A deletion hybrid breakpoint map of the chromosomal region 13q14-q21 orders 19 genetic markers in 10 intervals

R. F. Kooy, E. Verlind, R. H.J. Houwen, D. N. Shapiro, Lesleyann Hawthorn, John Kenneth Cowell, H. Scheffer, C. H.C.M. Buys

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A deletion hybrid breakpoint map of the chromosomal region 13q14-q21 has been constructed using 19 DNA markers and 13 cell lines with breakpoints in this chromosomal region. The cell lines define 10 distinct intervals in this region, which spans approximately 20 Mb. The markers include 6 RFLP markers, 11 microsatellites that provisionally had been mapped to the region 13q14-21, and 2 new polymorphic CA-repeats that were developed from an EMBL3 library of cell line ICD, containing 13pter-q14.3. The following order of markers was established: CEN - D13S320 - (D13S118, D13S153) - RB1- D13S319 - D13S25 - (D13S31, D13S59, D13S133, D13S137) - D13S163 - D13S119 - (D13S26, D13S55) - (D13S131, D13S134, D13S135, D13S144, D13S152) - TEL.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalEuropean Journal of Human Genetics
Volume2
Issue number1
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Genetic Markers
Cell Line
Restriction Fragment Length Polymorphisms
Microsatellite Repeats

Keywords

  • Chromosome 13
  • Physical mapping
  • Wilson disease

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

A deletion hybrid breakpoint map of the chromosomal region 13q14-q21 orders 19 genetic markers in 10 intervals. / Kooy, R. F.; Verlind, E.; Houwen, R. H.J.; Shapiro, D. N.; Hawthorn, Lesleyann; Cowell, John Kenneth; Scheffer, H.; Buys, C. H.C.M.

In: European Journal of Human Genetics, Vol. 2, No. 1, 01.01.1994, p. 59-65.

Research output: Contribution to journalArticle

Kooy, R. F. ; Verlind, E. ; Houwen, R. H.J. ; Shapiro, D. N. ; Hawthorn, Lesleyann ; Cowell, John Kenneth ; Scheffer, H. ; Buys, C. H.C.M. / A deletion hybrid breakpoint map of the chromosomal region 13q14-q21 orders 19 genetic markers in 10 intervals. In: European Journal of Human Genetics. 1994 ; Vol. 2, No. 1. pp. 59-65.
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