A hypothesis concerning the general basis of organogenetic congenital anomalies

Frederick Naftolin, Michael Peter Diamond, Emese Pinter, E. Albert Reece, M. K. Sanyal

Research output: Contribution to journalArticle

16 Scopus citations


Evidence supports the idea that it is the degree of metabolic imbalance present in diabetic gravid women during the period of organogenesis that accounts for organogenetic congenital defects. In light of the proved and inferred metabolic instability occurring during early pregnancy, we propose that metabolic imbalances may occur that result in organogenetic congenital defects in offspring of apparently normal gravid women.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1
Publication statusPublished - Jan 1 1987
Externally publishedYes



  • Organogenesis
  • birth defect
  • diabetes mellitus

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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