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2020
1 Citation (Scopus)

The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking β-catenin target gene expression

Cai, J., Liu, Z., Huang, X., Shu, S., Hu, X., Zheng, M., Tang, C., Liu, Y., Chen, G., Sun, L., Liu, H., Liu, F., Cheng, J. & Dong, Z., Jan 2020, In : Kidney International. 97, 1, p. 106-118 13 p.

Research output: Contribution to journalArticle

Catenins
Fibrosis
Kidney
Gene Expression
Transforming Growth Factors
2019
2 Citations (Scopus)

Aberrant DNA methylation of mTOR pathway genes promotes inflammatory activation of immune cells in diabetic kidney disease

Chen, G., Chen, H., Ren, S., Xia, M., Zhu, J., Liu, Y., Zhang, L., Tang, L., Sun, L., Liu, H. & Dong, Z., Aug 2019, In : Kidney International. 96, 2, p. 409-420 12 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
DNA Methylation
Sirolimus
Methyltransferases
Cytosine
2 Citations (Scopus)

Activation of BNIP3-mediated mitophagy protects against renal ischemia–reperfusion injury

Tang, C., Han, H., Liu, Z., Liu, Y., Yin, L., Cai, J., He, L., Liu, Y., Chen, G., Zhang, Z., Yin, X. M. & Dong, Z., Sep 1 2019, In : Cell Death and Disease. 10, 9, 677.

Research output: Contribution to journalArticle

Open Access
Proto-Oncogene Proteins c-bcl-2
Mitochondrial Degradation
Kidney
Wounds and Injuries
Acute Kidney Injury
1 Citation (Scopus)

Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

Cho, S. G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S., Huang, S., Ding, H. F., Yoon, Y., Kirken, R. A., Yin, X. M., Wang, H. G. & Dong, Z., Jul 2019, In : Journal of the American Society of Nephrology. 30, 7, p. 1174-1191 18 p.

Research output: Contribution to journalArticle

Mitochondrial Membranes
Apoptosis
Proteolysis
Mitochondrial Dynamics
Kidney
1 Citation (Scopus)

Cell Apoptosis and Autophagy in Renal Fibrosis

Zhao, X. C., Livingston, M. J., Liang, X. L. & Dong, Z., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 557-584 28 p. (Advances in Experimental Medicine and Biology; vol. 1165).

Research output: Chapter in Book/Report/Conference proceedingChapter

Autophagy
Fibrosis
Apoptosis
Kidney
Kidney Diseases

Chronic effects of repeated low-dose cisplatin treatment in mouse kidneys and renal tubular cells

Fu, Y., Cai, J., Li, F., Liu, Z., Shu, S., Wang, Y., Liu, Y., Tang, C. & Dong, Z., Dec 1 2019, In : American journal of physiology. Renal physiology. 317, 6, p. F1582-F1592

Research output: Contribution to journalArticle

Cisplatin
Kidney
Chronic Renal Insufficiency
Therapeutics
Fibrosis
1 Citation (Scopus)

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

Livingston, M. J., Wang, J., Zhou, J., Wu, G., Ganley, I. G., Hill, J. A., Yin, X. M. & Dong, Z., Dec 2 2019, In : Autophagy. 15, 12, p. 2142-2162 21 p.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Degradation
Ischemic Preconditioning
Mitochondria
Autophagy
Kidney
5 Citations (Scopus)

Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications

Guo, C., Dong, G., Liang, X. & Dong, Z., Apr 1 2019, In : Nature Reviews Nephrology. 15, 4, p. 220-239 20 p.

Research output: Contribution to journalReview article

Acute Kidney Injury
Epigenomics
Kidney
DNA Methylation
MicroRNAs
1 Citation (Scopus)

Epigenetic Regulation in Kidney Toxicity: Insights From Cisplatin Nephrotoxicity

Xiang, X., Guo, C., Tang, C., Cai, J. & Dong, Z., Mar 2019, In : Seminars in Nephrology. 39, 2, p. 152-158 7 p.

Research output: Contribution to journalReview article

Epigenomics
Cisplatin
Kidney
Histone Code
Untranslated RNA

Erratum: HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers(J Clin Invest. (2018)128:6(2419–2435) DOI: 10.1172/JCI91814)

Khambu, B., Huda, N., Chen, X., Antoine, D. J., Li, Y., Dai, G., Köhler, U. A., Zong, W. X., Waguri, S., Werner, S., Oury, T. D., Dong, Z. & Yin, X. M., May 1 2019, In : Journal of Clinical Investigation. 129, 5, 1 p.

