TY - JOUR
T1 - A hybrid approach to direct pulp capping by using emdogain with a capping material
AU - Al-Hezaimi, Khalid
AU - Al-Tayar, Badr Abdullah
AU - Bajuaifer, Yaseer Salim
AU - Salameh, Ziad
AU - Al-Fouzan, Khalid
AU - Tay, Franklin R.
PY - 2011/5
Y1 - 2011/5
N2 - Introduction: This study evaluated the formation of reparative hard tissues in baboon pulps after Emdogain (EMD) application in conjunction with 3 pulp-capping materials. Methods: Thirty-two premolars in four 3-year-old baboons were randomly assigned to 1 of 3 pulp-capping materials. A split-mouth design and intra-animal side randomization were applied to 3 ex-perimental groups (calcium hydroxide, ProRoot White mineral trioxide aggregate, white Portland cement) and the control group (no pulp-capping material). In the hybrid EMD approach, a small drop of EMD was placed over the exposure site after arrest of hemorrhage. The designated pulp-capping material was placed over the EMD, followed by placement of resin-modified glass ionomer cement over the set/unset pulp-capping material. The animals were killed after 4 months. Histomorphometric analysis and micro-computed tomography were performed on the re-trieved specimens. Results: All groups capped with EMD and 1 of the 3 capping materials exhibited similar reparative tissue thickness (P > .05). Dentin tunnel defects were absent in the mineral trioxide aggregate and Portland cement groups after the use of EMD. However, only a tubular was identified from all specimens. Conclusions: Mineral trioxide aggregate produces a better quality reparative hard tissue response with the adjunctive use of Emdogain, when compared with the use of calcium hydroxide.
AB - Introduction: This study evaluated the formation of reparative hard tissues in baboon pulps after Emdogain (EMD) application in conjunction with 3 pulp-capping materials. Methods: Thirty-two premolars in four 3-year-old baboons were randomly assigned to 1 of 3 pulp-capping materials. A split-mouth design and intra-animal side randomization were applied to 3 ex-perimental groups (calcium hydroxide, ProRoot White mineral trioxide aggregate, white Portland cement) and the control group (no pulp-capping material). In the hybrid EMD approach, a small drop of EMD was placed over the exposure site after arrest of hemorrhage. The designated pulp-capping material was placed over the EMD, followed by placement of resin-modified glass ionomer cement over the set/unset pulp-capping material. The animals were killed after 4 months. Histomorphometric analysis and micro-computed tomography were performed on the re-trieved specimens. Results: All groups capped with EMD and 1 of the 3 capping materials exhibited similar reparative tissue thickness (P > .05). Dentin tunnel defects were absent in the mineral trioxide aggregate and Portland cement groups after the use of EMD. However, only a tubular was identified from all specimens. Conclusions: Mineral trioxide aggregate produces a better quality reparative hard tissue response with the adjunctive use of Emdogain, when compared with the use of calcium hydroxide.
KW - Emdogain
KW - histomorphometric analysis
KW - micro-CT
KW - pulp capping
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U2 - 10.1016/j.joen.2011.02.003
DO - 10.1016/j.joen.2011.02.003
M3 - Article
C2 - 21496668
AN - SCOPUS:79956209890
SN - 0099-2399
VL - 37
SP - 667
EP - 672
JO - Journal of endodontics
JF - Journal of endodontics
IS - 5
ER -