A gene for recessive nonsyndromic sensorineural deafness (DFNB18) maps to the chromosomal region 11p14-p15.1 containing the Usher syndrome type 1C gene

Pawan K. Jain, Anil K. Lalwani, Xiaoyan C. Li, Teresa L. Singleton, Tenesha N. Smith, Hung Chih Chen, Dilip Deshmukh, Ishwar C. Verma, Richard J.H. Smith, Edward R. Wilcox

Research output: Contribution to journalArticle

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Abstract

Autosomal recessive nonsyndromic sensorineural deafness segregating in a large consanguineous Indian family was mapped to chromosome 11p14-p15.1 defining a new locus, DFNB18. A maximum lod score of 4.4 at O = 0 was obtained for the polymorphic microsatellite marker D11S1888. Haplotype analysis localizes this gene between markers D11S1307 and D11S2368, which is approximately 1.6 cM and encompasses the region of Usher syndrome type 1C (USHIC). We postulate that DFNB18 and USHIC are allelic variants of the same gene.

Original languageEnglish (US)
Pages (from-to)290-292
Number of pages3
JournalGenomics
Volume50
Issue number2
DOIs
StatePublished - Jun 1 1998

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Recessive Genes
Lod Score
Microsatellite Repeats
Haplotypes
Genes
Chromosomes
Autosomal Recessive 18 Deafness
Nonsyndromic Deafness
Type 1C Usher syndrome

ASJC Scopus subject areas

  • Genetics

Cite this

A gene for recessive nonsyndromic sensorineural deafness (DFNB18) maps to the chromosomal region 11p14-p15.1 containing the Usher syndrome type 1C gene. / Jain, Pawan K.; Lalwani, Anil K.; Li, Xiaoyan C.; Singleton, Teresa L.; Smith, Tenesha N.; Chen, Hung Chih; Deshmukh, Dilip; Verma, Ishwar C.; Smith, Richard J.H.; Wilcox, Edward R.

In: Genomics, Vol. 50, No. 2, 01.06.1998, p. 290-292.

Research output: Contribution to journalArticle

Jain, PK, Lalwani, AK, Li, XC, Singleton, TL, Smith, TN, Chen, HC, Deshmukh, D, Verma, IC, Smith, RJH & Wilcox, ER 1998, 'A gene for recessive nonsyndromic sensorineural deafness (DFNB18) maps to the chromosomal region 11p14-p15.1 containing the Usher syndrome type 1C gene', Genomics, vol. 50, no. 2, pp. 290-292. https://doi.org/10.1006/geno.1998.5320
Jain, Pawan K. ; Lalwani, Anil K. ; Li, Xiaoyan C. ; Singleton, Teresa L. ; Smith, Tenesha N. ; Chen, Hung Chih ; Deshmukh, Dilip ; Verma, Ishwar C. ; Smith, Richard J.H. ; Wilcox, Edward R. / A gene for recessive nonsyndromic sensorineural deafness (DFNB18) maps to the chromosomal region 11p14-p15.1 containing the Usher syndrome type 1C gene. In: Genomics. 1998 ; Vol. 50, No. 2. pp. 290-292.
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abstract = "Autosomal recessive nonsyndromic sensorineural deafness segregating in a large consanguineous Indian family was mapped to chromosome 11p14-p15.1 defining a new locus, DFNB18. A maximum lod score of 4.4 at O = 0 was obtained for the polymorphic microsatellite marker D11S1888. Haplotype analysis localizes this gene between markers D11S1307 and D11S2368, which is approximately 1.6 cM and encompasses the region of Usher syndrome type 1C (USHIC). We postulate that DFNB18 and USHIC are allelic variants of the same gene.",
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