Research output: Contribution to journalComment/debate

HMGB1 Protein
Autophagy
Mass Spectrometry
Carcinogenesis
Liver
Glycolysis
Fibrosis
Fibroblasts
Kidney
Ureteral Obstruction
5 Citations (Scopus)

Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury

Khambu, B., Li, T., Yan, S., Yu, C., Chen, X., Goheen, M., Li, Y., Lin, J., Cummings, O. W., Lee, Y. A., Friedman, S., Dong, Z., Feng, G. S., Wu, S. & Yin, X. M., May 2019, In : Hepatology. 69, 5, p. 2196-2213 18 p.

Research output: Contribution to journalArticle

Autophagy
Liver
Wounds and Injuries
Bile Acids and Salts
Genes
1 Citation (Scopus)

Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation

Yang, L., Zha, Y., Ding, J., Ye, B., Liu, M., Yan, C., Dong, Z., Cui, H. & Ding, H. F., Jan 1 2019, In : Oncogenesis. 8, 1, 3.

Research output: Contribution to journalArticle

Histone Demethylases
Neuroblastoma
Epigenomics
Cell Differentiation
Histones

Identification of key biomarkers in diabetic nephropathy via bioinformatic analysis

Zeng, M., Liu, J., Yang, W., Zhang, S., Liu, F., Dong, Z., Peng, Y., Sun, L. & Xiao, L., May 1 2019, In : Journal of cellular biochemistry. 120, 5, p. 8676-8688 13 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Biomarkers
Bioinformatics
Computational Biology
Genes
6 Citations (Scopus)

Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway

Xia, Y., Ye, B., Ding, J., Yu, Y., Alptekin, A., Thangaraju, M., Prasad, P. D., Ding, Z. C., Park, E. J., Choi, J. H., Gao, B., Fiehn, O., Yan, C., Dong, Z., Zha, Y. & Ding, H. F., Aug 1 2019, In : Cancer Research. 79, 15, p. 3837-3850 14 p.

Research output: Contribution to journalArticle

Open Access
Physiological Stress
Biosynthetic Pathways
Glycine
Serine
Carbon
2 Citations (Scopus)

Multiple-microarray analysis for identification of hub genes involved in tubulointerstial injury in diabetic nephropathy

Zeng, M., Liu, J., Yang, W., Zhang, S., Liu, F., Dong, Z., Peng, Y., Sun, L. & Xiao, L., Sep 1 2019, In : Journal of Cellular Physiology. 234, 9, p. 16447-16462 16 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Microarray Analysis
Microarrays
Genes
Wounds and Injuries
3 Citations (Scopus)

Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation

Zheng, M., Cai, J., Liu, Z., Shu, S., Wang, Y., Tang, C. & Dong, Z., Jun 2019, In : Journal of Cellular and Molecular Medicine. 23, 6, p. 3995-4004 10 p.

Research output: Contribution to journalArticle

Open Access
Niacinamide
Fibrosis
Inflammation
Kidney
Wounds and Injuries

p53-cyclophilin D mediates renal tubular cell apoptosis in ischemia-reperfusion-induced acute kidney injury

Yang, H., Li, R., Zhang, L., Zhang, S., Dong, W., Chen, Y., Wang, W., Li, C., Ye, Z., Zhao, X., Li, Z., Wu, Y., Zhang, M., Liu, S., Dong, Z. & Liang, X., Nov 1 2019, In : American journal of physiology. Renal physiology. 317, 5, p. F1311-F1317

Research output: Contribution to journalArticle

Acute Kidney Injury
Reperfusion
Ischemia
Apoptosis
Kidney
6 Citations (Scopus)

P53 in kidney injury and repair: Mechanism and therapeutic potentials

Tang, C., Ma, Z., Zhu, J., Liu, Z., Liu, Y., Liu, Y., Cai, J. & Dong, Z., Mar 2019, In : Pharmacology and Therapeutics. 195, p. 5-12 8 p.

