A cytochrome P‐450 gene family mapped to human chromosome 19

I. R. PHILLIPS, E. A. SHEPHARD, S. POVEY, M. B. DAVIS, G. KELSEY, M. MONTEIRO, L. F. WEST, John Kenneth Cowell

Research output: Contribution to journalArticle

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Abstract

We have recently isolated a cloned cDNA coding for a cytochrome P‐450 of human liver microsomal membranes, which corresponds to a major phenobarbital‐inducible cytochrome P‐450 of rat liver. This human cytochrome P‐450 is encoded by a member of a multigene family. DNA extracted from a panel of 12 independent human‐rodent somatic cell hybrids was analysed by Southern blot hybridization with the cloned cDNA. The results indicate that all components of this cytochrome P‐450 gene family are located on chromosome 19. Evidence from hybrids derived from an individual carrying a balanced translocation suggests a regional localization of 19p13.2→qter. Analysis of human metaphase chromosomes by in situ hybridization localizes this cytochrome P‐450 gene family further to the long arm of chromosome 19 in the region q13.1→qter. We propose the designation P450PB for this locus.

Original languageEnglish (US)
Pages (from-to)267-274
Number of pages8
JournalAnnals of Human Genetics
Volume49
Issue number4
DOIs
StatePublished - Jan 1 1985

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Chromosomes, Human, Pair 19
Human Chromosomes
Cytochrome P-450 Enzyme System
Genes
Complementary DNA
Hybrid Cells
Liver
Metaphase
Multigene Family
Southern Blotting
In Situ Hybridization
Membranes
DNA

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

PHILLIPS, I. R., SHEPHARD, E. A., POVEY, S., DAVIS, M. B., KELSEY, G., MONTEIRO, M., ... Cowell, J. K. (1985). A cytochrome P‐450 gene family mapped to human chromosome 19. Annals of Human Genetics, 49(4), 267-274. https://doi.org/10.1111/j.1469-1809.1985.tb01702.x

A cytochrome P‐450 gene family mapped to human chromosome 19. / PHILLIPS, I. R.; SHEPHARD, E. A.; POVEY, S.; DAVIS, M. B.; KELSEY, G.; MONTEIRO, M.; WEST, L. F.; Cowell, John Kenneth.

In: Annals of Human Genetics, Vol. 49, No. 4, 01.01.1985, p. 267-274.

Research output: Contribution to journalArticle

PHILLIPS, IR, SHEPHARD, EA, POVEY, S, DAVIS, MB, KELSEY, G, MONTEIRO, M, WEST, LF & Cowell, JK 1985, 'A cytochrome P‐450 gene family mapped to human chromosome 19', Annals of Human Genetics, vol. 49, no. 4, pp. 267-274. https://doi.org/10.1111/j.1469-1809.1985.tb01702.x
PHILLIPS IR, SHEPHARD EA, POVEY S, DAVIS MB, KELSEY G, MONTEIRO M et al. A cytochrome P‐450 gene family mapped to human chromosome 19. Annals of Human Genetics. 1985 Jan 1;49(4):267-274. https://doi.org/10.1111/j.1469-1809.1985.tb01702.x
PHILLIPS, I. R. ; SHEPHARD, E. A. ; POVEY, S. ; DAVIS, M. B. ; KELSEY, G. ; MONTEIRO, M. ; WEST, L. F. ; Cowell, John Kenneth. / A cytochrome P‐450 gene family mapped to human chromosome 19. In: Annals of Human Genetics. 1985 ; Vol. 49, No. 4. pp. 267-274.
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