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  • Abdullah Kutlar
2020

American Society of Hematology 2020 guidelines for sickle cell disease: Management of acute and chronic pain

Brandow, A. M., Carroll, C. P., Creary, S., Edwards-Elliott, R., Glassberg, J., Hurley, R. W., Kutlar, A., Seisa, M., Stinson, J., Strouse, J. J., Yusuf, F., Zempsky, W. & Lang, E., Jun 23 2020, In : Blood Advances. 4, 12, p. 2656-2701 46 p.

Research output: Contribution to journalReview article

Open Access

Characteristics and potential biomarkers of adult sickle cell patients with chronic pain

Albo, C., Kumar, S., Pope, M., Kidwell, K. M., Xu, H., Bowman, L., Wells, L., Barrett, N., Fields, S., Bora, P., Patel, N. & Kutlar, A., Oct 1 2020, In : European Journal of Haematology. 105, 4, p. 419-425 7 p.

Research output: Contribution to journalArticle

DIAPH1 Mutation as a Novel Cause of Autosomal Dominant Macrothrombocytopenia and Hearing Loss

Karki, N. R., Ajebo, G. H., Savage, N. & Kutlar, A., 2020, (Accepted/In press) In : Acta Haematologica.

Research output: Contribution to journalArticle

Integration of mobile health into sickle cell disease care to increase hydroxyurea utilization: Protocol for an efficacy and implementation study

Sickle Cell Disease Implementation Consortium, Jul 2020, In : JMIR Research Protocols. 9, 7, e16319.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access

Regulation of iron homeostasis through the erythroferrone-hepcidin axis in sickle cell disease

Mangaonkar, A. A., Thawer, F., Son, J., Ajebo, G. H., Xu, H., Barrett, N. J., Wells, L. G., Bowman, L., Clair, B., Patel, N., Bora, P., Jung, G., Nemeth, E. & Kutlar, A., Jun 1 2020, In : British Journal of Haematology. 189, 6, p. 1204-1209 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Effect of crizanlizumab on pain crises in subgroups of patients with sickle cell disease: A SUSTAIN study analysis

Kutlar, A., Kanter, J., Liles, D. K., Alvarez, O. A., Cançado, R. D., Friedrisch, J. R., Knight-Madden, J. M., Bruederle, A., Shi, M., Zhu, Z. & Ataga, K. I., Jan 2019, In : American Journal of Hematology. 94, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease

Li, B., Zhu, X., Ward, C. M., Starlard-Davenport, A., Takezaki, M., Berry, A., Ward, A., Wilder, C., Neunert, C., Kutlar, A. & Pace, B. S., Feb 2019, In : Experimental Hematology. 70, p. 85-96.e5

Research output: Contribution to journalArticle

11 Scopus citations
2018

A thalidomide–hydroxyurea hybrid increases HbF production in sickle cell mice and reduces the release of proinflammatory cytokines in cultured monocytes

Lanaro, C., Franco-Penteado, C. F., Silva, F. H., Fertrin, K. Y., dos Santos, J. L., Wade, M., Yerigenahally, S., de Melo, T. R., Chin, C. M., Kutlar, A., Meiler, S. E. & Costa, F. F., Feb 2018, In : Experimental Hematology. 58, p. 35-38 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

CB1R-mediated activation of caspase-3 causes epigenetic and neurobehavioral abnormalities in postnatal ethanol-exposed mice

Subbanna, S., Nagre, N. N., Shivakumar, M., Joshi, V., Psychoyos, D., Kutlar, A., Umapathy, N. S. & Basavarajappa, B. S., Feb 20 2018, In : Frontiers in Molecular Neuroscience. 11, 45.

Research output: Contribution to journalArticle

10 Scopus citations

The missing middle of sickle therapeutics: Multi-agent therapy, targeting risk, using biomarkers

Hebbel, R. P., Elion, J. & Kutlar, A., Dec 2018, In : American Journal of Hematology. 93, 12, p. 1439-1443 5 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
2017

Clinical evaluation of glycoPEGylated recombinant FVIII: Efficacy and safety in severe haemophilia A

Giangrande, P., Andreeva, T., Chowdary, P., Ehrenforth, S., Hanabusa, H., Leebeek, F. W. G., Lentz, S. R., Nemes, L., Poulsen, L. H., Santagostino, E., You, C. W., Clausen, W. H. O., Jönsson, P. G., Oldenburg, J., Rothschild, C., Lambert, T., Trossaert, M., Negrier, C., Miesbach, W., Tiede, A. & 64 others, Klamroth, R., Eichler, H., Tosetto, A., Dunsmore, K., Escobar, M., Wright, J., Gruppo, R., Guron, G. K., Kearney, S., Lasky, J., Kutlar, A., Paroskie-Wheeler, A., Powell, J. S., Recht, M., Takemoto, C., Cockrell, E., Yee, D., Felgenhauer, J., Apollonsky, N., Lazarchick, J., Kulkarni, R., Knoll, C., Morales, J., Kavasch, P., Nagasubramanian, G. R., Guerrera, M., Chitlur, M., Lowe, E., Tsay, W., Shen, M. C., Zupancic-Salek, S., Kampmann, P., Boda, Z., Meijer, K., Holme, P. A., Jiménez Yuste, V., Mingot, E. M., Zetterberg, E., Brand, B., Alberio, L., Boehlen, F., Thomson, G., Collins, P. W., Curry, N., Hampton, K., Rangarajan, S., Barnes, C., Brown, S., Dunkley, S., Castro Ozelo, M., Misgav, M., Karim, F. A., Sathar, J., Kavakli, K., Sasmaz, I., Albayrak, C., Fukutake, K., Matsushita, T., Madoiwa, S., Shima, M., Fujii, T., Sato, T., Takedani, H. & Shibuya, A., 2017, In : Thrombosis and Haemostasis. 117, 2, p. 252-261 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Crizanlizumab for the prevention of pain crises in sickle cell disease

