A functional analysis and the potential clinical significance of 7 categories of sperm morphology

D. T. Carrell, R. L. Zobell, R. G. Middleton, R. L. Urry, Ronald W Lewis

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Sperm morphology is a critical factor in the evaluation of infertile men. Patients often exhibit a morphology profile with consistent increases of specific abnormal categories of sperm morphology. We analyzed the functional ability of 7 categories of sperm morphology using assays that measure sperm viability longevity, deoxyribonucleic acid packing, acrosomal status, and the stimulation of the acrosome reaction with human cumulus/oocyte complexes and calcium ionophore A23187. Each morphology category was separately analyzed initially and at 3, 6, 12, 18 and 24 hours of in vitro culture. The data indicate that all categories of abnormal sperm morphology exhibit various functional debilities. However, tapered sperm most closely approached normal sperm function. All abnormal categories possessed subpopulations of sperm that functioned normally to the limits of these assays. These data indicate that increases in any of the categories of abnormal sperm morphology may lead to decreased fertility due to diminished functional ability indicated by the assays performed in this study.

Original languageEnglish (US)
Pages (from-to)377-380
Number of pages4
JournalJournal of Urology
Volume151
Issue number2
StatePublished - Jan 1 1994

Fingerprint

Spermatozoa
Acrosome Reaction
Calcium Ionophores
Calcimycin
Oocytes
Fertility
DNA

Keywords

  • infertility, male
  • semen
  • spermatozoa

ASJC Scopus subject areas

  • Urology

Cite this

Carrell, D. T., Zobell, R. L., Middleton, R. G., Urry, R. L., & Lewis, R. W. (1994). A functional analysis and the potential clinical significance of 7 categories of sperm morphology. Journal of Urology, 151(2), 377-380.

A functional analysis and the potential clinical significance of 7 categories of sperm morphology. / Carrell, D. T.; Zobell, R. L.; Middleton, R. G.; Urry, R. L.; Lewis, Ronald W.

In: Journal of Urology, Vol. 151, No. 2, 01.01.1994, p. 377-380.

Research output: Contribution to journalArticle

Carrell, DT, Zobell, RL, Middleton, RG, Urry, RL & Lewis, RW 1994, 'A functional analysis and the potential clinical significance of 7 categories of sperm morphology', Journal of Urology, vol. 151, no. 2, pp. 377-380.
Carrell DT, Zobell RL, Middleton RG, Urry RL, Lewis RW. A functional analysis and the potential clinical significance of 7 categories of sperm morphology. Journal of Urology. 1994 Jan 1;151(2):377-380.
Carrell, D. T. ; Zobell, R. L. ; Middleton, R. G. ; Urry, R. L. ; Lewis, Ronald W. / A functional analysis and the potential clinical significance of 7 categories of sperm morphology. In: Journal of Urology. 1994 ; Vol. 151, No. 2. pp. 377-380.
@article{6b33f751d362483581a1d31e1ceffb8f,
title = "A functional analysis and the potential clinical significance of 7 categories of sperm morphology",
abstract = "Sperm morphology is a critical factor in the evaluation of infertile men. Patients often exhibit a morphology profile with consistent increases of specific abnormal categories of sperm morphology. We analyzed the functional ability of 7 categories of sperm morphology using assays that measure sperm viability longevity, deoxyribonucleic acid packing, acrosomal status, and the stimulation of the acrosome reaction with human cumulus/oocyte complexes and calcium ionophore A23187. Each morphology category was separately analyzed initially and at 3, 6, 12, 18 and 24 hours of in vitro culture. The data indicate that all categories of abnormal sperm morphology exhibit various functional debilities. However, tapered sperm most closely approached normal sperm function. All abnormal categories possessed subpopulations of sperm that functioned normally to the limits of these assays. These data indicate that increases in any of the categories of abnormal sperm morphology may lead to decreased fertility due to diminished functional ability indicated by the assays performed in this study.",
keywords = "infertility, male, semen, spermatozoa",
author = "Carrell, {D. T.} and Zobell, {R. L.} and Middleton, {R. G.} and Urry, {R. L.} and Lewis, {Ronald W}",
year = "1994",
month = "1",
day = "1",
language = "English (US)",
volume = "151",
pages = "377--380",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - A functional analysis and the potential clinical significance of 7 categories of sperm morphology

AU - Carrell, D. T.

AU - Zobell, R. L.

AU - Middleton, R. G.

AU - Urry, R. L.

AU - Lewis, Ronald W

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Sperm morphology is a critical factor in the evaluation of infertile men. Patients often exhibit a morphology profile with consistent increases of specific abnormal categories of sperm morphology. We analyzed the functional ability of 7 categories of sperm morphology using assays that measure sperm viability longevity, deoxyribonucleic acid packing, acrosomal status, and the stimulation of the acrosome reaction with human cumulus/oocyte complexes and calcium ionophore A23187. Each morphology category was separately analyzed initially and at 3, 6, 12, 18 and 24 hours of in vitro culture. The data indicate that all categories of abnormal sperm morphology exhibit various functional debilities. However, tapered sperm most closely approached normal sperm function. All abnormal categories possessed subpopulations of sperm that functioned normally to the limits of these assays. These data indicate that increases in any of the categories of abnormal sperm morphology may lead to decreased fertility due to diminished functional ability indicated by the assays performed in this study.

AB - Sperm morphology is a critical factor in the evaluation of infertile men. Patients often exhibit a morphology profile with consistent increases of specific abnormal categories of sperm morphology. We analyzed the functional ability of 7 categories of sperm morphology using assays that measure sperm viability longevity, deoxyribonucleic acid packing, acrosomal status, and the stimulation of the acrosome reaction with human cumulus/oocyte complexes and calcium ionophore A23187. Each morphology category was separately analyzed initially and at 3, 6, 12, 18 and 24 hours of in vitro culture. The data indicate that all categories of abnormal sperm morphology exhibit various functional debilities. However, tapered sperm most closely approached normal sperm function. All abnormal categories possessed subpopulations of sperm that functioned normally to the limits of these assays. These data indicate that increases in any of the categories of abnormal sperm morphology may lead to decreased fertility due to diminished functional ability indicated by the assays performed in this study.

KW - infertility, male

KW - semen

KW - spermatozoa

UR - http://www.scopus.com/inward/record.url?scp=0028091198&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028091198&partnerID=8YFLogxK

M3 - Article

VL - 151

SP - 377

EP - 380

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 2

ER -