A double-blind comparison of three dosages of flutroline (CP-36,584) in the treatment of schizophrenia

Joseph Patrick McEvoy, S. Berney, W. H. Wilson, T. A. Ban, W. Guy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Therapeutic and adverse effects of three dosages (1, 20 and 100 mg daily) of flutroline, a new γ-carboline with a preclinical pharmacological profile similar to active neuroleptic agents, were compared in a double-blind clinical trial in 25 newly-admitted schizophrenic patients. Therapeutic effects and extrapyramidal signs were seen at the 20 and 100-mg daily dosages, but not at the 1-mg dosage. Serum prolactin levels were significantly elevated only at the 100-mg daily dose.

Original languageEnglish (US)
Pages (from-to)318-324
Number of pages7
JournalUnknown Journal
Volume15
Issue number5
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

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Therapeutic Uses
schizophrenia
Schizophrenia
Carbolines
Prolactin
Antipsychotic Agents
Clinical Trials
Pharmacology
Therapeutics
Serum
flutroline

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A double-blind comparison of three dosages of flutroline (CP-36,584) in the treatment of schizophrenia. / McEvoy, Joseph Patrick; Berney, S.; Wilson, W. H.; Ban, T. A.; Guy, W.

In: Unknown Journal, Vol. 15, No. 5, 01.01.1980, p. 318-324.

Research output: Contribution to journalArticle

McEvoy, Joseph Patrick ; Berney, S. ; Wilson, W. H. ; Ban, T. A. ; Guy, W. / A double-blind comparison of three dosages of flutroline (CP-36,584) in the treatment of schizophrenia. In: Unknown Journal. 1980 ; Vol. 15, No. 5. pp. 318-324.
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