • Neoplasm Metastasis
  • Hypoxia
  • Response Elements
  • Genetic Promoter Regions
  • Genes
  22 Scopus citations

• Homozygous deletion of the LGI1 gene in mice leads to developmental abnormalities resulting in cortical dysplasia

  Silva, J., Sharma, S. & Cowell, J. K., Sep 1 2015, In: Brain Pathology. 25, 5, p. 587-597 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Malformations of Cortical Development
  • Gene Deletion
  • Synapses
  • Neurons
  • Spine
  11 Scopus citations

• Inactivation of Lgi1 in murine neuronal precursor cells leads to dysregulation of axon guidance pathways

  Silva, J., Hawthorn, L. & Cowell, J. K., Mar 2020, In: Genomics. 112, 2, p. 1167-1172 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Axon Guidance
  • Cell Movement
  • Malformations of Cortical Development
  • Epileptic Syndromes
  • Null Lymphocytes

• Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5 + CK8 + epithelial cells

  Wang, Z., Kim, J., Teng, Y., Ding, H., Zhang, J., Hai, T., Cowell, J. K. & Yan, C., Jul 7 2016, In: Oncogene. 35, 27, p. 3555-3564 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Activating Transcription Factor 3
  • Prostate
  • Carcinogenesis
  • Epithelial Cells
  • Hormones
  11 Scopus citations

• MiR-339 promotes development of stem cell leukemia/lymphoma syndrome via downregulation of the BCL2L11 and BAX proapoptotic genes

  Hu, T., Chong, Y., Lu, S., Wang, R., Qin, H., Silva, J., Kitamura, E., Chang, C. S., Hawthorn, L. A. & Cowell, J. K., Jul 1 2018, In: Cancer Research. 78, 13, p. 3522-3531 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Lymphoma
  • Leukemia
  • Stem Cells
  • Down-Regulation
  • B-Lymphoid Precursor Cells
  13 Scopus citations

• Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein

  Teng, Y., Ren, X., Li, H., Shull, A., Kim, J. & Cowell, J. K., Jan 21 2016, In: Oncogene. 35, 3, p. 333-343 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Wiskott-Aldrich Syndrome Protein Family
  • Mitochondrial Membranes
  • Mitochondria
  • Neoplasm Metastasis
  • AAA Domain
  43 Scopus citations

• Novel FGFR inhibitor ponatinib suppresses the growth of non-small cell lung cancer cells overexpressing FGFR1

  Ren, M., Hong, M., Liu, G., Wang, H., Patel, V. S., Biddinger, P. W., Silva, M. J., Cowell, J. K. & Hao, Z., Jun 2013, In: Oncology Reports. 29, 6, p. 2181-2190 10 p.

  Research output: Contribution to journal › Article › peer-review

  • ponatinib
  • Receptor, Fibroblast Growth Factor, Type 1
  • Non-Small Cell Lung Carcinoma
  • Growth
  • Lung Neoplasms
  46 Scopus citations

• Ponatinib suppresses the development of myeloid and lymphoid malignancies associated with FGFR1 abnormalities

  Ren, M., Qin, H., Ren, R. & Cowell, J. K., Jan 2013, In: Leukemia. 27, 1, p. 32-40 9 p.

  Research output: Contribution to journal › Article › peer-review

  • ponatinib
  • Receptor, Fibroblast Growth Factor, Type 1
  • Stem Cells
  • Lymphoma
  • Leukemia
  53 Scopus citations

• Targeting FGFR1 to suppress leukemogenesis in syndromic and de novo AML in murine models

  Wu, Q., Bhole, A., Qin, H., Karp, J., Malek, S., Cowell, J. K. & Ren, M., 2016, In: Oncotarget. 7, 31, p. 49733-49742 10 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea
  • AZD4547
  • 4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one
  • PD 173074
  • Heterografts
  10 Scopus citations

• Targeting the WASF3-CYFIP1 complex using stapled peptides suppresses cancer cell invasion

  Teng, Y., Bahassan, A., Dong, D., Hanold, L. E., Ren, X., Kennedy, E. J. & Cowell, J. K., Feb 15 2016, In: Cancer Research. 76, 4, p. 965-973 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Peptides
  • Wiskott-Aldrich Syndrome Protein Family
  • Neoplasms
  • Neoplasm Metastasis
  • Actin Cytoskeleton
  33 Scopus citations

• The MIR-17/92 cluster is involved in the molecular etiology of the SCLL syndrome driven by the BCR-FGFR1 chimeric kinase

  Hu, T., Chong, Y., Qin, H., Kitamura, E., Chang, C. S., Silva, J., Ren, M. & Cowell, J. K., Apr 1 2018, In: Oncogene. 37, 14, p. 1926-1938 13 p.

