A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-Hydroxyvitamin D, adiposity, and arterial stiffness

Yanbin Dong, Inger S. Stallmann-Jorgensen, Norman K. Pollock, Ryan A. Harris, Daniel Keeton, Ying Huang, Ke Li, Reda W Bassali, De Huang Guo, Jeffrey Thomas, Gary L. Pierce, Jennifer White, Michael F. Holick, Haidong Zhu

Research output: Contribution to journalArticle

187 Citations (Scopus)

Abstract

Context: Vitamin D insufficiency/deficiency is commonly observed in black youth. Objective: The aim was to determine 25-hydroxyvitamin D [25(OH)D] in response to 2000 IU vitamin D supplementation over time; to evaluate the relation between 25(OH)D concentrations and total body fat mass by dual-energy x-ray absorptiometry; and to determine whether vitamin D supplementation improves arterial stiffness measured by pulse wave velocity (PWV). Design: We conducted a randomized, blinded, controlled clinical trial. Setting and Participants: Forty-nine normotensive black boys and girls, aged 16.3 ± 1.4 yr, were randomly assigned to either the control group (400 IU/d; n = 24) or the experimental group (2000 IU/d; n = 25). Results: Plasma 25(OH)D values at baseline and at 4, 8, and 16 wk were 34.0 ± 10.6, 44.9 ± 9.4, 51.2 ± 11.1, and 59.8 ± 18.2 nmol/liter, respectively, for the control group; and 33.1 ± 8.7, 55.0 ± 11.8, 70.9 ± 22.0, and 85.7 ± 30.1 nmol/liter, respectively, for the experimental group. The experimental group vs. the control group reached significantly higher 25(OH)D concentrations at 8 and 16 wk, respectively. Partial correlation analyses indicated that total body fat mass at baseline was significantly and inversely associated with 25(OH)D concentrations in response to the 2000-IU supplement across time. Furthermore, carotid-femoral PWV increased from baseline (5.38 ± 0.53 m/sec) to posttest (5.71 ± 0.75 m/sec) in the control group (P = 0.016), whereas in the experimental group carotid-femoral PWV decreased from baseline (5.41 ± 0.73 m/sec) to posttest (5.33 ± 0.79 m/sec) (P = 0.031). Conclusion: Daily 2000 IU vitamin D supplementation may be effective in optimizing vitamin D status and counteracting the progression of aortic stiffness in black youth. Plasma 25(OH)D concentrations in response to the 2000 IU/d supplementation are negatively modulated by adiposity.

Original languageEnglish (US)
Pages (from-to)4584-4591
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume95
Issue number10
DOIs
StatePublished - Oct 2010

Fingerprint

Vascular Stiffness
Cholecalciferol
Adiposity
Vitamin D
Pulse Wave Analysis
Randomized Controlled Trials
Stiffness
Control Groups
Thigh
Adipose Tissue
Vitamin D Deficiency
Fats
Plasmas
X-Rays
25-hydroxyvitamin D
X rays

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth : 25-Hydroxyvitamin D, adiposity, and arterial stiffness. / Dong, Yanbin; Stallmann-Jorgensen, Inger S.; Pollock, Norman K.; Harris, Ryan A.; Keeton, Daniel; Huang, Ying; Li, Ke; Bassali, Reda W; Guo, De Huang; Thomas, Jeffrey; Pierce, Gary L.; White, Jennifer; Holick, Michael F.; Zhu, Haidong.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 10, 10.2010, p. 4584-4591.

