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• 2020

  Astrocyte-derived estrogen regulates reactive astrogliosis and is neuroprotective following ischemic brain injury

  Wang, J., Sareddy, G. R., Lu, Y., Pratap, U. P., Tang, F., Greene, K. M., Meyre, P. L., Tekmal, R. R., Vadlamudi, R. K. & Brann, D. W., Dec 9 2020, In: Journal of Neuroscience. 40, 50, p. 9751-9771 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain Injuries
  • Glial Fibrillary Acidic Protein
  • Astrocytes
  • Estrogens
  • Aromatase

• G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: Implications for neuronal self-defense

  Bai, N., Zhang, Q., Zhang, W., Liu, B., Yang, F., Brann, D. & Wang, R., Feb 1 2020, In: Journal of Neuroinflammation. 17, 1, 45.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-1 Receptors
  • G-Protein-Coupled Receptors
  • Brain Ischemia
  • Estrogen Receptors
  • Hippocampus
  3 Scopus citations

• Neuron-derived estrogen is critical for astrocyte activation and neuroprotection of the ischemic brain

  Lu, Y., Sareddy, G. R., Wang, J., Zhang, Q., Tang, F. L., Pratap, U. P., Tekmal, R. R., Vadlamudi, R. K. & Brann, D. W., Sep 16 2020, In: Journal of Neuroscience. 40, 38, p. 7355-7374 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroprotection
  • Mouse Cyp19a1 protein
  • Astrocytes
  • Estrogens
  • Prosencephalon
  1 Scopus citations
• 2019

  Beneficial Effects of Theta-Burst Transcranial Magnetic Stimulation on Stroke Injury via Improving Neuronal Microenvironment and Mitochondrial Integrity

  Zong, X., Dong, Y., Li, Y., Yang, L., Li, Y., Yang, B., Tucker, L., Zhao, N., Brann, D. W., Yan, X., Hu, S. & Zhang, Q., Jan 1 2019, (Accepted/In press) In: Translational Stroke Research.

  Research output: Contribution to journal › Article › peer-review

  • Transcranial Magnetic Stimulation
  • Stroke
  • Wounds and Injuries
  • Cytokines
  • Phenotype
  3 Scopus citations

• Expression of aromatase and synthesis of sex steroid hormones in skeletal muscle following exercise training in ovariectomized rats

  Shi, R., Tian, X., Feng, Y., Cheng, Z., Lu, J., Brann, D. W. & Zhang, Q., Mar 2019, In: Steroids. 143, p. 91-96 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Aromatase
  • Rats
  • Gonadal Steroid Hormones
  • Muscle
  • Skeletal Muscle
  3 Scopus citations

• Neuron-derived estrogen regulates synaptic plasticity and memory

  Lu, Y., Sareddy, G. R., Wang, J., Wang, R., Li, Y., Dong, Y., Zhang, Q., Liu, J., O’Connor, J. C., Xu, J., Vadlamudi, R. K. & Brann, D. W., Apr 10 2019, In: Journal of Neuroscience. 39, 15, p. 2792-2809 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Aromatase
  • Prosencephalon
  • Neuronal Plasticity
  • Estrogens
  • Memory
  32 Scopus citations

• Photobiomodulation for Global Cerebral Ischemia: Targeting Mitochondrial Dynamics and Functions

  Wang, R., Dong, Y., Lu, Y., Zhang, W., Brann, D. W. & Zhang, Q., Mar 1 2019, In: Molecular Neurobiology. 56, 3, p. 1852-1869 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondrial Dynamics
  • Brain Ischemia
  • Low-Level Light Therapy
  • phytobacteriomycin
  • Apoptosomes
  16 Scopus citations
• 2017

  Activation of myeloid TLR4 Mediates T lymphocyte polarization after traumatic brain injury

  Braun, M., Vaibhav, K., Saad, N., Fatima, S., Brann, D. W., Vender, J. R., Wang, L. P., Hoda, M. N., Baban, B. & Dhandapani, K. M., May 1 2017, In: Journal of Immunology. 198, 9, p. 3615-3626 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Traumatic Brain Injury
  • T-Lymphocytes
  • Macrophages
  • Monocytes
  • Adaptive Immunity
  22 Scopus citations

• Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis

  Liu, Y., Xu, H., Geng, Y., Xu, D., Zhang, L., Yang, Y., Wei, Z., Zhang, B., Li, S., Gao, X., Wang, R., Zhang, X., Brann, D. W. & Yang, F., Feb 21 2017, In: Respiratory Research. 18, 1, 38.

