TY - JOUR
T1 - A Controlled Trial of Methylphenidate in Black Adolescents
T2 - Attentional, Behavioral, and Physiological Effects
AU - Brown, Ronald T.
AU - Sexson, Sandra B.
PY - 1988/2
Y1 - 1988/2
N2 - The short-term effects of methylphenidate were examined on behavioral, laboratory, academic, and physiological measures in 11 black male adolescents diagnosed as having attention deficit disorder (ADD). In a double-blind, crossover design with randomized order, the subjects received placebo and each of three methylphenidate doses (0.15 mg/kg, 0.30 mg/kg, and 0.50 mg/kg) for a period of 2 weeks per medication dosage. Significant drug effects were found for the majority of measures. In general, the higher doses resulted in the most beneficial response in behavioral, academic, and laboratory measures of attention and impulsivity. However, a significant linear increase occurred in diastolic blood pressure. The results suggest that methylphenidate is an effective adjunct to the treatment of ADD in adolescents.
AB - The short-term effects of methylphenidate were examined on behavioral, laboratory, academic, and physiological measures in 11 black male adolescents diagnosed as having attention deficit disorder (ADD). In a double-blind, crossover design with randomized order, the subjects received placebo and each of three methylphenidate doses (0.15 mg/kg, 0.30 mg/kg, and 0.50 mg/kg) for a period of 2 weeks per medication dosage. Significant drug effects were found for the majority of measures. In general, the higher doses resulted in the most beneficial response in behavioral, academic, and laboratory measures of attention and impulsivity. However, a significant linear increase occurred in diastolic blood pressure. The results suggest that methylphenidate is an effective adjunct to the treatment of ADD in adolescents.
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U2 - 10.1177/000992288802700204
DO - 10.1177/000992288802700204
M3 - Article
C2 - 3338232
AN - SCOPUS:0023898173
SN - 0009-9228
VL - 27
SP - 74
EP - 81
JO - Clinical Pediatrics
JF - Clinical Pediatrics
IS - 2
ER -