A current view of G protein-coupled receptor - mediated signaling in pulmonary hypertension: finding opportunities for therapeutic intervention

Derek Strassheim, Vijaya Karoor, Kurt Stenmark, Alexander Verin, Evgenia Gerasimovskaya

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Pathological vascular remodeling is observed in various cardiovascular diseases including pulmonary hypertension (PH), a disease of unknown etiology that has been characterized by pulmonary artery vasoconstriction, right ventricular hypertrophy, vascular inflammation, and abnormal angiogenesis in pulmonary circulation. G protein-coupled receptors (GPCRs) are the largest family in the genome and widely expressed in cardiovascular system. They regulate all aspects of PH pathophysiology and represent therapeutic targets. We overview GPCRs function in vasoconstriction, vasodilation, vascular inflammation-driven remodeling and describe signaling cross talk between GPCR, inflammatory cytokines, and growth factors. Overall, the goal of this review is to emphasize the importance of GPCRs as critical signal transducers and targets for drug development in PH.

Original languageEnglish (US)
Article number29
JournalVessel Plus
Volume2
DOIs
StatePublished - 2018

Keywords

  • GPCR
  • Intracellular signaling
  • Pulmonary hypertension
  • Vascular inflammation
  • Vascular remodeling
  • Vasoconstriction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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