Research output: Contribution to journalArticle

Dong, Yanbin ; Stallmann-Jorgensen, Inger S. ; Pollock, Norman K. ; Harris, Ryan A. ; Keeton, Daniel ; Huang, Ying ; Li, Ke ; Bassali, Reda W ; Guo, De Huang ; Thomas, Jeffrey ; Pierce, Gary L. ; White, Jennifer ; Holick, Michael F. ; Zhu, Haidong. / A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth : 25-Hydroxyvitamin D, adiposity, and arterial stiffness. In: Journal of Clinical Endocrinology and Metabolism. 2010 ; Vol. 95, No. 10. pp. 4584-4591.
@article{f1fef7b4c5384261ad82d08ea1c269c3,
title = "A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-Hydroxyvitamin D, adiposity, and arterial stiffness",
abstract = "Context: Vitamin D insufficiency/deficiency is commonly observed in black youth. Objective: The aim was to determine 25-hydroxyvitamin D [25(OH)D] in response to 2000 IU vitamin D supplementation over time; to evaluate the relation between 25(OH)D concentrations and total body fat mass by dual-energy x-ray absorptiometry; and to determine whether vitamin D supplementation improves arterial stiffness measured by pulse wave velocity (PWV). Design: We conducted a randomized, blinded, controlled clinical trial. Setting and Participants: Forty-nine normotensive black boys and girls, aged 16.3 ± 1.4 yr, were randomly assigned to either the control group (400 IU/d; n = 24) or the experimental group (2000 IU/d; n = 25). Results: Plasma 25(OH)D values at baseline and at 4, 8, and 16 wk were 34.0 ± 10.6, 44.9 ± 9.4, 51.2 ± 11.1, and 59.8 ± 18.2 nmol/liter, respectively, for the control group; and 33.1 ± 8.7, 55.0 ± 11.8, 70.9 ± 22.0, and 85.7 ± 30.1 nmol/liter, respectively, for the experimental group. The experimental group vs. the control group reached significantly higher 25(OH)D concentrations at 8 and 16 wk, respectively. Partial correlation analyses indicated that total body fat mass at baseline was significantly and inversely associated with 25(OH)D concentrations in response to the 2000-IU supplement across time. Furthermore, carotid-femoral PWV increased from baseline (5.38 ± 0.53 m/sec) to posttest (5.71 ± 0.75 m/sec) in the control group (P = 0.016), whereas in the experimental group carotid-femoral PWV decreased from baseline (5.41 ± 0.73 m/sec) to posttest (5.33 ± 0.79 m/sec) (P = 0.031). Conclusion: Daily 2000 IU vitamin D supplementation may be effective in optimizing vitamin D status and counteracting the progression of aortic stiffness in black youth. Plasma 25(OH)D concentrations in response to the 2000 IU/d supplementation are negatively modulated by adiposity.",
author = "Yanbin Dong and Stallmann-Jorgensen, {Inger S.} and Pollock, {Norman K.} and Harris, {Ryan A.} and Daniel Keeton and Ying Huang and Ke Li and Bassali, {Reda W} and Guo, {De Huang} and Jeffrey Thomas and Pierce, {Gary L.} and Jennifer White and Holick, {Michael F.} and Haidong Zhu",
year = "2010",
month = "10",
doi = "10.1210/jc.2010-0606",
language = "English (US)",
volume = "95",
pages = "4584--4591",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "10",

}

TY - JOUR

T1 - A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth

T2 - 25-Hydroxyvitamin D, adiposity, and arterial stiffness

AU - Dong, Yanbin

AU - Stallmann-Jorgensen, Inger S.

AU - Pollock, Norman K.

AU - Harris, Ryan A.

AU - Keeton, Daniel

AU - Huang, Ying

AU - Li, Ke

AU - Bassali, Reda W

AU - Guo, De Huang

AU - Thomas, Jeffrey

AU - Pierce, Gary L.

AU - White, Jennifer

AU - Holick, Michael F.

