A double-blind comparison of three dosages of flutroline (CP-36,584) in the treatment of schizophrenia

J. P. McEvoy, S. Berney, W. H. Wilson, T. A. Ban, W. Guy

Research output: Contribution to journalArticle

6 Scopus citations


Therapeutic and adverse effects of three dosages (1, 20 and 100 mg daily) of flutroline, a new γ-carboline with a preclinical pharmacological profile similar to active neuroleptic agents, were compared in a double-blind clinical trial in 25 newly-admitted schizophrenic patients. Therapeutic effects and extrapyramidal signs were seen at the 20 and 100-mg daily dosages, but not at the 1-mg dosage. Serum prolactin levels were significantly elevated only at the 100-mg daily dose.

Original languageEnglish (US)
Pages (from-to)318-324
Number of pages7
JournalUnknown Journal
Issue number5
StatePublished - Jan 1 1980
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

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