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  • Rudolf Lucas
2020

Impact of bacterial toxins in the lungs

Lucas, R., Hadizamani, Y., Gonzales, J., Gorshkov, B., Bodmer, T., Berthiaume, Y., Moehrlen, U., Lode, H., Huwer, H., Hudel, M., Mraheil, M. A., Toque, H. A. F., Chakraborty, T. & Hamacher, J., Apr 2020, In : Toxins. 12, 4, 223.

Research output: Contribution to journalArticle

Open Access

Loaded Leukosomes: A Smart Bomb to Halt Vascular Inflammation

Csányi, G., Lucas, R. & Annex, B. H., Jan 3 2020, In : Circulation research. 126, 1, p. 38-40 3 p.

Research output: Contribution to journalEditorial

Short report: Does the 6-minute walk test in hospitalized COPD patients exclusively correlate with lung function parameters or should psychological factors also be taken into account?

Borgmann, M., Ivanda, M., Hadizamani, Y., Mohaupt, M., Bals, R., Lucas, R., Hamacher, J. & Köllner, V., May 2020, In : PloS one. 15, 5, e0232587.

Research output: Contribution to journalArticle

Open Access
2019
1 Scopus citations

The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

Madaio, M. P., Czikora, I., Kvirkvelia, N., McMenamin, M., Yue, Q., Liu, T., Flores Toque, H. A., Sridhar, S., Covington, K., Alaisami, R., O'Connor, P. M., Caldwell, R. W., Chen, J., Clauss, M., Brands, M. W., Eaton, D. C., Romero Lucas, M. J. & Lucas, R., Jun 2019, In : Kidney International. 95, 6, p. 1359-1372 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome

Benson, T. W., Weintraub, N. L., Kim, H. W., Seigler, N., Kumar, S., Pye, J., Horimatsu, T., Pellenberg, R., Stepp, D. W., Lucas, R., Bogdanov, V. Y., Litwin, S. E., Brittain, J. E. & Harris, R. A., Oct 1 2018, In : Laboratory Investigation. 98, 10, p. 1300-1310 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cytokine-ion channel interactions in pulmonary inflammation

Hamacher, J., Hadizamani, Y., Borgmann, M., Mohaupt, M., Männel, D. N., Moehrlen, U., Lucas, R. & Stammberger, U., Jan 4 2018, In : Frontiers in immunology. 8, JAN, 1644.

Research output: Contribution to journalReview article

9 Scopus citations

Editorial: Cytokine-ion channel interactions in pulmonary inflammation

Vadász, I. & Lucas, R., Nov 6 2018, In : Frontiers in immunology. 9, NOV, 02598.

Research output: Contribution to journalReview article

Hsp70 suppresses mitochondrial reactive oxygen species and preserves pulmonary microvascular barrier integrity following exposure to bacterial toxins

Li, X., Yu, Y., Gorshkov, B., Haigh, S., Bordan, Z., Weintraub, D., Rudic, R. D., Chakraborty, T., Barman, S. A., Verin, A. D., Su, Y., Lucas, R., Stepp, D. W., Chen, F. & Fulton, D. J., Jun 12 2018, In : Frontiers in immunology. 9, JUN, 1309.

Research output: Contribution to journalArticle

11 Scopus citations

Kidney-targeted inhibition of protein kinase C-α ameliorates nephrotoxic nephritis with restoration of mitochondrial dysfunction

Kvirkvelia, N., McMenamin, M., Warren, M., Jadeja, R. N., Kodeboyina, S. K., Sharma, A., Zhi, W., O'Connor, P. M., Raju, R., Lucas, R. & Madaio, M. P., Aug 2018, In : Kidney International. 94, 2, p. 280-291 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Listeriolysin O causes ENaC dysfunction in human airway epithelial cells

Yang, G., Pillich, H., White, R., Czikora, I., Pochic, I., Yue, Q., Hudel, M., Gorshkov, B. A., Verin, A. D., Sridhar, S., Isales, C. M., Eaton, D. C., Hamacher, J., Chakraborty, T. & Lucas, R., Feb 11 2018, In : Toxins. 10, 2, 79.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Epithelial sodium channel-α mediates the protective effect of the TNF-derived TIP peptide in pneumolysin-induced endothelial barrier dysfunction

Czikora, I., Alli, A. A., Sridhar, S., Matthay, M. A., Pillich, H., Hudel, M., Berisha, B., Gorshkov, B. A., Romero Lucas, M. J., Gonzales, J. N., Wu, G., Huo, Y., Su, Y., Verin, A. D., Fulton, D. J., Chakraborty, T., Eaton, D. C. & Lucas, R., Jul 21 2017, In : Frontiers in immunology. 8, JUL, 842.

