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2019

Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress

Lv, H., Zhu, C., Wu, R., Ni, H., Lian, J., Xu, Y., Xia, Y., Shi, G., Li, Z., Caldwell, R. B., Caldwell, R. W., Yao, L. & Chen, Y., Jul 2019, In : Journal of Psychiatric Research. 114, p. 55-66 12 p.

Research output: Contribution to journalArticle

Oxidative Stress
Anxiety
Anxiety Disorders
Pyramidal Cells
NADP
Arginase
Vasodilation
Hyperglycemia
p38 Mitogen-Activated Protein Kinases
Phosphotransferases
2 Citations (Scopus)

Mechanisms of obesity-induced metabolic and vascular dysfunctions

Atawia, R. T., Bunch, K. L., Flores Toque, H. A., Caldwell, R. B. & Caldwell, R. W., Mar 1 2019, In : Frontiers in Bioscience - Landmark. 24, 5, p. 890-934 45 p.

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Nitric Oxide
Adipocytes
Obesity
1 Citation (Scopus)

Regulation of MAP kinase-mediated endothelial dysfunction in hyperglycemia via arginase I and eNOS dysregulation

Mazrouei, S., Sharifpanah, F., Caldwell, R. W., Franz, M., Shatanawi, A., Muessig, J., Fritzenwanger, M., Schulze, P. C. & Jung, C., Sep 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 9, p. 1398-1411 14 p.

Research output: Contribution to journalArticle

Arginase
Hyperglycemia
Phosphotransferases
p38 Mitogen-Activated Protein Kinases
Phosphorylation
2 Citations (Scopus)
Open Access
adipose tissues
Arginase
Obese Mice
diets
sucrose

The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

Madaio, M. P., Czikora, I., Kvirkvelia, N., McMenamin, M., Yue, Q., Liu, T., Flores Toque, H. A., Sridhar, S., Covington, K., Alaisami, R., O'Connor, P. M., Caldwell, R. W., Chen, J., Clauss, M., Brands, M. W., Eaton, D. C., Romero Lucas, M. J. & Lucas, R., Jun 2019, In : Kidney International. 95, 6, p. 1359-1372 14 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Nephritis
Tumor Necrosis Factor-alpha
Peptides
Serum
2018
22 Citations (Scopus)

Arginase: A multifaceted enzyme important in health and disease

Caldwell, R. W., Rodriguez, P. C., Flores Toque, H. A., Narayanan, S. P. & Caldwell, R. B., Apr 1 2018, In : Physiological reviews. 98, 2, p. 641-665 25 p.

Research output: Contribution to journalReview article

Arginase
Health
Enzymes
Ornithine
Urea
3 Citations (Scopus)

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In : Cell Death and Disease. 9, 10, 1001.

Research output: Contribution to journalArticle

Arginase
Ischemia
Macrophages
Reperfusion Injury
Knockout Mice
3 Citations (Scopus)

Mechanisms of diabetes-induced endothelial cell senescence: Role of arginase 1

Shosha, E., Xu, Z., Priya Narayanan, S., Lemtalsi, T., Fouda, A. Y., Rojas, M., Xing, J., Fulton, D., William Caldwell, R. & Caldwell, R. B., Apr 17 2018, In : International journal of molecular sciences. 19, 4, 1215.

Research output: Contribution to journalArticle

Arginase
Cell Aging
Endothelial cells
Medical problems
Endothelial Cells
2017
7 Citations (Scopus)

Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock

Subramani, K., Lu, S., Warren, M., Chu, X., Flores Toque, H. A., Caldwell, R. W., Diamond, M. P. & Raju, R. P., Dec 1 2017, In : Scientific Reports. 7, 1, 2653.

Research output: Contribution to journalArticle

Hemorrhagic Shock
Resuscitation
AMP-Activated Protein Kinases
Wounds and Injuries
Orphan Drug Production
7 Citations (Scopus)

Netrin-1 is a novel regulator of vascular endothelial function in diabetes

Toque, H. A., Fernandez-Flores, A., Mohamed, R., Caldwell, R. B., Ramesh, G. & Caldwell, R. W., Oct 2017, In : PloS one. 12, 10, e0186734.

Research output: Contribution to journalArticle

Medical problems
blood vessels
Blood Vessels
diabetes
aorta
24 Citations (Scopus)

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

Bhatta, A., Yao, L., Xu, Z., Toque, H. A., Chen, J., Atawia, R. T., Fouda, A. Y., Bagi, Z., Lucas, R., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In : Cardiovascular Research. 113, 13, p. 1664-1676 13 p.

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Endothelial Cells
Obesity
Sucrose
8 Citations (Scopus)

Obesity-induced vascular inflammation involves elevated arginase activity

Yao, L., Bhatta, A., Xu, Z., Chen, J., Toque, H. A., Chen, Y., Xu, Y., Bagi, Z., Lucas, R., Huo, Y., Caldwell, R. B. & Caldwell, R. W., Nov 2017, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 313, 5, p. R560-R571

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Intra-Abdominal Fat
Obesity
Inflammation
2016
14 Citations (Scopus)

Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury

Shosha, E., Xu, Z., Yokota, H., Saul, A., Rojas, M., William Caldwell, R., Caldwell, R. B. & Priya Narayanan, S., Jan 1 2016, In : Cell Death and Disease. 7, 11, e2483.

Research output: Contribution to journalArticle

Arginase
Reperfusion Injury
Ischemia
Reperfusion
Electroretinography
9 Citations (Scopus)

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

Bhatta, A., Sangani, R., Kolhe, R. B., Flores Toque, H. A., Cain, M., Wong, A., Howie, N., Shinde, R., Elsalanty, M. E., Yao, L., Chutkan, N., Hunter, M., Caldwell, R. B., Isales, C. M., Caldwell, R. W. & Fulzele, S. T., Feb 15 2016, In : Molecular and Cellular Endocrinology. 422, p. 211-220 10 p.

Research output: Contribution to journalArticle

Arginase
Deregulation
High Fat Diet
Nutrition
Sucrose
5 Citations (Scopus)

Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy

Patel, C., Xu, Z., Shosha, E., Xing, J., Lucas, R., Caldwell, R. W., Caldwell, R. B. & Narayanan, S. P., Sep 1 2016, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 9, p. 1628-1639 12 p.

Research output: Contribution to journalArticle

Hyperoxia
Vascular System Injuries
Retinal Vessels
Endothelial Cells
Polyamines