Research output: Contribution to journalReview article

Acute Kidney Injury
Kidney
Wounds and Injuries
Chronic Renal Insufficiency
Therapeutics
4 Citations (Scopus)

PFKFB3 in smooth muscle promotes vascular remodeling in pulmonary arterial hypertension

Kovacs, L., Cao, Y., Han, W., Meadows, L., Kovacs-Kasa, A., Kondrikov, D., Verin, A. D., Barman, S. A., Dong, Z., Huo, Y. & Su, Y., Sep 1 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 5, p. 617-627 11 p.

Research output: Contribution to journalArticle

Phosphofructokinase-2
Pulmonary Hypertension
Smooth Muscle
Phosphotransferases
Pulmonary Artery
1 Citation (Scopus)

RNA interference may suppress stress granule formation by preventing argonaute 2 recruitment

Lou, Q., Hu, Y., Ma, Y. & Dong, Z., Jan 1 2019, In : American Journal of Physiology - Cell Physiology. 316, 1, p. C81-C91

Research output: Contribution to journalArticle

RNA-Induced Silencing Complex
RNA Interference
Hypoxia-Inducible Factor 1
Clustered Regularly Interspaced Short Palindromic Repeats
Heat-Shock Proteins
1 Citation (Scopus)

Specific TBC Domain-Containing Proteins Control the ER-Golgi-Plasma Membrane Trafficking of GPCRs

Wei, Z., Zhang, M., Li, C., Huang, W., Fan, Y., Guo, J., Khater, M., Fukuda, M., Dong, Z., Hu, G. & Wu, G., Jul 9 2019, In : Cell Reports. 28, 2, p. 554-566.e4

Research output: Contribution to journalArticle

Open Access
Cell membranes
G-Protein-Coupled Receptors
Cell Membrane
Proteins
GTPase-Activating Proteins
Physiological Stress
Cell Survival
Kidney
Wounds and Injuries
Reperfusion
2018
20 Citations (Scopus)

Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential

Yang, D., Livingston, M. J., Liu, Z., Dong, G., Zhang, M., Chen, J. & Dong, Z., Feb 1 2018, In : Cellular and Molecular Life Sciences. 75, 4, p. 669-688 20 p.

Research output: Contribution to journalReview article

Autophagy
Diabetic Nephropathies
Therapeutics
Diabetes Complications
Organelles
1 Citation (Scopus)
Receptor-Interacting Protein Serine-Threonine Kinases
Muromegalovirus
Photoreceptor Cells
Cytomegalovirus Infections
Protein Kinases
2 Citations (Scopus)
Proximal Kidney Tubule
Fibrosis
Up-Regulation
Kidney
Wounds and Injuries
1 Citation (Scopus)

Embryonic Fate Mapping Uncovers the Critical Role of microRNAs in the Development of Epidermal γδ T Cells

Yao, Y., Liu, Q., Martin, C., Yin, C., Dong, Z., Mi, Q. S. & Zhou, L., Jan 2018, In : Journal of Investigative Dermatology. 138, 1, p. 236-239 4 p.

Research output: Contribution to journalArticle

DEAD-box RNA Helicases
Granulocyte-Macrophage Colony-Stimulating Factor Receptors
Antigen Receptors, T-Cell, gamma-delta
Ribonuclease III
T-cells
12 Citations (Scopus)

Endoplasmic reticulum stress in ischemic and nephrotoxic acute kidney injury

Yan, M., Shu, S., Guo, C., Tang, C. & Dong, Z., Jul 4 2018, In : Annals of Medicine. 50, 5, p. 381-390 10 p.

Research output: Contribution to journalReview article

Endoplasmic Reticulum Stress
Acute Kidney Injury
Unfolded Protein Response
Kidney
Protein Unfolding
8 Citations (Scopus)

Endoplasmic reticulum stress is activated in post-ischemic kidneys to promote chronic kidney disease

Shu, S., Zhu, J., Liu, Z., Tang, C., Cai, J. & Dong, Z., Nov 2018, In : EBioMedicine. 37, p. 269-280 12 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Chronic Renal Insufficiency
Acute Kidney Injury
Kidney
Transcription Factor CHOP
8 Citations (Scopus)

FGF21 is induced in cisplatin nephrotoxicity to protect against kidney tubular cell injury

Li, F., Liu, Z., Tang, C., Cai, J. & Dong, Z., Jun 2018, In : FASEB Journal. 32, 6, p. 3423-3433 11 p.