  Research output: Contribution to journal › Article › peer-review

  • MicroRNAs
  • Phosphotransferases
  • B-Cell Leukemia
  • Cell Proliferation
  • Porifera
  9 Scopus citations

• The WASF3-NCKAP1-CYFIP1 complex is essential for breast cancer metastasis

  Teng, Y., Qin, H., Bahassan, A., Bendzunas, N. G., Kennedy, E. J. & Cowell, J. K., Sep 1 2016, In: Cancer Research. 76, 17, p. 5133-5142 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Breast Neoplasms
  • Neoplasm Metastasis
  • Proteins
  • Gene Silencing
  • Colonic Neoplasms
  29 Scopus citations

• Transformation of human CD34+ hematopoietic progenitor cells with DEK-NUP214 induces AML in an immunocompromised mouse model

  Qin, H., Malek, S., Cowell, J. K. & Ren, M., Oct 27 2016, In: Oncogene. 35, 43, p. 5686-5691 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Hematopoietic Stem Cells
  • Acute Myeloid Leukemia
  • Gene Expression
  • Human Development
  • Myeloid Cells
  16 Scopus citations

• Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility

  Zhou, H. M., Fang, Y. Y., Weinberger, P. M., Ding, L. L., Cowell, J. K., Hudson, F. Z., Ren, M., Lee, J. R., Chen, Q. K., Su, H., Dynan, W. S. & Lin, Y., Feb 4 2016, In: BMC Cancer. 16, 1, 55.

  Research output: Contribution to journal › Article › peer-review

  • transgelin
  • Cell Movement
  • Colorectal Neoplasms
  • Gene Expression
  • Neoplasm Metastasis
  24 Scopus citations

• Variant profiles of genes mapping to chromosome 16q loss in wilms tumors reveals link to cilia-related genes and pathways

  Kitamura, E., Cowell, J. K., Chang, C. S. & Hawthorn, L., 2020, In: Genes and Cancer. 11, 3-4, p. 137-153 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chromosome Mapping
  • Wilms Tumor
  • Cilia
  • Chromosomes
  • Loss of Heterozygosity

• WASF3 provides the conduit to facilitate invasion and metastasis in breast cancer cells through HER2/HER3 signaling

  Teng, Y., Pi, W., Wang, Y. & Cowell, J. K., Sep 1 2016, In: Oncogene. 35, 35, p. 4633-4640 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Breast Neoplasms
  • Neoplasm Metastasis
  • Genes
  • Transcriptional Activation
  • Up-Regulation
  14 Scopus citations
• Comment/debate

  Corrigendum to "WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, And MMP-9 expression" [Exp. Cell Res. 308 (2005) 135-145]

  Sossey-Alaoui, K., Ranalli, T. A., Li, X., Bakin, A. V. & Cowell, J. K., Mar 10 2013, In: Experimental Cell Research. 319, 5, 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review
• Letter

  A model of BCR-FGFR1 driven human AML in immunocompromised mice

  Cowell, J. K., Qin, H., Chang, C. S., Kitamura, E. & Ren, M., Nov 1 2016, In: British Journal of Haematology. 175, 3, p. 542-545 4 p.

  Research output: Contribution to journal › Letter › peer-review
  10 Scopus citations

• FGFR1OP2-FGFR1 induced myeloid leukemia and T-cell lymphoma in a mouse model

  Qin, H., Wu, Q., Cowell, J. K. & Ren, M., 2016, In: Haematologica. 101, 3, p. e91-e94

  Research output: Contribution to journal › Letter › peer-review
  9 Scopus citations

• Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome

  Hu, T., Chong, Y., Lu, S., McGuinness, M., Williams, D. A. & Cowell, J. K., Jan 31 2020, In: Haematologica. 105, 2, p. E68-E71

  Research output: Contribution to journal › Letter › peer-review

  Open Access
• Review article

  The promise of zebrafish as a chemical screening tool in cancer therapy

  Xie, X., Ross, J. L., Cowell, J. K. & Teng, Y., Aug 1 2015, In: Future Medicinal Chemistry. 7, 11, p. 1395-1405 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Zebrafish
  • Neoplasms
  • Therapeutics
  • Heterologous Transplantation
  • Preclinical Drug Evaluations
  11 Scopus citations

• Ubiquitin-conjugating enzyme UBE2C: Molecular biology, role in tumorigenesis, and potential as a biomarker

  Hao, Z., Zhang, H. & Cowell, J., Jun 1 2012, In: Tumor Biology. 33, 3, p. 723-730 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Ubiquitin-Conjugating Enzymes
  • Molecular Biology
  • Carcinogenesis
  • Biomarkers
  • M Phase Cell Cycle Checkpoints
  66 Scopus citations