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2019
1 Citation (Scopus)

PD-L1-specific helper T-cells exhibit effective antitumor responses: New strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma

Hirata-Nozaki, Y., Ohkuri, T., Ohara, K., Kumai, T., Nagata, M., Harabuchi, S., Kosaka, A., Nagato, T., Ishibashi, K., Oikawa, K., Aoki, N., Ohara, M., Harabuchi, Y., Uno, Y., Takei, H., Celis, E. & Kobayashi, H., Jun 20 2019, In : Journal of Translational Medicine. 17, 1, 207.

Research output: Contribution to journalArticle

Open Access
Th1 Cells
T-cells
Immunotherapy
Ligands
Helper-Inducer T-Lymphocytes
4 Citations (Scopus)

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

Piranlioglu, R., Lee, E. M., Ouzounova, M., Bollag, R. J., Vinyard, A., Arbab, A. S., Marasco, D., Guzel, M., Cowell, J. K., Thangaraju, M., Chadli, A., Hassan, K. A., Wicha, M. S., Celis, E. & Korkaya, H., Dec 1 2019, In : Nature Communications. 10, 1, 1430.

Research output: Contribution to journalArticle

immunity
mice
Tumors
Immunity
tumors
2 Citations (Scopus)

The route of administration dictates the immunogenicity of peptide-based cancer vaccines in mice

Sultan, H., Kumai, T., Nagato, T., Wu, J., Salazar, A. M. & Celis, E., Mar 13 2019, In : Cancer Immunology, Immunotherapy. 68, 3, p. 455-466 12 p.

Research output: Contribution to journalArticle

Cancer Vaccines
Subunit Vaccines
Cytotoxic T-Lymphocytes
Peptides
Vaccines
2018
6 Citations (Scopus)

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

Klement, J. D., Paschall, A. V., Redd, P. S., Ibrahim, M. L., Lu, C., Yang, D., Celis, E., Abrams, S. I., Ozato, K. & Liu, K., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5549-5560 12 p.

Research output: Contribution to journalArticle

Tumor Escape
Osteopontin
T-Lymphocytes
Immunotherapy
Colon
3 Citations (Scopus)

H3K4me3 mediates the NF-κB p50 homodimer binding to the pdcd1 promoter to activate PD-1 transcription in T cells

Redd, P. S., Lu, C., Klement, J. D., Ibrahim, M. L., Zhou, G., Kumai, T., Celis, E. & Liu, K., Sep 2 2018, In : OncoImmunology. 7, 9, e1483302.

Research output: Contribution to journalArticle

T-Lymphocytes
CD8 Antigens
Immunologic Monitoring
CD4 Antigens
T-Cell Antigen Receptor
7 Citations (Scopus)

Identification of α-fetoprotein-specific T-cell receptors for hepatocellular carcinoma immunotherapy

Zhu, W., Peng, Y., Wang, L., Hong, Y., Jiang, X., Li, Q., Liu, H., Huang, L., Wu, J., Celis, E., Merchen, T. D., Kruse, E. J. & He, Y., Aug 2018, In : Hepatology. 68, 2, p. 574-589 16 p.

Research output: Contribution to journalArticle

Fetal Proteins
T-Cell Antigen Receptor
Immunotherapy
Hepatocellular Carcinoma
T-Lymphocytes
1 Citation (Scopus)

Role of MDA5 and interferon-I in dendritic cells for T cell expansion by anti-tumor peptide vaccines in mice

Sultan, H., Wu, J., Kumai, T., Salazar, A. M. & Celis, E., Jul 1 2018, In : Cancer Immunology, Immunotherapy. 67, 7, p. 1091-1103 13 p.

Research output: Contribution to journalArticle

Melanoma-Specific Antigens
Cancer Vaccines
Subunit Vaccines
Differentiation Antigens
Cytotoxic T-Lymphocytes
3 Citations (Scopus)

Sustained persistence of il2 signaling enhances the antitumor effect of peptide vaccines through t-cell expansion and preventing pd-1 inhibition

Sultan, H., Kumai, T., Fesenkova, V. I., Fan, A. E., Wu, J., Cho, H. II., Kobayashi, H., Harabuchi, Y. & Celis, E., May 2018, In : Cancer Immunology Research. 6, 5, p. 617-627 11 p.

