A basic solution to activate the cholinergic anti-inflammatory pathway via the mesothelium?

Elinor C. Mannon, Jingping Sun, Katie Wilson, Michael W Brands, Patricia Martinez-Quinones, Babak Baban, Paul M O'Connor

Research output: Contribution to journalReview article

Abstract

Much research now indicates that vagal nerve stimulation results in a systemic reduction in inflammatory cytokine production and an increase in anti-inflammatory cell populations that originates from the spleen. Termed the ‘cholinergic anti-inflammatory pathway’ therapeutic activation of this innate physiological response holds enormous promise for the treatment of inflammatory disease. Much controversy remains however, regarding the underlying physiological pathways mediating this response. This controversy is anchored in the fact that the vagal nerve itself does not innervate the spleen. Recent research from our own laboratory indicating that oral intake of sodium bicarbonate stimulates splenic anti-inflammatory pathways, and that this effect may require transmission of signals to the spleen through the mesothelium, provide new insight into the physiological pathways mediating the cholinergic anti-inflammatory pathway. In this review, we examine proposed models of the cholinergic anti-inflammatory pathway and attempt to frame our recent results in relation to these hypotheses. Following this discussion, we then provide an alternative model of the cholinergic anti-inflammatory pathway which is consistent both with our recent findings and the published literature. We then discuss experimental approaches that may be useful to delineate these hypotheses. We believe the outcome of these experiments will be critical in identifying the most appropriate methods to harness the therapeutic potential of the cholinergic anti-inflammatory pathway for the treatment of disease and may also shed light on the etiology of other pathologies, such as idiopathic fibrosis.

Original languageEnglish (US)
Pages (from-to)236-248
Number of pages13
JournalPharmacological Research
Volume141
DOIs
StatePublished - Mar 1 2019

Fingerprint

Cholinergic Agents
Anti-Inflammatory Agents
Epithelium
Spleen
Vagus Nerve Stimulation
Sodium Bicarbonate
Therapeutics
Research
Fibrosis
Pathology
Cytokines
Population

Keywords

  • Macrophage polarization
  • Perisplenitis
  • Sodium bicarbonate
  • Tumor-necrosis factor
  • Vagal nerve stimulation

ASJC Scopus subject areas

  • Pharmacology

Cite this

A basic solution to activate the cholinergic anti-inflammatory pathway via the mesothelium? / Mannon, Elinor C.; Sun, Jingping; Wilson, Katie; Brands, Michael W; Martinez-Quinones, Patricia; Baban, Babak; O'Connor, Paul M.

In: Pharmacological Research, Vol. 141, 01.03.2019, p. 236-248.

Research output: Contribution to journalReview article

Mannon, Elinor C. ; Sun, Jingping ; Wilson, Katie ; Brands, Michael W ; Martinez-Quinones, Patricia ; Baban, Babak ; O'Connor, Paul M. / A basic solution to activate the cholinergic anti-inflammatory pathway via the mesothelium?. In: Pharmacological Research. 2019 ; Vol. 141. pp. 236-248.
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