  Research output: Contribution to journal › Article › peer-review

  • CREB-Binding Protein
  • Silicosis
  • Pulmonary Fibrosis
  • Myofibroblasts
  • Cyclic AMP-Dependent Protein Kinases
  23 Scopus citations

• NADPH Oxidase 2 Regulates NLRP3 Inflammasome Activation in the Brain after Traumatic Brain Injury

  Ma, M. W., Wang, J., Dhandapani, K. M. & Brann, D. W., 2017, In: Oxidative medicine and cellular longevity. 2017, 6057609.

  Research output: Contribution to journal › Article › peer-review

  • NADPH Oxidase 2
  • Inflammasomes
  • Oxidative stress
  • Traumatic Brain Injury
  • Chemical activation
  41 Scopus citations

• NADPH oxidase in brain injury and neurodegenerative disorders

  Ma, M. W., Wang, J., Zhang, Q., Wang, R., Dhandapani, K. M., Vadlamudi, R. K. & Brann, D. W., Jan 17 2017, In: Molecular Neurodegeneration. 12, 1, 7.

  Research output: Contribution to journal › Review article › peer-review

  • NADPH Oxidases
  • Brain Injuries
  • Brain Diseases
  • Neurodegenerative Diseases
  • Free Radicals
  136 Scopus citations

• Protective Effect of 17β-Estradiol Upon Hippocampal Spine Density and Cognitive Function in an Animal Model of Vascular Dementia

  Zhu, Y., Zhang, Q., Zhang, W., Li, N., Dai, Y., Tu, J., Yang, F., Brann, D. W. & Wang, R., Feb 16 2017, In: Scientific reports. 7, 42660.

  Research output: Contribution to journal › Article › peer-review

  • Vascular Dementia
  • Common Carotid Artery
  • Estradiol
  • Cognition
  • Spine
  24 Scopus citations

• Regulatory role of NADPH oxidase 2 in the polarization dynamics and neurotoxicity of microglia/macrophages after traumatic brain injury

  Wang, J., Ma, M. W., Dhandapani, K. M. & Brann, D. W., Dec 2017, In: Free Radical Biology and Medicine. 113, p. 119-131 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Microglia
  • Macrophages
  • NADPH Oxidase 2
  • Traumatic Brain Injury
  • Polarization
  25 Scopus citations

• Treadmill Exercise Exerts Neuroprotection and Regulates Microglial Polarization and Oxidative Stress in a Streptozotocin-Induced Rat Model of Sporadic Alzheimer's Disease

  Lu, Y., Dong, Y., Tucker, D., Wang, R., Ahmed, M. E., Brann, D. W. & Zhang, Q., 2017, In: Journal of Alzheimer's Disease. 56, 4, p. 1469-1484 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuroprotection
  • Streptozocin
  • Alzheimer Disease
  • Oxidative Stress
  • Hippocampus
  51 Scopus citations
• 2016

  Acetylated α-Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Proline(Ac-SDKP) Exerts the Anti-fibrotic Effect in Rat Lung Fibrosis Induced by Silica

  Xiaojun, W., Yan, L., Hong, X., Xianghong, Z., Shifeng, L., Dingjie, X., Xuemin, G., Lijuan, Z., Bonan, Z., Zhongqiu, W., Ruimin, W., Brann, D. & Fang, Y., Aug 31 2016, In: Scientific reports. 6, 32257.

  Research output: Contribution to journal › Article › peer-review

  • goralatide
  • Silicon Dioxide
  • Tubulin
  • Silicosis
  • Fibrosis
  10 Scopus citations

• Neuroprotection Mediated through GluN2C-Containing N-methyl-D-aspartate (NMDA) Receptors Following Ischemia

  Chung, C., Marson, J. D., Zhang, Q., Kim, J., Wu, W. H., Brann, D. W. & Chen, B. S., Nov 15 2016, In: Scientific reports. 6, 37033.