Research output: Contribution to journalArticle

Subunit Vaccines
Interleukin-2
T-Lymphocytes
Neoplasms
Neoplasm Antigens

Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinoma

Ohara, K., Ohkuri, T., Kumai, T., Nagato, T., Nozaki, Y., Ishibashi, K., Kosaka, A., Nagata, M., Harabuchi, S., Ohara, M., Oikawa, K., Aoki, N., Harabuchi, Y., Celis, E. & Kobayashi, H., Sep 2 2018, In : OncoImmunology. 7, 9, e1466771.

Research output: Contribution to journalArticle

Epitopes
Peptides
Squamous Cell Neoplasms
Neoplasms
Head and Neck Neoplasms
2017
18 Citations (Scopus)

Cancer immunotherapy: moving forward with peptide T cell vaccines

Kumai, T., Fan, A., Harabuchi, Y. & Celis, E., Aug 2017, In : Current Opinion in Immunology. 47, p. 57-63 7 p.

Research output: Contribution to journalReview article

Peptide T
Immunotherapy
Vaccines
T-Lymphocytes
Neoplasms
Immunotherapy
Canada
Neoplasms
15 Citations (Scopus)

Designing therapeutic cancer vaccines by mimicking viral infections

Sultan, H., Fesenkova, V. I., Addis, D., Fan, A. E., Kumai, T., Wu, J., Salazar, A. M. & Celis, E., Feb 1 2017, In : Cancer Immunology, Immunotherapy. 66, 2, p. 203-213 11 p.

Research output: Contribution to journalReview article

Cancer Vaccines
Virus Diseases
Epitopes
Peptides
Neoplasm Antigens
4 Citations (Scopus)

Effective antitumor peptide vaccines can induce severe autoimmune pathology

Sultan, H., Trillo-Tinoco, J., Rodriguez, P. & Celis, E., Jan 1 2017, In : Oncotarget. 8, 41, p. 70317-70331 15 p.

Research output: Contribution to journalArticle

Subunit Vaccines
Interleukin-2
Pathology
Antibodies
T-Lymphocytes
16 Citations (Scopus)

Enhanced therapeutic efficacy and memory of tumor-specific CD8 T cells by ex vivo PI3K-δ inhibition

Abu Eid, R., Ahmad, S., Lin, Y., Webb, M., Berrong, Z., Shrimali, R. K., Kumai, T., Ananth, S., Rodriguez, P. C., Celis, E., Janik, J. E., Mkrtichyan, M. & Khleif, S. N., Aug 1 2017, In : Cancer Research. 77, 15, p. 4135-4145 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
T-Lymphocytes
Aptitude
Neoplasms
Protein Isoforms
21 Citations (Scopus)

Intratumoral administration of cGAMP transiently accumulates potent macrophages for anti-tumor immunity at a mouse tumor site

Ohkuri, T., Kosaka, A., Ishibashi, K., Kumai, T., Hirata, Y., Ohara, K., Nagato, T., Oikawa, K., Aoki, N., Harabuchi, Y., Celis, E. & Kobayashi, H., Jun 1 2017, In : Cancer Immunology, Immunotherapy. 66, 6, p. 705-716 12 p.

Research output: Contribution to journalArticle

Immunity
Macrophages
Neoplasms
Tumor Microenvironment
Genes
20 Citations (Scopus)

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

Veglia, F., Tyurin, V. A., Mohammadyani, D., Blasi, M., Duperret, E. K., Donthireddy, L., Hashimoto, A., Kapralov, A., Amoscato, A., Angelini, R., Patel, S., Alicea-Torres, K., Weiner, D., Murphy, M. E., Klein-Seetharaman, J., Celis, E., Kagan, V. E. & Gabrilovich, D. I., Dec 1 2017, In : Nature communications. 8, 1, 2122.

