A critical appraisal of the evidence for using cardiotocography plus ECG ST interval analysis for fetal surveillance in labor. Part I: The randomized controlled trials

Per Olofsson, Diogo Ayres-De-Campos, Jörg Kessler, Britta Tendal, Branka M. Yli, Lawrence Devoe

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

We reappraised the five randomized controlled trials that compared cardiotocography plus ECG ST interval analysis (CTG+ST) vs. cardiotocography. The numbers enrolled ranged from 5681 (Dutch randomized controlled trial) to 799 (French randomized controlled trial). The Swedish randomized controlled trial (n = 5049) was the only trial adequately powered to show a difference in metabolic acidosis, and the Plymouth randomized controlled trial (n = 2434) was only powered to show a difference in operative delivery for fetal distress. There were considerable differences in study design: the French randomized controlled trial used different inclusion criteria, and the Finnish randomized controlled trial (n = 1483) used a different metabolic acidosis definition. In the CTG+ST study arms, the larger Plymouth, Swedish and Dutch trials showed lower operative delivery and metabolic acidosis rates, whereas the smaller Finnish and French trials showed minor differences in operative delivery and higher metabolic acidosis rates. We conclude that the differences in outcomes are likely due to the considerable differences in study design and size. This will enhance heterogeneity effects in any subsequent meta-analysis.

Original languageEnglish (US)
Pages (from-to)556-568
Number of pages13
JournalActa Obstetricia et Gynecologica Scandinavica
Volume93
Issue number6
DOIs
StatePublished - Jun 2014

Keywords

  • Cardiotocography
  • ST analysis
  • fetal surveillance
  • meta-analysis
  • metabolic acidosis
  • randomized controlled trial

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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