TY - JOUR
T1 - A current view of G protein-coupled receptor - mediated signaling in pulmonary hypertension
T2 - finding opportunities for therapeutic intervention
AU - Strassheim, Derek
AU - Karoor, Vijaya
AU - Stenmark, Kurt
AU - Verin, Alexander
AU - Gerasimovskaya, Evgenia
N1 - Funding Information:
The study was supported by grants from National Institute of Health R01-HL-086783 (to Gerasimovskaya E).
Publisher Copyright:
© The Author(s) 2018.
PY - 2018
Y1 - 2018
N2 - Pathological vascular remodeling is observed in various cardiovascular diseases including pulmonary hypertension (PH), a disease of unknown etiology that has been characterized by pulmonary artery vasoconstriction, right ventricular hypertrophy, vascular inflammation, and abnormal angiogenesis in pulmonary circulation. G protein-coupled receptors (GPCRs) are the largest family in the genome and widely expressed in cardiovascular system. They regulate all aspects of PH pathophysiology and represent therapeutic targets. We overview GPCRs function in vasoconstriction, vasodilation, vascular inflammation-driven remodeling and describe signaling cross talk between GPCR, inflammatory cytokines, and growth factors. Overall, the goal of this review is to emphasize the importance of GPCRs as critical signal transducers and targets for drug development in PH.
AB - Pathological vascular remodeling is observed in various cardiovascular diseases including pulmonary hypertension (PH), a disease of unknown etiology that has been characterized by pulmonary artery vasoconstriction, right ventricular hypertrophy, vascular inflammation, and abnormal angiogenesis in pulmonary circulation. G protein-coupled receptors (GPCRs) are the largest family in the genome and widely expressed in cardiovascular system. They regulate all aspects of PH pathophysiology and represent therapeutic targets. We overview GPCRs function in vasoconstriction, vasodilation, vascular inflammation-driven remodeling and describe signaling cross talk between GPCR, inflammatory cytokines, and growth factors. Overall, the goal of this review is to emphasize the importance of GPCRs as critical signal transducers and targets for drug development in PH.
KW - GPCR
KW - Intracellular signaling
KW - Pulmonary hypertension
KW - Vascular inflammation
KW - Vascular remodeling
KW - Vasoconstriction
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U2 - 10.20517/2574-1209.2018.44
DO - 10.20517/2574-1209.2018.44
M3 - Review article
AN - SCOPUS:85065491155
SN - 2574-1209
VL - 2
JO - Vessel Plus
JF - Vessel Plus
M1 - 29
ER -