Research output: Contribution to journalArticle

Cisplatin
Kidney
Wounds and Injuries
Acute Kidney Injury
fibroblast growth factor 21
18 Citations (Scopus)

Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells

Liu, J., Livingston, M. J., Dong, G., Tang, C., Su, Y., Wu, G., Yin, X. M. & Dong, Z., Mar 1 2018, In : Cell Death and Disease. 9, 3, 322.

Research output: Contribution to journalArticle

trichostatin A
Histone Deacetylase Inhibitors
Autophagy
Acute Kidney Injury
Cisplatin
18 Citations (Scopus)

HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers

Khambu, B., Huda, N., Chen, X., Antoine, D. J., Li, Y., Dai, G., Köhler, U. A., Zong, W. X., Waguri, S., Werner, S., Oury, T. D., Dong, Z. & Yin, X. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2419-2435 17 p.

Research output: Contribution to journalArticle

Autophagy
Carcinogenesis
Hepatocytes
Liver
Inflammasomes

Inflammation and outer blood-retina barrier (BRB) compromise following choroidal murine cytomegalovirus (MCMV) infections

Xu, J., Liu, X., Mo, J., Marshall, B., Perry, L., Dong, Z. & Zhang, M., May 18 2018, In : Molecular Vision. 24, p. 379-394 16 p.

Research output: Contribution to journalArticle

Muromegalovirus
Cytomegalovirus Infections
Retina
Inflammation
Bruch Membrane
14 Citations (Scopus)

MicroRNA-668 represses MTP18 to preserve mitochondrial dynamics in ischemic acute kidney injury

Wei, Q., Sun, H., Song, S., Liu, Y., Liu, P., Livingston, M. J., Wang, J., Liang, M., Mi, Q. S., Huo, Y., Nahman, N. S., Mei, C. & Dong, Z., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5448-5464 17 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Mitochondrial Proteins
MicroRNAs
Acute Kidney Injury
Kidney
1 Citation (Scopus)

Micro RNAs are required for Langerhans cell, skin- and lung-resident macrophage ontogeny

Yao, Y., Martin, C., Yin, C., Guo, C., Dong, Z., Zhou, L. & Mi, Q. S., Sep 2018, In : Journal of Allergy and Clinical Immunology. 142, 3, p. 976-978.e2

Research output: Contribution to journalArticle

Langerhans Cells
MicroRNAs
Macrophages
Lung
Skin
1 Citation (Scopus)

Neutrophil extracellular traps in ischemic AKI: new way to kill

Liu, J. & Dong, Z., Feb 2018, In : Kidney International. 93, 2, p. 303-305 3 p.

Research output: Contribution to journalComment/debate

Infection
Kidney
Acute Kidney Injury
Neutrophils
Inflammation
12 Citations (Scopus)

PINK1/Parkin-mediated mitophagy is activated in cisplatin nephrotoxicity to protect against kidney injury

Wang, Y., Tang, C., Cai, J., Chen, G., Zhang, D., Zhang, Z. & Dong, Z., Nov 1 2018, In : Cell Death and Disease. 9, 11, 1113.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Degradation
Cisplatin
Kidney
Wounds and Injuries
Autophagy
33 Citations (Scopus)

PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury

Tang, C., Han, H., Yan, M., Zhu, S., Liu, J., Liu, Z., He, L., Tan, J., Liu, Y., Liu, H., Sun, L., Duan, S., Peng, Y., Liu, F., Yin, X. M., Zhang, Z. & Dong, Z., May 4 2018, In : Autophagy. 14, 5, p. 880-897 18 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Reperfusion Injury
Kidney
Acute Kidney Injury
Reactive Oxygen Species
6 Citations (Scopus)

PKCδ-mediated Nox2 activation promotes fluid-phase pinocytosis of antigens by immature dendritic cells

Singla, B., Ghoshal, P., Lin, H., Wei, Q., Dong, Z. & Csányi, G., Mar 26 2018, In : Frontiers in immunology. 9, MAR, 537.

