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2020

Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton

Hagan, M. L., Yu, K., Zhu, J., Vinson, B. N., Roberts, R. L., Montesinos Cartagena, M., Johnson, M. H., Wang, L., Isales, C. M., Hamrick, M. W., McNeil, P. L. & McGee-Lawrence, M. E., Jan 1 2020, In : Aging Cell. 19, 1, e13056.

Research output: Contribution to journalArticle

Open Access
Osteocytes
Skeleton
Cell Membrane
Oxidative Stress
Bone and Bones

Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo

Pierce, J. L., Roberts, R. L., Yu, K., Kendall, R. K., Kaiser, H., Davis, C., Johnson, M. H., Hill, W. D., Isales, C. M., Bollag, W. B., Hamrick, M. W. & McGee-Lawrence, M. E., Feb 2020, In : Experimental Gerontology. 130, 110818.

Research output: Contribution to journalArticle

Kynurenine
Osteoblasts
Energy Metabolism
Bone
Aging of materials
2019

Delayed Administration of Angiotensin II Type 2 Receptor (AT2R) Agonist Compound 21 Prevents the Development of Post-stroke Cognitive Impairment in Diabetes Through the Modulation of Microglia Polarization

Jackson, L., Dong, G., Althomali, W., Sayed, M. A., Eldahshan, W., Baban, B., Johnson, M. H., Filosa, J., Fagan, S. C. & Ergul, A., Jan 1 2019, (Accepted/In press) In : Translational Stroke Research.

Research output: Contribution to journalArticle

Angiotensin Type 2 Receptor
Microglia
Stroke
Demyelinating Diseases
Inflammation
2 Citations (Scopus)

Inhibition of Osteocyte Membrane Repair Activity via Dietary Vitamin E Deprivation Impairs Osteocyte Survival

Hagan, M. L., Bahraini, A., Pierce, J. L., Bass, S. M., Yu, K., Elsayed, R., Elsalanty, M. E., Johnson, M. H., McNeil, A., McNeil, P. L. & McGee Lawrence, M. E., Feb 15 2019, In : Calcified Tissue International. 104, 2, p. 224-234 11 p.

Research output: Contribution to journalArticle

Osteocytes
Vitamin E
Cell Membrane
Membranes
Diet
1 Citation (Scopus)
Open Access
Kynurenine
Muscular Atrophy
Metabolites
Tryptophan
Lipid Peroxidation
4 Citations (Scopus)

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

Fulzele, S. T., Mendhe, B., Khayrullin, A., Johnson, M. H., Kaiser, H., Liu, Y., Isales, C. M. & Hamrick, M. W., Mar 31 2019, In : Aging. 11, 6, p. 1791-1803 13 p.

Research output: Contribution to journalArticle

Bone Marrow Cells
Stem Cells
Muscles
Mesenchymal Stromal Cells
MicroRNAs
2018
1 Citation (Scopus)
Osteogenesis
Bone Density
Protein Kinases
Minerals
Bone

Protein kinase D1 conditional null mice show minimal bone loss following ovariectomy

Bollag, W. B., Ding, K., Choudhary, V., Xu, J., Zhong, Q., Elsayed, R., Bailey, L. J., Elsalanty, M. E., Yu, K., Johnson, M. H., McGee Lawrence, M. E. & Isales, C. M., Oct 15 2018, In : Molecular and Cellular Endocrinology. 474, p. 176-183 8 p.

Research output: Contribution to journalArticle

Ovariectomy
Protein Kinases
Bone
Bone and Bones
Knockout Mice
2 Citations (Scopus)

Soy phosphatidylglycerol reduces inflammation in a contact irritant ear edema mouse model in vivo

Xie, D., Choudhary, V., Seremwe, M., Edwards, J. G., Wang, A., Emmons, A. C., Bollag, K. A., Johnson, M. H. & Bollag, W. B., Jul 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 366, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Phosphatidylglycerols
Irritants
Ear
Edema
Inflammation
2017
7 Citations (Scopus)

Enhanced VEGF signalling mediates cerebral neovascularisation via downregulation of guidance protein ROBO4 in a rat model of diabetes

