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2020

Accumulation of kynurenine elevates oxidative stress and alters microRNA profile in human bone marrow stromal cells

Dalton, S., Smith, K., Singh, K., Kaiser, H., Kolhe, R., Mondal, A. K., Khayrullin, A., Isales, C. M., Hamrick, M. W., Hill, W. D. & Fulzele, S., Feb 2020, In : Experimental Gerontology. 130, 110800.

Research output: Contribution to journalArticle

Kynurenine
Oxidative stress
MicroRNAs
Mesenchymal Stromal Cells
Bone

Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton

Hagan, M. L., Yu, K., Zhu, J., Vinson, B. N., Roberts, R. L., Montesinos Cartagena, M., Johnson, M. H., Wang, L., Isales, C. M., Hamrick, M. W., McNeil, P. L. & McGee-Lawrence, M. E., Jan 1 2020, In : Aging Cell. 19, 1, e13056.

Research output: Contribution to journalArticle

Open Access
Osteocytes
Skeleton
Cell Membrane
Oxidative Stress
Bone and Bones

Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway

Kondrikov, D., Elmansi, A., Bragg, R. T., Mobley, T., Barrett, T., Eisa, N., Kondrikova, G., Schoeinlein, P., Aguilar-Perez, A., Shi, X. M., Fulzele, S., Lawrence, M. M. G., Hamrick, M., Isales, C. & Hill, W., Feb 2020, In : Experimental Gerontology. 130, 110805.

Research output: Contribution to journalArticle

Kynurenine
Aryl Hydrocarbon Receptors
Autophagy
Stem cells
Mesenchymal Stromal Cells

Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan

Kaiser, H., Parker, E. & Hamrick, M. W., Feb 2020, In : Experimental Gerontology. 130, 110797.

Research output: Contribution to journalReview article

Kynurenine
Aryl Hydrocarbon Receptors
Aging of materials
Inflammation
Tryptophan

Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo

Pierce, J. L., Roberts, R. L., Yu, K., Kendall, R. K., Kaiser, H., Davis, C., Johnson, M. H., Hill, W. D., Isales, C. M., Bollag, W. B., Hamrick, M. W. & McGee-Lawrence, M. E., Feb 2020, In : Experimental Gerontology. 130, 110818.

Research output: Contribution to journalArticle

Kynurenine
Osteoblasts
Energy Metabolism
Bone
Aging of materials
2019

Age-dependent oxidative stress elevates arginase 1 and uncoupled nitric oxide synthesis in skeletal muscle of aged mice

Pandya, C. D., Lee, B., Toque, H. A., Mendhe, B., Bragg, R. T., Pandya, B., Atawia, R. T., Isales, C., Hamrick, M., Caldwell, R. W. & Fulzele, S., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 1704650.

Research output: Contribution to journalArticle

Open Access
Arginase
Oxidative stress
Muscle
Nitric Oxide
Skeletal Muscle

Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture

Kim, B. J., Yoo, H. J., Park, S. J., Kwak, M. K., Lee, S. H., Kim, S. J., Hamrick, M. W., Isales, C. M., Ahn, S. H. & Koh, J. M., May 1 2019, In : Osteoporosis International. 30, 5, p. 1071-1078 8 p.

Research output: Contribution to journalArticle

Omega-3 Fatty Acids
Hip Fractures
Bone Marrow
Bone and Bones
Osteoarthritis

Elevated ceramides 18:0 and 24:1 with aging are associated with hip fracture risk through increased bone resorption

Kim, B. J., Lee, J. Y., Park, S. J., Lee, S. H., Kim, S. J., Yoo, H. J., De Pena, S. I. R., McGee-Lawrence, M., Isales, C. M., Koh, J. M. & Hamrick, M. W., Jan 1 2019, In : Aging. 11, 21, p. 9388-9404 17 p.

