A hyaluronate based gel for the prevention of postsurgical adhesions: Evaluation in two animal species

J. W. Burns, K. Skinner, M. J. Colt, L. Burgess, R. Rose, M. P. Diamond

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Objective: To assess in two animal surgery models, the efficacy of a bioabsorbable gel to prevent postoperative adhesions. Design: A randomized, prospective, blinded study using animal abdominal surgery models. Setting: Two animals species with surgical traumas to induce adhesion formation. Interventions: A chemically modified hyaluronate and carboxymethylcellulose- based gel formulation. Main Outcome Measures: The number of animals with no adhesions, mean number of adhesions, and total adhesion score. Results: Treatment with the bioabsorbable gel increased the number of animals without any adhesion by 70% in a rat cecal abrasion model and by >90% in a rabbit sidewall defect-bowel abrasion model when compared with nontreatment control animals. Other outcome measures showed similar efficacy. Conclusion: The modified hyaluronate-carboxymethylcellulose gel was effective in two animal species after surgery in the abdominal cavity. The gel appears to act as a physical harrier between damaged peritoneal tissue and may be appropriate for human clinical trials in open and laparoscopic surgical procedures.

Original languageEnglish (US)
Pages (from-to)814-821
Number of pages8
JournalFertility and sterility
Volume66
Issue number5
StatePublished - Jan 1 1996

Fingerprint

Gels
Carboxymethylcellulose Sodium
Outcome Assessment (Health Care)
Abdominal Cavity
Laparoscopy
Animal Models
Clinical Trials
Prospective Studies
Rabbits
Wounds and Injuries

Keywords

  • Postsurgical adhesions
  • adhesion prevention
  • hyaluronate gel

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

A hyaluronate based gel for the prevention of postsurgical adhesions : Evaluation in two animal species. / Burns, J. W.; Skinner, K.; Colt, M. J.; Burgess, L.; Rose, R.; Diamond, M. P.

In: Fertility and sterility, Vol. 66, No. 5, 01.01.1996, p. 814-821.

Research output: Contribution to journalArticle

Burns, JW, Skinner, K, Colt, MJ, Burgess, L, Rose, R & Diamond, MP 1996, 'A hyaluronate based gel for the prevention of postsurgical adhesions: Evaluation in two animal species', Fertility and sterility, vol. 66, no. 5, pp. 814-821.
Burns, J. W. ; Skinner, K. ; Colt, M. J. ; Burgess, L. ; Rose, R. ; Diamond, M. P. / A hyaluronate based gel for the prevention of postsurgical adhesions : Evaluation in two animal species. In: Fertility and sterility. 1996 ; Vol. 66, No. 5. pp. 814-821.
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