A developmental switch affecting growth of fatty rats

Fatty (fa/fa) rats accumulate more adipose mass than their littermates soon after birth, but they first appear obese during the fourth week of life. We analyzed the effects of fa genotype on growth of pups housed with their dams through 4 wk of age. The fa genotype effects on daily gain were undetectable from 7 to 22 days of age but became highly significant (P = 10^-18) at 23 days of age. When litters were reduced to 4 pups, fa genotype effects on daily gain also became detectable at 23 days of age. The fa genotype effects on daily gain, stomach contents weight, liver weight, and plasma insulin of rats killed from 20 to 24 days of age displayed a marked genotype by age interaction, becoming highly significant at 23 days of age. These changes occur without the environmental changes induced by separating pups from their dams. These observations suggest that a developmental switch triggers hyperphagia and rapidly increases growth rate of fatty rats after 22 days of age.