A model combining age, equivalent uniform dose and IL-8 may predict radiation esophagitis in patients with non-small cell lung cancer

Shulian Wang, Jeff Campbell, Matthew H. Stenmark, Paul Stanton, Jing Zhao, Martha M. Matuszak, Randall K. Ten Haken, Feng Ming Kong

Research output: Contribution to journalArticle

Abstract

Background and purpose: To study whether cytokine markers may improve predictive accuracy of radiation esophagitis (RE) in non-small cell lung cancer (NSCLC) patients. Materials and methods: A total of 129 patients with stage I–III NSCLC treated with radiotherapy (RT) from prospective studies were included. Thirty inflammatory cytokines were measured in platelet-poor plasma samples. Logistic regression was performed to evaluate the risk factors of RE. Stepwise Akaike information criterion (AIC) and likelihood ratio test were used to assess model predictions. Results: Forty-nine of 129 patients (38.0%) developed grade ≥2 RE. Univariate analysis showed that age, stage, concurrent chemotherapy, and eight dosimetric parameters were significantly associated with grade ≥2 RE (p < 0.05). IL-4, IL-5, IL-8, IL-13, IL-15, IL-1α TGFα and eotaxin were also associated with grade ≥2 RE (p < 0.1). Age, esophagus generalized equivalent uniform dose (EUD), and baseline IL-8 were independently associated grade ≥2 RE. The combination of these three factors had significantly higher predictive power than any single factor alone. Addition of IL-8 to toxicity model significantly improves RE predictive accuracy (p = 0.019). Conclusions: Combining baseline level of IL-8, age and esophagus EUD may predict RE more accurately. Refinement of this model with larger sample sizes and validation from multicenter database are warranted.

Original languageEnglish (US)
Pages (from-to)506-510
Number of pages5
JournalRadiotherapy and Oncology
Volume126
Issue number3
DOIs
StatePublished - Mar 1 2018

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Esophagitis
Interleukin-8
Non-Small Cell Lung Carcinoma
Radiation
Esophagus
Cytokines
Interleukin-15
Interleukin-13
Interleukin-5
Interleukin-1
Interleukin-4
Sample Size
Radiotherapy
Blood Platelets
Logistic Models
Databases
Prospective Studies
Drug Therapy

Keywords

  • Cytokines
  • Lung neoplasm
  • Non-small cell
  • Radiation esophagitis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

A model combining age, equivalent uniform dose and IL-8 may predict radiation esophagitis in patients with non-small cell lung cancer. / Wang, Shulian; Campbell, Jeff; Stenmark, Matthew H.; Stanton, Paul; Zhao, Jing; Matuszak, Martha M.; Ten Haken, Randall K.; Kong, Feng Ming.

In: Radiotherapy and Oncology, Vol. 126, No. 3, 01.03.2018, p. 506-510.

Research output: Contribution to journalArticle

Wang, S, Campbell, J, Stenmark, MH, Stanton, P, Zhao, J, Matuszak, MM, Ten Haken, RK & Kong, FM 2018, 'A model combining age, equivalent uniform dose and IL-8 may predict radiation esophagitis in patients with non-small cell lung cancer', Radiotherapy and Oncology, vol. 126, no. 3, pp. 506-510. https://doi.org/10.1016/j.radonc.2017.12.026
Wang, Shulian ; Campbell, Jeff ; Stenmark, Matthew H. ; Stanton, Paul ; Zhao, Jing ; Matuszak, Martha M. ; Ten Haken, Randall K. ; Kong, Feng Ming. / A model combining age, equivalent uniform dose and IL-8 may predict radiation esophagitis in patients with non-small cell lung cancer. In: Radiotherapy and Oncology. 2018 ; Vol. 126, No. 3. pp. 506-510.
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