Research output: Contribution to journalArticle

Ceramides
Hip Fractures
Bone Resorption
Bone Marrow
Osteogenesis
1 Citation (Scopus)
Open Access
Kynurenine
Muscular Atrophy
Metabolites
Tryptophan
Lipid Peroxidation
1 Citation (Scopus)

Lower hand grip strength in older adults with non-alcoholic fatty liver disease: A nationwide population-based study

Kim, B. J., Ahn, S. H., Lee, S. H., Hong, S., Hamrick, M. W., Isales, C. M. & Koh, J. M., Jul 1 2019, In : Aging. 11, 13, p. 4547-4560 14 p.

Research output: Contribution to journalArticle

Hand Strength
Muscle Strength
Population
Liver
Korea
1 Citation (Scopus)

Meta-analysis and evidence base for the efficacy of autologous bone marrow mesenchymal stem cells in knee cartilage repair: Methodological guidelines and quality assessment

Awad, M. E., Hussein, K. A., Helwa, I., Abdelsamid, M. F., Aguilar-Perez, A., Mohsen, I., Hunter, M., Hamrick, M. W., Isales, C. M., Elsalanty, M., Hill, W. D. & Fulzele, S., Jan 1 2019, In : Stem Cells International. 2019, 3826054.

Research output: Contribution to journalArticle

Open Access
Mesenchymal Stromal Cells
Cartilage
Meta-Analysis
Knee
Bone Marrow
3 Citations (Scopus)

MicroRNA-141-3p Negatively Modulates SDF-1 Expression in Age-Dependent Pathophysiology of Human and Murine Bone Marrow Stromal Cells

Periyasamy-Thandavan, S., Burke, J., Mendhe, B., Kondrikova, G., Kolhe, R., Hunter, M., Isales, C. M., Hamrick, M. W., Hill, W. D., Fulzele, S., Beerman, I. & Hare, J., Aug 16 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 9, p. 1368-1374 7 p.

Research output: Contribution to journalArticle

MicroRNAs
Mesenchymal Stromal Cells
Bone Marrow
Chemokine CXCL12
Small Untranslated RNA
4 Citations (Scopus)

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

Fulzele, S. T., Mendhe, B., Khayrullin, A., Johnson, M. H., Kaiser, H., Liu, Y., Isales, C. M. & Hamrick, M. W., Mar 31 2019, In : Aging. 11, 6, p. 1791-1803 13 p.

Research output: Contribution to journalArticle

Bone Marrow Cells
Stem Cells
Muscles
Mesenchymal Stromal Cells
MicroRNAs
4 Citations (Scopus)

Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview

Fariyike, B., Singleton, Q., Hunter, D. M., Hill, W. D., Isales, C. M., Hamrick, M. W. & Fulzele, S. T., Mar 1 2019, In : Mechanisms of Ageing and Development. 178, p. 9-15 7 p.

Research output: Contribution to journalReview article

Musculoskeletal System
MicroRNAs
Osteogenesis
Osteoarthritis
Osteoporosis
1 Citation (Scopus)

Stromal cell-derived factor-1 (CXCL12) and its role in bone and muscle biology

Gilbert, W., Bragg, R., Elmansi, A. M., McGee Lawrence, M. E., Isales, C. M., Hamrick, M. W., Hill, W. D. & Fulzele, S. T., Nov 1 2019, In : Cytokine. 123, 154783.

Research output: Contribution to journalReview article

Chemokine CXCL12
Stem cells
Muscle
Bone
Stem Cells

Stromal cell-derived factor-1 as a potential therapeutic target for osteoarthritis and rheumatoid arthritis

Bragg, R., Gilbert, W., Elmansi, A. M., Isales, C. M., Hamrick, M. W., Hill, W. D. & Fulzele, S., Jan 1 2019, In : Therapeutic Advances in Chronic Disease. 10

Research output: Contribution to journalReview article

Open Access
Chemokine CXCL12
Osteoarthritis
Rheumatoid Arthritis
Cartilage
Therapeutics
7 Citations (Scopus)

The detrimental effects of kynurenine, a tryptophan metabolite, on human bone metabolism

Kim, B. J., Hamrick, M. W., Yoo, H. J., Lee, S. H., Kim, S. J., Koh, J. M. & Isales, C. M., Jun 1 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 6, p. 2334-2342 9 p.

