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2019
12 Citations (Scopus)

Effect of crizanlizumab on pain crises in subgroups of patients with sickle cell disease: A SUSTAIN study analysis

Kutlar, A., Kanter, J., Liles, D. K., Alvarez, O. A., Cançado, R. D., Friedrisch, J. R., Knight-Madden, J. M., Bruederle, A., Shi, M., Zhu, Z. & Ataga, K. I., Jan 2019, In : American Journal of Hematology. 94, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Pain
Placebos
Hydroxyurea
P-Selectin
8 Citations (Scopus)

MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease

Li, B., Zhu, X., Ward, C. M., Starlard-Davenport, A., Takezaki, M., Berry, A., Ward, A., Wilder, C., Neunert, C., Kutlar, A. & Pace, B. S., Feb 2019, In : Experimental Hematology. 70, p. 85-96.e5

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
Sickle Cell Anemia
Gene Silencing
MicroRNAs
2018
2 Citations (Scopus)

A thalidomide–hydroxyurea hybrid increases HbF production in sickle cell mice and reduces the release of proinflammatory cytokines in cultured monocytes

Lanaro, C., Franco-Penteado, C. F., Silva, F. H., Fertrin, K. Y., dos Santos, J. L., Wade, M., Yerigenahally, S., de Melo, T. R., Chin, C. M., Kutlar, A., Meiler, S. E. & Costa, F. F., Feb 2018, In : Experimental Hematology. 58, p. 35-38 4 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Monocytes
Hydroxyurea
Cytokines
Thalidomide
8 Citations (Scopus)

CB1R-mediated activation of caspase-3 causes epigenetic and neurobehavioral abnormalities in postnatal ethanol-exposed mice

Subbanna, S., Nagre, N. N., Shivakumar, M., Joshi, V., Psychoyos, D., Kutlar, A., Umapathy, N. S. & Basavarajappa, B. S., Feb 20 2018, In : Frontiers in Molecular Neuroscience. 11, 45.

Research output: Contribution to journalArticle

Epigenomics
Caspase 3
Ethanol
Methyl-CpG-Binding Protein 2
Fetal Alcohol Spectrum Disorders

The missing middle of sickle therapeutics: Multi-agent therapy, targeting risk, using biomarkers

Hebbel, R. P., Elion, J. & Kutlar, A., Dec 2018, In : American Journal of Hematology. 93, 12, p. 1439-1443 5 p.

Research output: Contribution to journalComment/debate

Biomarkers
Therapeutics
2017
140 Citations (Scopus)

Crizanlizumab for the prevention of pain crises in sickle cell disease

Ataga, K. I., Kutlar, A., Kanter, J., Liles, D., Cancado, R., Friedrisch, J., Guthrie, T. H., Knight-Madden, J., Alvarez, O. A., Gordeuk, V. R., Gualandro, S., Colella, M. P., Smith, W. R., Rollins, S. A., Stocker, J. W. & Rother, R. P., Feb 2 2017, In : New England Journal of Medicine. 376, 5, p. 429-439 11 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Placebos
Pain
Acute Chest Syndrome
P-Selectin
10 Citations (Scopus)

Crizanlizumab in sickle cell disease

Ataga, K. I., Kutlar, A. & Kanter, J., May 4 2017, In : New England Journal of Medicine. 376, 18, p. 1795-1796 2 p.

Research output: Contribution to journalLetter

Sickle Cell Anemia
1 Citation (Scopus)

Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with index of hydroxyurea responsiveness

Zhu, X., Hu, T., Ho, M. H., Wang, Y., Yu, M., Patel, N., Pi, W., Choi, J-H., Xu, H., Ganapathy, V., Kutlar, F., Kutlar, A. & Tuan Lo, D., Nov 30 2017, In : Haematologica. 102, 12, p. 1995-2004 10 p.

Research output: Contribution to journalArticle

Erythroblasts
Hydroxyurea
Globins
Sickle Cell Anemia
Genes
23 Citations (Scopus)

Long-term endothelin-a receptor antagonism provides robust renal protection in humanized sickle cell disease mice

Kasztan, M., Fox, B. M., Speed, J. S., De Miguel, C., Gohar, E. Y., Townes, T. M., Kutlar, A., Pollock, J. S. & Pollock, D. M., Aug 2017, In : Journal of the American Society of Nephrology. 28, 8, p. 2443-2458 16 p.