Research output: Contribution to journalArticle

12 Scopus citations

Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: A phase IIa randomized placebo-controlled trial

Krenn, K., Lucas, R., Croizé, A., Boehme, S., Klein, K. U., Hermann, R., Markstaller, K. & Ullrich, R., Jul 27 2017, In : Critical Care. 21, 1, 194.

Research output: Contribution to journalArticle

12 Scopus citations

Listeriolysin O regulates the expression of optineurin, an autophagy adaptor that inhibits the growth of Listeria monocytogenes

Puri, M., La Pietra, L., Mraheil, M. A., Lucas, R., Chakraborty, T. & Pillich, H., Sep 5 2017, In : Toxins. 9, 9, 273.

Research output: Contribution to journalArticle

8 Scopus citations

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

Bhatta, A., Yao, L., Xu, Z., Toque, H. A., Chen, J., Atawia, R. T., Fouda, A. Y., Bagi, Z., Lucas, R., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In : Cardiovascular Research. 113, 13, p. 1664-1676 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Obesity-induced vascular inflammation involves elevated arginase activity

Yao, L., Bhatta, A., Xu, Z., Chen, J., Toque, H. A., Chen, Y., Xu, Y., Bagi, Z., Lucas, R., Huo, Y., Caldwell, R. B. & Caldwell, R. W., Nov 2017, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 313, 5, p. R560-R571

Research output: Contribution to journalArticle

11 Scopus citations

Restoration of epithelial sodium channel function by synthetic peptides in pseudohypoaldosteronism type 1B mutants

Willam, A., Aufy, M., Tzotzos, S., Evanzin, H., Chytracek, S., Geppert, S., Fischer, B., Fischer, H., Pietschmann, H., Czikora, I., Lucas, R., Lemmens-Gruber, R. & Shabbir, W., Feb 24 2017, In : Frontiers in Pharmacology. 8, FEB, 85.

Research output: Contribution to journalArticle

3 Scopus citations

RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins

Chen, F., Wang, Y., Rafikov, R., Haigh, S., Kumar, S., Rafikova, O., Lucas, R., Verin, A. D., Black, S. M. & Fulton, D. J. R., Mar 1 2017, In : Biochemical Pharmacology. 127, p. 34-45 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction

Dou, H., Feher, A., Davila, A. C., Romero, M. J., Patel, V. S., Kamath, V. M., Gooz, M. B., Rudic, R. D., Lucas, R., Fulton, D. J., Weintraub, N. L. & Bagi, Z., Jun 1 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 6, p. 1180-1193 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Solnatide Demonstrates Profound Therapeutic Activity in a Rat Model of Pulmonary Edema Induced by Acute Hypobaric Hypoxia and Exercise

Zhou, Q., Wang, D., Liu, Y., Yang, X., Lucas, R. & Fischer, B., Mar 1 2017, In : CHEST. 151, 3, p. 658-667 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

TNF lectin-like domain restores epithelial sodium channel function in frameshift mutants associated with pseudohypoaldosteronism type 1B

Willam, A., Aufy, M., Tzotzos, S., El-Malazi, D., Poser, F., Wagner, A., Unterköfler, B., Gurmani, D., Martan, D., Iqbal, S. M., Fischer, B., Fischer, H., Pietschmann, H., Czikora, I., Lucas, R., Lemmens-Gruber, R. & Shabbir, W., May 29 2017, In : Frontiers in immunology. 8, MAY, 601.

Research output: Contribution to journalArticle

2016

Role of growth hormone-releasing hormone in dyslipidemia associated with experimental type 1 diabetes

Romero Lucas, M. J., Lucas, R., Dou, H., Sridhar, S., Czikora, I., Mosieri, E. M., Rick, F. G., Block, N. L., Sridhar, S., Fulton, D. J., Weintraub, N. L. & Bagi, Z., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. 1895-1900 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

The lectin-like domain of TNF increases ENaC open probability through a novel site at the interface between the second transmembrane and C-terminal domains of the α-subunit

Lucas, R., Yue, Q., Alli, A., Duke, B. J., Al-Khalili, O., Thai, T. L., Hamacher, J., Sridhar, S., Lebedyeva, I., Su, H., Tzotzos, S., Fischer, B., Gameiro, A. F., Loose, M., Chakraborty, T., Shabbir, W., Aufy, M., Lemmens-Gruber, R., Eaton, D. C. & Czikora, I., Nov 4 2016, In : Journal of Biological Chemistry. 291, 45, p. 23440-23451 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy

Patel, C., Xu, Z., Shosha, E., Xing, J., Lucas, R., Caldwell, R. W., Caldwell, R. B. & Narayanan, S. P., Sep 1 2016, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 9, p. 1628-1639 12 p.

Research output: Contribution to journalArticle

5 Scopus citations