A dynamic model for assessing universal Hepatitis A vaccination in Canada

C. T. Bauch, Arni S R Rao, B. Z. Pham, M. Krahn, V. Gilca, B. Duval, M. H. Chen, A. C. Tricco

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Vaccination against Hepatitis A virus (HAV) in Canada is currently targeted toward high-risk groups. However, universal vaccination has been adopted in several other countries with a similar disease burden. Here we develop an age-structured compartmental model of HAV transmission and vaccination in Canada to assess potential universal vaccination strategies. The model predicts that universal vaccination at age 1 (respectively 4, 9, 15), with phasing out of targeted vaccination, would reduce reported incidence by 60% (respectively 52, 36, 31%) and mortality attributable to HAV by 56% (respectively 45, 26, 25%), relative to continued targeted vaccination, over 80 years.

Original languageEnglish (US)
Pages (from-to)1719-1726
Number of pages8
JournalVaccine
Volume25
Issue number10
DOIs
StatePublished - Feb 26 2007
Externally publishedYes

Keywords

  • Hepatitis A
  • Transmission model
  • Universal vaccination

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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  • Cite this

    Bauch, C. T., Rao, A. S. R., Pham, B. Z., Krahn, M., Gilca, V., Duval, B., Chen, M. H., & Tricco, A. C. (2007). A dynamic model for assessing universal Hepatitis A vaccination in Canada. Vaccine, 25(10), 1719-1726. https://doi.org/10.1016/j.vaccine.2006.11.020