A modified bronchial anastomosis technique for lung transplantation

Carsten Schröder, Frank Scholl, Emmanuel Daon, Andrea Goodwin, William H. Frist, John R. Roberts, Karla G. Christian, Mathew Ninan, Aaron P. Milstone, James E. Loyd, Walter H. Merrill, Richard N. Pierson

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background. Low rates of major complications have been reported for the intussuscepting bronchial anastomotic technique but stenosis, malacia, and granulation tissue at the anastomosis may cause clinically important morbidity. We hypothesized that a modification of the telescoping technique that improves bronchial wall apposition might be associated with improved bronchial healing and clinical outcomes. Methods. The telescoping horizontal mattress "U-stitch" suture technique was modified to incorporate figure-of-eight sutures placed in the cartilaginous wall between each of three intussuscepting U stitches. Serial videotape records of 152 individual anastomoses (99 modified, 53 telescoped) in 118 consecutive operative survivors were retrospectively reviewed by examiners blinded with respect to technique used. Stenosis, airway instability, mucosa quality, and devascularized luminal tissue were graded at 4 to 14 days (initial), 4 to 12 weeks (early), and 6 to 12 months (late) after transplantation. Results. The incidence of anastomotic stenosis was significantly lower using the modified technique at the initial (p = 0.025) and late (p = 0.015) observations. In the initial phase airway instability (p = 0.015) and devascularization grades (p = 0.001) were also significant lower in the modified group. There were no significant differences in mucosal condition between techniques. The modified telescoping technique was associated with significant survival advantage (mean 17.7%; p = 0.029) by multivariate analysis. The incidence of major airway complications (dehiscences and stenoses required stents) tended to be lower (3% versus 6%) in the modified group. Conclusions. The modified telescoping bronchial anastomosis technique is associated with improved early and late bronchial healing and higher 5-year survival without increased major airway complications.

Original languageEnglish (US)
Pages (from-to)1697-1704
Number of pages8
JournalAnnals of Thoracic Surgery
Volume75
Issue number6
DOIs
StatePublished - Jun 1 2003

Fingerprint

Telescopes
Lung Transplantation
Pathologic Constriction
Suture Techniques
Videotape Recording
Survival
Granulation Tissue
Incidence
Sutures
Stents
Survivors
Mucous Membrane
Multivariate Analysis
Transplantation
Morbidity

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Schröder, C., Scholl, F., Daon, E., Goodwin, A., Frist, W. H., Roberts, J. R., ... Pierson, R. N. (2003). A modified bronchial anastomosis technique for lung transplantation. Annals of Thoracic Surgery, 75(6), 1697-1704. https://doi.org/10.1016/S0003-4975(03)00011-0

A modified bronchial anastomosis technique for lung transplantation. / Schröder, Carsten; Scholl, Frank; Daon, Emmanuel; Goodwin, Andrea; Frist, William H.; Roberts, John R.; Christian, Karla G.; Ninan, Mathew; Milstone, Aaron P.; Loyd, James E.; Merrill, Walter H.; Pierson, Richard N.

In: Annals of Thoracic Surgery, Vol. 75, No. 6, 01.06.2003, p. 1697-1704.

Research output: Contribution to journalArticle

Schröder, C, Scholl, F, Daon, E, Goodwin, A, Frist, WH, Roberts, JR, Christian, KG, Ninan, M, Milstone, AP, Loyd, JE, Merrill, WH & Pierson, RN 2003, 'A modified bronchial anastomosis technique for lung transplantation', Annals of Thoracic Surgery, vol. 75, no. 6, pp. 1697-1704. https://doi.org/10.1016/S0003-4975(03)00011-0
Schröder C, Scholl F, Daon E, Goodwin A, Frist WH, Roberts JR et al. A modified bronchial anastomosis technique for lung transplantation. Annals of Thoracic Surgery. 2003 Jun 1;75(6):1697-1704. https://doi.org/10.1016/S0003-4975(03)00011-0
Schröder, Carsten ; Scholl, Frank ; Daon, Emmanuel ; Goodwin, Andrea ; Frist, William H. ; Roberts, John R. ; Christian, Karla G. ; Ninan, Mathew ; Milstone, Aaron P. ; Loyd, James E. ; Merrill, Walter H. ; Pierson, Richard N. / A modified bronchial anastomosis technique for lung transplantation. In: Annals of Thoracic Surgery. 2003 ; Vol. 75, No. 6. pp. 1697-1704.
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abstract = "Background. Low rates of major complications have been reported for the intussuscepting bronchial anastomotic technique but stenosis, malacia, and granulation tissue at the anastomosis may cause clinically important morbidity. We hypothesized that a modification of the telescoping technique that improves bronchial wall apposition might be associated with improved bronchial healing and clinical outcomes. Methods. The telescoping horizontal mattress {"}U-stitch{"} suture technique was modified to incorporate figure-of-eight sutures placed in the cartilaginous wall between each of three intussuscepting U stitches. Serial videotape records of 152 individual anastomoses (99 modified, 53 telescoped) in 118 consecutive operative survivors were retrospectively reviewed by examiners blinded with respect to technique used. Stenosis, airway instability, mucosa quality, and devascularized luminal tissue were graded at 4 to 14 days (initial), 4 to 12 weeks (early), and 6 to 12 months (late) after transplantation. Results. The incidence of anastomotic stenosis was significantly lower using the modified technique at the initial (p = 0.025) and late (p = 0.015) observations. In the initial phase airway instability (p = 0.015) and devascularization grades (p = 0.001) were also significant lower in the modified group. There were no significant differences in mucosal condition between techniques. The modified telescoping technique was associated with significant survival advantage (mean 17.7{\%}; p = 0.029) by multivariate analysis. The incidence of major airway complications (dehiscences and stenoses required stents) tended to be lower (3{\%} versus 6{\%}) in the modified group. Conclusions. The modified telescoping bronchial anastomosis technique is associated with improved early and late bronchial healing and higher 5-year survival without increased major airway complications.",
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T1 - A modified bronchial anastomosis technique for lung transplantation