  Research output: Contribution to journal › Article › peer-review

  • Neuroprotection
  • N-Methyl-D-Aspartate Receptors
  • Ischemia
  • Neurons
  • Spatial Memory
  11 Scopus citations

• NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17 β -Estradiol

  Thakkar, R., Wang, R., Sareddy, G., Wang, J., Thiruvaiyaru, D., Vadlamudi, R., Zhang, Q. & Brann, D., 2016, In: Oxidative medicine and cellular longevity. 2016, 8309031.

  Research output: Contribution to journal › Article › peer-review

  • human PELP1 protein
  • Inflammasomes
  • Brain Ischemia
  • Chemical activation
  • Estradiol
  36 Scopus citations

• Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-β1/ROCK1 pathway in silicosis in rat

  Deng, H., Xu, H., Zhang, X., Sun, Y., Wang, R., Brann, D. W. & Yang, F., Mar 1 2016, In: Toxicology and Applied Pharmacology. 294, p. 1-10 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Alveolar Epithelial Cells
  • goralatide
  • Silicosis
  • Rats
  • Epithelial-Mesenchymal Transition
  17 Scopus citations
• 2015

  Cell-permeable peptide targeting the Nrf2-keap1 interaction: A potential novel therapy for global cerebral ischemia

  Tu, J., Zhang, X., Zhu, Y., Dai, Y., Li, N., Yang, F., Zhang, Q., Brann, D. W. & Wang, R., Nov 4 2015, In: Journal of Neuroscience. 35, 44, p. 14727-14739 13 p.

  Research output: Contribution to journal › Article › peer-review

  • NF-E2-Related Factor 2
  • Trans-Activators
  • Brain Ischemia
  • Peptides
  • Kelch-Like ECH-Associated Protein 1
  43 Scopus citations

• Proline-, glutamic acid-, and leucine-rich protein 1 mediates estrogen rapid signaling and neuroprotection in the brain

  Sareddy, G. R., Zhang, Q., Wang, R., Scott, E., Zou, Y., O'Connor, J. C., Chen, Y., Dong, Y., Vadlamudi, R. K. & Brann, D. W., Dec 1 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 48, p. E6673-E6682

  Research output: Contribution to journal › Article › peer-review

  • human PELP1 protein
  • Neuroprotection
  • Estrogens
  • Glycogen Synthase Kinase 3
  • Brain
  25 Scopus citations

• Prosurvival NMDA 2A receptor signaling mediates postconditioning neuroprotection in the hippocampus

  Zhang, X., Zhang, Q., Tu, J., Zhu, Y., Yang, F., Liu, B., Brann, D. W. & Wang, R., Mar 1 2015, In: Hippocampus. 25, 3, p. 286-296 11 p.

  Research output: Contribution to journal › Article › peer-review

  • N-methyl D-aspartate receptor subtype 2A
  • Neuroprotection
  • Brain Ischemia
  • Hippocampus
  • Phosphorylation
  21 Scopus citations

• Selective estrogen receptor modulators (SERMs) enhance neurogenesis and spine density following focal cerebral ischemia

  Khan, M. M., Wakade, C. G., De Sevilla, L. & Brann, D. W., Feb 2015, In: Journal of Steroid Biochemistry and Molecular Biology. 146, p. 38-47 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Selective Estrogen Receptor Modulators
  • Rats
  • Neurogenesis
  • Brain Ischemia
  • Spine
  39 Scopus citations
• 2014

  Beneficial effects of estrogens in the brain and cardiovascular system

  Brann, D. W. & Mahesh, V. B., May 25 2014, In: Molecular and Cellular Endocrinology. 389, 1-2, 1 p.

