A multimodal sono-contrast NIR spectroscopy system for breast cancer diagnosis: System design and safety considerations

Kaiguo Yan; Ke Huang; Tarun Podder; Yan Yu; Lydia Liao

doi:10.1109/BMEI.2010.5639396

A multimodal sono-contrast NIR spectroscopy system for breast cancer diagnosis: System design and safety considerations

Kaiguo Yan, Ke Huang, Tarun Podder, Yan Yu, Lydia Liao

Medical Laboratory, Imaging and Radiologic Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

This paper presents a novel multimodal imaging system, which combines optical spectroscopy, ultrasonography and acoustic radiation force (ARF) for improving diagnosis of breast cancer based on noninvasive interrogation of vasculature. System design including both hardware and software is described in detail. Patient safety related considerations are also addressed in this paper. Calibrations and tests have been performed accordingly. Based on safety guidelines, the maximum exposure to skin for laser was controlled within 0.2 W·cm^-2; exposure from ARF fields were maintained below the FDA diagnostic limit (0.72 W·cm^-2), and electrical leakage was controlled below 300 μA. This multimodal system has the potential to improve tumor detection by deploying ARF to produce a measurable difference in the dynamic behavior of the tissue blood supply environment as interrogated by optical spectroscopy, which was demonstrated to be highly diagnostic in a murine tumor model. Pilot clinical study is being carried out.

Original language	English (US)
Title of host publication	Proceedings - 2010 3rd International Conference on Biomedical Engineering and Informatics, BMEI 2010
Pages	1386-1390
Number of pages	5
Volume	4
DOIs	https://doi.org/10.1109/BMEI.2010.5639396
State	Published - Dec 1 2010
Event	3rd International Conference on BioMedical Engineering and Informatics, BMEI 2010 - Yantai, China Duration: Oct 16 2010 → Oct 18 2010

Other

Other	3rd International Conference on BioMedical Engineering and Informatics, BMEI 2010
Country/Territory	China
City	Yantai
Period	10/16/10 → 10/18/10

Keywords

ARF
Breast cancer
Multimodal imaging system
Optical spectroscopy

ASJC Scopus subject areas

Biomedical Engineering
Health Informatics
Health Information Management

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10.1109/BMEI.2010.5639396

Cite this

A multimodal sono-contrast NIR spectroscopy system for breast cancer diagnosis : System design and safety considerations. / Yan, Kaiguo; Huang, Ke; Podder, Tarun et al.

Proceedings - 2010 3rd International Conference on Biomedical Engineering and Informatics, BMEI 2010. Vol. 4 2010. p. 1386-1390 5639396.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Yan, K, Huang, K, Podder, T, Yu, Y & Liao, L 2010, A multimodal sono-contrast NIR spectroscopy system for breast cancer diagnosis: System design and safety considerations. in Proceedings - 2010 3rd International Conference on Biomedical Engineering and Informatics, BMEI 2010. vol. 4, 5639396, pp. 1386-1390, 3rd International Conference on BioMedical Engineering and Informatics, BMEI 2010, Yantai, China, 10/16/10. https://doi.org/10.1109/BMEI.2010.5639396

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abstract = "This paper presents a novel multimodal imaging system, which combines optical spectroscopy, ultrasonography and acoustic radiation force (ARF) for improving diagnosis of breast cancer based on noninvasive interrogation of vasculature. System design including both hardware and software is described in detail. Patient safety related considerations are also addressed in this paper. Calibrations and tests have been performed accordingly. Based on safety guidelines, the maximum exposure to skin for laser was controlled within 0.2 W·cm-2; exposure from ARF fields were maintained below the FDA diagnostic limit (0.72 W·cm-2), and electrical leakage was controlled below 300 μA. This multimodal system has the potential to improve tumor detection by deploying ARF to produce a measurable difference in the dynamic behavior of the tissue blood supply environment as interrogated by optical spectroscopy, which was demonstrated to be highly diagnostic in a murine tumor model. Pilot clinical study is being carried out.",

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AB - This paper presents a novel multimodal imaging system, which combines optical spectroscopy, ultrasonography and acoustic radiation force (ARF) for improving diagnosis of breast cancer based on noninvasive interrogation of vasculature. System design including both hardware and software is described in detail. Patient safety related considerations are also addressed in this paper. Calibrations and tests have been performed accordingly. Based on safety guidelines, the maximum exposure to skin for laser was controlled within 0.2 W·cm-2; exposure from ARF fields were maintained below the FDA diagnostic limit (0.72 W·cm-2), and electrical leakage was controlled below 300 μA. This multimodal system has the potential to improve tumor detection by deploying ARF to produce a measurable difference in the dynamic behavior of the tissue blood supply environment as interrogated by optical spectroscopy, which was demonstrated to be highly diagnostic in a murine tumor model. Pilot clinical study is being carried out.

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A multimodal sono-contrast NIR spectroscopy system for breast cancer diagnosis: System design and safety considerations

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