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  • David J Fulton
2020

Origins of Hypertension in Obesity: Plain Vanilla(oid) or Multiple Flavors?

Fulton, D. J. R. & Stepp, D. W., Jan 1 2020, (Accepted/In press) In : Circulation. p. 1334-1337 4 p.

Research output: Contribution to journalReview article

2019
2 Scopus citations

Differential mechanisms of adenosine- and ATPγS-induced microvascular endothelial barrier strengthening

Bátori, R., Kumar, S., Bordán, Z., Cherian-Shaw, M., Kovács-Kása, A., MacDonald, J. A., Fulton, D. J. R., Erdődi, F. & Verin, A. D., May 2019, In : Journal of Cellular Physiology. 234, 5, p. 5863-5879 17 p.

Research output: Contribution to journalArticle

Disruption of Immune Homeostasis in Human Dendritic Cells via Regulation of Autophagy and Apoptosis by Porphyromonas gingivalis

Meghil, M. M., Tawfik, O. K., Elashiry, M., Rajendran, M., Arce, R. M., Fulton, D. J., Schoenlein, P. V. & Cutler, C. W., Sep 24 2019, In : Frontiers in immunology. 10, 2286.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Galectin-3: A Harbinger of Reactive Oxygen Species, Fibrosis, and Inflammation in Pulmonary Arterial Hypertension

Fulton, D. J. R., Li, X., Bordan, Z., Wang, Y., Mahboubi, K., Rudic, R. D., Haigh, S., Chen, F. & Barman, S. A., Nov 10 2019, In : Antioxidants and Redox Signaling. 31, 14, p. 1053-1069 17 p.

Research output: Contribution to journalReview article

3 Scopus citations

Galectin-3 is expressed in vascular smooth muscle cells and promotes pulmonary hypertension through changes in proliferation, apoptosis, and fibrosis

Barman, S. A., Li, X., Haigh, S., Kondrikov, D., Mahboubi, K., Bordan, Z., Stepp, D. W., Zhou, J., Wang, Y., Weintraub, D. S., Traber, P., Snider, W., Jonigk, D., Sullivan, J., Ryan Crislip, G., Butcher, J. T., Thompson, J., Su, Y., Chen, F. & Fulton, D. J. R., May 2019, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 316, 5, p. L784-L797

Research output: Contribution to journalArticle

5 Scopus citations
3 Scopus citations

Leptin restores endothelial function via endothelial PPARγ-nox1-mediated mechanisms in a mouse model of congenital generalized lipodystrophy

Bruder-Nascimento, T., Faulkner, J. L., Haigh, S., Kennard, S., Antonova, G., Patel, V. S., Fulton, D. J. R., Chen, W. & De Chantemèle, E. J. B., Dec 1 2019, In : Hypertension. 74, 6, p. 1399-1408 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension

Cao, Y., Zhang, X., Wang, L., Yang, Q., Ma, Q., Xu, J., Wang, J., Kovacs, L., Ayon, R. J., Liu, Z., Zhang, M., Zhou, Y., Zeng, X., Xu, Y., Wang, Y., Fulton, D. J., Weintraub, N. L., Lucas, R., Dong, Z., Yuan, J. X. J. & 8 others, Sullivan, J. C., Meadows, L., Barman, S. A., Wu, C., Quan, J., Hong, M., Su, Y. & Huo, Y., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13394-13403 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Progesterone predisposes females to obesity-associated leptin-mediated endothelial dysfunction via upregulating endothelial mr (mineralocorticoid receptor) expression

Faulkner, J. L., Kennard, S., Huby, A. C., Antonova, G., Lu, Q., Jaffe, I. Z., Patel, V. S., Fulton, D. J. R. & Belin De Chantemèle, E. J., Sep 1 2019, In : Hypertension. 74, 3, p. 678-686 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
1 Scopus citations

The molecular regulation and functional roles of NOX5

Fulton, D. J. R., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 353-375 23 p. (Methods in Molecular Biology; vol. 1982).

