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  • 2020
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  • Ruth B Caldwell
2020

Arginase Pathway in Acute Retina and Brain Injury: Therapeutic Opportunities and Unexplored Avenues

Fouda, A. Y., Eldahshan, W., Narayanan, S. P., Caldwell, R. W. & Caldwell, R. B., Mar 17 2020, In : Frontiers in Pharmacology. 11, 277.

Research output: Contribution to journalReview article

Open Access

Utility of LysM-Cre and CdH5-Cre driver mice in retinal and brain research: An imaging study using tdtomato reporter mouse

Fouda, A. Y., Xu, Z., Priya Narayanan, S., William Caldwell, R. & Caldwell, R. B., Mar 2020, In : Investigative Ophthalmology and Visual Science. 61, 3, 51.

Research output: Contribution to journalArticle

Open Access
2019

Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress

Lv, H., Zhu, C., Wu, R., Ni, H., Lian, J., Xu, Y., Xia, Y., Shi, G., Li, Z., Caldwell, R. B., Caldwell, R. W., Yao, L. & Chen, Y., Jul 2019, In : Journal of Psychiatric Research. 114, p. 55-66 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis

Palani, C. D., Fouda, A. Y., Liu, F., Xu, Z., Mohamed, E., Giri, S., Smith, S. B., Caldwell, R. B. & Narayanan, S. P., Dec 1 2019, In : Molecular Neurobiology. 56, 12, p. 8589-8602 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mechanisms of obesity-induced metabolic and vascular dysfunctions

Atawia, R. T., Bunch, K. L., Toque, H. A., Caldwell, R. B. & Caldwell, R. W., Mar 1 2019, In : Frontiers in Bioscience - Landmark. 24, 5, p. 890-934 45 p.

Research output: Contribution to journalArticle

6 Scopus citations
Open Access
3 Scopus citations

Targeting polyamine oxidase to prevent excitotoxicity-induced retinal neurodegeneration

Pichavaram, P., Palani, C. D., Patel, C., Xu, Z., Shosha, E., Fouda, A. Y., Caldwell, R. B. & Narayanan, S. P., Jan 1 2019, In : Frontiers in Neuroscience. 13, JAN, 956.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Arginase: A multifaceted enzyme important in health and disease

Caldwell, R. W., Rodriguez, P. C., Flores Toque, H. A., Narayanan, S. P. & Caldwell, R. B., Apr 1 2018, In : Physiological reviews. 98, 2, p. 641-665 25 p.

Research output: Contribution to journalReview article

39 Scopus citations

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In : Cell Death and Disease. 9, 10, 1001.

Research output: Contribution to journalArticle

6 Scopus citations

Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy

Rojas, M. A., Shen, Z. T., Caldwell, R. B. & Sigalov, A. B., Sep 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 9, p. 2761-2768 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Mechanisms of diabetes-induced endothelial cell senescence: Role of arginase 1

Shosha, E., Xu, Z., Priya Narayanan, S., Lemtalsi, T., Fouda, A. Y., Rojas, M., Xing, J., Fulton, D., William Caldwell, R. & Caldwell, R. B., Apr 17 2018, In : International journal of molecular sciences. 19, 4, 1215.

Research output: Contribution to journalArticle

5 Scopus citations

Neurofibromin deficiency induces endothelial cell proliferation and retinal neovascularization

Zhang, H., Hudson, F. Z., Xu, Z., Tritz, R., Rojas, M., Patel, C., Haigh, S. B., Bordán, Z., Ingram, D. A., Fulton, D. J., Weintraub, N. L., Caldwell, R. B. & Stansfield, B. K., May 2018, In : Investigative Ophthalmology and Visual Science. 59, 6, p. 2520-2528 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Correction: Diabetes-induced superoxide anion and breakdown of the blood-retinal barrier: Role of the VEGF/uPAR pathway (PLoS ONE (2013) 8:8 (e71868) DOI: 10.1371/journal.pone.0071868)

El-Remessy, A. B., Franklin, T., Ghaley, N., Yang, J., Brands, M. W., Caldwell, R. B. & Behzadian, M. A., Oct 2017, In : PloS one. 12, 10, e0186749.

Research output: Contribution to journalComment/debate

Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis

Liu, Z., Yan, S., Wang, J., Xu, Y., Wang, Y., Zhang, S., Xu, X., Yang, Q., Zeng, X., Zhou, Y., Gu, X., Lu, S., Fu, Z., Fulton, D. J., Weintraub, N. L., Caldwell, R. B., Zhang, W., Wu, C., Liu, X. L., Chen, J. F. & 10 others, Ahmad, A., Kaddour-Djebbar, I., Al-Shabrawey, M., Li, Q., Jiang, X., Sun, Y., Sodhi, A., Smith, L., Hong, M. & Huo, Y., Dec 1 2017, In : Nature communications. 8, 1, 584.

Research output: Contribution to journalArticle

20 Scopus citations

Netrin-1 is a novel regulator of vascular endothelial function in diabetes

Toque, H. A., Fernandez-Flores, A., Mohamed, R., Caldwell, R. B., Ramesh, G. & Caldwell, R. W., Oct 2017, In : PloS one. 12, 10, e0186734.

Research output: Contribution to journalArticle

7 Scopus citations

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

Bhatta, A., Yao, L., Xu, Z., Toque, H. A., Chen, J., Atawia, R. T., Fouda, A. Y., Bagi, Z., Lucas, R., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In : Cardiovascular Research. 113, 13, p. 1664-1676 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Obesity-induced vascular inflammation involves elevated arginase activity

Yao, L., Bhatta, A., Xu, Z., Chen, J., Toque, H. A., Chen, Y., Xu, Y., Bagi, Z., Lucas, R., Huo, Y., Caldwell, R. B. & Caldwell, R. W., Nov 2017, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 313, 5, p. R560-R571

Research output: Contribution to journalArticle

11 Scopus citations
2016

Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury

Shosha, E., Xu, Z., Yokota, H., Saul, A., Rojas, M., William Caldwell, R., Caldwell, R. B. & Priya Narayanan, S., Jan 1 2016, In : Cell Death and Disease. 7, 11, e2483.

Research output: Contribution to journalArticle

18 Scopus citations

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

Bhatta, A., Sangani, R., Kolhe, R. B., Flores Toque, H. A., Cain, M., Wong, A., Howie, N., Shinde, R., Elsalanty, M. E., Yao, L., Chutkan, N., Hunter, M., Caldwell, R. B., Isales, C. M., Caldwell, R. W. & Fulzele, S. T., Feb 15 2016, In : Molecular and Cellular Endocrinology. 422, p. 211-220 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Neuroprotective effect of water-dispersible hesperetin in retinal ischemia reperfusion injury

Shimouchi, A., Yokota, H., Ono, S., Matsumoto, C., Tamai, T., Takumi, H., Narayanan, S. P., Kimura, S., Kobayashi, H., Caldwell, R. B., Nagaoka, T. & Yoshida, A., Jan 1 2016, In : Japanese Journal of Ophthalmology. 60, 1, p. 51-61 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
3 Scopus citations

Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy

Patel, C., Xu, Z., Shosha, E., Xing, J., Lucas, R., Caldwell, R. W., Caldwell, R. B. & Narayanan, S. P., Sep 1 2016, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 9, p. 1628-1639 12 p.

Research output: Contribution to journalArticle

5 Scopus citations