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  • 2020
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  • Esteban Celis
2020

Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw

Elsayed, R., Kurago, Z., Cutler, C. W., Arce, R. M., Gerber, J., Celis, E., Sultan, H., Elashiry, M., Meghil, M., Sun, C., Auersvald, C. M., Awad, M. E., Zeitoun, R., Elsayed, R., Eldin M. Elshikh, M., Isales, C. & Elsalanty, M. E., Feb 1 2020, In : FASEB Journal. 34, 2, p. 2595-2608 14 p.

Research output: Contribution to journalArticle

Open Access
2019

PD-L1-specific helper T-cells exhibit effective antitumor responses: New strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma

Hirata-Nozaki, Y., Ohkuri, T., Ohara, K., Kumai, T., Nagata, M., Harabuchi, S., Kosaka, A., Nagato, T., Ishibashi, K., Oikawa, K., Aoki, N., Ohara, M., Harabuchi, Y., Uno, Y., Takei, H., Celis, E. & Kobayashi, H., Jun 20 2019, In : Journal of Translational Medicine. 17, 1, 207.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

Piranlioglu, R., Lee, E. M., Ouzounova, M., Bollag, R. J., Vinyard, A., Arbab, A. S., Marasco, D., Guzel, M., Cowell, J. K., Thangaraju, M., Chadli, A., Hassan, K. A., Wicha, M. S., Celis, E. & Korkaya, H., Dec 1 2019, In : Nature communications. 10, 1, 1430.

Research output: Contribution to journalArticle

5 Scopus citations

The route of administration dictates the immunogenicity of peptide-based cancer vaccines in mice

Sultan, H., Kumai, T., Nagato, T., Wu, J., Salazar, A. M. & Celis, E., Mar 13 2019, In : Cancer Immunology, Immunotherapy. 68, 3, p. 455-466 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

Klement, J. D., Paschall, A. V., Redd, P. S., Ibrahim, M. L., Lu, C., Yang, D., Celis, E., Abrams, S. I., Ozato, K. & Liu, K., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5549-5560 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

H3K4me3 mediates the NF-κB p50 homodimer binding to the pdcd1 promoter to activate PD-1 transcription in T cells

Redd, P. S., Lu, C., Klement, J. D., Ibrahim, M. L., Zhou, G., Kumai, T., Celis, E. & Liu, K., Sep 2 2018, In : OncoImmunology. 7, 9, e1483302.

Research output: Contribution to journalArticle

5 Scopus citations

Identification of α-fetoprotein-specific T-cell receptors for hepatocellular carcinoma immunotherapy

Zhu, W., Peng, Y., Wang, L., Hong, Y., Jiang, X., Li, Q., Liu, H., Huang, L., Wu, J., Celis, E., Merchen, T. D., Kruse, E. J. & He, Y., Aug 2018, In : Hepatology. 68, 2, p. 574-589 16 p.

Research output: Contribution to journalArticle

13 Scopus citations

Role of MDA5 and interferon-I in dendritic cells for T cell expansion by anti-tumor peptide vaccines in mice

Sultan, H., Wu, J., Kumai, T., Salazar, A. M. & Celis, E., Jul 1 2018, In : Cancer Immunology, Immunotherapy. 67, 7, p. 1091-1103 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Sustained persistence of il2 signaling enhances the antitumor effect of peptide vaccines through t-cell expansion and preventing pd-1 inhibition

Sultan, H., Kumai, T., Fesenkova, V. I., Fan, A. E., Wu, J., Cho, H. II., Kobayashi, H., Harabuchi, Y. & Celis, E., May 2018, In : Cancer Immunology Research. 6, 5, p. 617-627 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinoma

Ohara, K., Ohkuri, T., Kumai, T., Nagato, T., Nozaki, Y., Ishibashi, K., Kosaka, A., Nagata, M., Harabuchi, S., Ohara, M., Oikawa, K., Aoki, N., Harabuchi, Y., Celis, E. & Kobayashi, H., Sep 2 2018, In : OncoImmunology. 7, 9, e1466771.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Cancer immunotherapy: moving forward with peptide T cell vaccines

Kumai, T., Fan, A., Harabuchi, Y. & Celis, E., Aug 2017, In : Current Opinion in Immunology. 47, p. 57-63 7 p.

Research output: Contribution to journalReview article

23 Scopus citations

Designing therapeutic cancer vaccines by mimicking viral infections

Sultan, H., Fesenkova, V. I., Addis, D., Fan, A. E., Kumai, T., Wu, J., Salazar, A. M. & Celis, E., Feb 1 2017, In : Cancer Immunology, Immunotherapy. 66, 2, p. 203-213 11 p.

Research output: Contribution to journalReview article

15 Scopus citations

Effective antitumor peptide vaccines can induce severe autoimmune pathology

Sultan, H., Trillo-Tinoco, J., Rodriguez, P. & Celis, E., Jan 1 2017, In : Oncotarget. 8, 41, p. 70317-70331 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Enhanced therapeutic efficacy and memory of tumor-specific CD8 T cells by ex vivo PI3K-δ inhibition

Abu Eid, R., Ahmad, S., Lin, Y., Webb, M., Berrong, Z., Shrimali, R. K., Kumai, T., Ananth, S., Rodriguez, P. C., Celis, E., Janik, J. E., Mkrtichyan, M. & Khleif, S. N., Aug 1 2017, In : Cancer Research. 77, 15, p. 4135-4145 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Intratumoral administration of cGAMP transiently accumulates potent macrophages for anti-tumor immunity at a mouse tumor site

Ohkuri, T., Kosaka, A., Ishibashi, K., Kumai, T., Hirata, Y., Ohara, K., Nagato, T., Oikawa, K., Aoki, N., Harabuchi, Y., Celis, E. & Kobayashi, H., Jun 1 2017, In : Cancer Immunology, Immunotherapy. 66, 6, p. 705-716 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

Veglia, F., Tyurin, V. A., Mohammadyani, D., Blasi, M., Duperret, E. K., Donthireddy, L., Hashimoto, A., Kapralov, A., Amoscato, A., Angelini, R., Patel, S., Alicea-Torres, K., Weiner, D., Murphy, M. E., Klein-Seetharaman, J., Celis, E., Kagan, V. E. & Gabrilovich, D. I., Dec 1 2017, In : Nature communications. 8, 1, 2122.

Research output: Contribution to journalArticle

28 Scopus citations

Local activation of p53 in the tumor microenvironment overcomes immune suppression and enhances antitumor immunity

Guo, G., Yu, M., Xiao, W., Celis, E. & Cui, Y., May 1 2017, In : Cancer Research. 77, 9, p. 2292-2305 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

Optimization of peptide vaccines to induce robust antitumor CD4 T-cell responses

Kumai, T., Lee, S., Cho, H. I., Sultan, H., Kobayashi, H., Harabuchi, Y. & Celis, E., Jan 2017, In : Cancer Immunology Research. 5, 1, p. 72-83 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Peptide vaccines in cancer — old concept revisited

Kumai, T., Kobayashi, H., Harabuchi, Y. & Celis, E., Apr 1 2017, In : Current Opinion in Immunology. 45, p. 1-7 7 p.

Research output: Contribution to journalReview article

38 Scopus citations

Programmed death-ligand 1 and its soluble form are highly expressed in nasal natural killer/T-cell lymphoma: a potential rationale for immunotherapy

Nagato, T., Ohkuri, T., Ohara, K., Hirata, Y., Kishibe, K., Komabayashi, Y., Ueda, S., Takahara, M., Kumai, T., Ishibashi, K., Kosaka, A., Aoki, N., Oikawa, K., Uno, Y., Akiyama, N., Sado, M., Takei, H., Celis, E., Harabuchi, Y. & Kobayashi, H., Jul 1 2017, In : Cancer Immunology, Immunotherapy. 66, 7, p. 877-890 14 p.

Research output: Contribution to journalArticle

47 Scopus citations
2016

CD4 T Cells in Antitumor Immunity

Fesenkova, V., Sultan, H. & Celis, E., Apr 27 2016, Immunity to Pathogens and Tumors. Elsevier Inc., Vol. 4. p. 441-450 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Editorial: A matter of survival: HMGB1 regulates autophagy in tumor MDSC

Kumai, T., Celis, E. & Rodriguez, P. C., Sep 2016, In : Journal of Leukocyte Biology. 100, 3, p. 447-449 3 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Epigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy

Ishibashi, K., Kumai, T., Ohkuri, T., Kosaka, A., Nagato, T., Hirata, Y., Ohara, K., Oikawa, K., Aoki, N., Akiyama, N., Sado, M., Kitada, M., Harabuchi, Y., Celis, E. & Kobayashi, H., Jun 2 2016, In : OncoImmunology. 5, 6, e1169356.

Research output: Contribution to journalArticle

8 Scopus citations

T cells conditioned with MDSC show an increased anti-tumor activity after adoptive T cell based immunotherapy

Raber, P. L., Sierra, R. A., Thevenot, P. T., Shuzhong, Z., Wyczechowska, D. D., Kumai, T., Celis, E. & Rodriguez, P. C., Jan 1 2016, In : Oncotarget. 7, 14, p. 17565-17578 14 p.

Research output: Contribution to journalArticle

11 Scopus citations