Research output: Chapter in Book/Report/Conference proceedingChapter

Transcription factor TEAD1 is essential for vascular development by promoting vascular smooth muscle differentiation

Wen, T., Liu, J., He, X., Dong, K., Hu, G., Yu, L., Yin, Q., Osman, I., Peng, J., Zheng, Z., Xin, H., Fulton, D. J., Du, Q., Zhang, W. & Zhou, J., Dec 1 2019, In : Cell Death and Differentiation. 26, 12, p. 2790-2806 17 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Ablation of Myeloid ADK (Adenosine Kinase) Epigenetically Suppresses Atherosclerosis in ApoE-/- (Apolipoprotein e Deficient) Mice

Zhang, M., Zeng, X., Yang, Q., Xu, J., Liu, Z., Zhou, Y., Cao, Y., Zhang, X., An, X., Xu, Y., Huang, L., Han, Z., Wang, T., Wu, C., Fulton, D. J., Weintraub, N. L., Hong, M. & Huo, Y., Jan 1 2018, In : Arteriosclerosis, thrombosis, and vascular biology. 38, 12, p. 2780-2792 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Extracellular adenosine-induced Rac1 activation in pulmonary endothelium: Molecular mechanisms and barrier-protective role

Kovacs-Kasa, A., Kim, K. M., Cherian-Shaw, M., Black, S. M., Fulton, D. J. & Verin, A. D., Aug 2018, In : Journal of Cellular Physiology. 233, 8, p. 5736-5746 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Galectin-3 promotes vascular remodeling and contributes to pulmonary hypertension

Barman, S. A., Chen, F., Li, X., Haigh, S., Stepp, D. W., Kondrikov, D., Mahboubi, K., Bordan, Z., Traber, P., Su, Y. & Fulton, D. J. R., Jun 1 2018, In : American Journal of Respiratory and Critical Care Medicine. 197, 11, p. 1488-1492 5 p.

Research output: Contribution to journalLetter

7 Scopus citations

Hsp70 suppresses mitochondrial reactive oxygen species and preserves pulmonary microvascular barrier integrity following exposure to bacterial toxins

Li, X., Yu, Y., Gorshkov, B., Haigh, S., Bordan, Z., Weintraub, D., Rudic, R. D., Chakraborty, T., Barman, S. A., Verin, A. D., Su, Y., Lucas, R., Stepp, D. W., Chen, F. & Fulton, D. J., Jun 12 2018, In : Frontiers in immunology. 9, JUN, 1309.

Research output: Contribution to journalArticle

11 Scopus citations

Increased muscle mass protects against hypertension and renal injury in obesity

Butcher, J. T., Mintz, J. D., Larion, S., Qiu, S., Ruan, L., Fulton, D. J. & Stepp, D. W., Aug 1 2018, In : Journal of the American Heart Association. 7, 16, e009358.

Research output: Contribution to journalArticle

6 Scopus citations

Mechanisms of diabetes-induced endothelial cell senescence: Role of arginase 1

Shosha, E., Xu, Z., Priya Narayanan, S., Lemtalsi, T., Fouda, A. Y., Rojas, M., Xing, J., Fulton, D., William Caldwell, R. & Caldwell, R. B., Apr 17 2018, In : International journal of molecular sciences. 19, 4, 1215.

Research output: Contribution to journalArticle

5 Scopus citations
12 Scopus citations

Neurofibromin deficiency induces endothelial cell proliferation and retinal neovascularization

Zhang, H., Hudson, F. Z., Xu, Z., Tritz, R., Rojas, M., Patel, C., Haigh, S. B., Bordán, Z., Ingram, D. A., Fulton, D. J., Weintraub, N. L., Caldwell, R. B. & Stansfield, B. K., May 2018, In : Investigative Ophthalmology and Visual Science. 59, 6, p. 2520-2528 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis

Yang, Q., Xu, J., Ma, Q., Liu, Z., Varadarajan, S., Cao, Y., Wang, L., Zeng, X., Zhou, Y., Zhang, M., Xu, Y., Wang, Y., Weintraub, N. L., Zhang, C., Fukai, T., Wu, C., Huang, L., Han, Z., Wang, T., Fulton, D. J. & 2 others, Hong, M. & Huo, Y., Dec 1 2018, In : Nature communications. 9, 1, 4667.