Research output: Contribution to journalArticle

Open Access
Kynurenine
Metabolites
Metabolism
Tryptophan
Bone

The effects of myokines on osteoclasts and osteoblasts

Lee, J. Y., Park, S. J., Han, S. A., Lee, S. H., Koh, J. M., Hamrick, M. W. & Kim, B. J., Oct 1 2019, In : Biochemical and Biophysical Research Communications. 517, 4, p. 749-754 6 p.

Research output: Contribution to journalArticle

Osteoblasts
Osteoclasts
Conditioned Culture Medium
Bone
Skeletal Muscle Fibers
3 Citations (Scopus)

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands

Elmansi, A. M., Awad, M. E., Eisa, N. H., Kondrikov, D., Hussein, K. A., Aguilar-Pérez, A., Herberg, S., Periyasamy-Thandavan, S., Fulzele, S., Hamrick, M. W., McGee-Lawrence, M. E., Isales, C. M., Volkman, B. F. & Hill, W. D., Jun 2019, In : Pharmacology and Therapeutics. 198, p. 90-108 19 p.

Research output: Contribution to journalArticle

Dipeptidyl Peptidase 4
Peptide Hormones
Proteolysis
Cytokines
Ligands
2018
5 Citations (Scopus)

Amino acids as signaling molecules modulating bone turnover

Ding, K., Cain, M., Davis, M., Bergson, C. M., McGee Lawrence, M. E., Perkins, C., Hardigan, T., Shi, X. M., Zhong, Q., Xu, J., Bollag, W. B., Hill, W. D., Elsalanty, M. E., Hunter, D. M., Isales, M. C., Lopez, P., Hamrick, M. W. & Isales, C. M., Oct 2018, In : Bone. 115, p. 15-24 10 p.

Research output: Contribution to journalReview article

Bone Remodeling
Amino Acids
Protein-Restricted Diet
Mesenchymal Stromal Cells
Calcium-Sensing Receptors
2 Citations (Scopus)

Association of serum TSH with handgrip strength in community-dwelling euthyroid elderly

Kim, B. J., Lee, S. H., Isales, C. M., Hamrick, M. W., Kwak, M. K. & Koh, J. M., Jan 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 11, p. 3986-3992 7 p.

Research output: Contribution to journalArticle

Independent Living
Muscle
Muscle Strength
Muscle Strength Dynamometer
Serum

Blocking Bone Loss with L-BAIBA

Hamrick, M. W. & McGee Lawrence, M. E., May 1 2018, In : Trends in Endocrinology and Metabolism. 29, 5, p. 284-286 3 p.

Research output: Contribution to journalShort survey

Osteocytes
Aminoisobutyric Acids
Bone and Bones
Muscles
Bone Matrix
15 Citations (Scopus)

Emerging role of extracellular vesicles in musculoskeletal diseases

Murphy, C., Withrow, J., Hunter, M., Liu, Y., Tang, Y. L., Fulzele, S. & Hamrick, M. W., Apr 2018, In : Molecular Aspects of Medicine. 60, p. 123-128 6 p.

Research output: Contribution to journalReview article

Musculoskeletal Diseases
MicroRNAs
Musculoskeletal system
Exosomes
Tissue
12 Citations (Scopus)

Impact of muscle atrophy on bone metabolism and bone strength: implications for muscle-bone crosstalk with aging and disuse

Bettis, T., Kim, B. J. & Hamrick, M. W., Aug 1 2018, In : Osteoporosis International. 29, 8, p. 1713-1720 8 p.