Ataga, K. I., Kutlar, A., Kanter, J., Liles, D., Cancado, R., Friedrisch, J., Guthrie, T. H., Knight-Madden, J., Alvarez, O. A., Gordeuk, V. R., Gualandro, S., Colella, M. P., Smith, W. R., Rollins, S. A., Stocker, J. W. & Rother, R. P., Feb 2 2017, In : New England Journal of Medicine. 376, 5, p. 429-439 11 p.

Research output: Contribution to journalArticle

186 Scopus citations

Crizanlizumab in sickle cell disease

Ataga, K. I., Kutlar, A. & Kanter, J., May 4 2017, In : New England Journal of Medicine. 376, 18, p. 1795-1796 2 p.

Research output: Contribution to journalLetter

23 Scopus citations

Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with index of hydroxyurea responsiveness

Zhu, X., Hu, T., Ho, M. H., Wang, Y., Yu, M., Patel, N., Pi, W., Choi, J-H., Xu, H., Ganapathy, V., Kutlar, F., Kutlar, A. & Tuan Lo, D., Nov 30 2017, In : Haematologica. 102, 12, p. 1995-2004 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Long-term endothelin-a receptor antagonism provides robust renal protection in humanized sickle cell disease mice

Kasztan, M., Fox, B. M., Speed, J. S., De Miguel, C., Gohar, E. Y., Townes, T. M., Kutlar, A., Pollock, J. S. & Pollock, D. M., Aug 2017, In : Journal of the American Society of Nephrology. 28, 8, p. 2443-2458 16 p.

Research output: Contribution to journalArticle

26 Scopus citations

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci

Canver, M. C., Lessard, S., Pinello, L., Wu, Y., Ilboudo, Y., Stern, E. N., Needleman, A. J., Galactéros, F., Brugnara, C., Kutlar, A., McKenzie, C., Reid, M., Chen, D. D., Das, P. P., A Cole, M., Zeng, J., Kurita, R., Nakamura, Y., Yuan, G. C., Lettre, G. & 2 others, Bauer, D. E. & Orkin, S. H., Mar 30 2017, In : Nature Genetics. 49, 4, p. 625-634 10 p.

Research output: Contribution to journalArticle

52 Scopus citations
2016

Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species

Brett Heimlich, J., Speed, J. S., O'Connor, P. M., Pollock, J. S., Townes, T. M., Meiler, S. E., Kutlar, A. & Pollock, D. M., Jan 1 2016, In : British Journal of Pharmacology. 173, 2, p. 386-395 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia - TCD with Transfusions Changing to Hydroxyurea (TWiTCH): A multicentre, open-label, phase 3, non-inferiority trial

Ware, R. E., Davis, B. R., Schultz, W. H., Brown, R. C., Aygun, B., Sarnaik, S., Odame, I., Fuh, B., George, A., Owen, W., Luchtman-Jones, L., Rogers, Z. R., Hilliard, L., Gauger, C., Piccone, C., Lee, M. T., Kwiatkowski, J. L., Jackson, S., Miller, S. T., Roberts, C. & 25 others, Heeney, M. M., Kalfa, T. A., Nelson, S., Imran, H., Nottage, K., Alvarez, O., Rhodes, M., Thompson, A. A., Rothman, J. A., Helton, K. J., Roberts, D., Coleman, J., Bonner, M. J., Kutlar, A., Patel, N., Wood, J., Piller, L., Wei, P., Luden, J., Mortier, N. A., Stuber, S. E., Luban, N. L. C., Cohen, A. R., Pressel, S. & Adams, R. J., Feb 13 2016, In : The Lancet. 387, 10019, p. 661-670 10 p.

Research output: Contribution to journalArticle

207 Scopus citations

Intrapatient variability in fetal hemoglobin measurements over time in sickle cell patients not on fetal hemoglobin inducing agents

Knapp, E., Cohen, H., Kutlar, A., Ghalie, R. & Manwani, D., Mar 1 2016, In : American Journal of Hematology. 91, 3, p. E11-E12

Research output: Contribution to journalLetter

Progressing Preemptive Genotyping of CYP2C19 Allelic Variants for Sickle Cell Disease Patients

Jaja, C., Barrett, N., Patel, N., Lyon, M., Xu, H. & Kutlar, A., Oct 1 2016, In : Genetic Testing and Molecular Biomarkers. 20, 10, p. 609-615 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Pulmonary platelet thrombi and vascular pathology in acute chest syndrome in patients with sickle cell disease

Anea, C. B., Lyon, M., Lee, I. A., Gonzales, J. N., Adeyemi, A., Falls, G., Kutlar, A. & Brittain, J. E., Feb 1 2016, In : American Journal of Hematology. 91, 2, p. 173-178 6 p.

Research output: Contribution to journalArticle

17 Scopus citations