Research output: Contribution to journalArticle

8 Scopus citations

Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matter

Bagi, Z., Brandner, D. D., Le, P., McNeal, D. W., Gong, X., Dou, H., Fulton, D. J., Beller, A., Ngyuen, T., Larson, E. B., Montine, T. J., Keene, C. D. & Back, S. A., Jan 2018, In : Annals of Neurology. 83, 1, p. 142-152 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016
16 Scopus citations

Cloning, characteristics, and functional analysis of rabbit NADPH oxidase 5

Chen, F., Yin, C., Dimitropoulou, C. & Fulton, D. J. R., Jul 19 2016, In : Frontiers in Physiology. 7, JUL, 284.

Research output: Contribution to journalArticle

8 Scopus citations

Endotoxin disrupts circadian rhythms in macrophages via reactive oxygen species

Wang, Y., Pati, P., Xu, Y., Chen, F., Stepp, D. W., Huo, Y., Rudic, R. D. & Fulton, D. J. R., May 1 2016, In : PloS one. 11, 5, e0155075.

Research output: Contribution to journalArticle

15 Scopus citations

Hsp90 inhibition suppresses NF-ĸB transcriptional activation via Sirt-2 in human lung microvascular endothelial cells

Thangjam, G. S., Birmpas, C., Barabutis, N., Gregory, B. W., Clemens, M. A., Newton, J. R., Fulton, D. & Catravas, J. D., May 15 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 310, 10, p. L964-L974

Research output: Contribution to journalArticle

8 Scopus citations
38 Scopus citations

Low-dose IL-17 therapy prevents and reverses diabetic nephropathy, metabolic syndrome, and associated organ fibrosis

Mohamed, R., Jayakumar, C., Chen, F., Fulton, D., Stepp, D., Gansevoort, R. T. & Ramesh, G., Mar 2016, In : Journal of the American Society of Nephrology. 27, 3, p. 745-765 21 p.

Research output: Contribution to journalArticle

36 Scopus citations

Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II-Dependent Hypertension in Mice

Pati, P., Fulton, D. J. R., Bagi, Z., Chen, F., Wang, Y., Kitchens, J., Cassis, L. A., Stepp, D. W. & Rudic, R. D., Mar 1 2016, In : Hypertension. 67, 3, p. 661-668 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Neurofibromin is a novel regulator of Ras-induced reactive oxygen species production in mice and humans

Bessler, W. K., Hudson, F. Z., Zhang, H., Harris, V., Wang, Y., Mund, J. A., Downing, B., Ingram, D. A., Case, J., Fulton, D. J. & Stansfield, B. K., Aug 1 2016, In : Free Radical Biology and Medicine. 97, p. 212-222 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pressor recovery after acute stress is impaired in high fructose-fed Lean Zucker rats

Thompson, J. A., D'Angelo, G., Mintz, J. D., Fulton, D. J. & Stepp, D. W., Jun 1 2016, In : Physiological reports. 4, 12, e12758.

Research output: Contribution to journalArticle

1 Scopus citations
3 Scopus citations

Role of growth hormone-releasing hormone in dyslipidemia associated with experimental type 1 diabetes

Romero Lucas, M. J., Lucas, R., Dou, H., Sridhar, S., Czikora, I., Mosieri, E. M., Rick, F. G., Block, N. L., Sridhar, S., Fulton, D. J., Weintraub, N. L. & Bagi, Z., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. 1895-1900 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo

Kovacs-Kasa, A., Gorshkov, B. A., Kim, K. M., Kumar, S., Black, S. M., Fulton, D. J., Dimitropoulou, C., Catravas, J. D. & Verin, A. D., Dec 15 2016, In : Scientific reports. 6, 39018.

Research output: Contribution to journalArticle

4 Scopus citations

TNFα reduces eNOS activity in endothelial cells through serine 116 phosphorylation and Pin1 binding: Confirmation of a direct, inhibitory interaction of Pin1 with eNOS

Kennard, S., Ruan, L., Buffett, R. J., Fulton, D. & Venema, R. C., Jun 1 2016, In : Vascular Pharmacology. 81, p. 61-68 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Transcriptional and Posttranslational Regulation of eNOS in the Endothelium

Fulton, D. J. R., Jan 1 2016, Endothelium, 2016. Khalil, R. A. (ed.). Academic Press Inc., p. 29-64 36 p. (Advances in Pharmacology; vol. 77).

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations