A 19-year-old man with sickle cell disease presenting with spinal infarction: A case report

April Edwards, E. Leila Jerome Clay, Valerie Jewells, Stacie Adams, Regina D. Crawford, Rupa Redding-Lallinger

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Introduction. Vasculopathy of the large vessels commonly occurs in sickle cell disease, and as a result cerebral infarction is a well characterized complication of this condition. However, spinal infarction appears to be rare. Spinal infarct is infrequent in the non-sickle cell population as well, and accounts for only about 1 percent of all central nervous system infarcts. Case presentation. In the present work, we report the case of a 19-year-old African-American man with sickle cell disease who experienced an anterior spinal infarct and subsequent quadriplegia. He was incidentally noted to be a heterozygote for factor V Leiden. We also reviewed the literature and found two previous cases of spinal cord infarction and sickle hemoglobin. Our literature search did not demonstrate that heterozygocity for factor V Leiden plays an important role in spinal cord infarction. Conclusions: The paucity of cases associated with sickle hemoglobin does not allow us to postulate any particular risk factors with sickle cell disease that might predispose patients to spinal cord infarction. Our patient's case raises the question as to whether spinal cord infarction is being missed in individuals with sickle cell disease and neurologic symptoms.

Original languageEnglish (US)
Article number210
JournalJournal of Medical Case Reports
Volume7
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Medicine(all)

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    Edwards, A., Clay, E. L. J., Jewells, V., Adams, S., Crawford, R. D., & Redding-Lallinger, R. (2013). A 19-year-old man with sickle cell disease presenting with spinal infarction: A case report. Journal of Medical Case Reports, 7, [210]. https://doi.org/10.1186/1752-1947-7-210