TY - GEN
T1 - A multimodal sono-contrast NIR spectroscopy system for breast cancer diagnosis
T2 - 3rd International Conference on BioMedical Engineering and Informatics, BMEI 2010
AU - Yan, Kaiguo
AU - Huang, Ke
AU - Podder, Tarun
AU - Yu, Yan
AU - Liao, Lydia
PY - 2010
Y1 - 2010
N2 - This paper presents a novel multimodal imaging system, which combines optical spectroscopy, ultrasonography and acoustic radiation force (ARF) for improving diagnosis of breast cancer based on noninvasive interrogation of vasculature. System design including both hardware and software is described in detail. Patient safety related considerations are also addressed in this paper. Calibrations and tests have been performed accordingly. Based on safety guidelines, the maximum exposure to skin for laser was controlled within 0.2 W·cm-2; exposure from ARF fields were maintained below the FDA diagnostic limit (0.72 W·cm-2), and electrical leakage was controlled below 300 μA. This multimodal system has the potential to improve tumor detection by deploying ARF to produce a measurable difference in the dynamic behavior of the tissue blood supply environment as interrogated by optical spectroscopy, which was demonstrated to be highly diagnostic in a murine tumor model. Pilot clinical study is being carried out.
AB - This paper presents a novel multimodal imaging system, which combines optical spectroscopy, ultrasonography and acoustic radiation force (ARF) for improving diagnosis of breast cancer based on noninvasive interrogation of vasculature. System design including both hardware and software is described in detail. Patient safety related considerations are also addressed in this paper. Calibrations and tests have been performed accordingly. Based on safety guidelines, the maximum exposure to skin for laser was controlled within 0.2 W·cm-2; exposure from ARF fields were maintained below the FDA diagnostic limit (0.72 W·cm-2), and electrical leakage was controlled below 300 μA. This multimodal system has the potential to improve tumor detection by deploying ARF to produce a measurable difference in the dynamic behavior of the tissue blood supply environment as interrogated by optical spectroscopy, which was demonstrated to be highly diagnostic in a murine tumor model. Pilot clinical study is being carried out.
KW - ARF
KW - Breast cancer
KW - Multimodal imaging system
KW - Optical spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=78650647011&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650647011&partnerID=8YFLogxK
U2 - 10.1109/BMEI.2010.5639396
DO - 10.1109/BMEI.2010.5639396
M3 - Conference contribution
AN - SCOPUS:78650647011
SN - 9781424464968
T3 - Proceedings - 2010 3rd International Conference on Biomedical Engineering and Informatics, BMEI 2010
SP - 1386
EP - 1390
BT - Proceedings - 2010 3rd International Conference on Biomedical Engineering and Informatics, BMEI 2010
Y2 - 16 October 2010 through 18 October 2010
ER -