AU - Schröder, Carsten

AU - Scholl, Frank

AU - Daon, Emmanuel

AU - Goodwin, Andrea

AU - Frist, William H.

AU - Roberts, John R.

AU - Christian, Karla G.

AU - Ninan, Mathew

AU - Milstone, Aaron P.

AU - Loyd, James E.

AU - Merrill, Walter H.

AU - Pierson, Richard N.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Background. Low rates of major complications have been reported for the intussuscepting bronchial anastomotic technique but stenosis, malacia, and granulation tissue at the anastomosis may cause clinically important morbidity. We hypothesized that a modification of the telescoping technique that improves bronchial wall apposition might be associated with improved bronchial healing and clinical outcomes. Methods. The telescoping horizontal mattress "U-stitch" suture technique was modified to incorporate figure-of-eight sutures placed in the cartilaginous wall between each of three intussuscepting U stitches. Serial videotape records of 152 individual anastomoses (99 modified, 53 telescoped) in 118 consecutive operative survivors were retrospectively reviewed by examiners blinded with respect to technique used. Stenosis, airway instability, mucosa quality, and devascularized luminal tissue were graded at 4 to 14 days (initial), 4 to 12 weeks (early), and 6 to 12 months (late) after transplantation. Results. The incidence of anastomotic stenosis was significantly lower using the modified technique at the initial (p = 0.025) and late (p = 0.015) observations. In the initial phase airway instability (p = 0.015) and devascularization grades (p = 0.001) were also significant lower in the modified group. There were no significant differences in mucosal condition between techniques. The modified telescoping technique was associated with significant survival advantage (mean 17.7%; p = 0.029) by multivariate analysis. The incidence of major airway complications (dehiscences and stenoses required stents) tended to be lower (3% versus 6%) in the modified group. Conclusions. The modified telescoping bronchial anastomosis technique is associated with improved early and late bronchial healing and higher 5-year survival without increased major airway complications.

AB - Background. Low rates of major complications have been reported for the intussuscepting bronchial anastomotic technique but stenosis, malacia, and granulation tissue at the anastomosis may cause clinically important morbidity. We hypothesized that a modification of the telescoping technique that improves bronchial wall apposition might be associated with improved bronchial healing and clinical outcomes. Methods. The telescoping horizontal mattress "U-stitch" suture technique was modified to incorporate figure-of-eight sutures placed in the cartilaginous wall between each of three intussuscepting U stitches. Serial videotape records of 152 individual anastomoses (99 modified, 53 telescoped) in 118 consecutive operative survivors were retrospectively reviewed by examiners blinded with respect to technique used. Stenosis, airway instability, mucosa quality, and devascularized luminal tissue were graded at 4 to 14 days (initial), 4 to 12 weeks (early), and 6 to 12 months (late) after transplantation. Results. The incidence of anastomotic stenosis was significantly lower using the modified technique at the initial (p = 0.025) and late (p = 0.015) observations. In the initial phase airway instability (p = 0.015) and devascularization grades (p = 0.001) were also significant lower in the modified group. There were no significant differences in mucosal condition between techniques. The modified telescoping technique was associated with significant survival advantage (mean 17.7%; p = 0.029) by multivariate analysis. The incidence of major airway complications (dehiscences and stenoses required stents) tended to be lower (3% versus 6%) in the modified group. Conclusions. The modified telescoping bronchial anastomosis technique is associated with improved early and late bronchial healing and higher 5-year survival without increased major airway complications.

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