Abdelsaid, M., Coucha, M., Hafez, S., Yasir, A., Johnson, M. H. & Ergul, A., Apr 1 2017, In : Diabetologia. 60, 4, p. 740-750 11 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Down-Regulation
Integrins
Endothelial Cells
Brain
22 Citations (Scopus)

Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss

Refaey, M. E., McGee-Lawrence, M. E., Fulzele, S., Kennedy, E. J., Bollag, W. B., Elsalanty, M., Zhong, Q., Ding, K. H., Bendzunas, N. G., Shi, X. M., Xu, J., Hill, W. D., Johnson, M. H., Hunter, M., Pierce, J. L., Yu, K., Hamrick, M. W. & Isales, C. M., Nov 2017, In : Journal of Bone and Mineral Research. 32, 11, p. 2182-2193 12 p.

Research output: Contribution to journalArticle

Kynurenine
Tryptophan
Bone and Bones
Aromatic Amino Acids
Anabolic Agents
3 Citations (Scopus)

Mechanisms of acute neurovascular protection with AT1 blockade after stroke: Effect of prestroke hypertension

Alhusban, A., Kozak, A., Pillai, B., Ahmed, H., Sayed, M. A., Johnson, M. H., Ishrat, T., Ergul, A. & Fagan, S. C., Jun 2017, In : PloS one. 12, 6, e0178867.

Research output: Contribution to journalArticle

stroke
hypertension
ischemia
Stroke
Hypertension
36 Citations (Scopus)
Cell Aging
Cell proliferation
Stem cells
MicroRNAs
Mesenchymal Stromal Cells
2016
30 Citations (Scopus)

Effect of topical intranasal therapy on epistaxis frequency in patients with hereditary hemorrhagic telangiectasia: A randomized clinical trial

Whitehead, K. J., Sautter, N. B., McWilliams, J. P., Chakinala, M. M., Merlo, C. A., Johnson, M. H., James, M., Everett, E. M., Clancy, M. S., Faughnan, M. E., Oh, S. P., Olitsky, S. E., Pyeritz, R. E. & Gossage, J. R., Jan 1 2016, In : JAMA - Journal of the American Medical Association. 316, 9, p. 943-951 9 p.

Research output: Contribution to journalArticle

Hereditary Hemorrhagic Telangiectasia
Epistaxis
Randomized Controlled Trials
Tranexamic Acid
Estriol
14 Citations (Scopus)

Linagliptin treatment improves cerebrovascular function and remodeling and restores reduced cerebral perfusion in Type 2 diabetes

Hardigan, T., Yasir, A., Abdelsaid, M., Coucha, M., El-Shaffey, S., Li, W., Johnson, M. H. & Ergul, A., Jan 1 2016, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 311, 3, p. R466-R477

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Perfusion
Insulin
Blood Glucose
Learning
23 Citations (Scopus)

Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke

Hafez, S., Abdelsaid, M., El-Shafey, S., Johnson, M. H., Fagan, S. C. & Ergul, A., Mar 1 2016, In : Stroke. 47, 3, p. 843-851 9 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 3
Metalloproteases
Stroke
Hyperglycemia
Reperfusion
6 Citations (Scopus)

Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle

Coucha, M., Abdelsaid, M., Li, W., Johnson, M. H., Orfi, L., El-Remessy, A. B., Fagan, S. C. & Ergul, A., Oct 15 2016, In : Life sciences. 163, p. 46-54 9 p.

Research output: Contribution to journalArticle

Actin Cytoskeleton
Smooth Muscle
Muscle
Actins
Depolymerization
4 Citations (Scopus)

VLDL-activated cell signaling pathways that stimulate adrenal cell aldosterone production

Tsai, Y. Y., Rainey, W. E., Johnson, M. H. & Bollag, W. B., Sep 15 2016, In : Molecular and Cellular Endocrinology. 433, p. 138-146 9 p.

Research output: Contribution to journalArticle

Cell signaling
VLDL Lipoproteins
Aldosterone
Hypertension
Obesity