A complex oscillating network of signaling genes underlies the mouse segmentation clock

Mary Lee Dequéant, Earl Glynn, Karin Gaudenz, Matthias Wahl, Jie Chen, Arcady Mushegian, Olivier Pourquié

Research output: Contribution to journalArticle

298 Citations (Scopus)

Abstract

The segmental pattern of the spine is established early in development, when the vertebral precursors, the somites, are rhythmically produced from the presomitic mesoderm. Microarray studies of the mouse presomitic mesoderm transcriptome reveal that the oscillator associated with this process, the segmentation clock, drives the periodic expression of a large network of cyclic genes involved in cell signaling. Mutually exclusive activation of the notch-fibroblast growth factor and Wnt pathways during each cycle suggests that coordinated regulation of these three pathways underlies the clock oscillator.

Original languageEnglish (US)
Pages (from-to)1595-1598
Number of pages4
JournalScience
Volume314
Issue number5805
DOIs
StatePublished - Dec 8 2006

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Gene Regulatory Networks
Mesoderm
Somites
Wnt Signaling Pathway
Fibroblast Growth Factors
Transcriptome
Spine

ASJC Scopus subject areas

  • General

Cite this

Dequéant, M. L., Glynn, E., Gaudenz, K., Wahl, M., Chen, J., Mushegian, A., & Pourquié, O. (2006). A complex oscillating network of signaling genes underlies the mouse segmentation clock. Science, 314(5805), 1595-1598. https://doi.org/10.1126/science.1133141

A complex oscillating network of signaling genes underlies the mouse segmentation clock. / Dequéant, Mary Lee; Glynn, Earl; Gaudenz, Karin; Wahl, Matthias; Chen, Jie; Mushegian, Arcady; Pourquié, Olivier.

In: Science, Vol. 314, No. 5805, 08.12.2006, p. 1595-1598.

Research output: Contribution to journalArticle

Dequéant, ML, Glynn, E, Gaudenz, K, Wahl, M, Chen, J, Mushegian, A & Pourquié, O 2006, 'A complex oscillating network of signaling genes underlies the mouse segmentation clock', Science, vol. 314, no. 5805, pp. 1595-1598. https://doi.org/10.1126/science.1133141
Dequéant ML, Glynn E, Gaudenz K, Wahl M, Chen J, Mushegian A et al. A complex oscillating network of signaling genes underlies the mouse segmentation clock. Science. 2006 Dec 8;314(5805):1595-1598. https://doi.org/10.1126/science.1133141
Dequéant, Mary Lee ; Glynn, Earl ; Gaudenz, Karin ; Wahl, Matthias ; Chen, Jie ; Mushegian, Arcady ; Pourquié, Olivier. / A complex oscillating network of signaling genes underlies the mouse segmentation clock. In: Science. 2006 ; Vol. 314, No. 5805. pp. 1595-1598.
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