Research output: Contribution to journalReview article

Muscular Atrophy
Muscle Strength
Bone and Bones
Muscles
Atrophic Muscular Disorders
1 Citation (Scopus)

Inverse relationship between serum hsCRP concentration and hand grip strength in older adults: A nationwide population-based study

Kim, B. J., Lee, S. H., Kwak, M. K., Isales, C. M., Koh, J. M. & Hamrick, M. W., Aug 1 2018, In : Aging. 10, 8, p. 2051-2061 11 p.

Research output: Contribution to journalArticle

Hand Strength
C-Reactive Protein
Muscle Strength
Serum
Population
9 Citations (Scopus)

Mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone

Yu, K., Sellman, D. P., Bahraini, A., Hagan, M. L., Elsherbini, A., Vanpelt, K. T., Marshall, P. L., Hamrick, M. W., McNeil, A., McNeil, P. L. & McGee Lawrence, M. E., Feb 1 2018, In : Journal of Orthopaedic Research. 36, 2, p. 653-662 10 p.

Research output: Contribution to journalArticle

Osteocytes
Cell Membrane
Bone and Bones
Calcium Signaling
Weight-Bearing
2 Citations (Scopus)

Modulation of miRNAS by vitamin C in human bone marrow stromal cells

Kolhe, R., Mondal, A. K., Pundkar, C., Periyasamy-Thandavan, S., Mendhe, B., Hunter, M., Isales, C. M., Hill, W. D., Hamrick, M. W. & Fulzele, S., Feb 8 2018, In : Nutrients. 10, 2, 186.

Research output: Contribution to journalArticle

stromal cells
bone marrow cells
MicroRNAs
Mesenchymal Stromal Cells
microRNA
3 Citations (Scopus)

The positive association of total protein intake with femoral neck strength (KNHANES IV)

Kim, B. J., Lee, S. H., Isales, C. M., Koh, J. M. & Hamrick, M. W., Jun 1 2018, In : Osteoporosis International. 29, 6, p. 1397-1405 9 p.

Research output: Contribution to journalArticle

Femur Neck
Dietary Proteins
Bone and Bones
Proteins
Bone Density
2017
145 Citations (Scopus)

A comparative study of serum exosome isolation using differential ultracentrifugation and three commercial reagents

Helwa, I., Cai, J., Drewry, M. D., Zimmerman, A., Dinkins, M. B., Khaled, M. L., Seremwe, M., Dismuke, W. M., Bieberich, E., Stamer, W. D., Hamrick, M. W. & Liu, Y., Jan 2017, In : PloS one. 12, 1, e0170628.

Research output: Contribution to journalArticle

exosomes
Exosomes
ultracentrifugation
Ultracentrifugation
RNA
9 Citations (Scopus)

Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study

Carbone, L. D., Bůžková, P., Fink, H. A., Robbins, J. A., Bethel, M., Hamrick, M. W. & Hill, W. D., Jun 1 2017, In : Calcified Tissue International. 100, 6, p. 599-608 10 p.

Research output: Contribution to journalArticle

Hip Fractures
Body Composition
Pelvic Bones
Bone Density
Osteoblasts

Complex Anatomic Abnormalities of the Lower Leg Muscles and Tendons Associated With Phocomelia: A Case Report

Hodo, T., Hamrick, M. & Melenevsky, Y., Nov 2017, In : Journal of Foot and Ankle Surgery. 56, 6, p. 1335-1338 4 p.

Research output: Contribution to journalArticle

Ectromelia
Flatfoot
Tendons
Leg
Thalidomide
10 Citations (Scopus)
stem cells
Stem cells
MicroRNAs
Stem Cells
Transforming Growth Factors
44 Citations (Scopus)

Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis

Kolhe, R. B., Hunter, D. M., Liu, S., Jadeja, R. N., Pundkar, C., Mondal, A. K., Mendhe, B., Drewry, M., Rojiani, M. V., Liu, Y., Isales, C. M., Guldberg, R. E., Hamrick, M. W. & Fulzele, S. T., Dec 1 2017, In : Scientific reports. 7, 1, 2029.