AU - Zhu, Haidong

PY - 2010/10

Y1 - 2010/10

N2 - Context: Vitamin D insufficiency/deficiency is commonly observed in black youth. Objective: The aim was to determine 25-hydroxyvitamin D [25(OH)D] in response to 2000 IU vitamin D supplementation over time; to evaluate the relation between 25(OH)D concentrations and total body fat mass by dual-energy x-ray absorptiometry; and to determine whether vitamin D supplementation improves arterial stiffness measured by pulse wave velocity (PWV). Design: We conducted a randomized, blinded, controlled clinical trial. Setting and Participants: Forty-nine normotensive black boys and girls, aged 16.3 ± 1.4 yr, were randomly assigned to either the control group (400 IU/d; n = 24) or the experimental group (2000 IU/d; n = 25). Results: Plasma 25(OH)D values at baseline and at 4, 8, and 16 wk were 34.0 ± 10.6, 44.9 ± 9.4, 51.2 ± 11.1, and 59.8 ± 18.2 nmol/liter, respectively, for the control group; and 33.1 ± 8.7, 55.0 ± 11.8, 70.9 ± 22.0, and 85.7 ± 30.1 nmol/liter, respectively, for the experimental group. The experimental group vs. the control group reached significantly higher 25(OH)D concentrations at 8 and 16 wk, respectively. Partial correlation analyses indicated that total body fat mass at baseline was significantly and inversely associated with 25(OH)D concentrations in response to the 2000-IU supplement across time. Furthermore, carotid-femoral PWV increased from baseline (5.38 ± 0.53 m/sec) to posttest (5.71 ± 0.75 m/sec) in the control group (P = 0.016), whereas in the experimental group carotid-femoral PWV decreased from baseline (5.41 ± 0.73 m/sec) to posttest (5.33 ± 0.79 m/sec) (P = 0.031). Conclusion: Daily 2000 IU vitamin D supplementation may be effective in optimizing vitamin D status and counteracting the progression of aortic stiffness in black youth. Plasma 25(OH)D concentrations in response to the 2000 IU/d supplementation are negatively modulated by adiposity.

AB - Context: Vitamin D insufficiency/deficiency is commonly observed in black youth. Objective: The aim was to determine 25-hydroxyvitamin D [25(OH)D] in response to 2000 IU vitamin D supplementation over time; to evaluate the relation between 25(OH)D concentrations and total body fat mass by dual-energy x-ray absorptiometry; and to determine whether vitamin D supplementation improves arterial stiffness measured by pulse wave velocity (PWV). Design: We conducted a randomized, blinded, controlled clinical trial. Setting and Participants: Forty-nine normotensive black boys and girls, aged 16.3 ± 1.4 yr, were randomly assigned to either the control group (400 IU/d; n = 24) or the experimental group (2000 IU/d; n = 25). Results: Plasma 25(OH)D values at baseline and at 4, 8, and 16 wk were 34.0 ± 10.6, 44.9 ± 9.4, 51.2 ± 11.1, and 59.8 ± 18.2 nmol/liter, respectively, for the control group; and 33.1 ± 8.7, 55.0 ± 11.8, 70.9 ± 22.0, and 85.7 ± 30.1 nmol/liter, respectively, for the experimental group. The experimental group vs. the control group reached significantly higher 25(OH)D concentrations at 8 and 16 wk, respectively. Partial correlation analyses indicated that total body fat mass at baseline was significantly and inversely associated with 25(OH)D concentrations in response to the 2000-IU supplement across time. Furthermore, carotid-femoral PWV increased from baseline (5.38 ± 0.53 m/sec) to posttest (5.71 ± 0.75 m/sec) in the control group (P = 0.016), whereas in the experimental group carotid-femoral PWV decreased from baseline (5.41 ± 0.73 m/sec) to posttest (5.33 ± 0.79 m/sec) (P = 0.031). Conclusion: Daily 2000 IU vitamin D supplementation may be effective in optimizing vitamin D status and counteracting the progression of aortic stiffness in black youth. Plasma 25(OH)D concentrations in response to the 2000 IU/d supplementation are negatively modulated by adiposity.

UR - http://www.scopus.com/inward/record.url?scp=77957800242&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957800242&partnerID=8YFLogxK

U2 - 10.1210/jc.2010-0606

DO - 10.1210/jc.2010-0606

M3 - Article

C2 - 20660028

AN - SCOPUS:77957800242

VL - 95

SP - 4584

EP - 4591

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 10

ER -