  Research output: Contribution to journal › Editorial › peer-review
  3 Scopus citations

• Brain-derived estrogen exerts anti-inflammatory and neuroprotective actions in the rat hippocampus

  Zhang, Q., Wang, R., Tang, H., Dong, Y., Chan, A., Sareddy, G. R., Vadlamudi, R. K. & Brann, D. W., May 25 2014, In: Molecular and Cellular Endocrinology. 389, 1-2, p. 84-91 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Aromatase
  • Rats
  • Brain Ischemia
  • Astrocytes
  • Brain
  63 Scopus citations

• GPR30 mediates estrogen rapid signaling and neuroprotection

  Tang, H., Zhang, Q., Yang, L., Dong, Y., Khan, M. B., Yang, F., Brann, D. W. & Wang, R., Apr 25 2014, In: Molecular and Cellular Endocrinology. 387, 1-2, p. 52-58 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuroprotection
  • G-Protein-Coupled Receptors
  • GTP-Binding Proteins
  • Estrogen Receptors
  • estradiol-bovine serum albumin
  63 Scopus citations

• Low dose Hsp90 inhibitor 17AAG protects neural progenitor cells from ischemia induced death

  Bradley, E., Zhao, X., Wang, R., Brann, D. W., Bieberich, E. & Wang, G., Dec 30 2014, In: Journal of Cell Communication and Signaling. 8, 4, p. 353-362 10 p.

  Research output: Contribution to journal › Article › peer-review

  • tanespimycin
  • Cell death
  • Ischemia
  • Stem Cells
  • Regenerative Medicine
  10 Scopus citations

• PELP1 oncogenic functions involve alternative splicing via PRMT6

  Mann, M., Zou, Y., Chen, Y., Brann, D. & Vadlamudi, R., Mar 2014, In: Molecular Oncology. 8, 2, p. 389-400 12 p.

  Research output: Contribution to journal › Article › peer-review

  • human PELP1 protein
  • Alternative Splicing
  • Estrogen Receptors
  • Breast Neoplasms
  • Genes
  13 Scopus citations

• Premature menopause and risk of neurological disease: Basic mechanisms and clinical implications

  Scott, E. L., Zhang, Q. G., Vadlamudi, R. K. & Brann, D. W., May 25 2014, In: Molecular and Cellular Endocrinology. 389, 1-2, p. 2-6 5 p.

  Research output: Contribution to journal › Review article › peer-review

  • Premature Menopause
  • Brain Ischemia
  • Nervous System Diseases
  • Estradiol
  • Dementia
  19 Scopus citations

• Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response

  Nair, B. C., Krishnan, S. R., Sareddy, G. R., Mann, M., Xu, B., Natarajan, M., Hasty, P., Brann, D., Tekmal, R. R. & Vadlamudi, R. K., Sep 2014, In: Cell Death and Differentiation. 21, 9, p. 1409-1418 10 p.

  Research output: Contribution to journal › Article › peer-review

  • human PELP1 protein
  • DNA Damage
  • Ataxia Telangiectasia
  • Camptothecin
  • p53 Genes
  26 Scopus citations

• Reprint of "GPR30 mediates estrogen rapid signaling and neuroprotection"

  Tang, H., Zhang, Q., Yang, L., Dong, Y., Khan, M. B., Yang, F., Brann, D. W. & Wang, R., May 25 2014, In: Molecular and Cellular Endocrinology. 389, 1-2, p. 92-98 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuroprotection
  • G-Protein-Coupled Receptors
  • GTP-Binding Proteins
  • Estrogen Receptors
  • estradiol-bovine serum albumin
  22 Scopus citations

• Surgical menopause enhances hippocampal amyloidogenesis following global cerebral ischemia

  Scott, E. L., Zhang, Q., Dong, Y., Han, D., Wang, R. M., Vadlamudi, R. K. & Brann, D. W., Sep 2014, In: Journal of Sport and Health Science. 3, 3, p. 206-216 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Menopause
  • Brain Ischemia
  • Ovariectomy
  • Nervous System Diseases
  • Dementia
  2 Scopus citations
• 2013

  Early effects of high-fat diet on neurovascular function and focal ischemic brain injury

  Li, W., Prakash, R., Chawla, D., Du, W., Didion, S. P., Filosa, J. A., Zhang, Q., Brann, D. W., Lima, V. V., Tostes, R. C. & Ergul, A., 2013, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 304, 11, p. R1001-R1008