Research output: Contribution to journalArticle

Synovial Fluid
MicroRNAs
Osteoarthritis
Exosomes
Encyclopedias
6 Citations (Scopus)

Insulin Resistance and the IGF-I-Cortical Bone Relationship in Children Ages 9 to 13 Years

Kindler, J. M., Pollock, N. K., Laing, E. M., Oshri, A., Jenkins, N. T., Isales, C. M., Hamrick, M. W., Ding, K. H., Hausman, D. B., McCabe, G. P., Martin, B. R., Hill Gallant, K. M., Warden, S. J., Weaver, C. M., Peacock, M. & Lewis, R. D., Jul 2017, In : Journal of Bone and Mineral Research. 32, 7, p. 1537-1545 9 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Insulin Resistance
Homeostasis
Fats
Sexual Maturation
22 Citations (Scopus)

Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss

Refaey, M. E., McGee-Lawrence, M. E., Fulzele, S., Kennedy, E. J., Bollag, W. B., Elsalanty, M., Zhong, Q., Ding, K. H., Bendzunas, N. G., Shi, X. M., Xu, J., Hill, W. D., Johnson, M. H., Hunter, M., Pierce, J. L., Yu, K., Hamrick, M. W. & Isales, C. M., Nov 2017, In : Journal of Bone and Mineral Research. 32, 11, p. 2182-2193 12 p.

Research output: Contribution to journalArticle

Kynurenine
Tryptophan
Bone and Bones
Aromatic Amino Acids
Anabolic Agents
36 Citations (Scopus)
Cell Aging
Cell proliferation
Stem cells
MicroRNAs
Mesenchymal Stromal Cells
10 Citations (Scopus)

Whole-body vibration mimics the metabolic effects of exercise in male leptin receptor-deficient mice

McGee-Lawrence, M. E., Wenger, K. H., Misra, S., Davis, C. L., Pollock, N. K., Elsalanty, M., Ding, K., Isales, C. M., Hamrick, M. W., Wosiski-Kuhn, M., Arounleut, P., Mattson, M. P., Cutler, R. G., Yu, J. C. & Stranahan, A. M., May 1 2017, In : Endocrinology. 158, 5, p. 1160-1171 12 p.

Research output: Contribution to journalArticle

Vibration
Leptin Receptors
Osteocalcin
Body Weight
Physiologic Calcification
2016
8 Citations (Scopus)

Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle

Khayrullin, A., Smith, L., Mistry, D., Dukes, A., Pan, Y. C. A. & Hamrick, M. W., Oct 21 2016, In : Biochemical and Biophysical Research Communications. 479, 3, p. 590-595 6 p.

Research output: Contribution to journalArticle

Muscular Atrophy
Zebrafish
Muscular Diseases
MicroRNAs
Muscle
62 Citations (Scopus)

Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis

Withrow, J., Murphy, C., Liu, Y., Hunter, M., Fulzele, S. & Hamrick, M. W., Dec 1 2016, In : Arthritis Research and Therapy. 18, 1, 286.

Research output: Contribution to journalReview article

Osteoarthritis
Rheumatoid Arthritis
MicroRNAs
Cell Communication
Joints
13 Citations (Scopus)

Insulin resistance negatively influences the muscle- dependent igf-1-bone mass relationship in premenarcheal girls

Kindler, J. M., Pollock, N. K., Laing, E. M., Jenkins, N. T., Oshri, A., Isales, C., Hamrick, M. & Lewis, R. D., Jan 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 1, p. 199-205 7 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Muscle
Insulin Resistance
Bone
Insulin
27 Citations (Scopus)

Stem cell-derived exosomes: A potential alternative therapeutic agent in orthopaedics

Burke, J., Kolhe, R., Hunter, M., Isales, C., Hamrick, M. & Fulzele, S., Jan 1 2016, In : Stem Cells International. 2016, 5802529.

Research output: Contribution to journalReview article

Exosomes
Orthopedics
Stem Cells
Regenerative Medicine
Therapeutics