A chromosome with five γ-globin genes

Y. J. Fei, D. Lanclos Ke., F. Kutlar, E. F. Walker, T. H.J. Huisman

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Globin gene mapping of DNA from a Black newborn resulted in the detection of a chromosome with five γ-globin genes. Based on results from digests with enzymes EcoRI and PstI, we concluded that the three genes between the 5'(G)γ and 3'(A)γ genes are (G)γ genes with a possible 5' segment derived from (A)γ. The high (G)γ level in the fetal hemoglobin (Hb F) of the baby is consistent with this view. Family relationships were such that speculation as to the mechanism causing this quintuplication of the γ-globin genes was not possible.

Original languageEnglish (US)
Pages (from-to)827-829
Number of pages3
JournalBlood
Volume72
Issue number2
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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