Novyǐ klass kardiotonicheskikh steroidov.

Translated title of the contribution: A new class of cardiotonic steroids

A. V. Kamernitskiǐ, I. A. Kutnevich, I. G. Reshetova, E. I. Chernoburova, B. A. Gorshkov, I. A. Gorshkova, I. I. Kapustina

Research output: Contribution to journalLetter

4 Citations (Scopus)

Abstract

A series of 23-oxosteroid derivatives have been synthesized and tested for their inhibiting Na+, K(+)-dependent ATPase from rat brain in the 1 x 10(-6)-1 x 10(-4) M concentrations. Natural 23-oxogenins from sea star Asterias amurensis and synthetic monoesters showed the inhibiting activity upto 50-55%. These compounds caused heart contraction in frogs at the level of the known cardiotonic strophanthin G, and inotropic activity on isolated heart of mollusk Spisula sachalinensis.

Original languageRussian
Pages (from-to)141-143
Number of pages3
JournalBioorganicheskaia khimiia
Volume17
Issue number1
StatePublished - Jan 1 1991

Fingerprint

Cardiac Glycosides
Spisula
Asterias
Strophanthins
Ketosteroids
Starfish
Cardiotonic Agents
Mollusca
Anura
Stars
Adenosine Triphosphatases
Rats
Brain
Derivatives

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry

Cite this

Kamernitskiǐ, A. V., Kutnevich, I. A., Reshetova, I. G., Chernoburova, E. I., Gorshkov, B. A., Gorshkova, I. A., & Kapustina, I. I. (1991). Novyǐ klass kardiotonicheskikh steroidov. Bioorganicheskaia khimiia, 17(1), 141-143.

Novyǐ klass kardiotonicheskikh steroidov. / Kamernitskiǐ, A. V.; Kutnevich, I. A.; Reshetova, I. G.; Chernoburova, E. I.; Gorshkov, B. A.; Gorshkova, I. A.; Kapustina, I. I.

In: Bioorganicheskaia khimiia, Vol. 17, No. 1, 01.01.1991, p. 141-143.

Research output: Contribution to journalLetter

Kamernitskiǐ, AV, Kutnevich, IA, Reshetova, IG, Chernoburova, EI, Gorshkov, BA, Gorshkova, IA & Kapustina, II 1991, 'Novyǐ klass kardiotonicheskikh steroidov.', Bioorganicheskaia khimiia, vol. 17, no. 1, pp. 141-143.
Kamernitskiǐ AV, Kutnevich IA, Reshetova IG, Chernoburova EI, Gorshkov BA, Gorshkova IA et al. Novyǐ klass kardiotonicheskikh steroidov. Bioorganicheskaia khimiia. 1991 Jan 1;17(1):141-143.
Kamernitskiǐ, A. V. ; Kutnevich, I. A. ; Reshetova, I. G. ; Chernoburova, E. I. ; Gorshkov, B. A. ; Gorshkova, I. A. ; Kapustina, I. I. / Novyǐ klass kardiotonicheskikh steroidov. In: Bioorganicheskaia khimiia. 1991 ; Vol. 17, No. 1. pp. 141-143.
@article{25ea8c137dd14e138d1891c318e0d717,
title = "Novyǐ klass kardiotonicheskikh steroidov.",
abstract = "A series of 23-oxosteroid derivatives have been synthesized and tested for their inhibiting Na+, K(+)-dependent ATPase from rat brain in the 1 x 10(-6)-1 x 10(-4) M concentrations. Natural 23-oxogenins from sea star Asterias amurensis and synthetic monoesters showed the inhibiting activity upto 50-55{\%}. These compounds caused heart contraction in frogs at the level of the known cardiotonic strophanthin G, and inotropic activity on isolated heart of mollusk Spisula sachalinensis.",
author = "Kamernitskiǐ, {A. V.} and Kutnevich, {I. A.} and Reshetova, {I. G.} and Chernoburova, {E. I.} and Gorshkov, {B. A.} and Gorshkova, {I. A.} and Kapustina, {I. I.}",
year = "1991",
month = "1",
day = "1",
language = "Russian",
volume = "17",
pages = "141--143",
journal = "Bioorganicheskaya Khimiya",
issn = "0132-3423",
publisher = "Izdatel'stvo Nauka",
number = "1",

}

TY - JOUR

T1 - Novyǐ klass kardiotonicheskikh steroidov.

AU - Kamernitskiǐ, A. V.

AU - Kutnevich, I. A.

AU - Reshetova, I. G.

AU - Chernoburova, E. I.

AU - Gorshkov, B. A.

AU - Gorshkova, I. A.

AU - Kapustina, I. I.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - A series of 23-oxosteroid derivatives have been synthesized and tested for their inhibiting Na+, K(+)-dependent ATPase from rat brain in the 1 x 10(-6)-1 x 10(-4) M concentrations. Natural 23-oxogenins from sea star Asterias amurensis and synthetic monoesters showed the inhibiting activity upto 50-55%. These compounds caused heart contraction in frogs at the level of the known cardiotonic strophanthin G, and inotropic activity on isolated heart of mollusk Spisula sachalinensis.

AB - A series of 23-oxosteroid derivatives have been synthesized and tested for their inhibiting Na+, K(+)-dependent ATPase from rat brain in the 1 x 10(-6)-1 x 10(-4) M concentrations. Natural 23-oxogenins from sea star Asterias amurensis and synthetic monoesters showed the inhibiting activity upto 50-55%. These compounds caused heart contraction in frogs at the level of the known cardiotonic strophanthin G, and inotropic activity on isolated heart of mollusk Spisula sachalinensis.

UR - http://www.scopus.com/inward/record.url?scp=17044447655&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17044447655&partnerID=8YFLogxK

M3 - Letter

VL - 17

SP - 141

EP - 143

JO - Bioorganicheskaya Khimiya

JF - Bioorganicheskaya Khimiya

SN - 0132-3423

IS - 1

ER -