  Research output: Contribution to journal › Article › peer-review

  • High Fat Diet
  • Brain Injuries
  • Neurovascular Coupling
  • Basilar Artery
  • Middle Cerebral Artery Infarction
  65 Scopus citations

• Erratum: GADD34 induces cell death through inactivation of Akt following traumatic brain injury (Cell Death and Disease (2013) 4 (e754) DOI: 10.1038/cddis.2013.280)

  Farook, J. M., Shields, J., Tawfik, A., Markand, S., Sen, T., Smith, S. B., Brann, D., Dhandapani, K. M. & Sen, N., Sep 2013, In: Cell Death and Disease. 4, 9, e813.

  Research output: Contribution to journal › Comment/debate › peer-review

• Estrogen regulation of Dkk1 and Wnt/β-Catenin signaling in neurodegenerative disease

  Scott, E. L. & Brann, D. W., Jun 13 2013, In: Brain Research. 1514, p. 63-74 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Catenins
  • Wnt Signaling Pathway
  • Neurodegenerative Diseases
  • Estrogens
  • Hormones
  46 Scopus citations

• Estrogen regulation of spine density and excitatory synapses in rat prefrontal and somatosensory cerebral cortex

  Khan, M. M., Dhandapani, K. M., Zhang, Q. & Brann, D. W., Jun 2013, In: Steroids. 78, 6, p. 614-623 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Rats
  • Somatosensory Cortex
  • Cerebral Cortex
  • Neurons
  • Synapses
  40 Scopus citations

• GADD34 induces cell death through inactivation of Akt following traumatic brain injury

  Farook, J. M., Shields, J., Tawfik, A., Markand, S., Sen, T., Smith, S. B., Brann, D., Dhandapani, K. M. & Sen, N., Aug 2013, In: Cell Death and Disease. 4, 8, e754.

  Research output: Contribution to journal › Article › peer-review

  • TNF Receptor-Associated Factor 6
  • Traumatic Brain Injury
  • Cell Death
  • Activating Transcription Factor 4
  • Phosphorylation
  45 Scopus citations

• Genistein attenuates ischemic oxidative damage and behavioral deficits via eNOS/Nrf2/HO-1 signaling

  Wang, R., Tu, J., Zhang, Q., Zhang, X., Zhu, Y., Ma, W., Cheng, C., Brann, D. W. & Yang, F., Jul 1 2013, In: Hippocampus. 23, 7, p. 634-647 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Genistein
  • Heme Oxygenase-1
  • Brain Ischemia
  • Oxidative Stress
  • Neurons
  76 Scopus citations

• Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause

  Zhang, Q., Wang, R. M., Scott, E., Han, D., Dong, Y., Tu, J. Y., Yang, F., Reddy Sareddy, G., Vadlamudi, R. K. & Brann, D. W., May 2013, In: Brain. 136, 5, p. 1432-1445 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Hippocampal CA3 Region
  • Anatomic Models
  • Ovariectomy
  • Menopause
  • Hypersensitivity
  34 Scopus citations

• KDM1 is a novel therapeutic target for the treatment of gliomas

  Sareddy, G. R., Nair, B. C., Krishnan, S. K., Gonugunta, V. K., Zhang, Q. G., Suzuki, T., Miyata, N., Brenner, A. J., Brann, D. W. & Vadlamudi, R. K., 2013, In: Oncotarget. 4, 1, p. 18-28 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Glioma
  • Heterografts
  • p53 Genes
  • Epigenomics
  • Therapeutics
  33 Scopus citations

• Long-term estrogen deprivation leads to elevation of Dickkopf-1 and dysregulation of Wnt/β-Catenin signaling in hippocampal CA1 neurons

  Scott, E. L., Zhang, Q. G., Han, D., Desai, B. N. & Brann, D. W., Jun 2013, In: Steroids. 78, 6, p. 624-632 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Catenins
  • Rats
  • Brain Ischemia
  • Neurons
  • Estrogens
  18 Scopus citations