A deletion hybrid breakpoint map of the chromosomal region 13q14-q21 orders 19 genetic markers in 10 intervals

R. F. Kooy; E. Verlind; R. H.J. Houwen; D. N. Shapiro; L. A. Hawthorn; J. K. Cowell; H. Scheffer; C. H.C.M. Buys

doi:10.1159/000472342

A deletion hybrid breakpoint map of the chromosomal region 13q14-q21 orders 19 genetic markers in 10 intervals

R. F. Kooy, E. Verlind, R. H.J. Houwen, D. N. Shapiro, L. A. Hawthorn, J. K. Cowell, H. Scheffer, C. H.C.M. Buys

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A deletion hybrid breakpoint map of the chromosomal region 13q14-q21 has been constructed using 19 DNA markers and 13 cell lines with breakpoints in this chromosomal region. The cell lines define 10 distinct intervals in this region, which spans approximately 20 Mb. The markers include 6 RFLP markers, 11 microsatellites that provisionally had been mapped to the region 13q14-21, and 2 new polymorphic CA-repeats that were developed from an EMBL3 library of cell line ICD, containing 13pter-q14.3. The following order of markers was established: CEN - D13S320 - (D13S118, D13S153) - RB1- D13S319 - D13S25 - (D13S31, D13S59, D13S133, D13S137) - D13S163 - D13S119 - (D13S26, D13S55) - (D13S131, D13S134, D13S135, D13S144, D13S152) - TEL.

Original language	English (US)
Pages (from-to)	59-65
Number of pages	7
Journal	European Journal of Human Genetics
Volume	2
Issue number	1
DOIs	https://doi.org/10.1159/000472342
State	Published - Jan 1 1994
Externally published	Yes

Keywords

Chromosome 13
Physical mapping
Wilson disease

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1159/000472342

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@article{452c5348d72e46f9b8a69f27ce7fa124,

title = "A deletion hybrid breakpoint map of the chromosomal region 13q14-q21 orders 19 genetic markers in 10 intervals",

abstract = "A deletion hybrid breakpoint map of the chromosomal region 13q14-q21 has been constructed using 19 DNA markers and 13 cell lines with breakpoints in this chromosomal region. The cell lines define 10 distinct intervals in this region, which spans approximately 20 Mb. The markers include 6 RFLP markers, 11 microsatellites that provisionally had been mapped to the region 13q14-21, and 2 new polymorphic CA-repeats that were developed from an EMBL3 library of cell line ICD, containing 13pter-q14.3. The following order of markers was established: CEN - D13S320 - (D13S118, D13S153) - RB1- D13S319 - D13S25 - (D13S31, D13S59, D13S133, D13S137) - D13S163 - D13S119 - (D13S26, D13S55) - (D13S131, D13S134, D13S135, D13S144, D13S152) - TEL.",

keywords = "Chromosome 13, Physical mapping, Wilson disease",

author = "Kooy, {R. F.} and E. Verlind and Houwen, {R. H.J.} and Shapiro, {D. N.} and Hawthorn, {L. A.} and Cowell, {J. K.} and H. Scheffer and Buys, {C. H.C.M.}",

year = "1994",

month = jan,

day = "1",

doi = "10.1159/000472342",

language = "English (US)",

volume = "2",

pages = "59--65",

journal = "European Journal of Human Genetics",

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T1 - A deletion hybrid breakpoint map of the chromosomal region 13q14-q21 orders 19 genetic markers in 10 intervals

AU - Kooy, R. F.

AU - Verlind, E.

AU - Houwen, R. H.J.

AU - Shapiro, D. N.

AU - Hawthorn, L. A.

AU - Cowell, J. K.

AU - Scheffer, H.

AU - Buys, C. H.C.M.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - A deletion hybrid breakpoint map of the chromosomal region 13q14-q21 has been constructed using 19 DNA markers and 13 cell lines with breakpoints in this chromosomal region. The cell lines define 10 distinct intervals in this region, which spans approximately 20 Mb. The markers include 6 RFLP markers, 11 microsatellites that provisionally had been mapped to the region 13q14-21, and 2 new polymorphic CA-repeats that were developed from an EMBL3 library of cell line ICD, containing 13pter-q14.3. The following order of markers was established: CEN - D13S320 - (D13S118, D13S153) - RB1- D13S319 - D13S25 - (D13S31, D13S59, D13S133, D13S137) - D13S163 - D13S119 - (D13S26, D13S55) - (D13S131, D13S134, D13S135, D13S144, D13S152) - TEL.

AB - A deletion hybrid breakpoint map of the chromosomal region 13q14-q21 has been constructed using 19 DNA markers and 13 cell lines with breakpoints in this chromosomal region. The cell lines define 10 distinct intervals in this region, which spans approximately 20 Mb. The markers include 6 RFLP markers, 11 microsatellites that provisionally had been mapped to the region 13q14-21, and 2 new polymorphic CA-repeats that were developed from an EMBL3 library of cell line ICD, containing 13pter-q14.3. The following order of markers was established: CEN - D13S320 - (D13S118, D13S153) - RB1- D13S319 - D13S25 - (D13S31, D13S59, D13S133, D13S137) - D13S163 - D13S119 - (D13S26, D13S55) - (D13S131, D13S134, D13S135, D13S144, D13S152) - TEL.

KW - Chromosome 13

KW - Physical mapping

KW - Wilson disease

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A deletion hybrid breakpoint map of the chromosomal region 13q14-q21 orders 19 genetic markers in 10 intervals

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Keywords

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