A critical evaluation of vestibular schwannoma surgery for patients younger than 40 years of age

Michael E. Sughrue, Rajwant Kaur, Martin J. Rutkowski, Ari J. Kane, Isaac Yang, Lawrence H. Pitts, Andrew T. Parsa

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

BACKGROUND: There are few published prospective data sets specifically focusing on patients younger than 40 years old undergoing microsurgery for vestibular schwannoma. OBJECTIVE: We describe functional outcomes and long-term tumor control after surgery in patients younger than 40 years old enrolled in a prospectively collected database over a 25-year period. METHODS: We selected all vestibular schwannoma patients from a prospectively collected database who were younger than 40 years old at the time of surgical resection for a vestibular schwannoma. Rates of tumor control and hearing preservation were analyzed using Kaplan-Meier analysis, and risk factors for facial nerve palsy, hearing loss, and trigeminal neuropathy were analyzed using multivariate logistic regression. RESULTS: A total of 204 patients younger than 40 years of age met our inclusion criteria and were included in the analysis. Our data indicate that surgical resection leads to durable long-term freedom from tumor recurrence or progression in 89% of young patients at 15 years of follow-up. Consistent with other published series, hearing was preserved in 68% of patients with smaller tumors (<3 cm). Facial nerve function was preserved in 76% of patients with smaller tumors and 52% of patients with larger tumors (P < .001). On multivariate logistic regression, tumor size was a significant predictor of hearing loss, whereas gross total resection was nearly a significant predictor of hearing loss controlling for other variables (P = .06). CONCLUSION: We present the largest prospectively studied cohort of young patients undergoing microsurgical resection of vestibular schwannoma. These data suggest that surgical resection provides excellent long-term tumor control in these patients.

Original languageEnglish (US)
Pages (from-to)1646-1653
Number of pages8
JournalNeurosurgery
Volume67
Issue number6
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Keywords

  • Acoustic neuroma
  • Long term
  • Microsurgery
  • Outcome
  • Vestibular schwannoma
  • Young

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Fingerprint Dive into the research topics of 'A critical evaluation of vestibular schwannoma surgery for patients younger than 40 years of age'. Together they form a unique fingerprint.

  • Cite this