Abstract
Objective: To assess in two animal surgery models, the efficacy of a bioabsorbable gel to prevent postoperative adhesions. Design: A randomized, prospective, blinded study using animal abdominal surgery models. Setting: Two animals species with surgical traumas to induce adhesion formation. Interventions: A chemically modified hyaluronate and carboxymethylcellulose- based gel formulation. Main Outcome Measures: The number of animals with no adhesions, mean number of adhesions, and total adhesion score. Results: Treatment with the bioabsorbable gel increased the number of animals without any adhesion by 70% in a rat cecal abrasion model and by >90% in a rabbit sidewall defect-bowel abrasion model when compared with nontreatment control animals. Other outcome measures showed similar efficacy. Conclusion: The modified hyaluronate-carboxymethylcellulose gel was effective in two animal species after surgery in the abdominal cavity. The gel appears to act as a physical harrier between damaged peritoneal tissue and may be appropriate for human clinical trials in open and laparoscopic surgical procedures.
Original language | English (US) |
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Pages (from-to) | 814-821 |
Number of pages | 8 |
Journal | Fertility and sterility |
Volume | 66 |
Issue number | 5 |
DOIs | |
State | Published - 1996 |
Externally published | Yes |
Keywords
- Postsurgical adhesions
- adhesion prevention
- hyaluronate gel
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology