Novyǐ klass kardiotonicheskikh steroidov.

Translated title of the contribution: A new class of cardiotonic steroids

A. V. Kamernitskiǐ, I. A. Kutnevich, I. G. Reshetova, E. I. Chernoburova, Boris A Gorshkov, I. A. Gorshkova, I. I. Kapustina

Research output: Contribution to journalLetter

4 Scopus citations

Abstract

A series of 23-oxosteroid derivatives have been synthesized and tested for their inhibiting Na+, K(+)-dependent ATPase from rat brain in the 1 x 10(-6)-1 x 10(-4) M concentrations. Natural 23-oxogenins from sea star Asterias amurensis and synthetic monoesters showed the inhibiting activity upto 50-55%. These compounds caused heart contraction in frogs at the level of the known cardiotonic strophanthin G, and inotropic activity on isolated heart of mollusk Spisula sachalinensis.

Translated title of the contributionA new class of cardiotonic steroids
Original languageRussian
Pages (from-to)141-143
Number of pages3
JournalBioorganicheskaia khimiia
Volume17
Issue number1
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Medicine(all)

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    Kamernitskiǐ, A. V., Kutnevich, I. A., Reshetova, I. G., Chernoburova, E. I., Gorshkov, B. A., Gorshkova, I. A., & Kapustina, I. I. (1991). Novyǐ klass kardiotonicheskikh steroidov. Bioorganicheskaia khimiia, 17(1), 141-143.