A Controlled Trial of Methylphenidate in Black Adolescents

Attentional, Behavioral, and Physiological Effects

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The short-term effects of methylphenidate were examined on behavioral, laboratory, academic, and physiological measures in 11 black male adolescents diagnosed as having attention deficit disorder (ADD). In a double-blind, crossover design with randomized order, the subjects received placebo and each of three methylphenidate doses (0.15 mg/kg, 0.30 mg/kg, and 0.50 mg/kg) for a period of 2 weeks per medication dosage. Significant drug effects were found for the majority of measures. In general, the higher doses resulted in the most beneficial response in behavioral, academic, and laboratory measures of attention and impulsivity. However, a significant linear increase occurred in diastolic blood pressure. The results suggest that methylphenidate is an effective adjunct to the treatment of ADD in adolescents.

Original languageEnglish (US)
Pages (from-to)74-81
Number of pages8
JournalClinical Pediatrics
Volume27
Issue number2
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

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Methylphenidate
Attention Deficit Disorder with Hyperactivity
Blood Pressure
Impulsive Behavior
Cross-Over Studies
Placebos
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

A Controlled Trial of Methylphenidate in Black Adolescents : Attentional, Behavioral, and Physiological Effects. / Brown, Ronald T.; Sexson, Sandra Griffin Bishop.

In: Clinical Pediatrics, Vol. 27, No. 2, 01.01.1988, p. 74-81.

Research output: Contribution to journalArticle

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