Novyǐ klass kardiotonicheskikh steroidov.

Translated title of the contribution: A new class of cardiotonic steroids

A. V. Kamernitskiǐ, I. A. Kutnevich, I. G. Reshetova, E. I. Chernoburova, Boris A Gorshkov, I. A. Gorshkova, I. I. Kapustina

Research output: Contribution to journalLetter

4 Scopus citations

Abstract

A series of 23-oxosteroid derivatives have been synthesized and tested for their inhibiting Na+, K(+)-dependent ATPase from rat brain in the 1 x 10(-6)-1 x 10(-4) M concentrations. Natural 23-oxogenins from sea star Asterias amurensis and synthetic monoesters showed the inhibiting activity upto 50-55%. These compounds caused heart contraction in frogs at the level of the known cardiotonic strophanthin G, and inotropic activity on isolated heart of mollusk Spisula sachalinensis.

Original languageRussian
Pages (from-to)141-143
Number of pages3
JournalBioorganicheskaia khimiia
Volume17
Issue number1
StatePublished - Jan 1 1991

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kamernitskiǐ, A. V., Kutnevich, I. A., Reshetova, I. G., Chernoburova, E. I., Gorshkov, B. A., Gorshkova, I. A., & Kapustina, I. I. (1991). Novyǐ klass kardiotonicheskikh steroidov. Bioorganicheskaia khimiia, 17(1), 141-143.