Abstract
Background: Adolescent alcohol abuse remains a serious public health concern, with nearly a third of high school seniors reporting heavy drinking in the previous month. Methods: Using the high ethanol-consuming C57BL/6J mouse strain, we examined the effects of ethanol (3.75 g/kg, IP, daily for 45 days) on body weight and brain region mass (cerebral cortex, cerebellum, corpus callosum) during peri-adolescence (postnatal day [P]25 to 70) or adulthood (P180 to 225) of both males and females. Results: In control peri-adolescent animals, body weight gain was greater in males compared with females. In the peri-adolescent exposure group, ethanol significantly reduced body weight gain to a similar extent in both male and female mice (82 and 84% of controls, respectively). In adult animals, body weight gain was much less than that of the peri-adolescent mice, with ethanol having a small but significant effect in males but not females. Between the control peri-adolescent and adult cohorts (measurements taken at P70 and 225, respectively), there were no significant differences in the mass of the cerebral cortex or the cerebellum from either male or female mice, although the rostro-caudal length of the corpus callosum increased slightly but significantly (6.1%) between these time points. Conclusions: Ethanol treatment significantly reduced the mass of the cerebral cortex in peri-adolescent (-3.1%), but not adult, treated mice. By contrast, ethanol significantly reduced the length of the corpus callosum in adult (-5.4%), but not peri-adolescent, treated mice. Future studies at the histological level may yield additional details concerning ethanol and the peri-adolescent brain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1728-1737 |
| Number of pages | 10 |
| Journal | Alcoholism: Clinical and Experimental Research |
| Volume | 36 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2012 |
| Externally published | Yes |
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Keywords
- Body weight
- Cerebellum
- Cerebral cortex
- Chronic
- Ethanol
- Gender
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Toxicology
- Psychiatry and Mental health
Cite this
A Mouse Model for Adolescent Alcohol Abuse : Stunted Growth and Effects in Brain. / Huang, Chiming; Titus, Jennifer A.; Bell, Richard L.; Kapros, Tamas; Chen, Jie; Huang, Rosa.
In: Alcoholism: Clinical and Experimental Research, Vol. 36, No. 10, 01.10.2012, p. 1728-1737.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A Mouse Model for Adolescent Alcohol Abuse
T2 - Stunted Growth and Effects in Brain
AU - Huang, Chiming
AU - Titus, Jennifer A.
AU - Bell, Richard L.
AU - Kapros, Tamas
AU - Chen, Jie
AU - Huang, Rosa
PY - 2012/10/1
Y1 - 2012/10/1
N2 - Background: Adolescent alcohol abuse remains a serious public health concern, with nearly a third of high school seniors reporting heavy drinking in the previous month. Methods: Using the high ethanol-consuming C57BL/6J mouse strain, we examined the effects of ethanol (3.75 g/kg, IP, daily for 45 days) on body weight and brain region mass (cerebral cortex, cerebellum, corpus callosum) during peri-adolescence (postnatal day [P]25 to 70) or adulthood (P180 to 225) of both males and females. Results: In control peri-adolescent animals, body weight gain was greater in males compared with females. In the peri-adolescent exposure group, ethanol significantly reduced body weight gain to a similar extent in both male and female mice (82 and 84% of controls, respectively). In adult animals, body weight gain was much less than that of the peri-adolescent mice, with ethanol having a small but significant effect in males but not females. Between the control peri-adolescent and adult cohorts (measurements taken at P70 and 225, respectively), there were no significant differences in the mass of the cerebral cortex or the cerebellum from either male or female mice, although the rostro-caudal length of the corpus callosum increased slightly but significantly (6.1%) between these time points. Conclusions: Ethanol treatment significantly reduced the mass of the cerebral cortex in peri-adolescent (-3.1%), but not adult, treated mice. By contrast, ethanol significantly reduced the length of the corpus callosum in adult (-5.4%), but not peri-adolescent, treated mice. Future studies at the histological level may yield additional details concerning ethanol and the peri-adolescent brain.
AB - Background: Adolescent alcohol abuse remains a serious public health concern, with nearly a third of high school seniors reporting heavy drinking in the previous month. Methods: Using the high ethanol-consuming C57BL/6J mouse strain, we examined the effects of ethanol (3.75 g/kg, IP, daily for 45 days) on body weight and brain region mass (cerebral cortex, cerebellum, corpus callosum) during peri-adolescence (postnatal day [P]25 to 70) or adulthood (P180 to 225) of both males and females. Results: In control peri-adolescent animals, body weight gain was greater in males compared with females. In the peri-adolescent exposure group, ethanol significantly reduced body weight gain to a similar extent in both male and female mice (82 and 84% of controls, respectively). In adult animals, body weight gain was much less than that of the peri-adolescent mice, with ethanol having a small but significant effect in males but not females. Between the control peri-adolescent and adult cohorts (measurements taken at P70 and 225, respectively), there were no significant differences in the mass of the cerebral cortex or the cerebellum from either male or female mice, although the rostro-caudal length of the corpus callosum increased slightly but significantly (6.1%) between these time points. Conclusions: Ethanol treatment significantly reduced the mass of the cerebral cortex in peri-adolescent (-3.1%), but not adult, treated mice. By contrast, ethanol significantly reduced the length of the corpus callosum in adult (-5.4%), but not peri-adolescent, treated mice. Future studies at the histological level may yield additional details concerning ethanol and the peri-adolescent brain.
KW - Body weight
KW - Cerebellum
KW - Cerebral cortex
KW - Chronic
KW - Ethanol
KW - Gender
UR - http://www.scopus.com/inward/record.url?scp=84867017331&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867017331&partnerID=8YFLogxK
U2 - 10.1111/j.1530-0277.2012.01759.x
DO - 10.1111/j.1530-0277.2012.01759.x
M3 - Article
C2 - 22433022
AN - SCOPUS:84867017331
VL - 36
SP - 1728
EP - 1737
JO - Alcoholism: Clinical and Experimental Research
JF - Alcoholism: Clinical and Experimental Research
SN - 0145-6008
IS - 10
ER -