A mouse model for the study of necrotizing enterocolitis

Irwin H. Krasna, Charles G Howell, Anita Vega, Moritz Ziegler, C. Evertt Koop

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A mouse model for the study of necrotizing enterocolitis is presented. It is a model of temporary intestinal ischemia and consists of occluding both superior mesenteric vessels with a bulldog clamp for varying periods of time. The resultant lesions resemble the intestinal lesions seen in necrotizing enterocolitis in respect to the gradual development of the necrotizing lesions and their patchy distribution. We also studied the effect of intravenous saline and low molecular weight dextran in preventing the development of these ischemic lesions. In moderate ischemia, saline and dextran show a similar protective effect, and in severe ischemia, both show a protective effect, with dextran being more effective than saline.

Original languageEnglish (US)
Pages (from-to)26-29
Number of pages4
JournalJournal of Pediatric Surgery
Volume21
Issue number1
DOIs
StatePublished - Jan 1 1986

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Necrotizing Enterocolitis
Ischemia
Dextrans
dextran - saline drug combination
Molecular Weight

Keywords

  • Necrotizing enterocolitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

A mouse model for the study of necrotizing enterocolitis. / Krasna, Irwin H.; Howell, Charles G; Vega, Anita; Ziegler, Moritz; Evertt Koop, C.

In: Journal of Pediatric Surgery, Vol. 21, No. 1, 01.01.1986, p. 26-29.

Research output: Contribution to journalArticle

Krasna, Irwin H. ; Howell, Charles G ; Vega, Anita ; Ziegler, Moritz ; Evertt Koop, C. / A mouse model for the study of necrotizing enterocolitis. In: Journal of Pediatric Surgery. 1986 ; Vol. 21, No. 1. pp. 26-29.
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