Research output: Contribution to journalArticle

Cross-Priming
Antigen Presentation
antigens
Dendritic Cells
lipids
21 Citations (Scopus)

Local activation of p53 in the tumor microenvironment overcomes immune suppression and enhances antitumor immunity

Guo, G., Yu, M., Xiao, W., Celis, E. & Cui, Y., May 1 2017, In : Cancer Research. 77, 9, p. 2292-2305 14 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Immunity
Neoplasms
Immunosuppression
Tumor Escape
20 Citations (Scopus)

Optimization of peptide vaccines to induce robust antitumor CD4 T-cell responses

Kumai, T., Lee, S., Cho, H. I., Sultan, H., Kobayashi, H., Harabuchi, Y. & Celis, E., Jan 2017, In : Cancer Immunology Research. 5, 1, p. 72-83 12 p.

Research output: Contribution to journalArticle

Subunit Vaccines
T-Lymphocytes
Vaccination
Immunotherapy
Peptides
29 Citations (Scopus)

Peptide vaccines in cancer — old concept revisited

Kumai, T., Kobayashi, H., Harabuchi, Y. & Celis, E., Apr 1 2017, In : Current Opinion in Immunology. 45, p. 1-7 7 p.

Research output: Contribution to journalReview article

Subunit Vaccines
T-Lymphocytes
Neoplasms
Synthetic Vaccines
Vaccines
42 Citations (Scopus)

Programmed death-ligand 1 and its soluble form are highly expressed in nasal natural killer/T-cell lymphoma: a potential rationale for immunotherapy

Nagato, T., Ohkuri, T., Ohara, K., Hirata, Y., Kishibe, K., Komabayashi, Y., Ueda, S., Takahara, M., Kumai, T., Ishibashi, K., Kosaka, A., Aoki, N., Oikawa, K., Uno, Y., Akiyama, N., Sado, M., Takei, H., Celis, E., Harabuchi, Y. & Kobayashi, H., Jul 1 2017, In : Cancer Immunology, Immunotherapy. 66, 7, p. 877-890 14 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
T-Cell Lymphoma
Nose
Immunotherapy
Ligands
2016
2 Citations (Scopus)

CD4 T Cells in Antitumor Immunity

Fesenkova, V., Sultan, H. & Celis, E., Apr 27 2016, Immunity to Pathogens and Tumors. Elsevier Inc., Vol. 4. p. 441-450 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Helper-Inducer T-Lymphocytes
Immunity
T-Lymphocytes
T-Lymphocyte Subsets
Neoplasms
1 Citation (Scopus)

Editorial: A matter of survival: HMGB1 regulates autophagy in tumor MDSC

Kumai, T., Celis, E. & Rodriguez, P. C., Sep 2016, In : Journal of Leukocyte Biology. 100, 3, p. 447-449 3 p.

Research output: Contribution to journalEditorial

HMGB1 Protein
Autophagy
Apoptosis
Inflammation
Neoplasms
8 Citations (Scopus)

Epigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy

Ishibashi, K., Kumai, T., Ohkuri, T., Kosaka, A., Nagato, T., Hirata, Y., Ohara, K., Oikawa, K., Aoki, N., Akiyama, N., Sado, M., Kitada, M., Harabuchi, Y., Celis, E. & Kobayashi, H., Jun 2 2016, In : OncoImmunology. 5, 6, e1169356.

Research output: Contribution to journalArticle

Neoplasm Antigens
HLA Antigens
Epigenomics
Immunotherapy
T-Lymphocytes
10 Citations (Scopus)

T cells conditioned with MDSC show an increased anti-tumor activity after adoptive T cell based immunotherapy

Raber, P. L., Sierra, R. A., Thevenot, P. T., Shuzhong, Z., Wyczechowska, D. D., Kumai, T., Celis, E. & Rodriguez, P. C., Jan 1 2016, In : Oncotarget. 7, 14, p. 17565-17578 14 p.

Research output: Contribution to journalArticle

Immunotherapy
T-Lymphocytes
Neoplasms
Sirolimus
Myeloid-Derived Suppressor Cells