Research output: Contribution to journalArticle

Pinocytosis
NADPH Oxidase
Dendritic Cells
Protein Kinase C
Antigens
2 Citations (Scopus)

Protective effect of the BET protein inhibitor JQ1 in cisplatin-induced nephrotoxicity

Sun, L., Liu, J., Yuan, Y., Zhang, I. & Dong, Z., Sep 2018, In : American Journal of Physiology - Renal Physiology. 315, 3, p. F469-F478

Research output: Contribution to journalArticle

Cisplatin
Proteins
Kidney
Acetylation
Apoptosis
12 Citations (Scopus)

Rodent models of AKI-CKD transition

Fu, Y., Tang, C., Cai, J., Chen, G., Zhang, D. & Dong, Z., Oct 5 2018, In : American Journal of Physiology - Renal Physiology. 315, 4, p. F1098-F1106

Research output: Contribution to journalReview article

Chronic Renal Insufficiency
Acute Kidney Injury
Rodentia
Reperfusion Injury
Diphtheria Toxin
8 Citations (Scopus)

Serum sclerostin in vascular calcification and clinical outcome in chronic kidney disease

Zeng, C., Guo, C., Cai, J., Tang, C. & Dong, Z., Mar 1 2018, In : Diabetes and Vascular Disease Research. 15, 2, p. 99-105 7 p.

Research output: Contribution to journalReview article

Vascular Calcification
Chronic Renal Insufficiency
Serum
Osteocytes
Wnt Signaling Pathway
3 Citations (Scopus)
STAT1 Transcription Factor
effectors
ischemia
kidneys
Reperfusion Injury
2017
47 Citations (Scopus)

AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms

He, L., Wei, Q., Liu, J., Yi, M., Liu, Y., Liu, H., Sun, L., Peng, Y., Liu, F., Venkatachalam, M. A. & Dong, Z., Nov 2017, In : Kidney International. 92, 5, p. 1071-1083 13 p.

Research output: Contribution to journalReview article

Chronic Renal Insufficiency
Acute Kidney Injury
Wounds and Injuries
Autophagy
Transforming Growth Factors
12 Citations (Scopus)

Autophagy is activated to protect against podocyte injury in adriamycin-induced nephropathy

Yi, M., Zhang, L., Liu, Y., Livingston, M. J., Chen, J., Nahman, N. S., Liu, F. & Dong, Z., Jan 1 2017, In : American Journal of Physiology - Renal Physiology. 313, 1, p. F74-F84

Research output: Contribution to journalArticle

Podocytes
Autophagy
Doxorubicin
Wounds and Injuries
Gene Knockout Techniques
10 Citations (Scopus)

DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8

Guo, C., Pei, L., Xiao, X., Wei, Q., Chen, J., Ding, H., Huang, S., Fan, G., Shi, H. & Dong, Z., Nov 2017, In : Kidney International. 92, 5, p. 1194-1205 12 p.

Research output: Contribution to journalArticle

DNA Methylation
Cisplatin
Acute Kidney Injury
Kidney
Wounds and Injuries
8 Citations (Scopus)
Urethral Obstruction
Proximal Kidney Tubule
Fibrosis
Apoptosis
Kidney
13 Citations (Scopus)

Exosome production and its regulation of EGFR during wound healing in renal tubular cells

Zhou, X., Zhang, W., Yao, Q., Zhang, H., Dong, G., Zhang, M., Liu, Y., Chen, J. & Dong, Z., Jan 1 2017, In : American Journal of Physiology - Renal Physiology. 312, 6, p. F963-F970

Research output: Contribution to journalArticle

Exosomes
Wound Healing
Kidney
Epidermal Growth Factor
Growth Factor Receptors
3 Citations (Scopus)

Genetic or pharmacologic inhibition of EGFR ameliorates sepsisinduced AKI

Xu, X., Wang, J., Yang, R., Dong, Z. & Zhang, D., Jan 1 2017, In : Oncotarget. 8, 53, p. 91577-91592 16 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Apoptosis
Cytokines
Kidney
Endotoxemia
20 Citations (Scopus)

HIF-1-mediated production of exosomes during hypoxia is protective in renal tubular cells

Zhang, W., Zhou, X., Yao, Q., Liu, Y., Zhang, H. & Dong, Z., Oct 2017, In : American Journal of Physiology - Renal Physiology. 313, 4, p. F906-F913

Research output: Contribution to journalArticle

Exosomes
Hypoxia-Inducible Factor 1
Kidney
Hypoxia
Adenosine Triphosphate