Research output: Contribution to journalArticle

Endothelin Receptors
Sickle Cell Anemia
Kidney
Endothelin A Receptors
Albuminuria
44 Citations (Scopus)

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci

Canver, M. C., Lessard, S., Pinello, L., Wu, Y., Ilboudo, Y., Stern, E. N., Needleman, A. J., Galactéros, F., Brugnara, C., Kutlar, A., McKenzie, C., Reid, M., Chen, D. D., Das, P. P., A Cole, M., Zeng, J., Kurita, R., Nakamura, Y., Yuan, G. C., Lettre, G. & 2 others, Bauer, D. E. & Orkin, S. H., Mar 30 2017, In : Nature Genetics. 49, 4, p. 625-634 10 p.

Research output: Contribution to journalArticle

Mutagenesis
Libraries
Fetal Hemoglobin
Intergenic DNA
Genome-Wide Association Study
2016
17 Citations (Scopus)

Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species

Brett Heimlich, J., Speed, J. S., O'Connor, P. M., Pollock, J. S., Townes, T. M., Meiler, S. E., Kutlar, A. & Pollock, D. M., Jan 1 2016, In : British Journal of Pharmacology. 173, 2, p. 386-395 10 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Endothelin-1
Reactive Oxygen Species
Kidney
Wounds and Injuries
170 Citations (Scopus)

Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia - TCD with Transfusions Changing to Hydroxyurea (TWiTCH): A multicentre, open-label, phase 3, non-inferiority trial

Ware, R. E., Davis, B. R., Schultz, W. H., Brown, R. C., Aygun, B., Sarnaik, S., Odame, I., Fuh, B., George, A., Owen, W., Luchtman-Jones, L., Rogers, Z. R., Hilliard, L., Gauger, C., Piccone, C., Lee, M. T., Kwiatkowski, J. L., Jackson, S., Miller, S. T., Roberts, C. & 25 others, Heeney, M. M., Kalfa, T. A., Nelson, S., Imran, H., Nottage, K., Alvarez, O., Rhodes, M., Thompson, A. A., Rothman, J. A., Helton, K. J., Roberts, D., Coleman, J., Bonner, M. J., Kutlar, A., Patel, N., Wood, J., Piller, L., Wei, P., Luden, J., Mortier, N. A., Stuber, S. E., Luban, N. L. C., Cohen, A. R., Pressel, S. & Adams, R. J., Feb 13 2016, In : The Lancet. 387, 10019, p. 661-670 10 p.

Research output: Contribution to journalArticle

Hydroxyurea
Sickle Cell Anemia
Maintenance
Random Allocation
Stroke

Intrapatient variability in fetal hemoglobin measurements over time in sickle cell patients not on fetal hemoglobin inducing agents

Knapp, E., Cohen, H., Kutlar, A., Ghalie, R. & Manwani, D., Mar 1 2016, In : American Journal of Hematology. 91, 3, p. E11-E12

Research output: Contribution to journalLetter

Antisickling Agents
Fetal Hemoglobin
Statistical Data Interpretation
Butyrates
Sickle Cell Anemia
1 Citation (Scopus)

Progressing Preemptive Genotyping of CYP2C19 Allelic Variants for Sickle Cell Disease Patients

Jaja, C., Barrett, N., Patel, N., Lyon, M., Xu, H. & Kutlar, A., Oct 1 2016, In : Genetic Testing and Molecular Biomarkers. 20, 10, p. 609-615 7 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Alleles
Pharmaceutical Preparations
Phenotype
Proton Pump Inhibitors
12 Citations (Scopus)

Pulmonary platelet thrombi and vascular pathology in acute chest syndrome in patients with sickle cell disease

Anea, C. B., Lyon, M., Lee, I. A., Gonzales, J. N., Adeyemi, A., Falls, G., Kutlar, A. & Brittain, J. E., Feb 1 2016, In : American Journal of Hematology. 91, 2, p. 173-178 6 p.

Research output: Contribution to journalArticle

Acute Chest Syndrome
Sickle Cell Anemia
Blood Vessels
Thrombosis
Blood Platelets