A multi-targeted approach to suppress tumor-promoting inflammation

Abbas K. Samadi, Alan Bilsland, Alexandros G. Georgakilas, Amedeo Amedei, Amr Amin, Anupam Bishayee, Asfar S. Azmi, Balakrishna L Lokeshwar, Brendan Grue, Carolina Panis, Chandra S. Boosani, Deepak Poudyal, Diana M. Stafforini, Dipita Bhakta, Elena Niccolai, Gunjan Guha, H. P. Vasantha Rupasinghe, Hiromasa Fujii, Kanya Honoki, Kapil MehtaKatia Aquilano, Leroy Lowe, Lorne J. Hofseth, Luigi Ricciardiello, Maria Rosa Ciriolo, Neetu Singh, Richard L. Whelan, Rupesh Chaturvedi, S. Salman Ashraf, H. M.C. Shantha Kumara, Somaira Nowsheen, Sulma I. Mohammed, W. Nicol Keith, William G. Helferich, Xujuan Yang

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes.

Original languageEnglish (US)
Pages (from-to)S151-S184
JournalSeminars in Cancer Biology
Volume35
DOIs
StatePublished - Dec 1 2015

Keywords

  • Cancer
  • Hallmarks
  • Inflammation
  • Phytochemicals
  • Tumor

ASJC Scopus subject areas

  • Cancer Research

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