A dynamic model for assessing universal Hepatitis A vaccination in Canada

C. T. Bauch, Arni S R Rao, B. Z. Pham, M. Krahn, V. Gilca, B. Duval, M. H. Chen, A. C. Tricco

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Vaccination against Hepatitis A virus (HAV) in Canada is currently targeted toward high-risk groups. However, universal vaccination has been adopted in several other countries with a similar disease burden. Here we develop an age-structured compartmental model of HAV transmission and vaccination in Canada to assess potential universal vaccination strategies. The model predicts that universal vaccination at age 1 (respectively 4, 9, 15), with phasing out of targeted vaccination, would reduce reported incidence by 60% (respectively 52, 36, 31%) and mortality attributable to HAV by 56% (respectively 45, 26, 25%), relative to continued targeted vaccination, over 80 years.

Original languageEnglish (US)
Pages (from-to)1719-1726
Number of pages8
JournalVaccine
Volume25
Issue number10
DOIs
StatePublished - Feb 26 2007
Externally publishedYes

Fingerprint

hepatitis A
Hepatitis A
dynamic models
Canada
Vaccination
vaccination
Hepatitis A virus
burden of disease
risk groups
virus transmission
incidence
Mortality
Incidence

Keywords

  • Hepatitis A
  • Transmission model
  • Universal vaccination

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Bauch, C. T., Rao, A. S. R., Pham, B. Z., Krahn, M., Gilca, V., Duval, B., ... Tricco, A. C. (2007). A dynamic model for assessing universal Hepatitis A vaccination in Canada. Vaccine, 25(10), 1719-1726. https://doi.org/10.1016/j.vaccine.2006.11.020

A dynamic model for assessing universal Hepatitis A vaccination in Canada. / Bauch, C. T.; Rao, Arni S R; Pham, B. Z.; Krahn, M.; Gilca, V.; Duval, B.; Chen, M. H.; Tricco, A. C.

In: Vaccine, Vol. 25, No. 10, 26.02.2007, p. 1719-1726.

Research output: Contribution to journalArticle

Bauch, CT, Rao, ASR, Pham, BZ, Krahn, M, Gilca, V, Duval, B, Chen, MH & Tricco, AC 2007, 'A dynamic model for assessing universal Hepatitis A vaccination in Canada', Vaccine, vol. 25, no. 10, pp. 1719-1726. https://doi.org/10.1016/j.vaccine.2006.11.020
Bauch, C. T. ; Rao, Arni S R ; Pham, B. Z. ; Krahn, M. ; Gilca, V. ; Duval, B. ; Chen, M. H. ; Tricco, A. C. / A dynamic model for assessing universal Hepatitis A vaccination in Canada. In: Vaccine. 2007 ; Vol. 25, No. 10. pp. 1719-1726.
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